The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility
Open accessAbstract
Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyperfibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19.
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Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 (Covid‐19)
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SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19
Gusev, E., Sarapultsev, A., Solomatina, L., & Chereshnev, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031716 · Cited by 281
Lai, A., Chang, M. L., O'Donnell, R. P., Zhou, C., Sumner, J. A., & Hsiai, T. K. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146464 · Cited by 25
Metadata
- Authors
- Ji, H.-L., Zhao, R., Matalon, S., & Matthay, M. A.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2020-07-01
- Volume
- 100
- Issue
- 3
- Pages
- 1065-1075
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W3013449264
- Cited by
- 399
- References
- 11
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- green
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