Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease

Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364

Gut microbiota in health and disease

Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

Kapoor, M., Martel-Pelletier, J., Lajeunesse, D., Pelletier, J.-P., & Fahmi, H. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.196 · Cited by 2,778

ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures

Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T. R., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,486

TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents

Bautista, D. M., Jordt, S.-E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. (2006) · Cell · doi:10.1016/j.cell.2006.02.023 · Cited by 1,932

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

Jordt, S.-E., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,899

Osteoarthritis

Martel-Pelletier, J., Barr, A. J., Cicuttini, F. M., Conaghan, P. G., Cooper, C., Goldring, M. B., Goldring, S. R., Jones, G., Teichtahl, A. J., & Pelletier, J.-P. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.72 · Cited by 1,877

Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin

Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., & Patapoutian, A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00150-3 · Cited by 1,827

The enteric nervous system and neurogastroenterology

Furness, J. B. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.32 · Cited by 1,619

TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction

Kwan, K. Y., Allchorne, A. J., Vollrath, M. A., Christensen, A. P., Zhang, D.-S., Woolf, C. J., & Corey, D. P. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.042 · Cited by 1,267

TRPA1 mediates formalin-induced pain

McNamara, C. R., Mandel-Brehm, J., Bautista, D. M., Siemens, J., Deranian, K. L., Zhao, M., Hayward, N. J., Chong, J. A., Julius, D., Moran, M. M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705924104 · Cited by 1,263

Atopic dermatitis and the atopic march

Spergel, J. M., & Paller, A. S. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.09.033 · Cited by 1,229

TRP Channels and Pain

Julius, D. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155833 · Cited by 1,140

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F., & Patapoutian, A. (2007) · Nature · doi:10.1038/nature05544 · Cited by 1,116

An internal thermal sensor controlling temperature preference in Drosophila

Hamada, F. N., Rosenzweig, M., Kang, K., Pulver, S. R., Ghezzi, A., Jegla, T. J., & Garrity, P. A. (2008) · Nature · doi:10.1038/nature07001 · Cited by 1,075

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation

Boguniewicz, M., & Leung, D. Y. M. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01027.x · Cited by 1,073

The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

Voets, T., Droogmans, G., Wissenbach, U., Janssens, A., Flockerzi, V., & Nilius, B. (2004) · Nature · doi:10.1038/nature02732 · Cited by 1,070

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

Wilson, S. R., Thé, L., Batia, L. M., Beattie, K., Katibah, G. E., McClain, S. P., Pellegrino, M., Estandian, D. M., & Bautista, D. M. (2013) · Cell · doi:10.1016/j.cell.2013.08.057 · Cited by 987

Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes

De Petrocellis, L., Ligresti, A., Moriello, A. S., Allarà, M., Bisogno, T., Petrosino, S., Stott, C. G., & Di Marzo, V. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01166.x · Cited by 946

TRPM8 Is Required for Cold Sensation in Mice

Dhaka, A., Murray, A. N., Mathur, J., Earley, T. J., Petrus, M. J., & Patapoutian, A. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.024 · Cited by 930

Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways

Bellono, N. W., Bayrer, J. R., Leitch, D. B., Castro, J., Zhang, C., O’Donnell, T. A., Brierley, S. M., Ingraham, H. A., & Julius, D. (2017) · Cell · doi:10.1016/j.cell.2017.05.034 · Cited by 910

TRP channel activation by reversible covalent modification

Hinman, A., Chuang, H.-H., Bautista, D. M., & Julius, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609598103 · Cited by 890

Pungent products from garlic activate the sensory ion channel TRPA1

Bautista, D. M., Movahed, P., Hinman, A., Axelsson, H. E., Sterner, O., Högestätt, E. D., Julius, D., Jordt, S.-E., & Zygmunt, P. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505356102 · Cited by 860

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

Cevikbas, F., Wang, X., Akiyama, T., Kempkes, C., Savinko, T., Antal, A., Kukova, G., Buhl, T., Ikoma, A., Buddenkotte, J., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.048 · Cited by 804

Attenuated Cold Sensitivity in TRPM8 Null Mice

Colburn, R. W., Lubin, M. L., Stone, D. J., Wang, Y., Lawrence, D., D'Andrea, M. R., Brandt, M. R., Liu, Y., Flores, C. M., & Qin, N. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.017 · Cited by 771

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Trevisani, M., Siemens, J., Materazzi, S., Bautista, D. M., Nassini, R., Campi, B., Imamachi, N., Andrè, E., Patacchini, R., Cottrell, G. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705923104 · Cited by 770

TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

Corey, D. P., García-Añoveros, J., Holt, J. R., Kwan, K. Y., Lin, S.-Y., Vollrath, M. A., Amalfitano, A., Cheung, E. L.-M., Derfler, B. H., Duggan, A., et al. (2004) · Nature · doi:10.1038/nature03066 · Cited by 738

Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors

Kobayashi, K., Fukuoka, T., Obata, K., Yamanaka, H., Dai, Y., Tokunaga, A., & Noguchi, K. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20794 · Cited by 729

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

Andersson, D. A., Gentry, C., Moss, S., & Bevan, S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5369-07.2008 · Cited by 718

Structure of the TRPA1 ion channel suggests regulatory mechanisms

Paulsen, C. E., Armache, J.-P., Gao, Y., Cheng, Y., & Julius, D. (2015) · Nature · doi:10.1038/nature14367 · Cited by 660

Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing

Nagata, K., Duggan, A., Kumar, G., & García-Añoveros, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0013-05.2005 · Cited by 644

Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels

Xu, H., Delling, M., Jun, J. C., & Clapham, D. E. (2006) · Nature Neuroscience · doi:10.1038/nn1692 · Cited by 644

TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury

Obata, K. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25437 · Cited by 630

Effect of garlic on cardiovascular disorders: a review

Banerjee, S. K., & Maulik, S. K. (2002) · Nutrition Journal · doi:10.1186/1475-2891-1-4 · Cited by 627

The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin

Macpherson, L. J., Geierstanger, B. H., Viswanath, V., Bandell, M., Eid, S. R., Hwang, S., & Patapoutian, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.018 · Cited by 612

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X., & Bautista, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2789 · Cited by 599

Tolerance for Rectosigmoid Distention in Irritable Bowel Syndrome

Whitehead, W. E., Holtkotter, B., Enck, P., Hoelzl, R., Holmes, K. D., Anthony, J., Shabsin, H. S., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90332-u · Cited by 593

TRPA1 acts as a cold sensor in vitro and in vivo

Karashima, Y., Talavera, K., Everaerts, W., Janssens, A., Kwan, K. Y., Vennekens, R., Nilius, B., & Voets, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808487106 · Cited by 585

Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with Aδ/C-fibers and colocalization with Trk receptors

小林, 希. (2007) · Medical Entomology and Zoology · Cited by 575

Heat activation of TRPM5 underlies thermal sensitivity of sweet taste

Talavera, K., Yasumatsu, K., Voets, T., Droogmans, G., Shigemura, N., Ninomiya, Y., Margolskee, R. F., & Nilius, B. (2005) · Nature · doi:10.1038/nature04248 · Cited by 523

Direct activation of the ion channel TRPA1 by Ca2+

Zurborg, S., Yurgionas, B., Jira, J. A., Caspani, O., & Heppenstall, P. A. (2007) · Nature Neuroscience · doi:10.1038/nn1843 · Cited by 505

Observations upon the reactions of the vessels of the human skin to cold

Lewis, T. (1930) · Medical Entomology and Zoology · Cited by 489

Molecular basis of infrared detection by snakes

Gracheva, E. O., Ingolia, N. T., Kelly, Y. M., Cordero-Morales, J. F., Hollopeter, G., Chesler, A. T., Sánchez, E. E., Perez, J. C., Weissman, J. S., & Julius, D. (2010) · Nature · doi:10.1038/nature08943 · Cited by 482

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

Meseguer, V., Alpizar, Y. A., Luis, E., Tajada, S., Denlinger, B., Fajardo, O., Manenschijn, J.-A., Fernández-Peña, C., Talavera, A., Kichko, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms4125 · Cited by 479

Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1

Karashima, Y., Damann, N., Prenen, J., Talavera, K., Segal, A., Voets, T., & Nilius, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2221-07.2007 · Cited by 477

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3

Shigetomi, E., Tong, X., Kwan, K. Y., Corey, D. P., & Khakh, B. S. (2012) · Nature Neuroscience · doi:10.1038/nn.3000 · Cited by 472

A TRP channel trio mediates acute noxious heat sensing

Vandewauw, I., De Clercq, K., Mulier, M., Held, K., Pinto, S., Van Ranst, N., Segal, A., Voet, T., Vennekens, R., Zimmermann, K., et al. (2018) · Nature · doi:10.1038/nature26137 · Cited by 470

Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall

Xiang, Y., Yuan, Q., Vogt, N., Looger, L. L., Jan, L. Y., & Jan, Y. N. (2010) · Nature · doi:10.1038/nature09576 · Cited by 462

TRPA1 is a major oxidant sensor in murine airway sensory neurons

Bessac, B. F., Sivula, M., von Hehn, C. A., Escalera, J., Cohn, L., & Jordt, S.-E. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34192 · Cited by 449

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

Eid, S. R., Crown, E. D., Moore, E. L., Liang, H. A., Choong, K.-C., Dima, S., Henze, D. A., Kane, S. A., & Urban, M. O. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-48 · Cited by 447

Peripheral thermosensation in mammals

Vriens, J., Nilius, B., & Voets, T. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3784 · Cited by 446

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

Kremeyer, B., Lopera, F., Cox, J. J., Momin, A., Rugiero, F., Marsh, S., Woods, C. G., Jones, N. G., Paterson, K. J., Fricker, F. R., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.030 · Cited by 443

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

Imamachi, N., Park, G. H., Lee, H., Anderson, D. J., Simon, M. I., Basbaum, A. I., & Han, S.-K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905605106 · Cited by 443

Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control

Bessac, B. F., & Jordt, S.-E. (2008) · Physiology · doi:10.1152/physiol.00026.2008 · Cited by 432

Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain

Dai, Y., Wang, S., Tominaga, M., Yamamoto, S., Fukuoka, T., Higashi, T., Kobayashi, K., Obata, K., Yamanaka, H., & Noguchi, K. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30951 · Cited by 432

TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization

Gouin, O., L’Herondelle, K., Lebonvallet, N., Le Gall-Ianotto, C., Sakka, M., Buhé, V., Plée-Gautier, E., Carré, J.-L., Lefeuvre, L., Misery, L., et al. (2017) · Protein & Cell · doi:10.1007/s13238-017-0395-5 · Cited by 425

Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism

Xu, H., Blair, N. T., & Clapham, D. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2574-05.2005 · Cited by 420

Transient Receptor Potential Channels in the Vasculature

Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

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A Role of TRPA1 in Mechanical Hyperalgesia is Revealed by Pharmacological Inhibition

Petrus, M., Peier, A. M., Bandell, M., Hwang, S. W., Huynh, T., Olney, N., Jegla, T., & Patapoutian, A. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-40 · Cited by 418

Asthma and Allergic Inflammation

Locksley, R. M. (2010) · Cell · doi:10.1016/j.cell.2010.03.004 · Cited by 408

More than cool: Promiscuous relationships of menthol and other sensory compounds

Macpherson, L. J., Hwang, S. W., Miyamoto, T., Dubin, A. E., Patapoutian, A., & Story, G. M. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.05.005 · Cited by 401

TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells

Nozawa, K., Kawabata-Shoda, E., Doihara, H., Kojima, R., Okada, H., Mochizuki, S., Sano, Y., Inamura, K., Matsushime, H., Koizumi, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805323106 · Cited by 399

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome

Camilleri, M., Lasch, K., & Zhou, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00155.2012 · Cited by 396

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

Eberhardt, M., Dux, M., Namer, B., Miljkovic, J., Cordasic, N., Will, C., Kichko, T. I., de la Roche, J., Fischer, M., Suárez, S. A., et al. (2014) · Nature Communications · doi:10.1038/ncomms5381 · Cited by 379

Cigarette smoke–induced neurogenic inflammation is mediated by α,β-unsaturated aldehydes and the TRPA1 receptor in rodents

Andrè, E., Campi, B., Materazzi, S., Trevisani, M., Amadesi, S., Massi, D., Creminon, C., Vaksman, N., Nassini, R., Civelli, M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34886 · Cited by 372

Oxaliplatin‐induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors

Descoeur, J., Pereira, V., Pizzoccaro, A., Francois, A., Ling, B., Maffre, V., Couette, B., Busserolles, J., Courteix, C., Noel, J., et al. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100134 · Cited by 368

Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs

Nassenstein, C., Kwong, K., Taylor‐Clark, T., Kollarik, M., MacGlashan, D. M., Braun, A., & Undem, B. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.148379 · Cited by 349

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

Soethoudt, M., Grether, U., Fingerle, J., Grim, T. W., Fezza, F., de Petrocellis, L., Ullmer, C., Rothenhäusler, B., Perret, C., van Gils, N., et al. (2017) · Nature Communications · doi:10.1038/ncomms13958 · Cited by 349

A new gaseous signaling molecule emerges: Cardioprotective role of hydrogen sulfide

Lefer, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709010104 · Cited by 347

Why we scratch an itch: the molecules, cells and circuits of itch

Bautista, D. M., Wilson, S. R., & Hoon, M. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3619 · Cited by 338

Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8

De Petrocellis, L., Vellani, V., Schiano-Moriello, A., Marini, P., Magherini, P. C., Orlando, P., & Di Marzo, V. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.134809 · Cited by 336

The transient receptor potential channel TRPA1: from gene to pathophysiology

Nilius, B., Appendino, G., & Owsianik, G. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1158-z · Cited by 335

An Ankyrin-like Protein with Transmembrane Domains Is Specifically Lost after Oncogenic Transformation of Human Fibroblasts

Jaquemar, D., Schenker, T., & Trueb, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.7325 · Cited by 332

Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea

Parra, A., Madrid, R., Echevarria, D., del Olmo, S., Morenilla-Palao, C., Acosta, M. C., Gallar, J., Dhaka, A., Viana, F., & Belmonte, C. (2010) · Nature Medicine · doi:10.1038/nm.2264 · Cited by 324

Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation

Nassini, R., Gees, M., Harrison, S., De Siena, G., Materazzi, S., Moretto, N., Failli, P., Preti, D., Marchetti, N., Cavazzini, A., et al. (2011) · Pain · doi:10.1016/j.pain.2011.02.051 · Cited by 324

Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

Xiao, B., Dubin, A. E., Bursulaya, B., Viswanath, V., Jegla, T. J., & Patapoutian, A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2772-08.2008 · Cited by 321

TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons

Kwan, K. Y., Glazer, J. M., Corey, D. P., Rice, F. L., & Stucky, C. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5380-08.2009 · Cited by 321

TRPA1 Channels Are Regulators of Astrocyte Basal Calcium Levels and Long-Term Potentiation via Constitutive D-Serine Release

Shigetomi, E., Jackson-Weaver, O., Huckstepp, R. T., O'Dell, T. J., & Khakh, B. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5779-12.2013 · Cited by 320

Transient Receptor Potential Channel A1 Is Directly Gated by Calcium Ions

Doerner, J. F., Gisselmann, G., Hatt, H., & Wetzel, C. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607849200 · Cited by 320

Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

Streng, T., Axelsson, H. E., Hedlund, P., Andersson, D. A., Jordt, S.-E., Bevan, S., Andersson, K.-E., Högestätt, E. D., & Zygmunt, P. M. (2008) · European Urology · doi:10.1016/j.eururo.2007.10.024 · Cited by 308

Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety

Zhu, R., Liu, H., Liu, C., Wang, L., Ma, R., Chen, B., Li, L., Niu, J., Fu, M., Zhang, D., et al. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.019 · Cited by 307

Regulation of Pain and Itch by TRP Channels

Moore, C., Gupta, R., Jordt, S.-E., Chen, Y., & Liedtke, W. B. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-017-0200-8 · Cited by 307

Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain

Chen, Y., Yang, C., & Wang, Z. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.085 · Cited by 302

Gating of TRP channels: a voltage connection?

