Mechanistic Pathways of Sex Differences in Cardiovascular Disease

Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function

Cavasin, M. A., Tao, Z.-Y., Yu, A.-L., & Yang, X.-P. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01121.2005 · Cited by 141

Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction

Lu, F. Y., Gao, X., Moore, X., Kiriazis, H., Su, Y., Ming, Z., Lim, Y. L., Dart, A. M., & Du, X. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.06.011 · Cited by 140

Gender differences in left ventricle geometry and function in patients undergoing balloon dilatation of the aortic valve for isolated aortic stenosis. NHLBI Balloon Valvuloplasty Registry.

Douglas, P. S., Otto, C. M., Mickel, M. C., Labovitz, A. J., Reid, C. L., & Davis, K. B. (1995) · Heart · doi:10.1136/hrt.73.6.548 · Cited by 139

Estrogen Receptor-β Activation Results in S-Nitrosylation of Proteins Involved in Cardioprotection

Lin, J. J., Steenbergen, C., Murphy, E., & Sun, J. (2009) · Circulation · doi:10.1161/circulationaha.109.868729 · Cited by 139

Unexpected Virilization in Male Mice Lacking Steroid 5 -Reductase Enzymes

Mahendroo, M., Cala, K. M., Hess, D. L., & Russell, D. W. (2001) · Endocrinology · doi:10.1210/endo.142.11.8510 · Cited by 139

4-vinylcyclohexene diepoxide: a model chemical for ovotoxicity

Mark-Kappeler, C. J., & Hoyer, P. B. (2012) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2011.648820 · Cited by 138

Gender differences in cardiac remodeling secondary to chronic volume overload

Gardner, J. D., Brower, G. L., & Janicki, J. S. (2002) · Journal of Cardiac Failure · doi:10.1054/jcaf.2002.32195 · Cited by 137

Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression

Kadokami, T., McTiernan, C. F., Kubota, T., Frye, C. S., & Feldman, A. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9307 · Cited by 136

Activation of estrogen receptor-α protects the in vivo rabbit heart from ischemia-reperfusion injury

Booth, E. A., Obeid, N. R., & Lucchesi, B. R. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00479.2005 · Cited by 136

Endocrine activity of the postmenopausal ovary: the effects of pituitary down-regulation and oophorectomy

Sluijmer, A. V., Heineman, M. J., de Jong, F. H., & Evers, J. L. H. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.7.7608272 · Cited by 135

Estrogen modulates TNF-α-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-β activation

Xing, D., Feng, W., Miller, A. P., Weathington, N. M., Chen, Y.-F., Novak, L., Blalock, J. E., & Oparil, S. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01107.2006 · Cited by 132

Idiopathic cardiomyopathy in the United States, 1970–1982

Gillum, R. F. (1986) · American Heart Journal · doi:10.1016/0002-8703(86)90111-0 · Cited by 131

Sex-Steroid Hormones and Electrocardiographic QT-Interval Duration: Findings From the Third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis

Zhang, Y., Ouyang, P., Post, W. S., Dalal, D., Vaidya, D. M., Blasco‐Colmenares, E., Soliman, E. Z., Tomaselli, G. F., & Güallar, E. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr172 · Cited by 131

Upregulation of Myocardial Estrogen Receptors in Human Aortic Stenosis

Nordmeyer, J., Eder, S., Mahmoodzadeh, S., Martus, P., Fielitz, J., Bass, J. K., Bethke, N., Zurbrügg, H. R., Pregla, R., Hetzer, R., et al. (2004) · Circulation · doi:10.1161/01.cir.0000147610.41984.e8 · Cited by 131

Nuclear Factor-κB Activation Leads to Down-regulation of Fatty Acid Oxidation during Cardiac Hypertrophy

Planavila, A., Laguna, J. C., & Vázquez‐Carrera, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414220200 · Cited by 129

Increased Mortality and Aggravation of Heart Failure in Estrogen Receptor-β Knockout Mice After Myocardial Infarction

Pelzer, T., Arias-Loza, P.-A., Hu, K., Bayer, B., Dienesch, C., Calvillo, L., Couse, J. F., Korach, K. S., Neyses, L., & Ertl, G. (2005) · Circulation · doi:10.1161/01.cir.0000159262.18512.46 · Cited by 128

