The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease
Abstract
Many cellular functions are regulated by calcium (Ca 2+) signals that are generated by different signaling pathways. One of these is the inositol 1,4,5-trisphosphate/calcium (InsP 3/Ca 2+) signaling pathway that operates through either primary or modulatory mechanisms. In its primary role, it generates the Ca 2+that acts directly to control processes such as metabolism, secretion, fertilization, proliferation, and smooth muscle contraction. Its modulatory role occurs in excitable cells where it modulates the primary Ca 2+signal generated by the entry of Ca 2+through voltage-operated channels that releases Ca 2+from ryanodine receptors (RYRs) on the internal stores. In carrying out this modulatory role, the InsP 3/Ca 2+signaling pathway induces subtle changes in the generation and function of the voltage-dependent primary Ca 2+signal. Changes in the nature of both the primary and modulatory roles of InsP 3/Ca 2+signaling are a contributory factor responsible for the onset of a large number human diseases.
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Cites
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Metadata
- Authors
- Berridge, M. J.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2016-10
- Volume
- 96
- Issue
- 4
- Pages
- 1261-1296
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2483776236
- Cited by
- 753
- References
- 41
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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