Cited by 403

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Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease

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Talavera, Karel, Startek, Justyna B., Alvarez-Collazo, Julio, Boonen, Brett, Alpizar, Yeranddy A., Sanchez, Alicia, Naert, Robbe, Nilius, Bernd·2020·Physiological Reviews

DOI 10.1152/physrev.00005.2019

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Abstract

The transient receptor potential ankyrin (TRPA) channels are Ca 2+ -permeable nonselective cation channels remarkably conserved through the animal kingdom. Mammals have only one member, TRPA1, which is widely expressed in sensory neurons and in non-neuronal cells (such as epithelial cells and hair cells). TRPA1 owes its name to the presence of 14 ankyrin repeats located in the NH 2 terminus of the channel, an unusual structural feature that may be relevant to its interactions with intracellular components. TRPA1 is primarily involved in the detection of an extremely wide variety of exogenous stimuli that may produce cellular damage. This includes a plethora of electrophilic compounds that interact with nucleophilic amino acid residues in the channel and many other chemically unrelated compounds whose only common feature seems to be their ability to partition in the plasma membrane. TRPA1 has been reported to be activated by cold, heat, and mechanical stimuli, and its function is modulated by multiple factors, including Ca 2+ , trace metals, pH, and reactive oxygen, nitrogen, and carbonyl species. TRPA1 is involved in acute and chronic pain as well as inflammation, plays key roles in the pathophysiology of nearly all organ systems, and is an attractive target for the treatment of related diseases. Here we review the current knowledge about the mammalian TRPA1 channel, linking its unique structure, widely tuned sensory properties, and complex regulation to its roles in multiple pathophysiological conditions.

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Dissociation of rewarding, anti‐aversive and anti‐nociceptive effects of different classes of anti‐nociceptives in the rat
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Identification of a putative binding site critical for general anesthetic activation of TRPA1
Ton, H. T., Phan, T. X., Abramyan, A. M., Shi, L., & Ahern, G. P. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618144114 · Cited by 52
Behavioural alterations and morphological changes are attenuated by the lack of TRPA1 receptors in the cuprizone-induced demyelination model in mice
Bölcskei, K., Kriszta, G., Sághy, É., Payrits, M., Sipos, É., Vranesics, A., Berente, Z., Ábrahám, H., Ács, P., Komoly, S., et al. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.03.020 · Cited by 52
Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1‐independent effects
Capasso, R., Aviello, G., Romano, B., Borrelli, F., PETROCELLIS, L. D., Marzo, V. D., & Izzo, A. A. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01703.x · Cited by 51
Distinct expression of cold receptors (TRPM8 and TRPA1) in the rat nodose–petrosal ganglion complex
Hondoh, A., Ishida, Y., Ugawa, S., Ueda, T., Shibata, Y., Yamada, T., Shikano, M., Murakami, S., & Shimada, S. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.016 · Cited by 51
Cinnamaldehyde inhibits L-type calcium channels in mouse ventricular cardiomyocytes and vascular smooth muscle cells
Alvarez‐Collazo, J., Alonso-Carbajo, L., Lopez-Medina, A. I., Alpizar, Y. A., Tajada, S., Nilius, B., Voets, T., López‐López, J. R., Talavera, K., Pérez-García, M. T., et al. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1472-8 · Cited by 51
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Nitro-Oleic Acid Inhibits Firing and Activates TRPV1- and TRPA1-Mediated Inward Currents in Dorsal Root Ganglion Neurons from Adult Male Rats
Sculptoreanu, A., Kullmann, F. A., Artim, D. E., Bazley, F. A., Schopfer, F. J., Woodcock, S. R., Freeman, B. Α., & de Groat, W. C. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.163154 · Cited by 51
Quaternary Lidocaine Derivative QX-314 Activates and Permeates Human TRPV1 and TRPA1 to Produce Inhibition of Sodium Channels and Cytotoxicity