Nilius, B., Talavera, K., Owsianik, G., Prenen, J., Droogmans, G., & Voets, T. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.088377 · Cited by 299

The Biology of Thymic Stromal Lymphopoietin (TSLP)

Ziegler, S. F., Roan, F., Bell, B. D., Stoklasek, T. A., Kitajima, M., & Han, H. (2013) · Advances in Pharmacology · doi:10.1016/b978-0-12-404717-4.00004-4 · Cited by 298

TRPA1 Contributes to Cold Hypersensitivity

del Camino, D., Murphy, S., Heiry, M., Barrett, L. B., Earley, T. J., Cook, C. A., Petrus, M. J., Zhao, M., D'Amours, M., Deering, N., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2580-10.2010 · Cited by 287

TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo

Knowlton, W. M., Bifolck-Fisher, A., Bautista, D. M., & McKemy, D. D. (2010) · Pain · doi:10.1016/j.pain.2010.05.021 · Cited by 287

Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain

Wang, S., Dai, Y., Fukuoka, T., Yamanaka, H., Kobayashi, K., Obata, K., Cui, X., Tominaga, M., & Noguchi, K. (2008) · Brain · doi:10.1093/brain/awn060 · Cited by 285

TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol

Andersson, D. A., Gentry, C., Alenmyr, L., Killander, D., Lewis, S. E., Andersson, A., Bucher, B., Galzi, J.-L., Sterner, O., Bevan, S., et al. (2011) · Nature Communications · doi:10.1038/ncomms1559 · Cited by 283

Opposite thermosensor in fruitfly and mouse

Viswanath, V., Story, G. M., Peier, A. M., Petrus, M. J., Lee, V. M., Hwang, S. W., Patapoutian, A., & Jegla, T. (2003) · Nature · doi:10.1038/423822a · Cited by 283

Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

De Logu, F., Nassini, R., Materazzi, S., Carvalho Gonçalves, M., Nosi, D., Rossi Degl’Innocenti, D., Marone, I. M., Ferreira, J., Li Puma, S., Benemei, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01739-2 · Cited by 283

The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

Wang, Y. Y., Chang, R. B., Waters, H. N., McKemy, D. D., & Liman, E. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803568200 · Cited by 282

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

Chen, J., Joshi, S. K., DiDomenico, S., Perner, R. J., Mikusa, J. P., Gauvin, D. M., Segreti, J. A., Han, P., Zhang, X.-F., Niforatos, W., et al. (2011) · Pain · doi:10.1016/j.pain.2011.01.049 · Cited by 276

TRPA1 Agonists Evoke Coughing in Guinea Pig and Human Volunteers

Birrell, M. A., Belvisi, M. G., Grace, M., Sadofsky, L., Faruqi, S., Hele, D. J., Maher, S. A., Freund-Michel, V., & Morice, A. H. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200905-0665oc · Cited by 275

Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1‐directed internalization

Akopian, A. N., Ruparel, N. B., Jeske, N. A., & Hargreaves, K. M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.133231 · Cited by 274

Neural processing of itch

Akiyama, T., & Carstens, E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.035 · Cited by 272

TRPA1 underlies a sensing mechanism for O2

Takahashi, N., Kuwaki, T., Kiyonaka, S., Numata, T., Kozai, D., Mizuno, Y., Yamamoto, S., Naito, S., Knevels, E., Carmeliet, P., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.640 · Cited by 272

In Search of the Hair-Cell Gating Spring

Sotomayor, M., Corey, D. P., & Schulten, K. (2005) · Structure · doi:10.1016/j.str.2005.03.001 · Cited by 269

Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca 2+ -Activated K + Channels

Earley, S., Gonzales, A. L., & Crnich, R. (2009) · Circulation Research · doi:10.1161/circresaha.108.189530 · Cited by 267

The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli

Brierley, S. M., Hughes, P. A., Page, A. J., Kwan, K. Y., Martin, C. M., O'Donnell, T. A., Cooper, N. J., Harrington, A. M., Adam, B., Liebregts, T., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.048 · Cited by 266

General anesthetics activate a nociceptive ion channel to enhance pain and inflammation

Matta, J. A., Cornett, P. M., Miyares, R. L., Abe, K., Sahibzada, N., & Ahern, G. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711038105 · Cited by 265

The multiple pathways for itch and their interactions with pain

Davidson, S., & Giesler, G. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.09.002 · Cited by 261

Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians

Habauzit, V., & Morand, C. (2012) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622311430006 · Cited by 261

Nicotine activates the chemosensory cation channel TRPA1

Talavera, K., Gees, M., Karashima, Y., Meseguer, V. M., Vanoirbeek, J. A. J., Damann, N., Everaerts, W., Benoit, M., Janssens, A., Vennekens, R., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2379 · Cited by 259

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

Bautista, D. M., Sigal, Y. M., Milstein, A. D., Garrison, J. L., Zorn, J. A., Tsuruda, P. R., Nicoll, R. A., & Julius, D. (2008) · Nature Neuroscience · doi:10.1038/nn.2143 · Cited by 258

