Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease

A Painful Trp Can Be a Bonding Experience

Peterlin, Z. A., Chesler, A. T., & Firestein, S. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.011 · Cited by 31

Differential Expression and Functionality of TRPA1 Protein Genetic Variants in Conditions of Thermal Stimulation

May, D., Baastrup, J., Nientit, M. R., Binder, A., Schünke, M., Baron, R., & Cascorbi, I. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.341776 · Cited by 31

Nitro-oleic acid targets transient receptor potential (TRP) channels in capsaicin sensitive afferent nerves of rat urinary bladder

Artim, D. E., Bazely, F., Daugherty, S. L., Sculptoreanu, A., Koronowski, K. B., Schopfer, F. J., Woodcock, S. R., Freeman, B. Α., & de Groat, W. C. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.007 · Cited by 31

Plasma membrane stretch activates transient receptor potential vanilloid and ankyrin channels in Merkel cells from hamster buccal mucosa

Soya, M., Sato, M., Sobhan, U., et al. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.02.015 · Cited by 31

Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain

Kondo, T., Sakùrai, J., Miwa, H., & Noguchi, K. (2012) · Neuroreport · doi:10.1097/wnr.0b013e32835c7df2 · Cited by 31

Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids

Pollastro, F., Caprioglio, D., Marotta, P., Moriello, A. S., PETROCELLIS, L. D., Taglialatela‐Scafati, O., & Appendino, G. (2017) · Journal of Natural Products · doi:10.1021/acs.jnatprod.7b00946 · Cited by 31

Endothelin-1 Elicits TRP-Mediated Pain in an Acid-Induced Oral Ulcer Model

Nodai, T., Hitomi, S., Ono, K., Masaki, C., Harano, N., Morii, A., Sago-Ito, M., Ujihara, I., Hibino, T., Terawaki, K., et al. (2018) · Journal of Dental Research · doi:10.1177/0022034518762381 · Cited by 31

Pinosylvin Inhibits TRPA 1‐Induced Calcium Influx In Vitro and TRPA 1‐Mediated Acute Paw Inflammation In Vivo

Moilanen, L., Hämäläinen, M., Lehtimäki, L. A., Nieminen, R. M., Muraki, K., & Moilanen, E. (2015) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12485 · Cited by 30

ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons

Ren, A., Wang, K., Zhang, H., Liu, A., Ma, X., Liang, Q. D., Cao, D., Wood, J. N., He, D. Z. Z., Ding, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms5984 · Cited by 30

Thermosensitive Transient Receptor Potential (TRP) Channel Agonists and Their Role in Mechanical, Thermal and Nociceptive Sensations as Assessed Using Animal Models

Klein, A. H., Trannyguen, M., Joe, C. L., Carstens, M. I., & Carstens, E. (2015) · Chemosensory Perception · doi:10.1007/s12078-015-9176-9 · Cited by 30

Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate, capsaicin, and ATP in Sprague-Dawley rats

Hooper, J. S., Hadley, S. H., Morris, K. F., Breslin, J. W., Dean, J. B., & Taylor‐Clark, T. E. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00944.2015 · Cited by 30

Anorexic action of deoxynivalenol in hypothalamus and intestine

Tominaga, M., Momonaka, Y., Yokose, C., Tadaishi, M., Shimizu, M., Yamane, T., Oishi, Y., & Kobayashi, K. (2016) · Toxicon · doi:10.1016/j.toxicon.2016.04.036 · Cited by 30

Calcium-Sensing Receptor and Transient Receptor Ankyrin-1 Mediate Emesis Induction by Deoxynivalenol (Vomitoxin)

Wu, W., Zhou, H.-R., Bursian, S. J., Link, J. E., & Pestka, J. J. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw191 · Cited by 30

Sites Contributing to TRPA1 Activation by the Anesthetic Propofol Identified by Photoaffinity Labeling

Woll, K. A., Skinner, K. A., Gianti, E., Bhanu, N. V., Garcia, B. A., Carnevale, V., Eckenhoff, R. G., & Gaudet, R. (2017) · Biophysical Journal · doi:10.1016/j.bpj.2017.08.040 · Cited by 30

The role of transient receptor potential ankyrin 1 (TRPA1) channel in activation of single unit mechanosensitive bladder afferent activities in the rat

Minagawa, T., Aizawa, N., Igawa, Y., & Wyndaele, J. (2013) · Neurourology and Urodynamics · doi:10.1002/nau.22449 · Cited by 29

TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep

Yonemitsu, T., Kuroki, C., Takahashi, N., Mori, Y., Kanmura, Y., Kashiwadani, H., Ootsuka, Y., & Kuwaki, T. (2013) · Scientific Reports · doi:10.1038/srep03100 · Cited by 29

Inhibition of TRPA1 Channel Activity in Sensory Neurons by the Glial Cell Line-Derived Neurotrophic Factor Family Member, Artemin

Yoshida, N., Kobayashi, K., Yu, L., Wang, S., Na, R., Yamamoto, S., Noguchi, K., & Dai, Y. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-41 · Cited by 29

Transnitrosylation Directs TRPA1 Selectivity in N-Nitrosamine Activators

Kozai, D., Kabasawaa, Y., Ebert, M., Kiyonaka, S., Otani, Y., Numata, T., Takahashi, N., Mori, Y., & Ohwada, T. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.088864 · Cited by 29

Activation of Cold-Sensitive Channels TRPM8 and TRPA1 Inhibits the Proliferative Airway Smooth Muscle Cell Phenotype

Zhang, L., An, X., Wang, Q., et al. (2016) · Lung · doi:10.1007/s00408-016-9901-4 · Cited by 29

TRPA1 Mediates Aromatase Inhibitor–Evoked Pain by the Aromatase Substrate Androstenedione

Logu, F. D., Tonello, R., Materazzi, S., Nassini, R., Fusi, C., Coppi, E., Puma, S. L., Marone, I. M., Sadofsky, L. R., Morice, A. H., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1492 · Cited by 29

A novel TRPA1 variant is associated with carbamazepine‐responsive cramp‐fasciculation syndrome

Nirenberg, M. J., Chaouni, R., Biller, T., Gilbert, R., & Paisán‐Ruiz, C. (2017) · Clinical Genetics · doi:10.1111/cge.13040 · Cited by 29

TRPA1 mediates the cardiac effects of acrolein through parasympathetic dominance but also sympathetic modulation in mice

Kurhanewicz, N. A., Ledbetter, A. D., Farraj, A. K., & Hazari, M. S. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.03.027 · Cited by 29

Neuroimmune pharmacological approaches

Holzer, P. D., Hassan, A. M., Jain, P., Reichmann, F., & Farzi, A. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.003 · Cited by 28

Leucettamols, Bifunctionalized Marine Sphingoids, Act as Modulators of TRPA1 and TRPM8 Channels

Chianese, G., Fattorusso, E., Putra, M. Y., Calcinai, B., Bavestrello, G., Moriello, A. S., PETROCELLIS, L. D., Marzo, V. D., & Taglialatela‐Scafati, O. (2012) · Marine Drugs · doi:10.3390/md10112435 · Cited by 28

Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells.

Numazawa, S., Takase, M., Ahiko, T., Ishii, M., Shimizu, S., & Yoshida, T. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.35.346 · Cited by 28

Mouse Monoclonal Antibodies to Transient Receptor Potential Ankyrin 1 Act as Antagonists of Multiple Modes of Channel Activation

Lee, K. J., Wang, W., Padaki, R., Bi, V., Plewa, C. A., & Gavva, N. R. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.215574 · Cited by 28

TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O2 sensing

Mori, Y., Takahashi, N., Kurokawa, T., & Kiyonaka, S. (2017) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.93.028 · Cited by 28

Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin

Miyake, T., Nakamura, S., Meng, Z., Hamano, S., Inoue, K., Numata, T., Takahashi, N., Nagayasu, K., Shirakawa, H., Mori, Y., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00878 · Cited by 28

Activation of the cation channel TRPM3 in perivascular nerves induces vasodilation of resistance arteries

Alonso-Carbajo, L., Alpizar, Y. A., Startek, J. B., López‐López, J. R., Pérez-García, M. T., & Talavera, K. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.03.003 · Cited by 28

Ameliorative potential of standardized fruit extract of Pterodon pubescens Benth on neuropathic pain in mice: Evidence for the mechanisms of action

Nucci-Martins, C., Martins, D. F., do Nascimento, L. F., Venzke, D., de Oliveira, A. S., Frederico, M. J. S., Silva, F. R. M. B., Brighente, I. M. C., Pizzolatti, M. G., & Santos, A. R. S. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.09.005 · Cited by 27

Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation

Wan, X., Lu, Y., Chen, X., Xiong, J., Zhou, Y., Li, P., Xia, B., Li, M., Zhu, M. X., & Gao, Z. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1345-6 · Cited by 27

Direct action and modulating effect of (+)- and (−)-nicotine on ion channels expressed in trigeminal sensory neurons

