Myelin in the Central Nervous System: Structure, Function, and Pathology

On the biogenesis of myelin membranes: Sorting, trafficking and cell polarity

Baron, W., & Hoekstra, D. (2010) · FEBS Letters · doi:10.1016/j.febslet.2009.10.085 · Cited by 162

Spectrins and AnkyrinB Constitute a Specialized Paranodal Cytoskeleton

Ogawa, Y., Schafer, D. P., Horresh, I., Bar, V., Hales, K., Yang, Y., Susuki, K., Peles, E., Stankewich, M. C., & Rasband, M. N. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0425-06.2006 · Cited by 162

Astrocytes are central in the pathomechanisms of vanishing white matter

Dooves, S., Bugiani, M., Postma, N. L., Polder, E., Land, N., Horan, S. T., van Deijk, A.-L. F., van de Kreeke, A., Jacobs, G., Vuong, C., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83908 · Cited by 162

Atypical inflammatory demyelinating syndromes of the CNS

Hardy, T. A., Reddel, S. W., Barnett, M. H., Palace, J., Lucchinetti, C. F., & Weinshenker, B. G. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30043-6 · Cited by 161

Alexander Disease-Associated Glial Fibrillary Acidic Protein Mutations in Mice Induce Rosenthal Fiber Formation and a White Matter Stress Response

Hagemann, T. L., Connor, J. X., & Messing, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3260-06.2006 · Cited by 161

NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination

De Biase, L. M., Kang, S. H., Baxi, E. G., Fukaya, M., Pucak, M. L., Mishina, M., Calabresi, P. A., & Bergles, D. E. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2455-11.2011 · Cited by 161

Leukodystrophy in Children: A Pictorial Review of MR Imaging Features

Cheon, J.-E., Kim, I.-O., Hwang, Y. S., Kim, K. J., Wang, K.-C., Cho, B.-K., Chi, J. G., Kim, C. J., Kim, W. S., & Yeon, K. M. (2002) · RadioGraphics · doi:10.1148/radiographics.22.3.g02ma01461 · Cited by 161

Pathological study of spinal cord atrophy in multiple sclerosis suggests limited role of local lesions

Evangelou, N., DeLuca, G. C., Owens, T., & Esiri, M. M. (2004) · Brain · doi:10.1093/brain/awh323 · Cited by 161

Oligodendrocyte and axon pathology in clinically silent multiple sclerosis lesions

Mews, I., Bergmann, M., Bunkowski, S., Gullotta, F., & Brück, W. (1998) · Multiple Sclerosis Journal · doi:10.1177/135245859800400203 · Cited by 160

Intrinsic and adaptive myelination—A sequential mechanism for smart wiring in the brain

Bechler, M. E., Swire, M., & ffrench‐Constant, C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22518 · Cited by 160

Myelination

Salzer, J. L., & Zalc, B. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.074 · Cited by 160

Molecular disruptions of the panglial syncytium block potassium siphoning and axonal saltatory conduction: pertinence to neuromyelitis optica and other demyelinating diseases of the central nervous system

Rash, J. E. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.10.028 · Cited by 159

The perinodal astrocyte

Black, J. A., & Waxman, S. G. (1988) · Glia · doi:10.1002/glia.440010302 · Cited by 158

Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival

Kougioumtzidou, E., Shimizu, T., Hamilton, N. B., Tohyama, K., Sprengel, R., Monyer, H., Attwell, D., & Richardson, W. D. (2017) · eLife · doi:10.7554/elife.28080 · Cited by 157

On the relation between fibre diameter and conduction velocity in myelinated nerve fibres

Ritchie, J. M. (1982) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1982.0092 · Cited by 156

Myelin‐associated glycoprotein and its axonal receptors

Schnaar, R. L., & López, P. H. H. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.21992 · Cited by 156

Overexpression of 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase in Transgenic Mice Alters Oligodendrocyte Development and Produces Aberrant Myelination

Gravel, M., Peterson, J. W., Yong, V. W., Kottis, V., Trapp, B. D., & Braun, P. E. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0033 · Cited by 156

Fibroblast Growth Factor Receptor Signaling in Oligodendrocytes Regulates Myelin Sheath Thickness

Furusho, M., Dupree, J. L., Nave, K., & Bansal, R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6005-11.2012 · Cited by 156

Ultrastructural studies of multiple sclerosis.