Non-Neuronal Expression of Transient Receptor Potential Type A1 (TRPA1) in Human Skin

Atoyan, R., Shander, D., & Botchkareva, N. V. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.58 · Cited by 257

The concept of neurogenic inflammation

Geppetti, P., Nassini, R., Materazzi, S., & Benemei, S. (2008) · BJU International · doi:10.1111/j.1464-410x.2008.07493.x · Cited by 257

TRPV1 Is Activated by Both Acidic and Basic pH

Dhaka, A., Uzzell, V., Dubin, A. E., Mathur, J., Petrus, M., Bandell, M., & Patapoutian, A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4901-08.2009 · Cited by 252

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators

Takahashi, N., Mizuno, Y., Kozai, D., Yamamoto, S., Kiyonaka, S., Shibata, T., Uchida, K., & Mori, Y. (2008) · Channels · doi:10.4161/chan.2.4.6745 · Cited by 247

Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system

Holzer, P. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.03.006 · Cited by 245

Pain-related electrical potentials of the human nasal mucosa elicited by chemical stimulation

Kobal, G. (1985) · Pain · doi:10.1016/0304-3959(85)90175-7 · Cited by 243

Thermosensory and Nonthermosensory Isoforms of Drosophila melanogaster TRPA1 Reveal Heat-Sensor Domains of a ThermoTRP Channel

Zhong, L., Bellemer, A., Yan, H., Honjo, K., Robertson, J., Hwang, R. Y., Pitt, G. S., & Tracey, W. D. (2012) · Cell Reports · doi:10.1016/j.celrep.2011.11.002 · Cited by 242

TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol

Namer, B., Seifert, F., Handwerker, H. O., & Maih??fner, C. (2005) · NeuroReport · doi:10.1097/00001756-200506210-00015 · Cited by 241

Pretty painful: Why does tooth bleaching hurt?

Markowitz, K. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2009.11.044 · Cited by 239

Caenorhabditis elegans TRPA-1 functions in mechanosensation

Kindt, K. S., Viswanath, V., Macpherson, L., Quast, K., Hu, H., Patapoutian, A., & Schafer, W. R. (2007) · Nature Neuroscience · doi:10.1038/nn1886 · Cited by 238

Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C‐fibres by the endogenous autacoid 4‐oxononenal

Taylor‐Clark, T. E., McAlexander, M. A., Nassenstein, C., Sheardown, S. A., Wilson, S., Thornton, J., Carr, M. J., & Undem, B. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.153585 · Cited by 237

Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation

Nassini, R., Pedretti, P., Moretto, N., Fusi, C., Carnini, C., Facchinetti, F., Viscomi, A. R., Pisano, A. R., Stokesberry, S., Brunmark, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042454 · Cited by 237

Thymic stromal lymphopoietin

He, R., & Geha, R. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05128.x · Cited by 235

Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila

Kang, K., Panzano, V. C., Chang, E. C., Ni, L., Dainis, A. M., Jenkins, A. M., Regna, K., Muskavitch, M. A. T., & Garrity, P. A. (2012) · Nature · doi:10.1038/nature10715 · Cited by 234

Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

Cordero-Morales, J. F., Gracheva, E. O., & Julius, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114124108 · Cited by 233

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis

Liu, B., Escalera, J., Balakrishna, S., Fan, L., Caceres, A. I., Robinson, E., Sui, A., McKay, M. C., McAlexander, M. A., Herrick, C. A., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-229948 · Cited by 232

Species differences and molecular determinant of TRPA1 cold sensitivity

Chen, J., Kang, D., Xu, J., Lake, M., Hogan, J. O., Sun, C., Walter, K., Yao, B., & Kim, D. (2013) · Nature Communications · doi:10.1038/ncomms3501 · Cited by 231

Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: A randomized, placebo-controlled, double-blind clinical trial

Akilen, R., Tsiami, A., Devendra, D., & Robinson, N. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03079.x · Cited by 230

Zinc activates damage-sensing TRPA1 ion channels

Hu, H., Bandell, M., Petrus, M. J., Zhu, M. X., & Patapoutian, A. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.146 · Cited by 229

Regular review: Peripheral neuropathy

Hughes, R. A. C. (2002) · BMJ · doi:10.1136/bmj.324.7335.466 · Cited by 228

Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane

Schmidt, M., Dubin, A. E., Petrus, M. J., Earley, T. J., & Patapoutian, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.030 · Cited by 225

TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism

Materazzi, S., Fusi, C., Benemei, S., Pedretti, P., Patacchini, R., Nilius, B., Prenen, J., Creminon, C., Geppetti, P., & Nassini, R. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1071-x · Cited by 224

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation

da Costa, D. S. M., Meotti, F. C., Andrade, E. L., Leal, P. C., Motta, E. M., & Calixto, J. B. (2010) · Pain · doi:10.1016/j.pain.2009.12.002 · Cited by 223

TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice

Miyamoto, T., Dubin, A. E., Petrus, M. J., & Patapoutian, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007596 · Cited by 223

TRPA1

Zygmunt, P. M., & Högestätt, E. D. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-54215-2_23 · Cited by 223

Hypothesis: A helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors

Howard, J., & Bechstedt, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.02.050 · Cited by 222

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

Lieu, T., Jayaweera, G., Zhao, P., Poole, D. P., Jensen, D., Grace, M., McIntyre, P., Bron, R., Wilson, Y. M., Krappitz, M., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.042 · Cited by 221

TRPA1 and Substance P Mediate Colitis in Mice

Engel, M. A., Leffler, A., Niedermirtl, F., Babes, A., Zimmermann, K., Filipović, M. R., Izydorczyk, I., Eberhardt, M., Kichko, T. I., Mueller–Tribbensee, S. M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.002 · Cited by 218

Hydrogen sulphide — a novel mediator of inflammation?