Schreiner, B., Lehmann, R., Thiel, U., Ziemba, P. M., Beltrán, L. R., Sherkheli, M. A., Jeanbourquin, P., Hugi, A. D., Werner, M., Gisselmann, G., et al. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.01.060 · Cited by 27

Differential pharmacological alleviation of oxaliplatin-induced hyperalgesia/allodynia at cephalic versus extra-cephalic level in rodents

Michot, B., Kayser, V., Bastian, G., Bourgoin, S., & Hamon, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.12.011 · Cited by 27

Transient receptor potential ankyrin 1 (TRPA1) ion channel in the pathophysiology of peripheral diabetic neuropathy

Koivisto, A., & Pertovaara, A. (2013) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2012.11.001 · Cited by 27

Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state

Zima, V., Witschas, K., Kádková, A., Zímová, L., Barvı́k, I., & Vlachová, V. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.02.018 · Cited by 27

Naringenin stimulates cholecystokinin secretion in STC-1 cells

Park, M. S., Kim, K., Lee, Y. M., Rhyu, M. R., & Kim, H. Y. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.2.146 · Cited by 27

TRPA1 is functionally expressed in melanoma cells but is not critical for impaired proliferation caused by allyl isothiocyanate or cinnamaldehyde

Oehler, B., Scholze, A., Schaefer, M., & Hill, K. (2012) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-012-0747-x · Cited by 27

Infrared Snake Eyes: TRPA1 and the Thermal Sensitivity of the Snake Pit Organ

Panzano, V. C., Kang, K., & Garrity, P. (2010) · Science Signaling · doi:10.1126/scisignal.3127pe22 · Cited by 27

TrpA1 activation in peripheral sensory neurons underlies the ionic basis of pain hypersensitivity in response to vinca alkaloids

Boiko, N., Medrano, G., Montano, E., Jiang, N., Williams, C., Madungwe, N. B., Bopassa, J. C., Kim, C. C., Parrish, J. Z., Hargreaves, K., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186888 · Cited by 27

Differential Activation of TRPA1 by Diesel Exhaust Particles: Relationships between Chemical Composition, Potency, and Lung Toxicity

Deering‐Rice, C. E., Memon, T. A., Lu, Z., Romero, E. G., Cox, J. E., Taylor‐Clark, T. E., Veranth, J. M., & Reilly, C. A. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00375 · Cited by 27

Transient Receptor Potential Channel Opening Releases Endogenous Acetylcholine, which Contributes to Endothelium-Dependent Relaxation Induced by Mild Hypothermia in Spontaneously Hypertensive Rat but Not Wistar-Kyoto Rat Arteries

Zou, Q., Leung, S. W. S., & Vanhoutte, P. M. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.223693 · Cited by 26

Hydrogen Sulfide Plays a Key Role in the Inhibitory Neurotransmission to the Pig Intravesical Ureter

Fernandes, V. S., Fernandes-Ribeiro, A. S., Martínez, M. P., López‐Oliva, M. E., Barahona, M. V., Orensanz, L. M., Martínez‐Sáenz, A., Recio, P., Benedito, S., Bustamante, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113580 · Cited by 26

Chemical Activation of Sensory TRP Channels

Boonen, B., Startek, J. B., & Talavera, K. (2016) · Topics in medicinal chemistry · doi:10.1007/7355_2015_98 · Cited by 26

The Outer Pore and Selectivity Filter of TRPA1

Christensen, A. P., Akyuz, N., & Corey, D. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166167 · Cited by 26

Accumulation of methylglyoxal increases the advanced glycation end-product levels in DRG and contributes to lumbar disk herniation-induced persistent pain

Liu, C., Zhang, X., Ruan, Y., Huang, Z., Zhang, S., Liu, M., Luo, H.-J., Wu, S., & Ma, C. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00745.2016 · Cited by 26

A SNAP-25 cleaving chimera of botulinum neurotoxin /A and /E prevents TNFα−induced elevation of the activities of native TRP channels on early postnatal rat dorsal root ganglion neurons

Nugent, M., Yusef, Y. R., Meng, J., Wang, J., & Dolly, J. O. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.06.016 · Cited by 26

A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1

Lv, J., Cao, L., Zhang, R., Bai, F., & Wei, P. (2018) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-865020180060000008 · Cited by 26

Carboxamido steroids inhibit the opening properties of transient receptor potential ion channels by lipid raft modulation

Sághy, É., Payrits, M., Biró-Sütő, T., Skoda‐Földes, R., Szánti‐Pintér, E., Erostyák, J., Makkai, G., Sétáló, G., Kollár, L., Kőszegi, T., et al. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m084723 · Cited by 26

