The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment
Open accessAbstract
Inflammation is a complicated biological and pathophysiological cascade of responses to infections and injuries, and inflammatory mechanisms are closely related to many diseases. The magnitude, the complicated network of pro- and anti-inflammatory factors, and the direction of the inflammatory response can impact on the development and progression of various disorders. The currently available treatment strategies often target the symptoms and not the causes of inflammatory disease and may often be ineffective. Since the onset and termination of inflammation are crucial to prevent tissue damage, a range of mechanisms has evolved in nature to regulate the process including negative and positive feedback loops. In this regard, microRNAs (miRNAs) have emerged as key gene regulators to control inflammation, and it is speculated that they are fine-tune signaling regulators to allow for proper resolution and prevent uncontrolled progress of inflammatory reactions. In this review, we discuss recent findings related to significant roles of miRNAs in immune regulation, especially the potential utility of these molecules as novel anti-inflammatory agents to treat inflammatory diseases. Furthermore, we discuss the possibilities of using miRNAs as drugs in the form of miRNA mimics or miRNA antagonists.
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Cites
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BackgroundRegulation of mRNA Translation and Stability by microRNAs
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Cited by
Inflammation and cardiovascular disease: From mechanisms to therapeutics
Alfaddagh, A., Martin, S. S., Leucker, T. M., Michos, E. D., Blaha, M. J., Lowenstein, C. J., Jones, S. R., & Toth, P. P. (2020) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2020.100130 · Cited by 473
Scioli, M. G., Storti, G., D’Amico, F., Rodríguez Guzmán, R., Centofanti, F., Doldo, E., Céspedes Miranda, E. M., & Orlandi, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061995 · Cited by 281
Genetically Engineered Microorganisms and Their Impact on Human Health
Mahdizade Ari, M., Dadgar, L., Elahi, Z., Ghanavati, R., & Taheri, B. (2024) · International Journal of Clinical Practice · doi:10.1155/2024/6638269 · Cited by 67
Human infrapatellar fat pad mesenchymal stem cells show immunomodulatory exosomal signatures
Kouroupis, D., Kaplan, L. D., & Best, T. M. (2022) · Scientific Reports · doi:10.1038/s41598-022-07569-7 · Cited by 50
MicroRNAs As Novel Biomarkers and Potential Therapeutic Options for Inflammatory Cardiomyopathy
Aleshcheva, G., Baumeier, C., Harms, D., Bock, C.-T., Escher, F., & Schultheiss, H.-P. (2023) · ESC Heart Failure · doi:10.1002/ehf2.14523 · Cited by 17
Metadata
- Authors
- Tahamtan, A., Teymoori-Rad, M., Nakstad, B., & Salimi, V.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2018-06-25
- Volume
- 9
- Pages
- 1377-1377
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2806388412
- Cited by
- 357
- References
- 149
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tahamtan, A., Teymoori-Rad, M., Nakstad, B., & Salimi, V. (2018). Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2018.01377
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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