Mechanistic Pathways of Sex Differences in Cardiovascular Disease

The Steroid and Thyroid Hormone Receptor Superfamily

Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,439

Cloning of a novel receptor expressed in rat prostate and ovary.

Kuiper, G. G., Enmark, E., Pelto-Huikko, M., Nilsson, S., & Gustafsson, J. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5925 · Cited by 4,788

Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study

Benjamin, E. J., Wolf, P. A., D’Agostino, R. B., Silbershatz, H., Kannel, W. B., & Levy, D. (1998) · Circulation · doi:10.1161/01.cir.98.10.946 · Cited by 4,575

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766

A Comparison of Antiarrhythmic-Drug Therapy with Implantable Defibrillators in Patients Resuscitated from Near-Fatal Ventricular Arrhythmias

(1997) · New England Journal of Medicine · doi:10.1056/nejm199711273372202 · Cited by 3,232

The Protective Effects of Estrogen on the Cardiovascular System

Mendelsohn, M. E., & Karas, R. H. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906103402306 · Cited by 3,103

Third Universal Definition of Myocardial Infarction

Thygesen, K., Alpert, J. S., Jaffe, A. S., Simoons, M. L., Chaitman, B. R., & White, H. D. (2012) · Circulation · doi:10.1161/cir.0b013e31826e1058 · Cited by 2,985

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

Tsai, M.-J., & O'Malley, B. W. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.002315 · Cited by 2,932

Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy

Templin, C., Ghadri, J. R., Diekmann, J., Napp, L. C., Bataiosu, D. R., Jaguszewski, M., Cammann, V. L., Sarcon, A., Geyer, V., Neumann, C. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1406761 · Cited by 2,595

A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease

Buxton, A. E., Lee, K. L., Fisher, J. D., Josephson, M. E., Prystowsky, E. N., & Hafley, G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912163412503 · Cited by 2,489 · cited 1×

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458 · cited 1×

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

Thum, T., Gross, C., Fiedler, J., Fischer, T., Kissler, S., Bussen, M., Galuppo, P., Just, S., Rottbauer, W., Frantz, S., et al. (2008) · Nature · doi:10.1038/nature07511 · Cited by 2,349

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2005) · Science · doi:10.1126/science.1106943 · Cited by 2,302

The progression from hypertension to congestive heart failure

Levy, D. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03530440037034 · Cited by 2,155 · cited 1×

Long-term trends in the incidence of and survival with heart failure

Levy, D., Kenchaiah, S., Larson, M. G., Benjamin, E. J., Kupka, M. J., Ho, K. K. L., Murabito, J. M., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020265 · Cited by 2,152

ESC Guidelines on the management of cardiovascular diseases during pregnancy

Endorsed by the European Society of Gynecology (ESG), T. A. F. E. P. C. (., Authors/Task Force Members, Regitz-Zagrosek, V., Blomstrom Lundqvist, C., Borghi, C., Cifkova, R., Ferreira, R., Foidart, J.-M., Gibbs, J. S. R., Gohlke-Baerwolf, C., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr218 · Cited by 1,924

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Morris, A. P., Voight, B. F., Teslovich, T. M., Ferreira, T., Segrè, A. V., Steinthorsdottir, V., Strawbridge, R. J., Khan, H., Grallert, H., et al. (2012) · Nature Genetics · doi:10.1038/ng.2383 · Cited by 1,912

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

Lubahn, D. B., Moyer, J. S., Golding, T. S., Couse, J. F., Korach, K. S., & Smithies, O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11162 · Cited by 1,898

MicroRNA-133 controls cardiac hypertrophy

Carè, A., Catalucci, D., Felicetti, F., Bonci, D., Addario, A., Gallo, P., Bang, M.-L., Segnalini, P., Gu, Y., Dalton, N. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1582 · Cited by 1,776

New genetic loci link adipose and insulin biology to body fat distribution

The ADIPOGen Consortium, Shungin, D., The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The GEFOS Consortium, The GENIE Consortium, The, G. L. G. C., The, I. C. B. P., The International Endogene Consortium, Study, T. L. C., et al. (2015) · Nature · doi:10.1038/nature14132 · Cited by 1,580

The EuroHeart Failure survey programme—a survey on the quality of care among patients with heart failure in Europe Part 1: patient characteristics and diagnosis

Cleland, J. (2003) · European Heart Journal · doi:10.1016/s0195-668x(02)00823-0 · Cited by 1,549

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D., & Liu, L. F. (1984) · Science · doi:10.1126/science.6093249 · Cited by 1,538

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

van Rooij, E., Sutherland, L. B., Liu, N., Williams, A. H., McAnally, J., Gerard, R. D., Richardson, J. A., & Olson, E. N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608791103 · Cited by 1,507

Estrogen-Induced Activation of Erk-1 and Erk-2 Requires the G Protein-Coupled Receptor Homolog, GPR30, and Occurs via Trans-Activation of the Epidermal Growth Factor Receptor through Release of HB-EGF

Filardo, E. J. (2000) · Molecular Endocrinology · doi:10.1210/me.14.10.1649 · Cited by 1,383

Estrogen receptors and human disease

Deroo, B. J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27987 · Cited by 1,320

Sex-Based Differences in Early Mortality after Myocardial Infarction

Vaccarino, V., Parsons, L., Every, N. R., Barron, H. V., & Krumholz, H. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410401 · Cited by 1,298

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

Tobi, E. W., Lumey, L. H., Talens, R. P., Kremer, D., Putter, H., Stein, A. D., Slagboom, P. E., & Heijmans, B. T. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp353 · Cited by 1,155

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120

Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes

Dupont, S., Krust, A., Gansmuller, A., Dierich, A., Chambon, P., & Mark, M. (2000) · Development · doi:10.1242/dev.127.19.4277 · Cited by 1,064

Production and Actions of Estrogens

Gruber, C. J., Tschugguel, W., Schneeberger, C., & Huber, J. C. (2002) · New England Journal of Medicine · doi:10.1056/nejmra000471 · Cited by 1,062

Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy

Zhang, C. L., McKinsey, T. A., Chang, S., Antos, C. L., Hill, J. A., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00861-9 · Cited by 973

Clinical Features, Management, and Prognosis of Spontaneous Coronary Artery Dissection