Stueber, T., Eberhardt, M. J., Hadamitzky, C., Jangra, A., Schenk, S., Dick, F., Stoetzer, C., Kistner, K., Reeh, P. W., Binshtok, A. M., et al. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001050 · Cited by 51
Chapter 11 Bv8/Prokineticins and their Receptors
Negri, L., Lattanzi, R., Giannini, E., Canestrelli, M., Nicotra, A., & Melchiorri, P. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85011-3 · Cited by 51
TRPA 1 gene polymorphisms and childhood asthma
Gallo, V., Dijk, F. N., Holloway, J. W., Ring, S. M., Koppelman, G. H., Postma, D. S., Strachan, D. P., Granell, R., de Jongste, J. C., Jaddoe, V. W. V., et al. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12673 · Cited by 51
Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation
Alvarenga, E. M., de Souza, L. K. M., Araújo, T. S. L., Nogueira, K. D. M., Sousa, F. B. M., de Araújo, A. R., Martins, C. S., Pacífico, D. M., Brito, G. A. D. C., de Souza, E. P., et al. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.11.009 · Cited by 51
Enhanced chemosensory sensitivity in patients with idiopathic rhinitis and its reversal by nasal capsaicin treatment
Gerven, L. V., Alpizar, Y. A., Steelant, B., Callebaut, I., Krohn, I. K., Wouters, M. M., Vermeulen, F. L., Boeckxstaens, G. E., Talavera, K., & Hellings, P. W. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.03.014 · Cited by 51
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A comparative study on the therapeutic effect of TRPV 1, TRPA 1, and TRPM 8 agonists on swallowing dysfunction associated with aging and neurological diseases
Álvarez-Berdugo, D., Rofes, L., Arreola, V., Martín, A., Molina, L. M., & Clavé, P. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13185 · Cited by 51
G-protein coupled receptors regulating cough
Maher, S. A., Dubuis, E. D., & Belvisi, M. G. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.06.005 · Cited by 50
Numbing the Senses: Role of TRPA1 in Mechanical and Cold Sensation
Story, G. M., & Gereau, R. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.009 · Cited by 50
TRP Channels and Thermosensation
Voets, T. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-05161-1_1 · Cited by 50
Comprehensive thermal preference phenotyping in mice using a novel automated circular gradient assay
Touška, F., Winter, Z., Mueller, A., Vlachová, V., Larsen, J. D., & Zimmermann, K. (2016) · Temperature · doi:10.1080/23328940.2015.1135689 · Cited by 50
Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice
So, K., Tei, Y., Zhao, M., Miyake, T., Hiyama, H., Shirakawa, H., Imai, S., Mori, Y., Nakagawa, T., Matsubara, K., et al. (2016) · Scientific Reports · doi:10.1038/srep23261 · Cited by 50
TRP Channels as Therapeutic Targets in Diabetes and Obesity
Zsombok, A., & Derbenev, A. V. (2016) · Pharmaceuticals · doi:10.3390/ph9030050 · Cited by 50
Roles of Transient Receptor Potential Ankyrin 1 in Oxaliplatin-Induced Peripheral Neuropathy
Nakagawa, T., & Kaneko, S. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00243 · Cited by 50
A Human TRPA1-Specific Pain Model
Heber, S., Gold-Binder, M., Ciotu, C. I., Witek, M., Ninidze, N., Kress, H. G., & Fischer, M. J. M. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.3048-18.2019 · Cited by 50
Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase
Al‐Shamlan, F., & El‐Hashim, A. Z. (2019) · Respiratory Research · doi:10.1186/s12931-019-1060-8 · Cited by 50
Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post‐inflammatory rat model for irritable bowel syndrome
Ceuleers, H., Hanning, N., Heirbaut, J., Van Remoortel, S., Joossens, J., Van Der Veken, P., Francque, S. M., De bruyn, M., Lambeir, A., De Man, J. G., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14396 · Cited by 49
Effects of methylglyoxal on human cardiac fibroblast: roles of transient receptor potential ankyrin 1 (TRPA1) channels
Oguri, G., Nakajima, T., Yamamoto, Y., Takano, N., Tanaka, T., Kikuchi, H., Morita, T., Nakamura, F., Yamasoba, T., & Komuro, I. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01021.2013 · Cited by 49
Colonic Hydrogen Sulfide^|^ndash;Induced Visceral Pain and Referred Hyperalgesia Involve Activation of Both Cav3.2 and TRPA1 Channels in Mice
Tsubota‐Matsunami, M., Noguchi, Y., Okawa, Y., Sekiguchi, F., & Kawabata, A. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12086sc · Cited by 49
