The DOI matches its Crossref record; 187 of the 187 references it cites were found in a registry or an index.
MicroRNA biogenesis: regulating the regulators
Open accessAbstract
MicroRNAs (miRNAs) function as 21-24 nucleotide guide RNAs that use partial base-pairing to recognize target messenger RNAs and repress their expression. As a large fraction of protein-coding genes are under miRNA control, production of the appropriate level of specific miRNAs at the right time and in the right place is integral to most gene regulatory pathways. MiRNA biogenesis initiates with transcription, followed by multiple processing steps to produce the mature miRNA. Every step of miRNA production is subject to regulation and disruption of these control mechanisms has been linked to numerous human diseases, where the balance between the expression of miRNAs and their targets becomes distorted. Here we review the basic steps of miRNA biogenesis and describe the various factors that control miRNA transcription, processing, and stability in animal cells. The tremendous effort put into producing the appropriate type and level of specific miRNAs underscores the critical role of these small RNAs in gene regulation.
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2 retracted
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RetractedA TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
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RetractedMicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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The nuclear RNase III Drosha initiates microRNA processing
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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
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Self-citationRole for a bidentate ribonuclease in the initiation step of RNA interference
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MicroRNA genes are transcribed by RNA polymerase II
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Cited by
miRNA interplay: mechanisms and consequences in cancer
Hill, M., & Tran, N. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.047662 · Cited by 674
Regulatory mechanisms of microRNA expression
Gulyaeva, L. F., & Kushlinskiy, N. E. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0893-x · Cited by 464
From guide to target: molecular insights into eukaryotic RNA-interference machinery
Ipsaro, J. J., & Joshua-Tor, L. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2931 · Cited by 281
Molecular Biomarkers for Gestational Diabetes Mellitus and Postpartum Diabetes
Lu, W., & Hu, C. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002160 · Cited by 52
Ryan, B., Logan, B. J., Abraham, W. C., & Williams, J. M. (2017) · PLOS ONE · doi:10.1371/journal.pone.0170407 · Cited by 23
Metadata
- Authors
- Finnegan, E. F., & Pasquinelli, A. E.
- Venue
- Critical Reviews in Biochemistry and Molecular Biology
- Publisher
- Informa UK Limited
- Published
- 2012-11-19
- Volume
- 48
- Issue
- 1
- Pages
- 51-68
- ISSN
- 0045-6411 (ISSN-L)
- 1040-9238
- 1549-7798
- OpenAlex
- W1964493174
- Cited by
- 311
- References
- 187
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- green
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