Tweet, M. S., Hayes, S. N., Pitta, S. R., Simari, R. D., Lerman, A., Lennon, R. J., Gersh, B. J., Khambatta, S., Best, P. J. M., Rihal, C. S., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.105718 · Cited by 925

Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

Chen, Z., Yuhanna, I. S., Galcheva-Gargova, Z., Karas, R. H., Mendelsohn, M. E., & Shaul, P. W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5347 · Cited by 923

Estrogen Action Via the G Protein-Coupled Receptor, GPR30: Stimulation of Adenylyl Cyclase and cAMP-Mediated Attenuation of the Epidermal Growth Factor Receptor-to-MAPK Signaling Axis

Filardo, E. J., Quinn, J. A., Frackelton, A. R., & Bland, K. I. (2002) · Molecular Endocrinology · doi:10.1210/me.16.1.70 · Cited by 904

Insights From the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study

Bairey Merz, C. N., Shaw, L. J., Reis, S. E., Bittner, V., Kelsey, S. F., Olson, M., Johnson, B. D., Pepine, C. J., Mankad, S., Sharaf, B. L., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.084 · Cited by 851

Estrogen production and action

Nelson, L. R., & Bulun, S. E. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.117432 · Cited by 834

Regulation of cancer cell migration and bone metastasis by RANKL.

Jones, D. H., Nakashima, T., Sanchez, O. H., Kozieradzki, I., Komarova, S. V., Sarosi, I., Morony, S., Rubin, E., Sarao, R., Hojilla, C. V., et al. (2006) · Nature · doi:10.1038/nature04524 · Cited by 796

Female mice liberated for inclusion in neuroscience and biomedical research

Prendergast, B. J., Onishi, K. G., & Zucker, I. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.001 · Cited by 788

MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy

Sayed, D., Hong, C., Chen, I.-Y., Lypowy, J., & Abdellatif, M. (2007) · Circulation Research · doi:10.1161/01.res.0000257913.42552.23 · Cited by 776

Spontaneous Coronary Artery Dissection: Association With Predisposing Arteriopathies and Precipitating Stressors and Cardiovascular Outcomes

Saw, J., Aymong, E., Sedlak, T., Buller, C. E., Starovoytov, A., Ricci, D., Robinson, S., Vuurmans, T., Gao, M., Humphries, K., et al. (2014) · Circulation: Cardiovascular Interventions · doi:10.1161/circinterventions.114.001760 · Cited by 769

Cloning of the human estrogen receptor cDNA.

Walter, P., Green, S., Greene, G., Krust, A., Bornert, J. M., Jeltsch, J. M., Staub, A., Jensen, E., Scrace, G., & Waterfield, M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.7889 · Cited by 730

Hypertension among adults in the United States: National Health and Nutrition Examination Survey, 2011-2012.

Nwankwo, T., Yoon, S. S., Burt, V. L., & Gu, Q. (2013) · PubMed · Cited by 689

Estrogen Receptors α and β Form Heterodimers on DNA

Cowley, S. M., Hoare, S., Mosselman, S., & Parker, M. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19858 · Cited by 689

Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males

Borrás, C., Sastre, J., García-Sala, D., Lloret, A., Pallardó, F. V., & Viña, J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01356-4 · Cited by 654

Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy. A population-based study in Olmsted County, Minnesota, 1975-1984.

Codd, M. B., Sugrue, D. D., Gersh, B. J., & Melton, L. J. (1989) · Circulation · doi:10.1161/01.cir.80.3.564 · Cited by 640

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

Halachmi, S., Marden, E., Martin, G., MacKay, H., Abbondanza, C., & Brown, M. (1994) · Science · doi:10.1126/science.8197458 · Cited by 637

Sex differences in the evolution of the electrocardiographic QT interval with age.

Rautaharju, P. M., Sh, Z., Wong, S., Hp, C., Berenson, G. S., Prineas, R., & Davignon, A. (1992) · PubMed · Cited by 635

The organizational–activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues

Arnold, A. P. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.011 · Cited by 625

Vascular Actions of Estrogens: Functional Implications

Miller, V. M., & Duckles, S. P. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.08002 · Cited by 593

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

Schramek, D., Leibbrandt, A., Sigl, V., Kenner, L., Pospisilik, J. A., Lee, H. J., Hanada, R., Joshi, P. A., Aliprantis, A., Glimcher, L., et al. (2010) · Nature · doi:10.1038/nature09387 · Cited by 592

Gender differences and aging: Effects on the human heart

Olivetti, G., Giordano, G., Corradi, D., Melissari, M., Lagrasta, C., Gambert, S. R., & Anversa, P. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00282-8 · Cited by 576

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase.

Metzger, D., Clifford, J., Chiba, H., & Chambon, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6991 · Cited by 570 · cited 1×

Epigenetics and the environmental regulation of the genome and its function

Zhang, T.-Y., & Meaney, M. J. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163625 · Cited by 565

Sex Differences in Mortality Following Acute Coronary Syndromes

Berger, J. S. (2009) · JAMA · doi:10.1001/jama.2009.1227 · Cited by 548

Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction

Mentz, R. J., Kelly, J. P., von Lueder, T. G., Voors, A. A., Lam, C. S. P., Cowie, M. R., Kjeldsen, K., Jankowska, E. A., Atar, D., Butler, J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.08.036 · Cited by 546

Steroid receptors and their associated proteins

Smith, D. F. (1993) · Molecular Endocrinology · doi:10.1210/me.7.1.4 · Cited by 545

Estrogen: A master regulator of bioenergetic systems in the brain and body

Rettberg, J. R., Yao, J., & Brinton, R. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.08.001 · Cited by 534

Nature of Functional Estrogen Receptors at the Plasma Membrane

Pedram, A., Razandi, M., & Levin, E. R. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0525 · Cited by 522

Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action.

Shibata, H., Spencer, T. E., Oñate, S. A., Jenster, G. W., Tsai, M., Tsai, M., & O’Malley, B. W. (1997) · PubMed · Cited by 520

Angina With “Normal” Coronary Arteries: A Changing Philosophy

Bugiardini, R., & Bairey Merz, C. N. (2005) · JAMA · doi:10.1001/jama.293.4.477 · Cited by 519

A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits

De Vries, G. J., Rissman, E. F., Simerly, R. B., Yang, L.-Y., Scordalakes, E. M., Auger, C. J., Swain, A., Lovell-Badge, R., Burgoyne, P. S., & Arnold, A. P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09005.2002 · Cited by 509

Structure–function relationship of estrogen receptor α and β: Impact on human health

Ascenzi, P., Bocedi, A., & Marino, M. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.07.001 · Cited by 499

Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women.