The upper limit of physiological cardiac hypertrophy in elite male and female athletes: the British experience

Whyte, G. P., George, K., Sharma, S., et al. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1052-2 · Cited by 128

Mechanisms of sex differences in rat cardiac myocyte response to β-adrenergic stimulation

Vizgirda, V. M., Wahler, G. M., SONDGEROTH, K. L., Ziolo, M. T., & Schwertz, D. W. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2002.282.1.h256 · Cited by 128

Epidemiology and Clinical Profile of Takotsubo Cardiomyopathy

Sharkey, S. W., & Maron, B. J. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0770 · Cited by 127

The transactivating function 1 of estrogen receptor α is dispensable for the vasculoprotective actions of 17β-estradiol

Billon-Galés, A., Fontaine, C., Filipe, C., Douin‐Echinard, V., Fouque, M.-J., Flouriot, G., Gourdy, P., Lenfant, F., Laurell, H., Krust, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808742106 · Cited by 127

Absence of gender differences in clinical outcomes in patients with cardiogenic shock complicating acute myocardial infarction

Wong, S. C., Sleeper, L. A., Monrad, E. S., Menegus, M. A., Palazzo, A. M., Džavík, V., Jacobs, A. K., Jiang, X., & Hochman, J. S. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01581-9 · Cited by 127

Influence of sex hormones and phytoestrogens on heart disease in men and women

Bhupathy, P., Haines, C. D., & Leinwand, L. A. (2010) · Women s Health · doi:10.2217/whe.09.80 · Cited by 125

Sex and Gender Differences in Pharmacology

Regitz‐Zagrosek, V. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3 · Cited by 125

Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion

Wang, M., Tsai, B. M., Kher, A., Baker, L., Wairiuko, G. M., & Meldrum, D. R. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00784.2004 · Cited by 125

Sex differences in the mechanisms underlying long QT syndrome

Salama, G., & Bett, G. C. L. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00864.2013 · Cited by 124

Circulating Estradiol and Mortality in Men With Systolic Chronic Heart Failure

Jankowska, E. A. (2009) · JAMA · doi:10.1001/jama.2009.639 · Cited by 120

Gonadectomy of adult male rats reduces contractility of isolated cardiac myocytes

Golden, K. L., Marsh, J. D., Jiang, Y., Brown, T., & Moulden, J. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00054.2003 · Cited by 120

Gender-specific differences of cardiac remodeling in subjects with left ventricular dysfunction: a population-based study

Luchner, A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00510-7 · Cited by 116

Gender-specific difference in cardiac ATP-sensitive K+channels

Ranki, H. J., Budas, G. R., Crawford, R. M., & Jovanović, A. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01428-0 · Cited by 116

Estrogen Receptor β Protects the Murine Heart Against Left Ventricular Hypertrophy

Babiker, F. A., Lips, D. J., Meyer, R., Delvaux, E., Zandberg, P., Janssen, B. J., van Eys, G. J. J. M., Grohé, C., & Doevendans, P. A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000223344.11128.23 · Cited by 116

Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries

Broughton, B. R. S., Miller, A. A., & Sobey, C. G. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00878.2009 · Cited by 116

Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women

Schuit, S. C. E., de Jong, F. H., Stolk, L., Koek, W. N. H., van Meurs, J. B. J., Schoofs, M. W. C. J., Zillikens, M. C., Albert Hofman, D., van Leeuwen, J. P. T. M., Pols, H. A. P., et al. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01973 · Cited by 115

Transcriptome Characterization of Estrogen-Treated Human Myocardium Identifies Myosin Regulatory Light Chain Interacting Protein as a Sex-Specific Element Influencing Contractile Function

Kararigas, G., Bito, V., Tinel, H., Becher, E., Baczkó, I., Knosalla, C., Albrecht-Küpper, B. E., Sipido, K. R., & Regitz‐Zagrosek, V. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.09.054 · Cited by 114

β-Estradiol, but not α-estradiol, reduces myocardial necrosis in rabbits after ischemia and reperfusion

