The DOI matches its Crossref record; 433 of the 433 references it cites were found in a registry or an index.
Mechanistic Pathways of Sex Differences in Cardiovascular Disease
Abstract
Major differences between men and women exist in epidemiology, manifestation, pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as coronary artery disease, pressure overload, hypertension, cardiomyopathy, and heart failure. Corresponding sex differences have been studied in a number of animal models, and mechanistic investigations have been undertaken to analyze the observed sex differences. We summarize the biological mechanisms of sex differences in CVD focusing on three main areas, i.e., genetic mechanisms, epigenetic mechanisms, as well as sex hormones and their receptors. We discuss relevant subtypes of sex hormone receptors, as well as genomic and nongenomic, activational and organizational effects of sex hormones. We describe the interaction of sex hormones with intracellular signaling relevant for cardiovascular cells and the cardiovascular system. Sex, sex hormones, and their receptors may affect a number of cellular processes by their synergistic action on multiple targets. We discuss in detail sex differences in organelle function and in biological processes. We conclude that there is a need for a more detailed understanding of sex differences and their underlying mechanisms, which holds the potential to design new drugs that target sex-specific cardiovascular mechanisms and affect phenotypes. The comparison of both sexes may lead to the identification of protective or maladaptive mechanisms in one sex that could serve as a novel therapeutic target in one sex or in both.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Items 401–433 of 433
Estrogen improves vascular function via peroxisome-proliferator-activated-receptor-γ
Tiyerili, V., Müller, C., Fung, S., Panek, D., Nickenig, G., & Becher, U. M. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.05.008 · Cited by 35
Mancusi, C., Gerdts, E., SIMONE, G. D., et al. (2014) · Blood Pressure · doi:10.3109/08037051.2013.858482 · Cited by 34
Coughlin, S. S., Comstock, G. W., & Baughman, K. L. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90167-y · Cited by 34
Liu, H., Yanamandala, M., Lee, T. C., & Kim, J. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085272 · Cited by 32
Thatcher, S. E., Zhang, X., Woody, S., Wang, Y., Alsiraj, Y., Charnigo, R. J., Daugherty, A., & Cassis, L. A. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0030-1 · Cited by 31
Update in Hyper- and Hypogonadotropic Amenorrhea
Santoro, N. F. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1419 · Cited by 31
Bloomer, L. D. S., Nelson, C. P., Denniff, M. J., Christofidou, P., Dębiec, R., Thompson, J. R., Zukowska-Szczechowska, E., Samani, N. J., Charchar, F. J., & Tomaszewski, M. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.12.012 · Cited by 30
Sex differences in the modulation of K+ currents in diabetic rat cardiac myocytes
Shimoni, Y., & Liu, X. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.041269 · Cited by 30
Taylor, K. C., Carty, C. L., Dumitrescu, L. C., Bůžková, P., Cole, S. A., Hindorff, L. A., Schumacher, F. R., Wilkens, L. R., Shohet, R. V., Quibrera, P. M., et al. (2013) · BMC Genetics · doi:10.1186/1471-2156-14-33 · Cited by 30
Heart protein expression related to age and sex in mice and humans
Diedrich, M., Tadic, J., Mao, L., Wacker, M. A., Nebrich, G., Hetzer, R., Regitz‐Zagrosek, V., & Klose, J. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.20.6.865 · Cited by 28
Self-citationNuclear Factor-κB Regulates Estrogen Receptor-α Transcription in the Human Heart
Mahmoodzadeh, S., Fritschka, S., Dworatzek, E., Pham, T. H., Becher, E., Kuehne, A., Davidson, M. M., & Regitz‐Zagrosek, V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.000463 · Cited by 28
Self-citationEssop, M. F., Chan, W. Y., & Taegtmeyer, H. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06051.x · Cited by 25
Langfort, J., Jagsz, S., Dobrzyń, P., Brzezinska, Z., Kłapcińska, B., Galbo, H., & Górski, J. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.140 · Cited by 25
Madhavan, M., Friedman, P. A., Lennon, R. J., Prasad, A., White, R. D., Sriram, C. S., Gulati, R., & Gersh, B. J. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.114.001255 · Cited by 25
Sex and Sex Hormone–Dependent Cardiovascular Stress Responses
Regitz‐Zagrosek, V., Dworatzek, E., Kintscher, U., & Dragun, D. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.189233 · Cited by 24
Self-citationLee, T. M., Lin, S. Z., & Chang, N. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1103-4 · Cited by 23