Losordo, D. W., Kearney, M., Kim, E. A., Jekanowski, J., & Isner, J. M. (1994) · Circulation · doi:10.1161/01.cir.89.4.1501 · Cited by 496

MicroRNAs Are Aberrantly Expressed in Hypertrophic Heart

Cheng, Y., Ji, R., Yue, J., Yang, J., Liu, X., Chen, H., Dean, D. B., & Zhang, C. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.061170 · Cited by 490

Human vascular smooth muscle cells contain functional estrogen receptor.

Karas, R. H., Patterson, B. L., & Mendelsohn, M. E. (1994) · Circulation · doi:10.1161/01.cir.89.5.1943 · Cited by 489

Sex-associated differences in left ventricular function in aortic stenosis of the elderly.

Carroll, J. D., Carroll, E. P., Feldman, T., Ward, D. M., Lang, R. M., McGaughey, D., & Karp, R. B. (1992) · Circulation · doi:10.1161/01.cir.86.4.1099 · Cited by 488

Modulation of Antioxidant Enzyme Expression and Function by Estrogen

Strehlow, K., Rotter, S., Wassmann, S., Adam, O., Grohé, C., Laufs, K., Böhm, M., & Nickenig, G. (2003) · Circulation Research · doi:10.1161/01.res.0000082334.17947.11 · Cited by 483 · cited 8×

Testosterone Physiology in Resistance Exercise and Training: The Up-Stream Regulatory Elements

Vingren, J. L., Kraemer, W. J., Ratamess, N. A., Anderson, J. M., Volek, J. S., & Maresh, C. M. (2010) · Sports Medicine · doi:10.2165/11536910-000000000-00000 · Cited by 472

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3β activity

Trivedi, C. M., Luo, Y., Yin, Z., Zhang, M., Zhu, W., Wang, T., Floss, T., Goettlicher, M., Noppinger, P. R., Wurst, W., et al. (2007) · Nature Medicine · doi:10.1038/nm1552 · Cited by 468

Polycystic ovary syndrome and cardiovascular disease: a premature association?

Legro, R. S. (2003) · Endocrine Reviews · doi:10.1210/er.2003-0004 · Cited by 466

Estrogen Promotes Angiogenic Activity in Human Umbilical Vein Endothelial Cells In Vitro and in a Murine Model

Morales, D. E., McGowan, K. A., Grant, D. S., Maheshwari, S., Bhartiya, D., Cid, M. C., Kleinman, H. K., & Schnaper, H. W. (1995) · Circulation · doi:10.1161/01.cir.91.3.755 · Cited by 463

Prenatal Famine and Adult Health

Lumey, L. H., Stein, A. D., & Susser, E. (2011) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031210-101230 · Cited by 457

Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy

Tatsuguchi, M., Seok, H. Y., Callis, T. E., Thomson, J. M., Chen, J.-F., Newman, M., Rojas, M., Hammond, S. M., & Wang, D.-Z. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.04.004 · Cited by 432

Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes

Marsh, J. D., Lehmann, M. H., Ritchie, R. H., Gwathmey, J. K., Green, G. E., & Schiebinger, R. J. (1998) · Circulation · doi:10.1161/01.cir.98.3.256 · Cited by 432

COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice

Egan, K. M., Lawson, J. A., Fries, S., Koller, B., Rader, D. J., Smyth, E. M., & FitzGerald, G. A. (2004) · Science · doi:10.1126/science.1103333 · Cited by 431

Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5

Czubryt, M. P., McAnally, J., Fishman, G. I., & Olson, E. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337639100 · Cited by 418

Sudden coronary death in women

Kannel, W. B., Wilson, P. W. F., D’Agostino, R. B., & Cobb, J. (1998) · American Heart Journal · doi:10.1053/hj.1998.v136.90226 · Cited by 417

Myocyte Death in the Failing Human Heart Is Gender Dependent

Guerra, S., Leri, A., Wang, X., Finato, N., Di Loreto, C., Beltrami, C. A., Kajstura, J., & Anversa, P. (1999) · Circulation Research · doi:10.1161/01.res.85.9.856 · Cited by 417

Testosterone Relaxes Rabbit Coronary Arteries and Aorta

Yue, P., Chatterjee, K., Beale, C., Poole-Wilson, P. A., & Collins, P. (1995) · Circulation · doi:10.1161/01.cir.91.4.1154 · Cited by 414

Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial

Malkin, C. J., Pugh, P. J., West, J. N., van Beek, E. J. R., Jones, T. H., & Channer, K. S. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi443 · Cited by 413

A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.

Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., & Kelly, D. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3949 · Cited by 410

Electrocardiographic quantitation of ventricular repolarization.

Merri, M., Benhorin, J., Alberti, M., Locati, E., & Moss, A. J. (1989) · Circulation · doi:10.1161/01.cir.80.5.1301 · Cited by 397

Cardiac myocytes and fibroblasts contain functional estrogen receptors1

Grohé, C., Kahlert, S., Löbbert, K., Stimpel, M., Karas, R. H., Vetter, H., & Neyses, L. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01179-4 · Cited by 382

Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity

Haas, E., Bhattacharya, I., Brailoiu, E., Damjanović, M., Brailoiu, G. C., Gao, X., Mueller-Guerre, L., Marjon, N. A., Gut, A., Minotti, R., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.190892 · Cited by 373

Estrogen Receptor-α Mediates the Protective Effects of Estrogen Against Vascular Injury

Pare, G., Krust, A., Karas, R. H., Dupont, S., Aronovitz, M., Chambon, P., & Mendelsohn, M. E. (2002) · Circulation Research · doi:10.1161/01.res.0000021114.92282.fa · Cited by 369

Gender differences in the cardiovascular effect of sex hormones

Vitale, C., Mendelsohn, M. E., & Rosano, G. M. C. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.105 · Cited by 368

Untitled work

(1997) · PubMed · Cited by 363

Mechanisms of Coronary Microcirculatory Dysfunction in Patients With Aortic Stenosis and Angiographically Normal Coronary Arteries

Rajappan, K., Rimoldi, O. E., Dutka, D. P., Ariff, B., Pennell, D. J., Sheridan, D. J., & Camici, P. G. (2002) · Circulation · doi:10.1161/hc0402.102931 · Cited by 358