Hale, S. L., Birnbaum, Y., & Kloner, R. A. (1996) · American Heart Journal · doi:10.1016/s0002-8703(96)90419-6 · Cited by 114

17β-Estradiol inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts

Mahmoodzadeh, S., Dworatzek, E., Fritschka, S., Pham, T. H., & Regitz‐Zagrosek, V. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp350 · Cited by 114

Focus on preclinical sex differences will not address women’s and men’s health disparities

Richardson, S. S., Reiches, M. W., Shattuck‐Heidorn, H., LaBonte, M. L., & Consoli, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516958112 · Cited by 114

Visualising androgen receptor activity in male and female mice

Dart, D. A., Waxman, J., Aboagye, E. O., & Bevan, C. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071694 · Cited by 112

Non-nuclear Estrogen Receptor Signaling in the Endothelium

Wu, Q., Chambliss, K. L., Umetani, M., Mineo, C., & Shaul, P. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.191791 · Cited by 112

Upregulation of mitochondrial respiratory complex IV by estrogen receptor-β is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma–hemorrhage

Hsieh, Y.-C., Yu, H.-P., Suzuki, T., Choudhry, M. A., Schwacha, M. G., Bland, K. I., & Chaudry, I. H. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.06.001 · Cited by 111

Maladaptive Remodeling Is Associated With Impaired Survival in Women But Not in Men After Aortic Valve Replacement

Petrov, G., Dworatzek, E., Schulze, T. M., Dandel, M., Kararigas, G., Mahmoodzadeh, S., Knosalla, C., Hetzer, R., & Regitz‐Zagrosek, V. (2014) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2014.06.017 · Cited by 111

The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences

Heidecker, B., Lamirault, G., Kasper, E. K., Wittstein, I. S., Champion, H. C., Breton, E., Russell, S. D., Hall, J. L., Kittleson, M. M., Baughman, K. L., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp549 · Cited by 110

17β-Estradiol regulates expression of KATPchannels in heart-derived H9c2 cells

Ranki, H. J., Budas, G. R., Crawford, R. M., Davies, A. M., & Jovanović, A. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01947-2 · Cited by 110

What a Difference an X or Y Makes: Sex Chromosomes, Gene Dose, and Epigenetics in Sexual Differentiation

Arnold, A. P., Chen, X., & Itoh, Y. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3_4 · Cited by 109

Probucol-associated tachyarrhythmic events and QT prolongation: Importance of gender

Reinoehl, J., Frankovich, D., Machado, C., Kawasaki, R., Baga, J. J., Pires, L. A., Steinman, R. T., Fromm, B. S., & Lehmann, M. H. (1996) · American Heart Journal · doi:10.1016/s0002-8703(96)90095-2 · Cited by 109

Cardioprotective effects of estradiol include the activation of large-conductance Ca2+-activated K+ channels in cardiac mitochondria

Ohya, S., Kuwata, Y., Sakamoto, K., Muraki, K., & Imaizumi, Y. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00016.2005 · Cited by 108

Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride

Yamana, K., Labrie, F., & Luu-The, V. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.035 · Cited by 107

Sex- and age-dependent human transcriptome variability: Implications for chronic heart failure

Boheler, K. R., Volkova, M. V., Morrell, C., Garg, R., Zhu, Y. Z., Margulies, K. B., Seymour, A. L., & Lakatta, E. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0436564100 · Cited by 106

Treatment with an estrogen receptor-beta-selective agonist is cardioprotective

Nikolic, I., Liu, D., Bell, J. A., Collins, J. B., Steenbergen, C., & Murphy, E. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.01.014 · Cited by 106

17-β-Estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia

Wang, M., Tsai, B. M., Reiger, K., BROWN, J., & Meldrum, D. R. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.06.019 · Cited by 106

Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart

Queirós, A. M., Eschen, C., Fliegner, D., Kararigas, G., Dworatzek, E., Westphal, C., Sanchez‐Ruderisch, H., & Regitz‐Zagrosek, V. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.09.002 · Cited by 106

Do androgens play a beneficial role in the regulation of vascular tone? Nongenomic vascular effects of testosterone metabolites