Booth, E. A., Marchesi, M., Knittel, A. K., Kilbourne, E. J., & Lucchesi, B. R. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3180544527 · Cited by 23
Thawornkaiwong, A., Pantharanontaga, J., & Wattanapermpool, J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00365.2006 · Cited by 22
Korićanac, G., Tepavčević, S., Romić, S., Živković, M., Stojiljković, M., Milosavljević, T., Stanković, A., Petković, M., Kamčeva, T., & Žakula, Z. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.08.007 · Cited by 21
Wakatsuki, A., Okatani, Y., & Ikenoue, N. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00350-0 · Cited by 20
Dose-dependent effects of a genistein-enriched diet in the heart of ovariectomized mice
Nguyen, B. T., Kararigas, G., & Jarry, H. (2012) · Genes & Nutrition · doi:10.1007/s12263-012-0323-5 · Cited by 20
Self-citationWu, H., Roks, A. J. M., Leijten, F. P. J., Garrelds, I. M., Musterd‐Bhaggoe, U. M., van den Bogaerdt, A. J., de Maat, M. P. M., Simoons, M. L., Danser, A. H. J., & Oeseburg, H. (2013) · Clinical Science · doi:10.1042/cs20130204 · Cited by 20
Androgen receptor independent cardiovascular action of the antiandrogen flutamide
Iliescu, R., Campos, L. A., Schlegel, W., Morano, I. L., Baltatu, O. C., & Bäder, M. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0449-4 · Cited by 19
Orłowska‐Baranowska, E., Góra, J., Baranowski, R., Stokłosa, P., Betka, Ł. G. V., Pędzich, E., Malogrzata, M., Koblowska, M., Hryniewiecki, T., Gaciong, Z. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096306 · Cited by 18
Schwab, K., Neumann, B., Vignon‐Zellweger, N., Fischer, A., Stein, R., Jungblut, P. R., Scheler, C., & Theuring, F. (2011) · PROTEOMICS · doi:10.1002/pmic.201000785 · Cited by 18
Sex-dimorphism in Cardiac Nutrigenomics: effect of Trans fat and/or Monosodium Glutamate consumption
Collison, K. S., Zaidi, M. Z., Maqbool, Z. M., Saleh, S. M., Inglis, A. L., Makhoul, N. J., Bakheet, R., Shoukri, M. M., & Al-Mohanna, F. A. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-555 · Cited by 18
Viegas, V. U., Liu, Z. Z., Nikitina, T., Perlewitz, A., Zavaritskaya, O., Schlichting, J., Persson, P. B., Regitz‐Zagrosek, V., Patzak, A. R., & Sendeski, M. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835731dd · Cited by 18
Self-citationYang, S., Prókai, L., & Simpkins, J. W. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.009 · Cited by 16
Vignon‐Zellweger, N., Relle, K., Rahnenführer, J., Schwab, K., Hocher, B., & Theuring, F. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.12.003 · Cited by 15
Romero, M., Caniffi, C., Bouchet, G., Elesgaray, R., Laughlin, M. M., Tomat, A. L., Arranz, C., & Costa, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071992 · Cited by 14
Sexual Autophagic Differences in the Androgen‐Dependent Flank Organ of Syrian Hamsters
Coto‐Montes, A. M., Tomás‐Zapico, C., Martínez‐Fraga, J., Vega‐Naredo, I., Sierra, V., Caballero, B., Huidobro, C., Soria‐Valles, C., Tolivia, D., & Rodríguez‐Colunga, M. J. (2009) · Journal of Andrology · doi:10.2164/jandrol.108.005355 · Cited by 14
Aspects of Cardiometabolic Risk in Women with Polycystic Ovary Syndrome
Paterakis, T., & Diamanti‐Kandarakis, E. (2014) · Current Obesity Reports · doi:10.1007/s13679-014-0127-6 · Cited by 10
Ruiz-Holst, C., Bölck, B., Ghanem, A., Tiemann, K., Brokat, S., Regitz‐Zagrosek, V., Bloch, W., Schwinger, R. H. G., & Brixius, K. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-115 · Cited by 7
Self-citation
Cited by
Sex and gender: modifiers of health, disease, and medicine
Mauvais-Jarvis, F., Bairey Merz, N., Barnes, P. J., Brinton, R. D., Carrero, J.-J., DeMeo, D. L., De Vries, G. J., Epperson, C. N., Govindan, R., Klein, S. L., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31561-0 · Cited by 2,001
Self-citationSex differences in pharmacokinetics predict adverse drug reactions in women
Zucker, I., & Prendergast, B. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00308-5 · Cited by 777
Schultheiss, H.-P., Fairweather, D., Caforio, A. L. P., Escher, F., Hershberger, R. E., Lipshultz, S. E., Liu, P. P., Matsumori, A., Mazzanti, A., McMurray, J., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0084-1 · Cited by 720
Cooke, P. S., Nanjappa, M. K., Ko, C., Prins, G. S., & Hess, R. A. (2017) · Physiological Reviews · doi:10.1152/physrev.00018.2016 · Cited by 466
The hematologic consequences of obesity
Purdy, J. C., & Shatzel, J. J. (2021) · European Journal Of Haematology · doi:10.1111/ejh.13560 · Cited by 227
Metadata
- Authors
- Regitz-Zagrosek, V., & Kararigas, G.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2017-01
- Volume
- 97
- Issue
- 1
- Pages
- 1-37
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2548440622
- Cited by
- 732
- References
- 433
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