LI, L., BHATIA, M., & MOORE, P. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.10.007 · Cited by 218

Spatial separation of endothelial small‐ and intermediate‐conductance calcium‐activated potassium channels (KCa) and connexins: possible relationship to vasodilator function?

Sandow, S. L., Neylon, C. B., Chen, M. X., & Garland, C. J. (2006) · Journal of Anatomy · doi:10.1111/j.1469-7580.2006.00647.x · Cited by 215

Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats

Katsura, H., Obata, K., Mizushima, T., Yamanaka, H., Kobayashi, K., Dai, Y., Fukuoka, T., Tokunaga, A., Sakagami, M., & Noguchi, K. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.01.031 · Cited by 213

TRPA1‐mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1

Salas, M. M., Hargreaves, K. M., & Akopian, A. N. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06702.x · Cited by 211

TRPA1 channels: molecular sentinels of cellular stress and tissue damage

Viana, F. (2016) · The Journal of Physiology · doi:10.1113/jp270935 · Cited by 210

The TRPA1 Channel in Inflammatory and Neuropathic Pain and Migraine

Nassini, R., Materazzi, S., Benemei, S., & Geppetti, P. (2014) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/112_2014_18 · Cited by 206

Emergence of Functional Sensory Subtypes as Defined by Transient Receptor Potential Channel Expression

Hjerling-Leffler, J., AlQatari, M., Ernfors, P., & Koltzenburg, M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5614-06.2007 · Cited by 205

TRPA1-Dependent Pruritus in IL-13–Induced Chronic Atopic Dermatitis

Oh, M.-H., Oh, S. Y., Lu, J., Lou, H., Myers, A. C., Zhu, Z., & Zheng, T. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300300 · Cited by 205

Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice

Knowlton, W. M., Daniels, R. L., Palkar, R., McCoy, D. D., & McKemy, D. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025894 · Cited by 203

A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic

Salazar, H., Llorente, I., Jara-Oseguera, A., García-Villegas, R., Munari, M., Gordon, S. E., Islas, L. D., & Rosenbaum, T. (2008) · Nature Neuroscience · doi:10.1038/nn2056 · Cited by 202

TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress

Trevisan, G., Benemei, S., Materazzi, S., De Logu, F., De Siena, G., Fusi, C., Fortes Rossato, M., Coppi, E., Marone, I. M., Ferreira, J., et al. (2016) · Brain · doi:10.1093/brain/aww038 · Cited by 202

Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field

Moran, M. M., & Szallasi, A. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14044 · Cited by 199

Chemosensory properties of the trigeminal system

Viana, F. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn100102c · Cited by 196

The ‘headache tree’ via umbellulone and TRPA1 activates the trigeminovascular system

Nassini, R., Materazzi, S., Vriens, J., Prenen, J., Benemei, S., De Siena, G., la Marca, G., Andrè, E., Preti, D., Avonto, C., et al. (2012) · Brain · doi:10.1093/brain/awr272 · Cited by 196

Transient Receptor Potential Vanilloid 1 is Essential for Cisplatin-Induced Heat Hyperalgesia in Mice

Ta, L. E., Bieber, A. J., Carlton, S. M., Loprinzi, C. L., Low, P. A., & Windebank, A. J. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-15 · Cited by 193

TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons

Anand, U., Otto, W. R., Facer, P., Zebda, N., Selmer, I., Gunthorpe, M. J., Chessell, I. P., Sinisi, M., Birch, R., & Anand, P. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.04.007 · Cited by 192

Transient receptor potential (TRP) channels in the airway: role in airway disease

Grace, M. S., Baxter, M., Dubuis, E., Birrell, M. A., & Belvisi, M. G. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12538 · Cited by 190

Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1)

Eberhardt, M. J., Filipovic, M. R., Leffler, A., de la Roche, J., Kistner, K., Fischer, M. J., Fleming, T., Zimmermann, K., Ivanovic-Burmazovic, I., Nawroth, P. P., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.328674 · Cited by 190

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

Camacho, S., Michlig, S., de Senarclens-Bezençon, C., Meylan, J., Meystre, J., Pezzoli, M., Markram, H., & le Coutre, J. (2015) · Scientific Reports · doi:10.1038/srep07919 · Cited by 189

Acute Cold Hypersensitivity Characteristically Induced by Oxaliplatin is Caused by the Enhanced Responsiveness of TRPA1 in Mice

Zhao, M., Isami, K., Nakamura, S., Shirakawa, H., Nakagawa, T., & Kaneko, S. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-55 · Cited by 189

HTR7 Mediates Serotonergic Acute and Chronic Itch

Morita, T., McClain, S. P., Batia, L. M., Pellegrino, M., Wilson, S. R., Kienzler, M. A., Lyman, K., Olsen, A. S. B., Wong, J. F., Stucky, C. L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.044 · Cited by 188

Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain

Inceoglu, B., Bettaieb, A., Trindade da Silva, C. A., Lee, K. S. S., Haj, F. G., & Hammock, B. D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510137112 · Cited by 184

TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats

McGaraughty, S., Chu, K. L., Perner, R. J., DiDomenico, S., Kort, M. E., & Kym, P. R. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-14 · Cited by 183

Cold sensitivity of recombinant TRPA1 channels

Sawada, Y., Hosokawa, H., Hori, A., Matsumura, K., & Kobayashi, S. (2007) · Brain Research · doi:10.1016/j.brainres.2007.05.047 · Cited by 182

Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade

Trevisan, G., Materazzi, S., Fusi, C., Altomare, A., Aldini, G., Lodovici, M., Patacchini, R., Geppetti, P., & Nassini, R. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4370 · Cited by 182

Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain

Weng, H.-J., Patel, K. N., Jeske, N. A., Bierbower, S. M., Zou, W., Tiwari, V., Zheng, Q., Tang, Z., Mo, G. C. H., Wang, Y., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.065 · Cited by 181

Nitrooleic Acid, an Endogenous Product of Nitrative Stress, Activates Nociceptive Sensory Nerves via the Direct Activation of TRPA1

Taylor-Clark, T. E., Ghatta, S., Bettner, W., & Undem, B. J. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.054445 · Cited by 180

Synergistic Role of TRPV1 and TRPA1 in Pancreatic Pain and Inflammation

Schwartz, E. S., Christianson, J. A., Chen, X., La, J., Davis, B. M., Albers, K. M., & Gebhart, G. F. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.12.033 · Cited by 178

Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model

Wang, M., Zhang, Y., Xu, M., Zhang, H., Chen, Y., Chung, K. F., Adcock, I. M., & Li, F. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.004 · Cited by 178

Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti‐nociception

Bang, S., Yoo, S., Yang, T., Cho, H., Kim, Y., & Hwang, S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00909.x · Cited by 176

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents

Baraldi, P. G., Preti, D., Materazzi, S., & Geppetti, P. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100062h · Cited by 176

Non‐psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action

Maione, S., Piscitelli, F., Gatta, L., Vita, D., De Petrocellis, L., Palazzo, E., de Novellis, V., & Di Marzo, V. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01063.x · Cited by 175

TRPA1 Channels Mediate Cold Temperature Sensing in Mammalian Vagal Sensory Neurons: Pharmacological and Genetic Evidence

Fajardo, O., Meseguer, V., Belmonte, C., & Viana, F. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1696-08.2008 · Cited by 173

TRPV1 and TRPA1 Antagonists Prevent the Transition of Acute to Chronic Inflammation and Pain in Chronic Pancreatitis

Schwartz, E. S., La, J.-H., Scheff, N. N., Davis, B. M., Albers, K. M., & Gebhart, G. F. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1806-12.2013 · Cited by 173

Two populations of cold‐sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor

Babes, A., Zorzon, D., & Reid, G. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03695.x · Cited by 173

TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation

Kunkler, P. E., Ballard, C. J., Oxford, G. S., & Hurley, J. H. (2011) · Pain · doi:10.1016/j.pain.2010.08.021 · Cited by 172

The G Protein–Coupled Receptor–Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation

Veldhuis, N. A., Poole, D. P., Grace, M., McIntyre, P., & Bunnett, N. W. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009555 · Cited by 172

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways

Deuis, J. R., Zimmermann, K., Romanovsky, A. A., Possani, L. D., Cabot, P. J., Lewis, R. J., & Vetter, I. (2013) · Pain · doi:10.1016/j.pain.2013.05.032 · Cited by 171

Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases

Bessac, B. F., Sivula, M., von Hehn, C. A., Caceres, A. I., Escalera, J., & Jordt, S.-E. (2009) · The FASEB Journal · doi:10.1096/fj.08-117812 · Cited by 171

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Materazzi, S., Nassini, R., Andrè, E., Campi, B., Amadesi, S., Trevisani, M., Bunnett, N. W., Patacchini, R., & Geppetti, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802354105 · Cited by 170

A Comparison of Oral Sensory Effects of Three TRPA1 Agonists in Young Adult Smokers and Non-smokers

Hansen, E. Ø., Arendt-Nielsen, L., & Boudreau, S. A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00663 · Cited by 170

Pharmacological Blockade of TRPA1 Inhibits Mechanical Firing in Nociceptors

Kerstein, P. C., del Camino, D., Moran, M. M., & Stucky, C. L. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-19 · Cited by 169

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis

Fernandes, E. S., Russell, F. A., Spina, D., McDougall, J. J., Graepel, R., Gentry, C., Staniland, A. A., Mountford, D. M., Keeble, J. E., Malcangio, M., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30150 · Cited by 168

Localized TRPA1 channel Ca 2+ signals stimulated by reactive oxygen species promote cerebral artery dilation

Sullivan, M. N., Gonzales, A. L., Pires, P. W., Bruhl, A., Leo, M. D., Li, W., Oulidi, A., Boop, F. A., Feng, Y., Jaggar, J. H., et al. (2015) · Science Signaling · doi:10.1126/scisignal.2005659 · Cited by 167

Thymol and related alkyl phenols activate the hTRPA1 channel

Lee, S. P., Buber, M. T., Yang, Q., Cerne, R., Cortés, R. Y., Sprous, D. G., & Bryant, R. W. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.85 · Cited by 166

Compounds from Sichuan and Melegueta peppers activate, covalently and non‐covalently, TRPA1 and TRPV1 channels