Perusquía, M., & Stallone, J. N. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00753.2009 · Cited by 106

Gender modulates cardiac phenotype development in genetically modified mice

Du, X. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.03.027 · Cited by 106

The number of X chromosomes influences protection from cardiac ischaemia/reperfusion injury in mice: one X is better than two

Li, J., Chen, X., McClusky, R., Ruiz-Sundstrom, M., Itoh, Y., Umar, S., Arnold, A. P., & Eghbali, M. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu064 · Cited by 105

Cardioprotective Effects of 17β-Estradiol Produced by Activation of Mitochondrial ATP-Sensitive K+Channels in Canine Hearts

Lee, T., Su, S., Tsai, C.-C., Lee, Y., & Tsai, C. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1167 · Cited by 105

Effects of physical training by running or swimming on ventricular performance of rat hearts

Schaible, T. F., & Scheuer, J. (1979) · Journal of Applied Physiology · doi:10.1152/jappl.1979.46.4.854 · Cited by 104

17β-Estradiol Antagonizes Cardiomyocyte Hypertrophy by Autocrine/Paracrine Stimulation of a Guanylyl Cyclase A Receptor-Cyclic Guanosine Monophosphate-Dependent Protein Kinase Pathway

Babiker, F. A., Windt, L. J. D., van Eickels, M., Thijssen, V. L., Bronsaer, R., Grohé, C., van Bilsen, M., & Doevendans, P. A. (2004) · Circulation · doi:10.1161/01.cir.0000105682.85732.bd · Cited by 103

Sex chromosome complement contributes to sex differences in coxsackievirus B3 but not influenza A virus pathogenesis

Robinson, D. P., Huber, S. A., Moussawi, M., Roberts, B., Teuscher, C., Watkins, R., Arnold, A. P., & Klein, S. L. (2011) · Biology of Sex Differences · doi:10.1186/2042-6410-2-8 · Cited by 103

Oestrogen prevents cardiomyocyte apoptosis by suppressing p38α-mediated activation of p53 and by down-regulating p53 inhibition on p38β

Liu, H., Pedram, A., & Kim, J. K. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq265 · Cited by 100

Effects of aging on cardiac extracellular matrix in men and women

Dworatzek, E., Baczkó, I., & Kararigas, G. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500031 · Cited by 99

Burden of Hospital Admission and Repeat Angiography in Angina Pectoris Patients with and without Coronary Artery Disease: A Registry-Based Cohort Study

Jespersen, L., Abildstrom, S. Z., Hvelplund, A., Madsen, J. K., Galatius, S., Pedersen, F., Højberg, S., & Prescott, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093170 · Cited by 98

Endothelial regulation of eNOS, PAI-1 and t-PA by testosterone and dihydrotestosterone in vitro and in vivo

Goglia, L., Tosi, V., Sanchez, A. M., Flamini, M. I., Fu, X., Zullino, S., Genazzani, A. R., & Simoncini, T. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq049 · Cited by 98

Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: A randomized, controlled trial

Borst, S. E., Yarrow, J. F., Conover, C. F., Nseyo, U., Meuleman, J. R., Lipinska, J. A., Braith, R. W., Beck, D. T., Martin, J. S., Morrow, M., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00592.2013 · Cited by 98

JTc prolongation with d,l-sotalol in women versus men

Lehmann, M. H., Hardy, S. A., Archibald, D., & MacNeil, D. J. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00868-6 · Cited by 96

Impact of testosterone on cardiac L-type calcium channels and Ca2+ sparks: Acute actions antagonize chronic effects

Er, F., Michels, G., Brandt, M. C., Khan, I., Haase, H., Eicks, M., Lindner, M., & Hoppe, U. C. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.09.003 · Cited by 96

Sex differences in myocardial infarct size are abolished by sarcolemmal KATPchannel blockade in rat

Johnson, M. S., Moore, R. L., & Brown, D. A. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01291.2005 · Cited by 95

Differential effects of ovariectomy on calcium activation of cardiac and soleus myofilaments

Wattanapermpool, J., & Reiser, P. J. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h467 · Cited by 95

