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Cited by 665

The DOI matches its Crossref record; 815 of the 815 references it cites were found in a registry or an index.

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman, Dirk, Goerge, Tobias, Schneider, Stefan W., Bunnett, Nigel W., Steinhoff, Martin·2006·Physiological Reviews
DOI 10.1152/physrev.00026.2005
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Abstract

This review focuses on the role of the peripheral nervous system in cutaneous biology and disease. During the last few years, a modern concept of an interactive network between cutaneous nerves, the neuroendocrine axis, and the immune system has been established. We learned that neurocutaneous interactions influence a variety of physiological and pathophysiological functions, including cell growth, immunity, inflammation, pruritus, and wound healing. This interaction is mediated by primary afferent as well as autonomic nerves, which release neuromediators and activate specific receptors on many target cells in the skin. A dense network of sensory nerves releases neuropeptides, thereby modulating inflammation, cell growth, and the immune responses in the skin. Neurotrophic factors, in addition to regulating nerve growth, participate in many properties of skin function. The skin expresses a variety of neurohormone receptors coupled to heterotrimeric G proteins that are tightly involved in skin homeostasis and inflammation. This neurohormone-receptor interaction is modulated by endopeptidases, which are able to terminate neuropeptide-induced inflammatory or immune responses. Neuronal proteinase-activated receptors or transient receptor potential ion channels are recently described receptors that may have been important in regulating neurogenic inflammation, pain, and pruritus. Together, a close multidirectional interaction between neuromediators, high-affinity receptors, and regulatory proteases is critically involved to maintain tissue integrity and regulate inflammatory responses in the skin. A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases.

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Crossref · 10.1152/physrev.00026.2005

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Citations

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Metadata

Authors
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2006-10
Volume
86
Issue
4
Pages
1309-1379
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00026.2005
OpenAlex
W2156965630
Cited by
665
References
815
FWCI
0.98
Type
journal article
Language
en
Open access
closed

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