Early Prenatal Stress Epigenetically Programs Dysmasculinization in Second-Generation Offspring via the Paternal Lineage

Morgan, C. P., & Bale, T. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1887-11.2011 · Cited by 346

17β-Estradiol Reduces Cardiomyocyte Apoptosis In Vivo and In Vitro via Activation of Phospho-Inositide-3 Kinase/Akt Signaling

Patten, R. D., Pourati, I., Aronovitz, M. J., Baur, J., Celestin, F., Chen, X., Michael, A., Haq, S., Nuedling, S., Grohe, C., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000144126.57786.89 · Cited by 336

Observations of the Treatment of Women in the United States With Myocardial Infarction<subtitle>A Report From the National Registry of Myocardial Infarction-I</subtitle>

Chandra, N. C. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.9.981 · Cited by 334

Testosterone Exacerbates Hypertension and Reduces Pressure-Natriuresis in Male Spontaneously Hypertensive Rats

Reckelhoff, J. F., Zhang, H., & Granger, J. P. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.435 · Cited by 333

Identification of Authentic Estrogen Receptor in Cultured Endothelial Cells: A Potential Mechanism for Steroid Hormone Regulation of Endothelial Function

Venkov, C. D., Rankin, A. B., & Vaughan, D. E. (1996) · Circulation · doi:10.1161/01.cir.94.4.727 · Cited by 329

Sex Differences in the Phosphorylation of Mitochondrial Proteins Result in Reduced Production of Reactive Oxygen Species and Cardioprotection in Females

Lagranha, C. J., Deschamps, A., Aponte, A., Steenbergen, C., & Murphy, E. (2010) · Circulation Research · doi:10.1161/circresaha.109.213645 · Cited by 326

Origin of Estrogen in Normal Men and in Women with Testicular Feminization*

MACDONALD, P. C., MADDEN, J. D., BRENNER, P. F., WILSON, J. D., & SIITERI, P. K. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-6-905 · Cited by 321

Differential Cardiac Remodeling in Preload Versus Afterload

Toischer, K., Rokita, A. G., Unsöld, B., Zhu, W., Kararigas, G., Sossalla, S., Reuter, S. P., Becker, A., Teucher, N., Seidler, T., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.943431 · Cited by 318

Estrogen Increases Mitochondrial Efficiency and Reduces Oxidative Stress in Cerebral Blood Vessels

Stirone, C., Duckles, S. P., Krause, D. N., & Procaccio, V. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.014662 · Cited by 315

17β-Estradiol Attenuates the Development of Pressure-Overload Hypertrophy

van Eickels, M., Grohé, C., Cleutjens, J. P. M., Janssen, B. J., Wellens, H. J. J., & Doevendans, P. A. (2001) · Circulation · doi:10.1161/hc3601.095577 · Cited by 300

Hypercontractile Female Hearts Exhibit Increased S -Nitrosylation of the L-Type Ca 2+ Channel α1 Subunit and Reduced Ischemia/Reperfusion Injury

Sun, J., Picht, E., Ginsburg, K. S., Bers, D. M., Steenbergen, C., & Murphy, E. (2006) · Circulation Research · doi:10.1161/01.res.0000202707.79018.0a · Cited by 294

Estrogen regulation of angiotensin-converting enzyme mRNA

Gallagher, P. E., Li, P., Lenhart, J. R., Chappell, M. C., & Brosnihan, K. B. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.323 · Cited by 290

Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy

Xin, H.-B., Senbonmatsu, T., Cheng, D.-S., Wang, Y.-X., Copello, J. A., Ji, G.-J., Collier, M. L., Deng, K.-Y., Jeyakumar, L. H., Magnuson, M. A., et al. (2002) · Nature · doi:10.1038/416334a · Cited by 286

Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload

Douglas, P. S., Katz, S. E., Weinberg, E. O., Chen, M. H., Bishop, S. P., & Lorell, B. H. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00347-7 · Cited by 282

Mitochondrial localization of ERα and ERβ in human MCF7 cells

Chen, J. Q., Delannoy, M., Cooke, C., & Yager, J. D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00508.2003 · Cited by 272

Takotsubo cardiomyopathy: Pathophysiology, diagnosis and treatment

Komamura, K. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i7.602 · Cited by 270

Estradiol Accelerates Reendothelialization in Mouse Carotid Artery Through Estrogen Receptor-α but Not Estrogen Receptor-β

Brouchet, L., Krust, A., Dupont, S., Chambon, P., Bayard, F., & Arnal, J. F. (2001) · Circulation · doi:10.1161/01.cir.103.3.423 · Cited by 268

Myocardial Akt Activation and Gender: Increased Nuclear Activity in Females Versus Males

Camper-Kirby, D., Welch, S., Walker, A., Shiraishi, I., Setchell, K. D. R., Schaefer, E., Kajstura, J., Anversa, P., & Sussman, M. A. (2001) · Circulation Research · doi:10.1161/hh1001.090858 · Cited by 268

Epidemiology of Idiopathic Cardiomyopathies in Children and Adolescents: A Nationwide Study in Finland

Arola, A., Jokinen, E., Ruuskanen, O., Saraste, M., Pesonen, E., Kuusela, A.-L., Tikanoja, T., Paavilainen, T., & Simell, O. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009291 · Cited by 265

Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications

Chen, J.-Q., Cammarata, P. R., Baines, C. P., & Yager, J. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.06.001 · Cited by 264

Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions

Adlanmerini, M., Solinhac, R., Abot, A., Fabre, A., Raymond-Letron, I., Guihot, A.-L., Boudou, F., Sautier, L., Vessières, E., Kim, S. H., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322057111 · Cited by 260

Repression of interleukin‐6 gene expression by 17β‐estradiol: inhibition of the DNA‐binding activity of the transcription factors NF‐IL6 and NF‐κB by the estrogen receptor

Ray, P., Ghosh, S. K., Zhang, D.-H., & Ray, A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00487-0 · Cited by 256

G Protein-Coupled Receptor 30 Localizes to the Endoplasmic Reticulum and Is Not Activated by Estradiol

Otto, C., Rohde-Schulz, B., Schwarz, G., Fuchs, I., Klewer, M., Brittain, D., Langer, G., Bader, B., Prelle, K., Nubbemeyer, R., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0269 · Cited by 254