The anti-diabetic drug glibenclamide is an agonist of the transient receptor potential Ankyrin 1 (TRPA1) ion channel
Babeș, A., Fischer, M. J. M., Filipović, M. R., Engel, M. A., Flonta, M., & Reeh, P. W. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.02.018 · Cited by 49
Somatosensory and vasomotor manifestations of individual and combined stimulation of TRPM 8 and TRPA 1 using topical L ‐menthol and trans‐cinnamaldehyde in healthy volunteers
Olsen, R. V., Andersen, H. H., Møller, H. G., Eskelund, P. W., & Arendt‐Nielsen, L. (2014) · European Journal of Pain · doi:10.1002/j.1532-2149.2014.494.x · Cited by 49
Resiniferatoxin Mediated Ablation of TRPV1+ Neurons Removes TRPA1 as Well
Pecze, L., Pelsőczi, P., Kecskés, M., Winter, Z., Papp, A., Kaszás, K., Letoha, T., Vízler, C., & Oláh, Z. (2009) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100006600 · Cited by 49
Effect of cigarette smoking on cough reflex induced by TRPV1 and TRPA1 stimulations
Kanezaki, M., Ebihara, S., Gui, P., Ebihara, T., & Kohzuki, M. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.12.007 · Cited by 48
Role of Transient Receptor Potential Channels in Intestinal Inflammation and Visceral Pain: Novel Targets in Inflammatory Bowel Diseases
Zielińska, M., Jarmuż, A., Wasilewski, A., Sałaga, M., & Fichna, J. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000234 · Cited by 48
Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner
Fernandes, E. S., Russell, F. A., Alawi, K. M., Sand, C. A., Liang, L., Salamon, R., Bodkin, J. V., Aubdool, A. A., Arno, M. J., Gentry, C., et al. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0905-x · Cited by 48
Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia and urinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis
Meotti, F. C., Forner, S., Lima-Garcia, J. F., et al. (2013) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2013.03.008 · Cited by 47
Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1
Liang, J., Ji, Q., & Ji, W. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.009 · Cited by 47
Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1- and TRPM8-containing small sensory neurons
Mizushima, T., Obata, K., Katsura, H., Yamanaka, H., Kobayashi, K., Dai, Y., Fukuoka, T., Tokunaga, A., Mashimo, T., & Noguchi, K. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.024 · Cited by 47
Neuro-immune interactions in chemical-induced airway hyperreactivity
Devos, F. C., Boonen, B., Alpizar, Y. A., Maes, T., Hox, V., Seys, S., Pollaris, L., Liston, A., Nemery, B., Talavera, K., et al. (2016) · European Respiratory Journal · doi:10.1183/13993003.01778-2015 · Cited by 47
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TRPA1 Channels
Laursen, W. J., Bagriantsev, S. N., & Gracheva, E. O. (2014) · Current topics in membranes · doi:10.1016/b978-0-12-800181-3.00004-x · Cited by 47
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1
Samad, A., Sura, L., Benedikt, J., Ettrich, R. H., Minofar, B., Teisinger, J., & Vlachová, V. (2010) · Biochemical Journal · doi:10.1042/bj20101256 · Cited by 46
Characterization of Two Models of Drug-Induced Constipation in Mice and Evaluation of Mustard Oil in These Models
Kojima, R., Doihara, H., Nozawa, K., Kawabata-Shoda, E., Yokoyama, T., & Ito, H. (2009) · Pharmacology · doi:10.1159/000236524 · Cited by 46
H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying
Guntur, A. R., Gou, B., Gu, P., He, R., Stern, U., Xiang, Y., & Yang, C.-H. (2016) · Genetics · doi:10.1534/genetics.116.195172 · Cited by 46
Transient receptor potential ankyrin 1: emerging pharmacology and indications for cardiovascular biology
Bodkin, J. V., & Brain, S. D. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02203.x · Cited by 45
Icilin induces a hyperthermia in rats that is dependent on nitric oxide production and NMDA receptor activation
Ding, Z., Gómez, T., Werkheiser, J. L., Cowan, A., & Rawls, S. M. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.030 · Cited by 45
Transient receptor potential channels in bladder function
Avelino, A., Charrua, A., Frias, B., Cruz, C. D., Boudes, M., Ridder, D. J. M. K. D., & Cruz, F. (2012) · Acta Physiologica · doi:10.1111/apha.12021 · Cited by 45