Unsaturated aldehydes induce CCK secretion via TRPA1 in STC‐1 cells

Nakajima, S., Hira, T., Yahagi, A., Nishiyama, C., Yamashita, T., Imagi, J., & Hara, H. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300412 · Cited by 25

Intragastric Administration of Allyl Isothiocyanate Reduces Hyperglycemia in Intraperitoneal Glucose Tolerance Test (IPGTT) by Enhancing Blood Glucose Consumption in Mice

Mori, N., Kurata, M., Yamazaki, H., Hosokawa, H., Nadamoto, T., Inoue, K., & Fushiki, T. (2013) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.59.56 · Cited by 25

Thermal grill‐evoked sensations of heat correlate with cold pain threshold and are enhanced by menthol and cinnamaldehyde

Averbeck, B., Rucker, F., Laubender, R. P., & Carr, R. W. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00239.x · Cited by 25

Transient Receptor Potential Channels in Intestinal Inflammation: What Is the Impact of Cigarette Smoking?

Allais, L., Smet, R. D., Verschuere, S., Talavera, K., Cuvelier, C. A., & Maes, T. (2016) · Pathobiology · doi:10.1159/000446568 · Cited by 25

The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature

Roessingh, S., & Stanewsky, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102028 · Cited by 25

Borneol inhibits TRPA1, a proinflammatory and noxious pain-sensing cation channel

Sherkheli, M. A. (2015) · Pakistan Journal of Pharmaceutical Sciences · doi:10.36721/pjps/28/4/2015/3048/1357-1363 · Cited by 24

Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy

Wei, H., Viisanen, H., Amorim, D., Koivisto, A., & Pertovaara, A. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.014 · Cited by 24

Analogues of perillaketone as highly potent agonists of TRPA1 channel

Bassoli, A., Borgonovo, G., Morini, G., PETROCELLIS, L. D., Moriello, A. S., & Marzo, V. D. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.05.063 · Cited by 24

Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation

LINDSAY, C. D., Green, C., Bird, M., Jones, J. T. A., Riches, J. R., McKee, K. K., Sandford, M. S., Wakefield, D. A., & Timperley, C. M. (2015) · Royal Society Open Science · doi:10.1098/rsos.140160 · Cited by 24

Gingerol activates noxious cold ion channel TRPA1 in gastrointestinal tract

Yang, M., Lin-Lan, Y. E., Liu, X., Xiao-Ming, Q. I., Jia-Di, L. V., Gang, W. A. N. G., FARHAN, U.-K., Waqas, N., Ding-Ding, C. H. E. N., Lei, H. A. N., et al. (2016) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(16)30040-1 · Cited by 24

Sensitivity of bronchopulmonary receptors to cold and heat mediated by transient receptor potential cation channel subtypes in an ex vivo rat lung preparation

Zhou, Y., Sun, B., Li, Q., Luo, P., Dong, L., & Rong, W. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.05.011 · Cited by 23

Isothiocyanates from Wasabia japonica Activate Transient Receptor Potential Ankyrin 1 Channel

Uchida, K., Miura, Y., Nagai, M., & Tominaga, M. (2012) · Chemical Senses · doi:10.1093/chemse/bjs065 · Cited by 23

A Mouse Model of Peripheral Postischemic Dysesthesia: Involvement of Reperfusion-Induced Oxidative Stress and TRPA1 Channel

Sasaki, A., Mizoguchi, S., Kagaya, K., Shiro, M., Sakai, A., Andoh, T., Kino, Y., Taniguchi, H., Saito, Y., Takahata, H., et al. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.217570 · Cited by 23

Hydrogen Peroxide Induces Muscle Nociception via Transient Receptor Potential Ankyrin 1 Receptors

Sugiyama, D., Kang, S., Arpey, N. C., Arunakul, P., Usachev, Y. M., & Brennan, T. J. (2017) · Anesthesiology · doi:10.1097/aln.0000000000001756 · Cited by 23

To flourish or perish: evolutionary TRiPs into the sensory biology of plant-herbivore interactions

Startek, J. B., Voets, T., & Talavera, K. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2205-1 · Cited by 23

Adamantyl Analogues of Paracetamol as Potent Analgesic Drugs via Inhibition of TRPA1

Fresno, N., Pérez-Fernández, R., Goicoechea, C., Alkorta, I., Fernández-Carvajal, A., de la Torre-Martínez, R., Quirce, S., Ferrer-Montiel, A., Martín, M. I., Goya, P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113841 · Cited by 22