Redox state and gender differences in vascular smooth muscle cells

Malorni, W., Straface, E., Matarrese, P., Ascione, B., Coinu, R., Canu, S., Galluzzo, P., Marino, M., & Franconi, F. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.01.034 · Cited by 94

Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators

Arao, Y., Hamilton, K. J., Ray, M. K., Scott, G., Mishina, Y. M., & Korach, K. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109180108 · Cited by 94

Effect of estrogen on calcium-handling proteins, β-adrenergic receptors, and function in rat heart

Chu, S. H., Goldspink, P. H., Kowalski, J., Beck, J., & Schwertz, D. W. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.03.037 · Cited by 94

Improvement of Endothelial Dysfunction by Selective Estrogen Receptor-α Stimulation in Ovariectomized SHR

Widder, J. D., Pelzer, T., von Poser-Klein, C., Hu, K., Jazbutyte, V., Fritzemeier, K., Hegele‐Hartung, C., Neyses, L., & Bauersachs, J. K. (2003) · Hypertension · doi:10.1161/01.hyp.0000098661.37637.89 · Cited by 94

Interstitial Fibrosis, Left Ventricular Remodeling, and Myocardial Mechanical Behavior in a Population-Based Multiethnic Cohort

Donekal, S., Ambale‐Venkatesh, B., Liu, Y. C., Liu, C., Yoneyama, K., Wu, C. O., Nacif, M. S., Gomes, A. S., Hundley, W. G., Bluemke, D. A., et al. (2014) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.001073 · Cited by 93

Retardation in the development of spontaneous hypertension in SH rats by gonadectomy.

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Selective Oestrogen Receptor Modulators Differentially Potentiate Brain Mitochondrial Function

Irwin, R. W., Yao, J., To, J., Hamilton, R. T., Cadenas, E., & Brinton, R. D. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02251.x · Cited by 92

Estrogen Receptor α Gene Variation Is Associated With Risk of Myocardial Infarction in More Than Seven Thousand Men From Five Cohorts

Shearman, A. M., Cooper, J. A., Kotwinski, P. J., Miller, G. J., Humphries, S. E., Ardlie, K., Jordan, B., Irenze, K., Lunetta, K. L., Schuit, S. C. E., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000210578.62102.a6 · Cited by 92

Sex differences in SR Ca2+ release in murine ventricular myocytes are regulated by the cAMP/PKA pathway

Parks, R. J., Ray, G., Bienvenu, L. A., Rose, R. A., & Howlett, S. E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.07.006 · Cited by 91

Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men

Blouin, K., Richard, C., Brochu, G., Hould, F.-S., Lebel, S., Marceau, S., Biron, S., Luu-The, V., & Tchernof, A. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06365 · Cited by 90

Gender mediated cardiac protection from adverse ventricular remodeling is abolished by ovariectomy

Brower, G. L., Gardner, J. D., & Janicki, J. S. (2003) · Springer eBooks · doi:10.1007/978-1-4419-9238-3_13 · Cited by 90

THE NORMAL DURATION OF THE ELECTROCARDIOGRAPHIC VENTRICULAR COMPLEX

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Significant role of estrogen in maintaining cardiac mitochondrial functions

Rattanasopa, C., Phungphong, S., Wattanapermpool, J., & Bupha‐Intr, T. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.009 · Cited by 90

Influence of ovariectomy and 17β-estradiol treatment on insulin sensitivity, lipid metabolism and post-ischemic cardiac function

Liu, M., Xu, X., Rang, W., Li, Y., & Song, H. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2003.11.046 · Cited by 90

17β-Estradiol as a Receptor-Mediated Cardioprotective Agent

Booth, E. A., Marchesi, M., Kilbourne, E. J., & Lucchesi, B. R. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054205 · Cited by 90

Rapid modulation of L‐type calcium current by acutely applied oestrogens in isolated cardiac myocytes from human, guinea‐pig and rat

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Gender mediated cardiac protection from adverse ventricular remodeling is abolished by ovariectomy

Brower, G. L., Gardner, J. D., & Janicki, J. S. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1025438000942 · Cited by 89