Transient Receptor Potential Vanilloid-1 (TRPV1) and Ankyrin-1 (TRPA1) Participate in Visceral Hyperalgesia in Chronic Water Avoidance Stress Rat Model
Yu, Y., Yang, J., Zuo, X., Gao, L., Wang, P., & Li, Y. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0137-z · Cited by 45
Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner
Komatsu, T., Uchida, K., Fujita, F., Zhou, Y., & Tominaga, M. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1069-4 · Cited by 45
Differences in the Chemesthetic Subqualities of Capsaicin, Ibuprofen, and Olive Oil
Bennett, S. M., & Hayes, J. E. (2012) · Chemical Senses · doi:10.1093/chemse/bjr129 · Cited by 45
Review article: transient receptor potential channels as possible therapeutic targets in irritable bowel syndrome
Beckers, A. B., Weerts, Z. Z. R. M., Helyes, Z., Masclee, A., & Keszthelyi, D. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14294 · Cited by 45
The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1‐mediated hypothermia and is associated with prostaglandin inhibition in the brain
Mirrasekhian, E., Nilsson, J. L. Å., Shionoya, K., Blomgren, A., Zygmunt, P. M., Engblom, D., Högestôtt, E. D., & Blomqvist, A. (2018) · The FASEB Journal · doi:10.1096/fj.201800272r · Cited by 44
Sensitization of the trigeminovascular system following environmental irritant exposure
Kunkler, P. E., Zhang, L., Pellman, J. J., Oxford, G. S., & Hurley, J. H. (2015) · Cephalalgia · doi:10.1177/0333102415574845 · Cited by 44
Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture
Pittman, S. K., Gracias, N. G., Vasko, M. R., & Fehrenbacher, J. C. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.011 · Cited by 44
Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons
Patil, M. J., Patwardhan, A. M., Salas, M. M., Hargreaves, K., & Akopian, A. N. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.024 · Cited by 44
Cigarette smoke has sensory effects through nicotinic and TRPA1 but not TRPV1 receptors on the isolated mouse trachea and larynx
Kichko, T. I., Kobal, G., & Reeh, P. W. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00164.2015 · Cited by 44
Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence
Du, E. J., Ahn, T. J., Wen, X., Seo, D., Na, D. L., Kwon, J. Y., Choi, M., Kim, H., Cho, H., & Kang, K. (2016) · eLife · doi:10.7554/elife.18425 · Cited by 44
TRPA1 and TRPV1 Antagonists Do Not Inhibit Human Acidosis-Induced Pain
Schwarz, M. G., Namer, B., Reeh, P. W., & Fischer, M. J. M. (2017) · Journal of Pain · doi:10.1016/j.jpain.2016.12.011 · Cited by 44
The planarian TRPA1 homolog mediates extraocular behavioral responses to near ultraviolet light
Birkholz, T. R., & Beane, W. S. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.152298 · Cited by 44
Effects of curcumin and curcumin analogues on TRP channels
Nalli, M., Ortar, G., Moriello, A. S., Marzo, V. D., & PETROCELLIS, L. D. (2017) · Fitoterapia · doi:10.1016/j.fitote.2017.09.007 · Cited by 44
The roles of TRPV1, TRPA1 and TRPM8 channels in chemical and thermal sensitivity of the mouse oral mucosa
Kichko, T. I., Neuhuber, W., Kobal, G., & Reeh, P. W. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13799 · Cited by 44
The Use of Cystometry in Small Rodents: A Study of Bladder Chemosensation
Uvin, P., Everaerts, W., Pinto, S., Alpizar, Y. A., Boudes, M., Gevaert, T., Voets, T., Nilius, B., Talavera, K., & Ridder, D. J. M. K. D. (2012) · Journal of Visualized Experiments · doi:10.3791/3869 · Cited by 43
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A Human Surrogate Model of Itch Utilizing the TRPA1 Agonist Trans-cinnamaldehyde
Højland, C. R., Andersen, H. H., Poulsen, J., Arendt‐Nielsen, L., & Gazerani, P. (2014) · Acta Dermato Venereologica · doi:10.2340/00015555-2103 · Cited by 43
Cinnamaldehyde and cinnamaldehyde-containing micelles induce relaxation of isolated porcine coronary arteries: role of nitric oxide and calcium
Raffai, G., Kim, B., Park, S., Khang, G., Lee, D., & Vanhoutte, P. M. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s56578 · Cited by 43
Differential interactions of bacterial lipopolysaccharides with lipid membranes: implications for TRPA1-mediated chemosensation
Startek, J. B., Talavera, K., Voets, T., & Alpizar, Y. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-30534-2 · Cited by 43