Chronic alteration in phosphatidylinositol 4,5-biphosphate levels regulates capsaicin and mustard oil responses

Patil, M. J., Belugin, S., & Akopian, A. N. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22597 · Cited by 22

Drugs Affecting TRP Channels

Wortley, M. A., Birrell, M. A., & Belvisi, M. G. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_63 · Cited by 22

Environmental toxin acrolein alters levels of endogenous lipids, including TRP agonists: A potential mechanism for headache driven by TRPA1 activation

Leishman, E., Kunkler, P. E., Manchanda, M., Sangani, K. A., Stuart, J. M., Oxford, G. S., Hurley, J. H., & Bradshaw, H. B. (2017) · Neurobiology of Pain · doi:10.1016/j.ynpai.2017.03.001 · Cited by 22

Zingiberis Siccatum Rhizoma, the active component of the Kampo formula Daikenchuto, induces anti‐inflammatory actions through α7 nicotinic acetylcholine receptor activation

Endo, M., Hori, M., Mihara, T., Ozaki, H., Oikawa, T., Odaguchi, H., & Hanawa, T. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13139 · Cited by 22

Airway Pathogenesis Is Linked to TRP Channels

Wallace, H. L. (2017) · CRC Press eBooks · doi:10.4324/9781315152837-13 · Cited by 21

Epidermal Expression of TRPM8 But Not of TRPA1 Ion Channels is Associated with Human Cold Pain Sensitivity Patterns

Weyer-Menkhoff, I., Pinter, A., Schlierbach, H., Schänzer, A., & Lötsch, J. (2018) · Pain · doi:10.1097/j.pain.0000000000001660 · Cited by 21

TRPA1 Channels Mediate Human Gingival Fibroblast Response to Phenytoin

López-González, M. J., Luis, E., Fajardo, O., Meseguer, V., Gers-Barlag, K., Niñerola, S., & Viana, F. (2017) · Journal of Dental Research · doi:10.1177/0022034517695518 · Cited by 20

Structure–affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

Brizzi, A., Aiello, F., Marini, P., Cascio, M. G., Corelli, F., Brizzi, V., PETROCELLIS, L. D., Ligresti, A., Luongo, L., Lamponi, S., et al. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.07.006 · Cited by 20

TRPA1 channels as targets for resveratrol and related stilbenoids

Nalli, M., Ortar, G., Moriello, A. S., Morera, E., Marzo, V. D., & PETROCELLIS, L. D. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.12.065 · Cited by 20

Pathophysiological Role of Transient Receptor Potential Ankyrin 1 in a Mouse Long-Lasting Cystitis Model Induced by an Intravesical Injection of Hydrogen Peroxide

Oyama, S., Dogishi, K., Kodera, M., Kakae, M., Nagayasu, K., Shirakawa, H., Nakagawa, T., & Kaneko, S. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00877 · Cited by 20

Comparisons of behavioural and TRPA1 heat sensitivities in three sympatric Cuban Anolis lizards

Akashi, H. D., Saito, S., Cádiz, A., Makino, T., Tominaga, M., & Kawata, M. (2018) · Molecular Ecology · doi:10.1111/mec.14572 · Cited by 20

Topical treatment with a transient receptor potential ankyrin 1 (TRPA1) antagonist reduced nociception and inflammation in a thermal lesion model in rats

Antoniazzi, C. T. D. D., Prá, S. D.-T. D., Ferro, P. R., da Silva, M. A., Adamante, G. D. O., de Almeida, A. S., Camponogara, C., da Silva, C. R., Silveira, G. D. B., Silveira, P. C. L., et al. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.09.012 · Cited by 20

The Antinociceptive and Antihyperalgesic Effects of Topical Propofol on Dorsal Horn Neurons in the Rat

Takechi, K., Carstens, M. I., Klein, A. H., & Carstens, E. (2013) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31827f560d · Cited by 19

Potential role of spinal TRPA1 channels in antinociceptive tolerance to spinally administered morphine

Wei, H., Wu, H., Fan, H. J., Li, T., Ma, A., Li, X., Wang, Y., & Pertovaara, A. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.11.008 · Cited by 19

Therapeutic effect of capsaicin nasal treatment in patients with mixed rhinitis unresponsive to intranasal steroids

Van Gerven, L., Steelant, B., Alpizar, Y. A., Talavera, K., & Hellings, P. W. (2018) · Allergy · doi:10.1111/all.13245 · Cited by 18

Enhanced production of nitric oxide in A549 cells through activation of TRPA1 ion channel by cold stress