Nontranscriptional Regulation of Cardiac Repolarization Currents by Testosterone

Bai, C.-X., Kurokawa, J., Tamagawa, M., Nakaya, H., & Furukawa, T. (2005) · Circulation · doi:10.1161/circulationaha.104.523217 · Cited by 254

Female sex and estrogen receptor-β attenuate cardiac remodeling and apoptosis in pressure overload

Fliegner, D., Schubert, C., Penkalla, A., Witt, H., Kararigas, G., Dworatzek, E., Staub, E., Martus, P., Noppinger, P. R., Kintscher, U., et al. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00825.2009 · Cited by 253

Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats

Deschamps, A. M., & Murphy, E. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00283.2009 · Cited by 252

Effect of 17β‐oestradiol on contraction, Ca2+ current and intracellular free Ca2+ in guinea‐pig isolated cardiac myocytes

Jiang, C., Poole‐Wilson, P. A., Sarrel, P. M., Mochizuki, S., Collins, P., & MacLeod, K. T. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14403.x · Cited by 247

Tissue physiology and pathology of aromatase

Stocco, C. (2012) · Steroids · doi:10.1016/j.steroids.2011.10.013 · Cited by 246

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

Holla, V. R., Adas, F., Imig, J. D., Zhao, X., Price, E., Olsen, N., Kovacs, W. J., Magnuson, M. A., Keeney, D. S., Breyer, M. D., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081627898 · Cited by 245

Sex-Specific Cardiovascular Structure and Function in Heart Failure with Preserved Ejection Fraction

Gori, M., Lam, C. S. P., Gupta, D. K., Santos, A. B. S., Cheng, S., Shah, A. M., Claggett, B., Zile, M. R., Kraigher-Krainer, E., Pieske, B., et al. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.67 · Cited by 241

Estradiol Accelerates Functional Endothelial Recovery After Arterial Injury

Krasinski, K., Spyridopoulos, I., Asahara, T., van der Zee, R., Isner, J. M., & Losordo, D. W. (1997) · Circulation · doi:10.1161/01.cir.95.7.1768 · Cited by 241

Gender differences in molecular remodeling in pressure overload hypertrophy

Weinberg, E. O., Thienelt, C. D., Katz, S. E., Bartunek, J., Tajima, M., Rohrbach, S., Douglas, P. S., & Lorell, B. H. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00165-5 · Cited by 240

Central control of fever and female body temperature by RANKL/RANK

Hanada, R., Leibbrandt, A., Hanada, T., Kitaoka, S., Furuyashiki, T., Fujihara, H., Trichereau, J., Paolino, M., Qadri, F., Plehm, R., et al. (2009) · Nature · doi:10.1038/nature08596 · Cited by 238

Sex Differences in Cardiac Arrest Survivors

Albert, C. M., McGovern, B. A., Newell, J. B., & Ruskin, J. N. (1996) · Circulation · doi:10.1161/01.cir.93.6.1170 · Cited by 235

Regression of Myocardial Hypertrophy After Aortic Valve Replacement: Faster in Women?

Petrov, G., Regitz-Zagrosek, V., Lehmkuhl, E., Krabatsch, T., Dunkel, A., Dandel, M., Dworatzek, E., Mahmoodzadeh, S., Schubert, C., Becher, E., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.927764 · Cited by 230

Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities

Mahadevaiah, S. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.4.715 · Cited by 226

The clinical development of a 5α-reductase inhibitor, finasteride

Stoner, E. (1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90487-6 · Cited by 224

Testosterone and the Cardiovascular System: A Comprehensive Review of the Clinical Literature

Oskui, P. M., French, W. J., Herring, M. J., Mayeda, G. S., Burstein, S., & Kloner, R. A. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000272 · Cited by 223

Estrogen Prevents Cardiomyocyte Apoptosis through Inhibition of Reactive Oxygen Species and Differential Regulation of p38 Kinase Isoforms

Kim, J. K., Pedram, A., Razandi, M., & Levin, E. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511024200 · Cited by 223

A Composite Measure of Gender and Its Association With Risk Factors in Patients With Premature Acute Coronary Syndrome

Pelletier, R., Ditto, B., & Pilote, L. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000186 · Cited by 223

Sex Differences in Clinical Characteristics and Outcomes in Elderly Patients With Heart Failure and Preserved Ejection Fraction: The Irbesartan in Heart Failure With Preserved Ejection Fraction (I-PRESERVE) Trial

Lam, C. S. P., Carson, P. E., Anand, I. S., Rector, T. S., Kuskowski, M., Komajda, M., McKelvie, R. S., McMurray, J. J., Zile, M. R., Massie, B. M., et al. (2012) · Circulation: Heart Failure · doi:10.1161/circheartfailure.112.970061 · Cited by 223

Environmentally induced epigenetic transgenerational inheritance of phenotype and disease

Guerrero-Bosagna, C., & Skinner, M. K. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.004 · Cited by 222

Estrogen receptor beta mediates gender differences in ischemia/reperfusion injury

GABEL, S., WALKER, V, LONDON, R., STEENBERGEN, C., KORACH, K., & MURPHY, E. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.013 · Cited by 222

Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state

Green, K. A., & Carroll, J. S. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2211 · Cited by 220

Gender differences in cardiac function during early remodeling after acute myocardial infarction in mice

Cavasin, M. A., Tao, Z., Menon, S., & Yang, X.-P. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.024 · Cited by 220

Expression of an Estrogen Receptor by Human Coronary Artery and Umbilical Vein Endothelial Cells

Kim-Schulze, S., McGowan, K. A., Hubchak, S. C., Cid, M. C., Martin, M. B., Kleinman, H. K., Greene, G. L., & Schnaper, H. W. (1996) · Circulation · doi:10.1161/01.cir.94.6.1402 · Cited by 218

Estrogen receptor-β mediates male-female differences in the development of pressure overload hypertrophy

Skavdahl, M., Steenbergen, C., Clark, J., Myers, P., Demianenko, T., Mao, L., Rockman, H. A., Korach, K. S., & Murphy, E. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00723.2004 · Cited by 216

Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome

Charchar, F. J., Bloomer, L. D., Barnes, T. A., Cowley, M. J., Nelson, C. P., Wang, Y., Denniff, M., Debiec, R., Christofidou, P., Nankervis, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61453-0 · Cited by 215