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Umbellulone modulates TRP channels
Zhong, J., Minassi, A., Prenen, J., Taglialatela‐Scafati, O., Appendino, G., & Nilius, B. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1043-1 · Cited by 42
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Methylglyoxal activates the human transient receptor potential ankyrin 1 channel
Ohkawara, S., Tanaka‐Kagawa, T., Furukawa, Y., & Jinno, H. (2012) · The Journal of Toxicological Sciences · doi:10.2131/jts.37.831 · Cited by 42
Annexin A2 Regulates TRPA1-Dependent Nociception
Avenali, L., Narayanan, P., Rouwette, T., Cervellini, I., Sereda, M. W., Gómez‐Varela, D., & Schmidt, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1801-14.2014 · Cited by 42
Potential roles for calcium-sensing receptor (CaSR) and transient receptor potential ankyrin-1 (TRPA1) in murine anorectic response to deoxynivalenol (vomitoxin)
Wu, W., Zhou, H.-R., & Pestka, J. J. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1687-x · Cited by 42
The effect of neutralization of nerve growth factor (NGF) on bladder and urethral dysfunction in mice with spinal cord injury
Wada, N., Shimizu, T., Shimizu, N., de Groat, W. C., Kanai, A., Tyagi, P., Κakizaki, H., & Yoshimura, N. (2018) · Neurourology and Urodynamics · doi:10.1002/nau.23539 · Cited by 42
Mammalian cold TRP channels: impact on thermoregulation and energy homeostasis
Señarís, R. M., Ordás, P., Reimúndez, A., & Viana, F. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2145-9 · Cited by 42
TRPs in Tox: Involvement of Transient Receptor Potential-Channels in Chemical-Induced Organ Toxicity—A Structured Review
Steinritz, D., Stenger, B., Dietrich, A., Gudermann, T. W., & Popp, T. (2018) · Cells · doi:10.3390/cells7080098 · Cited by 42
Transient receptor potential channels as novel drug targets in respiratory diseases.
Nassini, R., Materazzi, S., Siena, G. D., et al. (2010) · PubMed · Cited by 41
TRPA1 mediates the effects of hypothermia on the monocyte inflammatory response
Billeter, A. T., Galbraith, N. J., Walker, S., Lawson, C., Gardner, S. A., Sarojini, H., Galandiuk, S., & Polk, H. C. (2015) · Surgery · doi:10.1016/j.surg.2015.03.065 · Cited by 41
Anatomical and functional characterization of a duodeno-pancreatic neural reflex that can induce acute pancreatitis
Li, C., Zhu, Y., Shenoy, M. M., Pai, R. K., Liu, L., & Pasricha, P. J. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00012.2012 · Cited by 41
Investigating the potential role of TRPA 1 in locomotion and cardiovascular control during hypertension
Bodkin, J. V., Thakore, P., Aubdool, A. A., Liang, L., Fernandes, E. S., Nandi, M., Spina, D., Clark, J., Aaronson, P. I., Shattock, M. J., et al. (2014) · Pharmacology Research & Perspectives · doi:10.1002/prp2.52 · Cited by 41
Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil
Yamaguchi, K., Ono, K., Hitomi, S., Sago-Ito, M., Nodai, T., Goto, T., Harano, N., Watanabe, S., Inoue, H., Miyano, K., et al. (2016) · Pain · doi:10.1097/j.pain.0000000000000498 · Cited by 41
Diet-induced obesity alters dural CGRP release and potentiates TRPA1-mediated trigeminovascular responses
Marics, B., Peitl, B., Varga, A., Pázmándi, K., Bácsi, A., Németh, J., Szilvássy, Z., Jancsó, G., & Dux, M. (2016) · Cephalalgia · doi:10.1177/0333102416654883 · Cited by 41
Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice: Links to calcitonin gene-related peptide and substance P
Utsumi, D., Matsumoto, K., Tsukahara, T., et al. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.12.012 · Cited by 41
trans-Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel
Memon, T. A., Yarishkin, O. V., Reilly, C. A., Križaj, D., Olivera, B. M., & Teichert, R. W. (2019) · Molecular Pharmacology · doi:10.1124/mol.118.114561 · Cited by 41
The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel
Logu, F. D., Puma, S. L., Landini, L., Tuccinardi, T., Poli, G., Preti, D., Siena, G. D., Patacchini, R., Tsagareli, M. G., Geppetti, P., et al. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.019 · Cited by 41
An ultrastructural evidence for the expression of transient receptor potential ankyrin 1 (TRPA1) in astrocytes in the rat trigeminal caudal nucleus.
