Brown Adipose Tissue: Function and Physiological Significance

CANNON, BARBARA, NEDERGAARD, JAN·2004·Physiological Reviews

DOI 10.1152/physrev.00015.2003

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Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures
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Increased expression of glucose transporter GLUT-4 in brown adipose tissue of fasted rats after cold exposure
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Corticotropin-Releasing Hormone-Mediated Pathway of Leptin to Regulate Feeding, Adiposity, and Uncoupling Protein Expression in Mice
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Quantitative differentiation of α- and β-adrenergic respiratory responses in isolated hamster brown fat cells: Evidence for the presence of an α1-adrenergic component
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The Expression of Subunit c Correlates with and Thus May Limit the Biosynthesis of the Mitochondrial F0F1-ATPase in Brown Adipose Tissue
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Adrenalectomy increases norepinephrine turnover in brown adipose tissue of obese (ob/ob) mice
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Norepinephrine‐Stimulated Fatty‐Acid Release and Oxygen Consumption in Isolated Hamster Brown‐Fat Cells
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Sympathetic activity is lower in rats fed a beef tallow diet than in rats fed a safflower oil diet
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Essential cis-Acting Elements in Rat Uncoupling Protein Gene Are in an Enhancer Containing a Complex Retinoic Acid Response Domain
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Intra-ventromedial hypothalamic injection of glutamate stimulates brown adipose tissue thermogenesis in the rat
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3,5,3′-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity
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Food restriction increases torpor and improves brown adipose tissue thermogenesis in ob/ob mice
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α1- and β-Adrenergic Agents Cause Synergistic Stimulation of the Iodothyronine Deiodinase in Rat Brown Adipocytes*
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Comparison of microspheres and 86Rb+ as tracers of the distribution of cardiac output in rats indicates invalidity of 86Rb+-based measurements
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Acute effects of food, 2-deoxy-d-glucose and noradrenaline on metabolic rate and brown adipose tissue in normal and atropinised lean and obese (fa/fa) Zucker rats
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Noradrenergic stimulation of mitochondriogenesis in brown adipocytes differentiating in culture
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IL-6 is essential in TNF-α-induced fever
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Glucose Transporter in Insulin Sensitive Tissues of Lean and Obese Mice. Effect of the Thermogenic Agent BRL 26830A*
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p42/p44 Mitogen-Activated Protein Kinases Activation Is Required for the Insulin-Like Growth Factor-I/Insulin Induced Proliferation, but Inhibits Differentiation, in Rat Fetal Brown Adipocytes
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Interactions among receptors, thyroid hormone response elements, and ligands in the regulation of the rat uncoupling protein gene expression by thyroid hormone
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The Cafeteria Diet as a Tool for Studies of Thermogenesis
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Hormonal regulation of iodothyronine 5'-deiodinase in rat brown adipose tissue
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A possible physiological function of pancreatic pro-colipase activation peptide in appetite regulation
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Leptin-Induced Leptin Resistance Reveals Separate Roles for the Anorexic and Thermogenic Responses in Weight Maintenance
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The uncoupling protein thermogenin during acclimation: indications for pretranslational control
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UCP1: The Original Uncoupling Protein—and Perhaps the Only One? New Perspectives on UCP1, UCP2, and UCP3 in the Light of the Bioenergetics of the UCP1-Ablated Mice
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Role of sympathetic activity in controlling the expression of vascular endothelial growth factor in brown fat cells of lean and genetically obese rats
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Tumor Necrosis Factor-α Causes Insulin Receptor Substrate-2-Mediated Insulin Resistance and Inhibits Insulin-Induced Adipogenesis in Fetal Brown Adipocytes1
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CCAAT/Enhancer Binding-Proteins α and β Are Transcriptional Activators of the Brown Fat Uncoupling Protein Gene Promoter
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Effect of norepinephrine, serotonin and tryptophan on the firing rate of sympathetic nerves
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Leptin selectively reduces white adipose tissue in mice via a UCP1-dependent mechanism in brown adipose tissue
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Neural control of brown adipose tissue thermogenesis, hypertrophy, and atrophy
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Divergence of the feeding and thermogenic pathways influenced by NPY in the hypothalamic PVN of the rat
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Stimulation of Respiration in Brown Fat Cells by Epinephrine, Dibutyryl-3′,5′-adenosine Monophosphate, and m-Chloro(carbonyl Cyanide)phenylhydrazone
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