Sudden Cardiac Arrest During Sports Activity in Middle Age

Marijon, E., Uy-Evanado, A., Reinier, K., Teodorescu, C., Narayanan, K., Jouven, X., Gunson, K., Jui, J., & Chugh, S. S. (2015) · Circulation · doi:10.1161/circulationaha.114.011988 · Cited by 213

Estradiol Enhances Recovery After Myocardial Infarction by Augmenting Incorporation of Bone Marrow–Derived Endothelial Progenitor Cells Into Sites of Ischemia-Induced Neovascularization via Endothelial Nitric Oxide Synthase–Mediated Activation of Matrix Metalloproteinase-9

Iwakura, A., Shastry, S., Luedemann, C., Hamada, H., Kawamoto, A., Kishore, R., Zhu, Y., Qin, G., Silver, M., Thorne, T., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.553925 · Cited by 211

Gender and Survival in Patients with Heart Failure: Interactions with Diabetes and Aetiology. Results from the MAGGIC Individual Patient Meta-Analysis

Martínez-Sellés, M., Doughty, R. N., Poppe, K., Whalley, G. A., Earle, N., Tribouilloy, C., McMurray, J. J. V., Swedberg, K., Køber, L., Berry, C., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs026 · Cited by 207

Premature Coronary Artery Disease Associated With a Disruptive Mutation in the Estrogen Receptor Gene in a Man

Sudhir, K., Chou, T. M., Chatterjee, K., Smith, E. P., Williams, T. C., Kane, J. P., Malloy, M. J., Korach, K. S., & Rubanyi, G. M. (1997) · Circulation · doi:10.1161/01.cir.96.10.3774 · Cited by 207

Gender Differences in Hypertension in Spontaneously Hypertensive Rats: Role of Androgens and Androgen Receptor

Reckelhoff, J. F., Zhang, H., Srivastava, K., & Granger, J. P. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.920 · Cited by 206

Starving Neurons Show Sex Difference in Autophagy

Du, L., Hickey, R. W., Bayir, H., Watkins, S. C., Tyurin, V. A., Guo, F., Kochanek, P. M., Jenkins, L. W., Ren, J., Gibson, G., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m804396200 · Cited by 204

Relationships between sex hormones assessed in amniotic fluid, and maternal and umbilical cord serum: What is the best source of information to investigate the effects of fetal hormonal exposure?

van de Beek, C., Thijssen, J. H. H., Cohen-Kettenis, P. T., van Goozen, S. H. M., & Buitelaar, J. K. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.06.010 · Cited by 203

Estrogen and testosterone have opposing effects on chronic cardiac remodeling and function in mice with myocardial infarction

Cavasin, M. A., Sankey, S. S., Yu, A.-L., Menon, S., & Yang, X.-P. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01087.2002 · Cited by 203

Sex modifies exercise and cardiac adaptation in mice

Konhilas, J. P., Maass, A. H., Luckey, S. W., Stauffer, B. L., Olson, E. N., & Leinwand, L. A. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00292.2004 · Cited by 203

Impact of chamber geometry and gender on left ventricular systolic function in patients >60 years of age with aortic stenosis

Aurigemma, G. P., Silver, K. H., McLaughlin, M., Mauser, J., & Gaasch, W. H. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90437-5 · Cited by 202

Testosterone Supplementation in Heart Failure: A Meta-Analysis

Toma, M., McAlister, F. A., Coglianese, E. E., Vidi, V., Vasaiwala, S., Bakal, J. A., Armstrong, P. W., & Ezekowitz, J. A. (2012) · Circulation: Heart Failure · doi:10.1161/circheartfailure.111.965632 · Cited by 200

Novel quantitative phenotypes of exercise training in mouse models

De Bono, J. P., Adlam, D., Paterson, D. J., & Channon, K. M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00694.2005 · Cited by 197

Determinants of DNA Sequence Specificity of the Androgen, Progesterone, and Glucocorticoid Receptors: Evidence for Differential Steroid Receptor Response Elements

Nelson, C. C. (1999) · Molecular Endocrinology · doi:10.1210/me.13.12.2090 · Cited by 197

Exposure to famine during gestation, size at birth, and blood pressure at age 59 y: evidence from the dutch famine

Stein, A. D., Zybert, P. A., van der Pal-de Bruin, K., & Lumey, L. H. (2006) · European Journal of Epidemiology · doi:10.1007/s10654-006-9065-2 · Cited by 196

Cardiac Actions of Erythromycin: Influence of Female Sex

Drici, M.-D., Knollmann, B. C., Wang, W.-X., & Woosley, R. L. (1998) · JAMA · doi:10.1001/jama.280.20.1774 · Cited by 194

Long-Term Anabolic-Androgenic Steroid Use Is Associated With Left Ventricular Dysfunction

Baggish, A. L., Weiner, R. B., Kanayama, G., Hudson, J. I., Picard, M. H., Hutter, A. M., & Pope, H. G. (2010) · Circulation: Heart Failure · doi:10.1161/circheartfailure.109.931063 · Cited by 193

17β-Estradiol stimulates expression of endothelial and inducible NO synthase in rat myocardium in-vitro and in-vivo

Nuedling, S. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00093-0 · Cited by 190

Expression Pattern of G Protein-Coupled Receptor 30 in LacZ Reporter Mice

Isensee, J., Meoli, L., Zazzu, V., Nabzdyk, C., Witt, H., Soewarto, D., Effertz, K., Fuchs, H., Gailus-Durner, V., Busch, D., et al. (2009) · Endocrinology · doi:10.1210/en.2008-1488 · Cited by 189

Increased Expression of the Cardiac L-type Calcium Channel in Estrogen Receptor–deficient Mice

Johnson, B. D., Zheng, W., Korach, K. S., Scheuer, T., Catterall, W. A., & Rubanyi, G. M. (1997) · The Journal of General Physiology · doi:10.1085/jgp.110.2.135 · Cited by 188

Reproductive hormone concentrations in pregnancy and neonates: a systematic review

Kuijper, E. A. M., Ket, J. C. F., Caanen, M. R., & Lambalk, C. B. (2013) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2013.03.009 · Cited by 187

Gender Differences in Substrate Metabolism During Endurance Exercise

Tarnopolsky, M. A. (2000) · Canadian Journal of Applied Physiology · doi:10.1139/h00-024 · Cited by 185