Sun, W., Wang, Z., Cao, J., Wang, X., Han, Y., & Ma, Z. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.04.009 · Cited by 18

Membrane translocation of transient receptor potential ankyrin 1 induced by inflammatory cytokines in lung cancer cells

Takahashi, K., & Ohta, T. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.082 · Cited by 18

Hydrogen Sulfide Mediating both Excitatory and Inhibitory Effects in a Rat Model of Meningeal Nociception and Headache Generation

Teicher, C., Col, R. D., & Meßlinger, K. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00336 · Cited by 18

TRPA1 channels: expression in non-neuronal murine lung tissues and dispensability for hyperoxia-induced alveolar epithelial hyperplasia

Kannler, M., Lüling, R., Yildirim, A. Ö., Gudermann, T. W., Steinritz, D., & Dietrich, A. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2148-6 · Cited by 18

Upregulation of extraneuronal TRPV1 expression in chronic rhinosinusitis with nasal polyps

Tóth, E., Tornóczky, T., Kneif, J., Perkecz, A., Katona, K., Piski, Z., Kemény, Á., Gerlinger, I., Szolcsányi, J., Kun, J., et al. (2018) · Rhinology Journal · doi:10.4193/rhin17.108 · Cited by 18

Pancreatic pain

Moran, R. A., James, T., & Pasricha, P. J. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000204 · Cited by 18

Sustained TRPA1 activation in vivo

Koivisto, A. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02318.x · Cited by 17

Transient receptor potential (TRP) A1 activated currents in TRPV1 and cholecystokinin-sensitive cranial visceral afferent neurons

Choi, M.-J., Jin, Z., Park, Y. S., Rhee, Y. K., & Jin, Y. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.009 · Cited by 17

Effect of Intravesical Liposome-Based Nerve Growth Factor Antisense Therapy on Bladder Overactivity and Nociception in a Rat Model of Cystitis Induced by Hydrogen Peroxide

Majima, T., Tyagi, P., Dogishi, K., Kashyap, M. P., Funahashi, Y., Gotoh, M., Chancellor, M. B., & Yoshimura, N. (2017) · Human Gene Therapy · doi:10.1089/hum.2016.121 · Cited by 17

Modulation of TRPA1 channel activity by Cdk5 in sensory neurons

Sulak, M. A., Ghosh, M., Sinharoy, P., Andrei, S. R., & Damron, D. S. (2018) · Channels · doi:10.1080/19336950.2018.1424282 · Cited by 17

The citrus flavanone hesperetin preferentially inhibits slow‐inactivating currents of a long QT syndrome type 3 syndrome Na+channel mutation

Alvarez‐Collazo, J., López‐Requena, A., Galán-Martínez, L., Talavera, A., Álvarez, J. L., & Talavera, K. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14577 · Cited by 17

Management of pruritus in patients with cholestatic liver disease.

Levy, C. (2011) · PubMed · Cited by 16

Effect of genetic background and postinfectious stress on visceral sensitivity in Citrobacter rodentium‐infected mice

Mondelaers, S., Theofanous, S. A., Florens, M., Perna, E., Aguilera-Lizarraga, J., Boeckxstaens, G., & Wouters, M. (2016) · Neurogastroenterology and Motility · doi:10.1111/nmo.12759 · Cited by 16

TRPA1 in the spinal dorsal horn is involved in post-inflammatory visceral hypersensitivity: in vivo study using TNBS-treated rat model

Li, Q., Guo, C., Chowdhury, M. A., Dai, T., & Han, W. (2016) · Journal of Pain Research · doi:10.2147/jpr.s118581 · Cited by 16

Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space

Lopatriello, A., Caprioglio, D., Minassi, A., Moriello, A. S., Formisano, C., PETROCELLIS, L. D., Appendino, G., & Taglialatela‐Scafati, O. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.07.044 · Cited by 16

Role of TNF-α in Regulating the Exercise Pressor Reflex in Rats With Femoral Artery Occlusion

Xing, J., Lü, J., & Li, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01461 · Cited by 16

TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers

Weyer-Menkhoff, I., & Lötsch, J. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000677 · Cited by 16

X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation

Su, C., Xu, J., Xu, L., Feng-Lun, Z., Pan, J., Ai-Ming, S., Hu, D., Yu, Y., Liu, T., & Zhang, Y. (2019) · Molecular Pain · doi:10.1177/1744806919849201 · Cited by 16

The phospholipase C inhibitor U73122 is a potent agonist of the polymodal transient receptor potential ankyrin type 1 (TRPA1) receptor channel