Riera, C., Menozzi‐Smarrito, C., Affolter, M., Michlig, S., Munari, C., Robert, F., Vogel, H., Simon, S., & Le Coutre, J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00307.x · Cited by 165

NGF Up-regulates TRPA1: Implications for Orofacial Pain

Diogenes, A., Akopian, A. N., & Hargreaves, K. M. (2007) · Journal of Dental Research · doi:10.1177/154405910708600612 · Cited by 163

Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli

Bráz, J. M., & Basbaum, A. I. (2010) · Pain · doi:10.1016/j.pain.2010.05.005 · Cited by 162

Urinary Biomarkers for Phthalates Associated with Asthma in Norwegian Children

Bertelsen, R. J., Carlsen, K. C. L., Calafat, A. M., Hoppin, J. A., Håland, G., Mowinckel, P., Carlsen, K.-H., & Løvik, M. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205256 · Cited by 161

Spices: The Savory and Beneficial Science of Pungency

Nilius, B., & Appendino, G. (2013) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/112_2013_11 · Cited by 160

Osteoarthritis year in review 2015: biology

Malfait, A. M. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.09.010 · Cited by 160

Attenuation of Mechanical Hypersensitivity by an Antagonist of the TRPA1 Ion Channel in Diabetic Animals

Wei, H., Hämäläinen, M. M., Saarnilehto, M., Koivisto, A., & Pertovaara, A. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181a1642b · Cited by 159

Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia

Hamilton, N. B., Kolodziejczyk, K., Kougioumtzidou, E., & Attwell, D. (2016) · Nature · doi:10.1038/nature16519 · Cited by 159

Increased NADPH-Oxidase Activity and Nox4 Expression During Chronic Hypertension Is Associated With Enhanced Cerebral Vasodilatation to NADPH In Vivo

Paravicini, T. M., Chrissobolis, S., Drummond, G. R., & Sobey, C. G. (2004) · Stroke · doi:10.1161/01.str.0000112974.37028.58 · Cited by 156

Functional characterization of transient receptor potential channels in mouse urothelial cells

Everaerts, W., Vriens, J., Owsianik, G., Appendino, G., Voets, T., Ridder, D. J. M. K. D., & Nilius, B. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00599.2009 · Cited by 156

Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity

Moparthi, L., Kichko, T. I., Eberhardt, M. J., Högestätt, E. D., Kjellbom, P. O., Johanson, U., Reeh, P. W., Leffler, A., Filipović, M. R., & Zygmunt, P. M. (2016) · Scientific Reports · doi:10.1038/srep28763 · Cited by 156

The Molecular and Cellular Basis of Cold Sensation

McKemy, D. D. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300193h · Cited by 155

Redox Regulation of Transient Receptor Potential Channels

Kozai, D., Ogawa, N., & Mori, Y. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5616 · Cited by 155

TRPA1 Mediates Mechanical Currents in the Plasma Membrane of Mouse Sensory Neurons

Vilceanu, D., & Stucky, C. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012177 · Cited by 155

Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

Moparthi, L., Survery, S., Kreir, M., Simonsen, C., Kjellbom, P. O., Högestätt, E. D., Johanson, U., & Zygmunt, P. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412689111 · Cited by 155

TRPA1 Is a Component of the Nociceptive Response to CO 2

Wang, Y. Y., Chang, R. B., & Liman, E. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2715-10.2010 · Cited by 155

TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity

Brierley, S. M., Castro, J., Harrington, A. M., Hughes, P. A., Page, A. J., Rychkov, G. Y., & Blackshaw, L. A. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.206789 · Cited by 153

TRPA1 antagonists as potential analgesic drugs

de Andrade, E. L., Meotti, F. C., & Calixto, J. Β. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.10.008 · Cited by 153

TRPA1 and Sympathetic Activation Contribute to Increased Risk of Triggered Cardiac Arrhythmias in Hypertensive Rats Exposed to Diesel Exhaust

Hazari, M. S., Haykal-Coates, N., Winsett, D. W., Krantz, Q. T., King, C. J., Costa, D. L., & Farraj, A. K. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1003200 · Cited by 152

The TRPA1 channel in migraine mechanism and treatment

Benemei, S., Fusi, C., Trevisan, G., & Geppetti, P. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12512 · Cited by 151

TRPs in Taste and Chemesthesis

Roper, S. D. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-05161-1_5 · Cited by 150

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01464-x · Cited by 522

TRPA1 rare variants in chronic neuropathic and nociplastic pain patients

Marchi, M., Salvi, E., Andelic, M., Mehmeti, E., D'Amato, I., Cazzato, D., Chiappori, F., Lombardi, R., Cartelli, D., Devigili, G., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002905 · Cited by 29

TRPA1 promotes melanosome phagocytosis in keratinocytes via PAR-2/CYLD axis

Wang, Y., Li, Z., Wu, W., Liu, Y., Xiao, Y., Qi, D., Zhao, G., Zhou, M., Wang, H., Liu, J., et al. (2022) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2022.05.005 · Cited by 12

Transient receptor potential Ankyrin‐1 (TRPA1) agonists suppress myelination and induce demyelination in organotypic cortical slices

Giacco, V., Flower, G., Artamonova, M., Hunter, J., Padilla Requerey, A., & Hamilton, N. B. (2023) · Glia · doi:10.1002/glia.24347 · Cited by 11