Acetylation of nuclear receptors in cellular growth and apoptosis

Fu, M., Wang, C., Zhang, X., & Pestell, R. G. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.037 · Cited by 182

Estrogen receptor-α mediates acute myocardial protection in females

Wang, M., Crisostomo, P., Wairiuko, G. M., & Meldrum, D. R. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01219.2005 · Cited by 182

Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats

Zhai, P., Eurell, T. E., Cotthaus, R., Jeffery, E. H., Bahr, J. M., & Gross, D. R. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.6.h2766 · Cited by 180

Sex-Dependent Regulation of Fibrosis and Inflammation in Human Left Ventricular Remodelling Under Pressure Overload

Kararigas, G., Dworatzek, E., Petrov, G., Summer, H., Schulze, T. M., Baczko, I., Knosalla, C., Golz, S., Hetzer, R., & Regitz-Zagrosek, V. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.171 · Cited by 180

Low Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men

AKISHITA, M., HASHIMOTO, M., OHIKE, Y., OGAWA, S., IIJIMA, K., ETO, M., & OUCHI, Y. (2007) · Hypertension Research · doi:10.1291/hypres.30.1029 · Cited by 179

Sex-dependent differences in left ventricular function and structure in chronic pressure overload

VILLARI, B., CAMPBELL, S. E., SCHNEIDER, J., VASSALLI, G., CHIARIELLO, M., & HESS, O. M. (1995) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a060749 · Cited by 179

Amelioration of Ischemia- and Reperfusion-Induced Myocardial Injury by 17β-Estradiol: Role of Nitric Oxide and Calcium-Activated Potassium Channels

Node, K., Kitakaze, M., Kosaka, H., Minamino, T., Funaya, H., & Hori, M. (1997) · Circulation · doi:10.1161/01.cir.96.6.1953 · Cited by 178

Estrogen rapid action via protein complex formation involving ERα and Src

Song, R. X.-D., Zhang, Z., & Santen, R. J. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.06.010 · Cited by 177

Hormonal modulation of endothelial NO production

Duckles, S. P., & Miller, V. M. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0797-1 · Cited by 175

Gender Differences in Cardioprotection against Ischemia/Reperfusion Injury in Adult Rat Hearts: Focus on Akt and Protein Kinase C Signaling

Bae, S., & Zhang, L. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.090803 · Cited by 175

Association of hyperandrogenemic and metabolic phenotype with carotid intima-media thickness in young women with polycystic ovary syndrome

Vryonidou, A., Papatheodorou, A., Tavridou, A., Terzi, T., Loi, V., Vatalas, I.-A., Batakis, N., Phenekos, C., & Dionyssiou-Asteriou, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2363 · Cited by 171

Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation

Muller, D. N., Schmidt, C., Barbosa-Sicard, E., Wellner, M., Gross, V., Hercule, H., Markovic, M., Honeck, H., Luft, F. C., & Schunck, W.-H. (2007) · Biochemical Journal · doi:10.1042/bj20061328 · Cited by 171

The AF-1 activation-function of ERα may be dispensable to mediate the effect of estradiol on endothelial NO production in mice

Pendaries, C., Darblade, B., Rochaix, P., Krust, A., Chambon, P., Korach, K. S., Bayard, F., & Arnal, J.-F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042688499 · Cited by 170

Regulation of cardiac long-chain fatty acid and glucose uptake by translocation of substrate transporters

Luiken, J. J. F. P., Coort, S. L. M., Koonen, D. P. Y., van der Horst, D. J., Bonen, A., Zorzano, A., & Glatz, J. F. C. (2004) · Pflügers Archiv · doi:10.1007/s00424-003-1199-4 · Cited by 169

Estrogen Receptors α and β Mediate Distinct Pathways of Vascular Gene Expression, Including Genes Involved in Mitochondrial Electron Transport and Generation of Reactive Oxygen Species

O’Lone, R., Knorr, K., Jaffe, I. Z., Schaffer, M. E., Martini, P. G. V., Karas, R. H., Bienkowska, J., Mendelsohn, M. E., & Hansen, U. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0497 · Cited by 169

Females Live Longer than Males: Role of Oxidative Stress

Vina, J., Gambini, J., Lopez-Grueso, R., M. Abdelaziz, K., Jove, M., & Borras, C. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798764942 · Cited by 169

Incidence, Clinical Findings, and Outcome of Women With Left Ventricular Apical Ballooning Syndrome

Parodi, G., Del Pace, S., Carrabba, N., Salvadori, C., Memisha, G., Simonetti, I., Antoniucci, D., & Gensini, G. F. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.07.080 · Cited by 166

Estradiol Metabolites Inhibit Endothelin Synthesis by an Estrogen Receptor-Independent Mechanism

Dubey, R. K., Jackson, E. K., Keller, P. J., Imthurn, B., & Rosselli, M. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.640 · Cited by 163

17β-Estradiol, Its Metabolites, and Progesterone Inhibit Cardiac Fibroblast Growth

Dubey, R. K., Gillespie, D. G., Jackson, E. K., & Keller, P. J. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.522 · Cited by 163

Impact of Gender on the Myocardial Metabolic Response to Obesity

Peterson, L. R., Soto, P. F., Herrero, P., Mohammed, B. S., Avidan, M. S., Schechtman, K. B., Dence, C., & Gropler, R. J. (2008) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2008.05.004 · Cited by 161

Genome‐wide histone methylation profile for heart failure

Kaneda, R., Takada, S., Yamashita, Y., Choi, Y. L., Nonaka‐Sarukawa, M., Soda, M., Misawa, Y., Isomura, T., Shimada, K., & Mano, H. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2008.01252.x · Cited by 161

Sex-specific pathways in early cardiac response to pressure overload in mice

Witt, H., Schubert, C., Jaekel, J., Fliegner, D., Penkalla, A., Tiemann, K., Stypmann, J., Roepcke, S., Brokat, S., Mahmoodzadeh, S., et al. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0385-4 · Cited by 159

The Heart Is a Target Organ for Androgen

McGill, H. C., Anselmo, V. C., Buchanan, J. M., & Sheridan, P. J. (1980) · Science · doi:10.1126/science.6766222 · Cited by 159

Sexual dimorphism of blood pressure in spontaneously hypertensive rats: effects of anti-androgen treatment