Neacsu, C., Sauer, S. K., Reeh, P. W., & Babeș, A. (2019) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01722-2 · Cited by 16

Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa

Moon, H., Kim, M. J., Son, H. J., Kweon, H.-J., Kim, J. T., Kim, Y., Shim, J., Suh, B., & Rhyu, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127060 · Cited by 15

STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes

Hidmark, A. S., Nawroth, P. P., & Fleming, T. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.03.008 · Cited by 15

LE135 , a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels

Yin, S., Luo, J., Qian, A., Yu, W., & Hu, H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12543 · Cited by 14

Noxious heat threshold temperature and pronociceptive effects of allyl isothiocyanate (mustard oil) in TRPV1 or TRPA1 gene-deleted mice

Tékus, V., Horváth, Á. I., Hajna, Z., Borbély, É., Bölcskei, K., Boros, M., Pintér, E., Helyes, Z., Pethö, G., & Szolcsányi, J. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.04.030 · Cited by 14

Development of an in vivo target‐engagement biomarker for TRPA1 antagonists in humans

Buntinx, L., Chang, L., Amin, A., Morlion, B. J., & Hoon, J. N. J. M. D. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13143 · Cited by 14

Photosensitization of TRPA1 and TRPV1 by 7-dehydrocholesterol: implications for the Smith–Lemli–Opitz syndrome

Babeș, A., Ciotu, C. I., Hoffmann, T., Kichko, T. I., Şelescu, T., Neacsu, C., Sauer, S. K., Reeh, P. W., & Fischer, M. J. M. (2017) · Pain · doi:10.1097/j.pain.0000000000001056 · Cited by 14

Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy

Wright, L., Baptista‐Hon, D. T., Bull, F. A., Dalgaty, F., Gallacher, M., Ibbotson, S. H., & Hales, T. G. (2017) · Pain · doi:10.1097/j.pain.0000000000001096 · Cited by 14

Transient receptor potential ankyrin 1 channels are involved in spontaneous peptide hormone release from astrocytes

Takizawa, M., Harada, K., Nakamura, K., & Tsuboi, T. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.097 · Cited by 14

The Role of TRP Channels in the Pancreatic Beta-Cell

Philippaert, K., & Vennekens, R. (2017) · CRC Press eBooks · doi:10.4324/9781315152837-12 · Cited by 13

Role of Transient Receptor Potential Ankyrin 1 in Gastric Accommodation in Conscious Guinea Pigs

Koseki, J., Oshima, T., Kondo, T., Tomita, T., Fukui, H., Watari, J., Hattori, T., Kase, Y., & Miwa, H. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.189027 · Cited by 12

Bidirectional effects of hydrogen sulfide via ATP-sensitive K+ channels and transient receptor potential A1 channels in RIN14B cells

Ujike, A., Otsuguro, K., Miyamoto, R., Yamaguchi, S., & Ito, S. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.07.029 · Cited by 12

Blocking PAR2 alleviates bladder pain and hyperactivity via TRPA1 signal

Chen, D., Liu, N., Li, M., & Liang, S. (2016) · Translational Neuroscience · doi:10.1515/tnsci-2016-0020 · Cited by 12

Intracolonic Administration of the TRPA1 Agonist Allyl Isothiocyanate Stimulates Colonic Motility and Defecation in Conscious Dogs

Someya, S., Nagao, M., Shibata, C., Tanaka, N., Sasaki, H., Kikuchi, D., Miyachi, T., Naitoh, T., & Unno, M. (2015) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-015-2813-4 · Cited by 11

Mechanical antihypersensitivity effect induced by repeated spinal administrations of a TRPA1 antagonist or a gap junction decoupler in peripheral neuropathy

Wei, H., Wu, H., Chen, Z., Ma, A., Mao, X.-F., Li, T., Li, X., Wang, Y., & Pertovaara, A. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.09.007 · Cited by 11

Naturally Produced Defensive Alkenal Compounds Activate TRPA1

Blair, N. T., Philipson, B. I., Richards, P. M., Doerner, J. F., Segura, A., Silver, W. L., & Clapham, D. E. (2016) · Chemical Senses · doi:10.1093/chemse/bjv071 · Cited by 10

Hydrogen sulfide activates TRPA1 and releases 5-HT from epithelioid cells of the chicken thoracic aorta

Dugar, D., Yamaguchi, S., Ichii, O., Kon, Y., Ito, S., & Otsuguro, K. (2016) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2016.05.004 · Cited by 10

Vasorelaxation to the Nitroxyl Donor Isopropylamine NONOate in Resistance Arteries Does Not Require Perivascular Calcitonin Gene–Related Peptide

