A biopolymer transistor: Electrical amplification by microtubules
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Microtubules (MTs) are important cytoskeletal structures engaged in a number of specific cellular activities, including vesicular traffic, cell cyto-architecture and motility, cell division, and information processing within neuronal processes. MTs have also been implicated in higher neuronal functions, including memory and the emergence of "consciousness". How MTs handle and process electrical information, however, is heretofore unknown. Here we show new electrodynamic properties of MTs. Isolated, taxol-stabilized MTs behave as biomolecular transistors capable of amplifying electrical information. Electrical amplification by MTs can lead to the enhancement of dynamic information, and processivity in neurons can be conceptualized as an "ionic-based" transistor, which may affect, among other known functions, neuronal computational capabilities.
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Priel et al. demonstrated MTs' ability to amplify ionic charge conductivity, with current transmission increasing by 69% along MTs.
“Priel et al. demonstrated MTs’ ability to amplify ionic charge conductivity, with current transmission increasing by 69% along MTs [60]”
From An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields (2016) · cites this paper as [60]
The electrical resistance for a complete tubulin ring is R0 = 6.2 × 107 Ω.
“Estimating the electrical resistance for a complete tubulin ring gives R0 = 6.2 × 107 Ω [60,100].”
From An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields (2016) · cites this paper as [60]
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- Authors
- Priel, A., Ramos, A. J., Tuszynski, J. A., & Cantiello, H. F.
- Affiliations
- University of Alberta (CA)
- Harvard University (US)
- Corresponding author
- Priel, Avner
- Cantiello, Horacio F.
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 90
- Issue
- 12
- Pages
- 4639-4643
- ISSN
- 0006-3495 (ISSN-L)
- PMC
- PMC1471843
- OpenAlex
- W2036572722
- Cited by
- 138
- References
- 28
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 16 · 2019: 11 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 7
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biophysical Journal (publishedVersion)
- arXiv (Cornell University) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- arXiv (Cornell University)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Molecular Junctions and Nanostructures
- Keywords
- microtubules, electrodynamic characteristics, taxol-stabilized microtubules, neural information processing, cytoskeleton
- MeSH terms
- Amplifiers, Electronic, Animals, Biopolymers, Cattle, Computer Simulation, Electric Conductivity, Microtubules, Models, Biological, Models, Chemical, Transistors, Electronic, Tubulin
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