Lee, S.-M., Cho, Y., Kim, T., Jin, M.-U., Ahn, D., Noguchi, K., & Bae, Y. (2012) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2012.07.003 · Cited by 40
Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain
Zayats, V., Samad, A., Minofar, B., Roelofs, K. E., Stockner, T., & Ettrich, R. H. (2012) · Journal of Molecular Modeling · doi:10.1007/s00894-012-1505-1 · Cited by 40
UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes
Bellono, N. W., Najera, J. A., & Oancea, E. (2014) · The Journal of General Physiology · doi:10.1085/jgp.201311094 · Cited by 40
Transient Receptor Potential Ankyrin 1 Channels Modulate Inflammatory Response in Respiratory Cells from Patients with Cystic Fibrosis
Prandini, P., Logu, F. D., Fusi, C., Provezza, L., Nassini, R., Montagner, G., Materazzi, S., Munari, S., Gilioli, E., Bezzerri, V., et al. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0089oc · Cited by 40
Recent Progress in the Discovery and Development of TRPA1 Modulators
Skerratt, S. E. (2017) · Progress in medicinal chemistry · doi:10.1016/bs.pmch.2016.11.003 · Cited by 40
Repeated exposure to temperature variation exacerbates airway inflammation through TRPA1 in a mouse model of asthma
Du, C., Kang, J. M., Yu, W., Chen, M., Li, B., Liu, H., & Wang, H. (2018) · Respirology · doi:10.1111/resp.13433 · Cited by 40
High Concentrations of Morphine Sensitize and Activate Mouse Dorsal Root Ganglia via TRPV1 and TRPA1 Receptors
Forster, A. B., Reeh, P. W., Meßlinger, K., & Fischer, M. J. M. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-17 · Cited by 39
Hydrogen Sulfide’s Involvement in Modulating Nociception
Smith, H. S. (2009) · Pain Physician · doi:10.36076/ppj.2009/12/901 · Cited by 39
Transient Receptor Potential Ankyrin 1 (TRPA1) Channel and Neurogenic Inflammation in Pathogenesis of Asthma
Yang, H., & Li, S. (2016) · Medical Science Monitor · doi:10.12659/msm.896557 · Cited by 39
Transient receptor potential ankyrin 1 agonists improve intestinal transit in a murine model of postoperative ileus
Tsuchiya, K., Kubota, K., Ohbuchi, K., Kaneko, A., Ohno, N., Mase, A., Matsushima, H., Yamamoto, M., Miyano, K., Uezono, Y., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12877 · Cited by 38
Agonist‐induced sensitisation of the irritant receptor ion channel TRPA1
Meents, J., Fischer, M. J. M., & McNaughton, P. A. (2016) · The Journal of Physiology · doi:10.1113/jp272237 · Cited by 38
TRPA1 mediated aggravation of allergic contact dermatitis induced by DINP and regulated by NF-κB activation
Kang, J. M., Ding, Y., Li, B., Liu, H., Yang, X., & Chen, M. (2017) · Scientific Reports · doi:10.1038/srep43586 · Cited by 38
BDNF overexpression in the bladder induces neuronal changes to mediate bladder overactivity
Kashyap, M. P., Pore, S. K., de Groat, W. C., Chermansky, C., Yoshimura, N., & Tyagi, P. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00386.2017 · Cited by 38
Transient Receptor Potential Ion Channels Mediate Adherens Junctions Dysfunction in a Toluene Diisocyanate-Induced Murine Asthma Model
Yao, L., Chen, S., Tang, H., Huang, P., Wei, S., Liang, Z., Chen, X., Wang, H., Tao, A., Chen, R., et al. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy285 · Cited by 38
The contribution of transient receptor potential ankyrin 1 (TRPA1) to the in vivo nociceptive effects of prostaglandin E2
Dall'Acqua, M. C., Bonet, I. J. M., Zampronio, A. R., Tambeli, C. H., Parada, C. A., & Fischer, L. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.02.031 · Cited by 37
Bimodal Concentration-Response of Nicotine Involves the Nicotinic Acetylcholine Receptor, Transient Receptor Potential Vanilloid Type 1, and Transient Receptor Potential Ankyrin 1 Channels in Mouse Trachea and Sensory Neurons
Kichko, T. I., Lennerz, J. K., Eberhardt, M. J., Babeș, R.-M., Neuhuber, W., Kobal, G., & Reeh, P. W. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.205971 · Cited by 37
Apomorphine Is a Bimodal Modulator of TRPA1 Channels
Schulze, A., Oehler, B., Urban, N. D., Schaefer, M., & Hill, K. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.081976 · Cited by 37