Pinkney, A., Lemmey, H. A. L., Dora, K. A., & Garland, C. J. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09737 · Cited by 10

Zinc chloride-induced TRPA1 activation does not contribute to toxicity in vitro

Steinritz, D., Zehfuß, F., Stenger, B., Schmidt, A., Popp, T., Kehe, K., Mückter, H., Thiermann, H., & Gudermann, T. W. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.09.008 · Cited by 10

Urothelial bladder afferent neurons in the rat are anatomically and neurochemically distinct from non-urothelial afferents

Clodfelder‐Miller, B., Kanda, H., Gu, J. G., Creighton, J. R., Ness, T. J., & DeBerry, J. J. (2017) · Brain Research · doi:10.1016/j.brainres.2017.12.023 · Cited by 10

β-eudesmol, an oxygenized sesquiterpene, affects efferent adrenal sympathetic nerve activity via transient receptor potential ankyrin 1 in rats

Ohara, K., Katayama, M., & Nagai, K. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.06.057 · Cited by 10

Deciphering Subtype-Selective Modulations in TRPA1 Biosensor Channels

Kozai, D., Sakaguchi, R., Ohwada, T., & Mori, Y. (2015) · Current Neuropharmacology · doi:10.2174/1570159x1302150525122020 · Cited by 8

The effect of the electrophilic fatty acid nitro-oleic acid on TRP channel function in sensory neurons

Beckel, J. M., & de Groat, W. C. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.03.015 · Cited by 8

Carbonyl stress-induced 5-hydroxytriptamine secretion from RIN-14B, rat pancreatic islet tumor cells, via the activation of transient receptor potential ankyrin 1

Suzawa, S., Takahashi, K., Shimada, T., & Ohta, T. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.07.005 · Cited by 7

Zinc directly stimulates cholecystokinin secretion from enteroendocrine cells and reduces gastric emptying in rats

Nakajima, S., Hira, T., Iwaya, H., & Hara, H. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.04.010 · Cited by 6

Taurolidine and congeners activate hTRPA 1 but not hTRPV 1 channels and stimulate CGRP release from mouse tracheal sensory nerves

Kichko, T. I., Pfirrmann, R. W., & Reeh, P. W. (2016) · Pharmacology Research & Perspectives · doi:10.1002/prp2.204 · Cited by 5

Gastric administration of garlic powder containing the trpa1‐ agonist allicin induces specific epigastric symptoms and gastric relaxation in healthy subjects

Führer, M., Dejaco, C., Kopp, B., & Hammer, J. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13470 · Cited by 5

Serotonin or the Mucosa Do Not Mediate the Motor Effect of Allyl Isothiocyanate in the Guinea-Pig Small Intestine

Sándor, Z., Bencsik, T., Dékány, A., & Barthó, L. (2016) · Pharmacology · doi:10.1159/000447427 · Cited by 4

Expression of transient receptor potential ankyrin 1 correlating to the recovery of colonic transit after pelvic nerve denervation in rats

Tong, W., Tian, Y., Yang, H., Wang, L., Zhao, S., Shi, H., Dai, F., & Ye, J. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.09.057 · Cited by 4

Translational Difficulties in Studying the TRPA1 Receptor

Keszthelyi, D., van Avesaat, M. H. P., Troost, F. J., & Masclee, A. (2016) · Nutrients · doi:10.3390/nu8120790 · Cited by 2

Boosting that tan with a bit of voltage

Caterina, M. J. (2013) · Channels · doi:10.4161/chan.26682 · Cited by 1

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01464-x · Cited by 522

TRPA1 rare variants in chronic neuropathic and nociplastic pain patients

Marchi, M., Salvi, E., Andelic, M., Mehmeti, E., D'Amato, I., Cazzato, D., Chiappori, F., Lombardi, R., Cartelli, D., Devigili, G., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002905 · Cited by 29

TRPA1 promotes melanosome phagocytosis in keratinocytes via PAR-2/CYLD axis

Wang, Y., Li, Z., Wu, W., Liu, Y., Xiao, Y., Qi, D., Zhao, G., Zhou, M., Wang, H., Liu, J., et al. (2022) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2022.05.005 · Cited by 12

Transient receptor potential Ankyrin‐1 (TRPA1) agonists suppress myelination and induce demyelination in organotypic cortical slices

Giacco, V., Flower, G., Artamonova, M., Hunter, J., Padilla Requerey, A., & Hamilton, N. B. (2023) · Glia · doi:10.1002/glia.24347 · Cited by 11