Ganten, U., der, G. S., Witt, M., Zimmermann, F., Ganten, D., & Stock, G. (1989) · Journal of Hypertension · doi:10.1097/00004872-198909000-00005 · Cited by 159

Sex differences in the myocardial inflammatory response to ischemia-reperfusion injury

Wang, M., Baker, L., Tsai, B. M., Meldrum, K. K., & Meldrum, D. R. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00278.2004 · Cited by 158

Estrogen protects transgenic hypertensive rats by shifting the vasoconstrictor-vasodilator balance of RAS

Brosnihan, K. B., Li, P., Ganten, D., & Ferrario, C. M. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.6.r1908 · Cited by 156

Sexual Dimorphism of Doxorubicin-Mediated Cardiotoxicity

Moulin, M., Piquereau, J., Matéo, P., Fortin, D., Rücker‐Martin, C., Gressette, M., Lefebvre, F., Grešíková, M., Solgadi, A., Veksler, V., et al. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001180 · Cited by 156

Estrogen receptor alpha up‐regulation and redistribution in human heart failure

Mahmoodzadeh, S., Eder, S., Nordmeyer, J., Ehler, E., Huber, O., Martus, P., Weiske, J., Pregla, R., Hetzer, R., & Regitz‐Zagrosek, V. (2006) · The FASEB Journal · doi:10.1096/fj.05-5148com · Cited by 155

Sexually dimorphic gene expression in the heart of mice and men

Isensee, J., Witt, H., Pregla, R., Hetzer, R., Regitz‐Zagrosek, V., & Ruíz, P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0240-z · Cited by 155

Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects

Mittendorfer, B., Horowitz, J. F., & Klein, S. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00504.2001 · Cited by 154

Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis

Ikeda, Y., Aihara, K., Sato, T., Akaike, M., Yoshizumi, M., Suzaki, Y., Izawa, Y., Fujimura, M., Hashizume, S., Kato, M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411694200 · Cited by 151

Gender Differences in Left Ventricular Structure and Function During Antihypertensive Treatment

Gerdts, E., Okin, P. M., SIMONE, G. D., Cramariuc, D., Wachtell, K., Boman, K., & Devereux, R. B. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.107474 · Cited by 151

G Protein-Coupled Receptor 30: Estrogen Receptor or Collaborator?

Levin, E. R. (2009) · Endocrinology · doi:10.1210/en.2008-1759 · Cited by 150

In vivo androgen treatment shortens the QT interval and increases the densities of inward and delayed rectifier potassium currents in orchiectomized male rabbits

Liu, X. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00673-9 · Cited by 150

Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes

Vicencio, J. M., Ibarra, C., Estrada, M., Chiong, M., Soto, D., Parra, V., Diaz-Araya, G., Jaimovich, E., & Lavandero, S. (2006) · Endocrinology · doi:10.1210/en.2005-1139 · Cited by 149

Sexual dimorphism of blood pressure in spontaneously hypertensive rats: effects of anti-androgen treatment.

Ganten, U., Schröder, G., Witt, M., Zimmermann‐Viehoff, F., Ganten, D., & Stock, G. (1989) · PubMed · Cited by 148

Estrogen Attenuates Left Ventricular and Cardiomyocyte Hypertrophy by an Estrogen Receptor–Dependent Pathway That Increases Calcineurin Degradation

Donaldson, C., Eder, S., Baker, C., Aronovitz, M. J., Weiss, A. D., Hall-Porter, M. R., Wang, F., Ackerman, A. M., Karas, R. H., Molkentin, J. D., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.190397 · Cited by 147

Binding of MCF‐7 cell mitochondrial proteins and recombinant human estrogen receptors α and β to human mitochondrial dna estrogen response elements

Chen, J. Q., Eshete, M., Alworth, W. L., & Yager, J. D. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20178 · Cited by 147

Susceptibility of the heart to ischaemia–reperfusion injury and exercise‐induced cardioprotection are sex‐dependent in the rat

Brown, D. A., Lynch, J. M., Armstrong, C. J., Caruso, N. M., Ehlers, L. B., Johnson, M. S., & Moore, R. L. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.081323 · Cited by 147

Females have a blunted cardiovascular response to one year of intensive supervised endurance training

Howden, E. J., Perhonen, M. A., Peshock, R. M., Zhang, R., Arbab‐Zadeh, A., ADAMS-HUET, B. A., & Levine, B. D. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00092.2015 · Cited by 146

Role of Gender in Heart Failure with Normal Left Ventricular Ejection Fraction

Regitz‐Zagrosek, V., Brokat, S., & Tschöpe, C. (2006) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2006.08.011 · Cited by 145

Impact of Sex and Gonadal Steroids on Prolongation of Ventricular Repolarization and Arrhythmias Induced byIK-Blocking Drugs

Pham, T. V., Sosunov, E. A., Gainullin, R. Z., Danilo, P., & Rosen, M. R. (2001) · Circulation · doi:10.1161/01.cir.103.17.2207 · Cited by 143

Myocardial ischemia-reperfusion injury in estrogen receptor-α knockout and wild-type mice

Zhai, P., Eurell, T. E., Cooke, P. S., Lubahn, D. B., & Gross, D. R. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.5.h1640 · Cited by 143

Sex and gender: modifiers of health, disease, and medicine

Mauvais-Jarvis, F., Bairey Merz, N., Barnes, P. J., Brinton, R. D., Carrero, J.-J., DeMeo, D. L., De Vries, G. J., Epperson, C. N., Govindan, R., Klein, S. L., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31561-0 · Cited by 2,001

Sex differences in pharmacokinetics predict adverse drug reactions in women

Zucker, I., & Prendergast, B. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00308-5 · Cited by 777

Dilated cardiomyopathy

Schultheiss, H.-P., Fairweather, D., Caforio, A. L. P., Escher, F., Hershberger, R. E., Lipshultz, S. E., Liu, P. P., Matsumori, A., Mazzanti, A., McMurray, J., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0084-1 · Cited by 720

Estrogens in Male Physiology

Cooke, P. S., Nanjappa, M. K., Ko, C., Prins, G. S., & Hess, R. A. (2017) · Physiological Reviews · doi:10.1152/physrev.00018.2016 · Cited by 466

The hematologic consequences of obesity

Purdy, J. C., & Shatzel, J. J. (2021) · European Journal Of Haematology · doi:10.1111/ejh.13560 · Cited by 227