Loss of Transient Receptor Potential Ankyrin 1 Channel Deregulates Emotion, Learning and Memory, Cognition, and Social Behavior in Mice
Lee, K.-I., Lin, H., Lee, H., Tsai, F.-C., & Lee, T. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9908-0 · Cited by 37
Analgesic effect of dimethyl trisulfide in mice is mediated by TRPA1 and sst 4 receptors
Pozsgai, G., Payrits, M., Sághy, É., Sebestyén-Bátai, R., Steen, E., Szőke, É., Zoltán, S., Solymár, M., Garami, A., Orvos, P., et al. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.01.012 · Cited by 37
The S4–S5 linker – gearbox of TRP channel gating
Hofmann, L., Wang, H., Zheng, W., Philipp, S. E., Hidalgo, P., Cavalié, A., Chen, X., Beck, A., & Flockerzi, V. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.04.002 · Cited by 37
Peripheral Interaction of Resolvin D1 and E1 with Opioid Receptor Antagonists for Antinociception in Inflammatory Pain in Rats
Oehler, B., Mohammadi, M., Perpiñá-Viciano, C., Hackel, D., Hoffmann, C., Brack, A., & Rittner, H. L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00242 · Cited by 37
Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells
Sadofsky, L. R., Sreekrishna, K., Lin, Y., et al. (2014) · Cells · doi:10.3390/cells3020616 · Cited by 36
Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release
Hajna, Z., Sághy, É., Payrits, M., Aubdool, A. A., Szőke, É., Pozsgai, G., Bátai, I. Z., Nagy, L., Filotás, D., Helyes, Z., et al. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0802-z · Cited by 36
TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo
Alenmyr, L., Herrmann, A., Högestätt, E. D., Greiff, L., & Zygmunt, P. M. (2011) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2011.01039.x · Cited by 35
In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model
Nyman, E., Franzén, Nolting, Klement, Liu, Nilsson, Rosén, Bjork, Weigelt, Wollberg, et al. (2013) · Journal of Pain Research · doi:10.2147/jpr.s37567 · Cited by 35
Role of Transient Receptor Potential A1 in Gastric Nociception
Kondo, T., Oshima, T., Obata, K., Sakùrai, J., Knowles, C. H., Matsumoto, T., Noguchi, K., & Miwa, H. (2010) · Digestion · doi:10.1159/000310836 · Cited by 35
Methyl syringate, a TRPA1 agonist represses hypoxia-induced cyclooxygenase-2 in lung cancer cells
Park, J., Shim, M. K., Jin, M., Rhyu, M., & Lee, Y. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.01.009 · Cited by 35
Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel
Zímová, L., Sinica, V., Kádková, A., Vyklicka, L., Zima, V., Barvı́k, I., & Vlachová, V. (2018) · Science Signaling · doi:10.1126/scisignal.aan8621 · Cited by 35
Induction of total insensitivity to capsaicin and hypersensitivity to garlic extract in human by decreased expression of TRPV1
Park, J., Lee, J., Kim, M. A., Back, S. K., Hong, S. K., & Na, H. S. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.10.046 · Cited by 34
Cigarette smoke extract (CSE) induces transient receptor potential ankyrin 1(TRPA1) expression via activation of HIF1αin A549 cells
Nie, Y., Huang, C., Zhong, S., Wortley, M. A., Luo, Y.-L., Luo, W., Xie, Y., Lai, K., & Zhong, N. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.07.028 · Cited by 34
Effects of Food Components That Activate TRPA1 Receptors on Mucosal Ion Transport in the Mouse Intestine
Fothergill, L. J., Callaghan, B. P., Rivera, L. R., Lieu, T., Poole, D. P., Cho, H., Bravo, D., & Furness, J. B. (2016) · Nutrients · doi:10.3390/nu8100623 · Cited by 34
TRPA1 expression levels and excitability brake by K V channels influence cold sensitivity of TRPA1-expressing neurons
Memon, T. A., Chase, K., Leavitt, L. S., Olivera, B. M., & Teichert, R. W. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.001 · Cited by 34
β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system
Ohara, K., Fukuda, T., Ishida, Y., Takahashi, C., Ohya, R., Katayama, M., Uchida, K., Tominaga, M., & Nagai, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-16150-6 · Cited by 34
Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation
Griggs, R. B., Laird, D. E., Donahue, R. R., Fu, W., & Taylor, B. K. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00679 · Cited by 33
Tasty and healthy TR(i)Ps