Men supplemented with 17β-estradiol have increased β-oxidation capacity in skeletal muscle

Maher, A. C., Akhtar, M., & Tarnopolsky, M. A. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00016.2010 · Cited by 87

Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy

Olsson, M. C., Palmer, B. M., Leinwand, L. A., & Moore, R. L. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.3.h1136 · Cited by 87

Myocardial Protection of Contractile Function After Global Ischemia by Physiologic Estrogen Replacement in the Ovariectomized Rat

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Aromatase activity of membrane fractions of human adipose tissue stromal cells and adipocytes

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Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability

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Androgen Contributes to Gender-Related Cardiac Hypertrophy and Fibrosis in Mice Lacking the Gene Encoding Guanylyl Cyclase-A

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The AF-1 Activation Function of Estrogen Receptor α Is Necessary and Sufficient for Uterine Epithelial Cell Proliferation In Vivo

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Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation

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Cardiomyocyte-specific Estrogen Receptor Alpha Increases Angiogenesis,Lymphangiogenesis and Reduces Fibrosis in the Female Mouse Heart Post-Myocardial Infarction

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Testosterone-Down-Regulated Akt Pathway During Cardiac Ischemia/Reperfusion: A Mechanism Involving BAD, Bcl-2 and FOXO3a

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Association of Estrogen Receptor β Gene Polymorphisms With Left Ventricular Mass and Wall Thickness in Women

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Castration Reduces mRNA Levels for Calcium Regulatory Proteins in Rat Heart

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Estrogen receptor-α regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells

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Androgen Receptor Counteracts Doxorubicin-Induced Cardiotoxicity in Male Mice

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Tako-Tsubo-Kardiomyopathie

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Androgens Contribute to Sex Differences in Myocardial Remodeling under Pressure Overload by a Mechanism Involving TGF-β

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Alternative Initiation of Translation Accounts for a 67/45 kDa Dimorphism of the Human Estrogen Receptor ERα

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Increased contractile potential of papillary muscles from exercise-trained rat hearts

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Oestrogen confers cardioprotection by suppressing Ca2+/calmodulin‐dependent protein kinase II

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CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy

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Female Mice Lacking Estrogen Receptor β Display Prolonged Ventricular Repolarization and Reduced Ventricular Automaticity After Myocardial Infarction

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Reduced Bone Mass and Muscle Strength in Male 5α-Reductase Type 1 Inactivated Mice

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Genetic background, gender, age, body temperature, and arterial blood pH have a major impact on myocardial infarct size in the mouse and need to be carefully measured and/or taken into account: results of a comprehensive analysis of determinants of infarct size in 1,074 mice

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Rapid Estrogen Receptor-α Activation Improves Ischemic Tolerance in Aged Female Rats through a Novel Protein Kinase Cε-Dependent Mechanism

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Long-Term and Immediate Effect of Testosterone on Single T-Type Calcium Channel in Neonatal Rat Cardiomyocytes

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LXR agonism improves TNF-α-induced endothelial dysfunction in the absence of its cholesterol-modulating effects

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Estrogens Mediate Cardiac Hypertrophy in a Stimulus-Dependent Manner

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Abolition of End-Organ Damage by Antiandrogen Treatment in Female Hypertensive Transgenic Rats

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Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure

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Abolition of Hypertension-Induced End-Organ Damage by Androgen Receptor Blockade in Transgenic Rats Harboring the Mouse Ren-2 Gene

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Comparative Proteomic Analysis Reveals Sex and Estrogen Receptor β Effects in the Pressure Overloaded Heart

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17β-Estradiol utilizes the estrogen receptor to regulate CD16 expression in monocytes

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Estrogen Elicits Cytochrome P450—Mediated Flow-Induced Dilation of Arterioles in NO Deficiency: Role of PI3K-Akt Phosphorylation in Genomic Regulation

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Cell sex determines anoikis resistance in vascular smooth muscle cells

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Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction

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Cardiomyocyte-specific overexpression of oestrogen receptor β improves survival and cardiac function after myocardial infarction in female and male mice

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Aromatase Deficiency Confers Paradoxical Postischemic Cardioprotection

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