The DOI matches its Crossref record; 815 of the 815 references it cites were found in a registry or an index.
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Abstract
This review focuses on the role of the peripheral nervous system in cutaneous biology and disease. During the last few years, a modern concept of an interactive network between cutaneous nerves, the neuroendocrine axis, and the immune system has been established. We learned that neurocutaneous interactions influence a variety of physiological and pathophysiological functions, including cell growth, immunity, inflammation, pruritus, and wound healing. This interaction is mediated by primary afferent as well as autonomic nerves, which release neuromediators and activate specific receptors on many target cells in the skin. A dense network of sensory nerves releases neuropeptides, thereby modulating inflammation, cell growth, and the immune responses in the skin. Neurotrophic factors, in addition to regulating nerve growth, participate in many properties of skin function. The skin expresses a variety of neurohormone receptors coupled to heterotrimeric G proteins that are tightly involved in skin homeostasis and inflammation. This neurohormone-receptor interaction is modulated by endopeptidases, which are able to terminate neuropeptide-induced inflammatory or immune responses. Neuronal proteinase-activated receptors or transient receptor potential ion channels are recently described receptors that may have been important in regulating neurogenic inflammation, pain, and pruritus. Together, a close multidirectional interaction between neuromediators, high-affinity receptors, and regulatory proteases is critically involved to maintain tissue integrity and regulate inflammatory responses in the skin. A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases.
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Items 801–815 of 815
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Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
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Fibroblasts and myofibroblasts in wound healing
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Self-citationSteinhoff, M. S., von Mentzer, B., Geppetti, P., Pothoulakis, C., & Bunnett, N. W. (2014) · Physiological Reviews · doi:10.1152/physrev.00031.2013 · Cited by 628
Self-citationNeurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity
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Metadata
- Authors
- Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2006-10
- Volume
- 86
- Issue
- 4
- Pages
- 1309-1379
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2156965630
- Cited by
- 665
- References
- 815
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
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