Nilius, B., & Appendino, G. (2011) · EMBO Reports · doi:10.1038/embor.2011.200 · Cited by 33
Self-citation
How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy
Brewster, M. S. J., & Gaudet, R. (2015) · BioEssays · doi:10.1002/bies.201500085 · Cited by 33
Galangal Pungent Component, 1′-Acetoxychavicol Acetate, Activates TRPA1
Narukawa, M., Koizumi, K., Iwasaki, Y., Kubota, K., & Watanabe, T. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100133 · Cited by 33
Allergen challenge sensitizes TRPA1 in vagal sensory neurons and afferent C-fiber subtypes in guinea pig esophagus
Liu, Z., Hu, Y., Yu, X., Xi, J., Fan, X., Tse, C., Myers, A. C., Pasricha, P. J., Li, X. D., & Yu, S. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00374.2014 · Cited by 33
Effects of fuel components and combustion particle physicochemical properties on toxicological responses of lung cells
Jaramillo, I. C., Sturrock, A., Ghiassi, H., Woller, D. J., Deering‐Rice, C. E., Lighty, J. S., Paine, R., Reilly, C. A., & Kelly, K. E. (2017) · Journal of Environmental Science and Health Part A · doi:10.1080/10934529.2017.1400793 · Cited by 33
Effects of ginger and its pungent constituents on transient receptor potential channels
Kim, Y., Hong, C., Lee, S. W., Nam, J., & Kim, B. J. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2791 · Cited by 33
UV light phototransduction depolarizes human melanocytes
Bellono, N. W., & Oancea, E. (2013) · Channels · doi:10.4161/chan.25322 · Cited by 32
Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice
Mori, N., Kawabata, F., Matsumura, S., Hosokawa, H., Kobayashi, S., Inoue, K., & Fushiki, T. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00645.2009 · Cited by 32
Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats
Lehto, S. G., Weyer, A. D., Youngblood, B. D., Zhang, M., Yin, R., Wang, W., Teffera, Y., Cooke, M., Stucky, C. L., Schenkel, L. B., et al. (2016) · Molecular Pain · doi:10.1177/1744806916677761 · Cited by 32
A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation
Brackley, A. D., Gómez, R. S., Dietert, K., Akopian, A. N., Glucksman, M., Du, J., Carlton, S. M., & Jeske, N. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-01999-4 · Cited by 32
The Alkamide trans-Pellitorine Targets PPARγ via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes
Lieder, B., Zaunschirm, M., Holik, A., Ley, J. P., Hans, J., Krammer, G. E., & Somoza, V. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00316 · Cited by 32
TRPA1 sensitization during diabetic vascular impairment contributes to cold hypersensitivity in a mouse model of painful diabetic peripheral neuropathy
Hiyama, H., Yano, Y., So, K., Imai, S., Nagayasu, K., Shirakawa, H., Nakagawa, T., & Kaneko, S. (2018) · Molecular Pain · doi:10.1177/1744806918789812 · Cited by 32

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases
Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01464-x · Cited by 522
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients
Marchi, M., Salvi, E., Andelic, M., Mehmeti, E., D'Amato, I., Cazzato, D., Chiappori, F., Lombardi, R., Cartelli, D., Devigili, G., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002905 · Cited by 29
TRPA1 promotes melanosome phagocytosis in keratinocytes via PAR-2/CYLD axis
Wang, Y., Li, Z., Wu, W., Liu, Y., Xiao, Y., Qi, D., Zhao, G., Zhou, M., Wang, H., Liu, J., et al. (2022) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2022.05.005 · Cited by 12
Transient receptor potential Ankyrin‐1 (TRPA1) agonists suppress myelination and induce demyelination in organotypic cortical slices
Giacco, V., Flower, G., Artamonova, M., Hunter, J., Padilla Requerey, A., & Hamilton, N. B. (2023) · Glia · doi:10.1002/glia.24347 · Cited by 11

See all 403

Authors: Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2020-04-01
Volume: 100
Issue: 2
Pages: 725-803
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00005.2019
OpenAlex: W2987691534
Cited by: 403
References: 728
FWCI: 6.62
Type: journal article
Language: en
Open access: green

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Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease

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