Suzuki, K., Jm, A., Waltz, J. M., & Terry, R. D. (1969) · PubMed · Cited by 156

Nasu–Hakola Disease (Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy—PLOSL): A Dementia Associated with Bone Cystic Lesions. From Clinical to Genetic and Molecular Aspects

Bianchin, M. M., Capella, H. M., Chaves, D. L., Steindel, M., Grisard, E. C., Ganev, G. G., da Silva, J. P., Neto, E. S., Poffo, M. A., Walz, R., et al. (2004) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000012721.08168.ee · Cited by 154

CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS

Rasband, M. N., Tayler, J. E., Kaga, Y., Yang, Y., Lappe-Siefke, C., Nave, K., & Bansal, R. (2005) · Glia · doi:10.1002/glia.20165 · Cited by 152

Productive infection of cerebellar granule cell neurons by JC virus in an HIV+ individual

Pasquier, R. D., Corey, S., Margolin, D. H., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000081306.86961.33 · Cited by 152

Acute disseminated encephalomyelitis followed by recurrent or monophasic optic neuritis in pediatric patients

Huppke, P., Rostasy, K. M., Karenfort, M., Huppke, B., Seidl, R., Leiz, S., Reindl, M., & Gärtner, J. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458512466317 · Cited by 151

Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis

Tartaglia, M. C., Narayanan, S., Stefano, N. D., Arnaoutelis, R., Antel, S. B., Francis, S. J., dos Santos, A. C., Lapierre, Y., & Arnold, D. L. (2002) · Journal of Neurology · doi:10.1007/s00415-002-0846-6 · Cited by 151

Untitled work

(1984) · PubMed · Cited by 150

Oligodendrocytes and the early multiple sclerosis lesion

Prineas, J. W., & Parratt, J. D. E. (2012) · Annals of Neurology · doi:10.1002/ana.23634 · Cited by 149

Structural basis of myelin-associated glycoprotein adhesion and signalling

Pronker, M. F., Lemstra, S., Snijder, J., Heck, A. J. R., Thies‐Weesie, D. M. E., Pasterkamp, R. J., & Janssen, B. J. C. (2016) · Nature Communications · doi:10.1038/ncomms13584 · Cited by 149

Movements of the Schwann cell nucleus implicate progression of the inner (axon-related) Schwann cell process during myelination.

Bunge, R. P., Bunge, M. B., & Bates, M. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.1.273 · Cited by 147

The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane

Baskin, J. M., Wu, X., Christiano, R., Oh, M. S., Schauder, C. M., Gazzerro, E., Messa, M., Baldassari, S., Assereto, S., Biancheri, R., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3271 · Cited by 147

Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: A retrospective study

Trapp, B. D., Vignos, M., Dudman, J., Chang, A., Fisher, E., Staugaitis, S. M., Battapady, H., Mork, S., Ontaneda, D., Jones, S. E., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30245-x · Cited by 146

ALEXANDER'S DISEASE

Borrett, D. S., & Becker, L. E. (1985) · Brain · doi:10.1093/brain/108.2.367 · Cited by 145

Postsynaptic Density-93 Clusters Kv1 Channels at Axon Initial Segments Independently of Caspr2

Ogawa, Y., Horresh, I., Trimmer, J. S., Bredt, D. S., Peles, E., & Rasband, M. N. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4431-07.2008 · Cited by 145

Meningeal T cells associate with diffuse axonal loss in multiple sclerosis spinal cords

Androdias, G., Reynolds, R., Chanal, M., Ritleng, C., Confavreux, C., & Nataf, S. (2010) · Annals of Neurology · doi:10.1002/ana.22054 · Cited by 145

Subcortical cytoskeleton periodicity throughout the nervous system

D’Este, E., Kamin, D., Velte, C., Göttfert, F., Simons, M., & Hell, S. W. (2016) · Scientific Reports · doi:10.1038/srep22741 · Cited by 144

Binding Specificities of the Sialoadhesin Family of I-type Lectins

Collins, B. E., Kiso, M., Hasegawa, A., Tropak, M. B., Roder, J., Crocker, P. R., & Schnaar, R. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16889 · Cited by 143

The history of myelin

Boullerne, A. I. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.06.005 · Cited by 143

Greenfieldʼs Neuropathology

Adams, J. H., & Duchen, L. W. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199801000-00010 · Cited by 143

Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNS

Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S. M., Nave, K.-A., Franklin, R. J. M., Brakebusch, C., Suter, U., & Relvas, J. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2158-06.2006 · Cited by 142 · cited 1×

Unique distributions of the gap junction proteins connexin29, connexin32, and connexin47 in oligodendrocytes

Kleopa, K. A., Orthmann, J., Enriquez, A. D., Paul, D. L., & Scherer, S. S. (2004) · Glia · doi:10.1002/glia.20043 · Cited by 142

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Weil, M.-T., Möbius, W., Winkler, A., Ruhwedel, T., Wrzos, C., Romanelli, E., Bennett, J. L., Enz, L., Goebels, N., Nave, K.-A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.008 · Cited by 142

The macrophage in MS: just a scavenger after all? Pathology and pathogenesis of the acute MS lesion

Barnett, M. H., Henderson, A. P. D., & Prineas, J. W. (2006) · Multiple Sclerosis Journal · doi:10.1191/135248506ms1304rr · Cited by 138

Metachromatic leukodystrophy: genetics, pathogenesis and therapeutic options

Gieselmann, V. (2008) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.00648.x · Cited by 138

Mutation Update of ARSA and PSAP Genes Causing Metachromatic Leukodystrophy

Cesani, M., Lorioli, L., Grossi, S., Amico, G., Fumagalli, F., Spiga, I., Filocamo, M., & Biffi, A. (2016) · Human Mutation · doi:10.1002/humu.22919 · Cited by 135

Neuromyelitis optica: a demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes

Parratt, J. D. E., & Prineas, J. W. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510382324 · Cited by 135

Inhibition of CNS Remyelination by the Presence of Semaphorin 3A

Syed, Y. A., Hand, E., Möbius, W., Zhao, C., Hofer, M., Nave, K. A., & Kotter, M. R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4930-10.2011 · Cited by 134

An Integrin–Contactin Complex Regulates CNS Myelination by Differential Fyn Phosphorylation

Laursen, L. S., Chan, C. W., & ffrench‐Constant, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5942-08.2009 · Cited by 134

A Matter of Identity: Transcriptional Control in Oligodendrocytes

Wegner, M. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-9008-8 · Cited by 134

Persistence and pathogenesis of the neurotropic polyomavirus JC

Wollebo, H. S., White, M. K., Gordon, J., Berger, J. R., & Khalili, K. (2015) · Annals of Neurology · doi:10.1002/ana.24371 · Cited by 134

Does Paranode Formation and Maintenance Require Partitioning of Neurofascin 155 into Lipid Rafts?

Schafer, D. P., Bansal, R., Hedstrom, K. L., Pfeiffer, S. E., & Rasband, M. N. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5427-03.2004 · Cited by 133

Weekly diffusion-weighted imaging of normal-appearing white matter in MS

Rocca, M. A., Cercignani, M., Iannucci, G., Comi, G., & Filippi, M. (2000) · Neurology · doi:10.1212/wnl.55.6.882 · Cited by 133

A critical role for the cholesterol‐associated proteolipids PLP and M6B in myelination of the central nervous system

Werner, H. B., Krämer‐Albers, E., Strenzke, N., Saher, G., Tenzer, S., Ohno‐Iwashita, Y., de Monasterio‐Schrader, P., Möbius, W., Moser, T., Griffiths, I. R., et al. (2013) · Glia · doi:10.1002/glia.22456 · Cited by 133

Ultrastructural anatomy of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy

D’Este, E., Kamin, D., Balzarotti, F., & Hell, S. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619553114 · Cited by 133

Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene

Anderson, T. J., Schneider, A., Barrie, J. A., Klugmann, M., McCulloch, M. C., Kirkham, D., Kyriakides, E., Nave, K., & Griffiths, I. R. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980518)394:4<506::aid-cne8>3.0.co;2-5 · Cited by 132

Imaging manifestations of progressive multifocal leukoencephalopathy

Shah, R., Bag, A. K., Chapman, P. R., et al. (2010) · Clinical Radiology · doi:10.1016/j.crad.2010.03.001 · Cited by 130

Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica

Zhang, H., & Verkman, A. S. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67554 · Cited by 130

Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica

Shimizu, F., Schaller, K., Owens, G. P., Cotleur, A. C., Kellner, D., Takeshita, Y., Obermeier, B., Kryzer, T. J., Sano, Y., Kanda, T., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai9111 · Cited by 128

Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and cx47 association with zonula occludens-1 (zo-1) in mouse brain

Li, X., Ionescu, A. V., Lynn, B. D., Lu, S., Kamasawa, N., Morita, M., Davidson, K. G. V., Yasumura, T., Rash, J. E., & Nagy, J. I. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.063 · Cited by 127

Astrocytic Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Promotes Oligodendrocyte Differentiation and Enhances CNS Myelination

Moore, C. S., Milner, R., Nishiyama, A., Frausto, R. F., Serwanski, D. R., Pagarigan, R. R., Whitton, J. L., Miller, R. H., & Crocker, S. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5474-10.2011 · Cited by 127

Sensory neuron-specific sodium channel SNS is abnormally expressed in the brains of mice with experimental allergic encephalomyelitis and humans with multiple sclerosis

Black, J. A., Dib‐Hajj, S. D., Baker, D., Newcombe, J., Cuzner, M. L., & Waxman, S. G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11598 · Cited by 127

Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination

Mei, F., Mayoral, S. R., Nobuta, H., Wang, F., Desponts, C., Lorrain, D. S., Xiao, L., Green, A., Rowitch, D. H., Whistler, J. L., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1493-16.2016 · Cited by 127

Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K

Laursen, L. S., Chan, C. W., & ffrench‐Constant, C. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201007014 · Cited by 126

Cortical demyelination in PML and MS: Similarities and differences

Moll, N. M., Rietsch, A. M., Ransohoff, A., Cossoy, M. B., Huang, D., Eichler, F., Trapp, B. D., & Ransohoff, R. M. (2007) · Neurology · doi:10.1212/01.wnl.0000284601.54436.e4 · Cited by 126

Distribution of papovavirus, myelin‐associated glycoprotein, and myelin basic protein in progressive multifocal leukoencephalopathy lesions

Itoyama, Y., Webster, H. D., Sternberger, N. H., Richardson, E. P., Walker, D. L., Quarles, R. H., & Padgett, B. L. (1982) · Annals of Neurology · doi:10.1002/ana.410110414 · Cited by 124

Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells

Zonouzi, M., Renzi, M., Farrant, M., & Cull-Candy, S. G. (2011) · Nature Neuroscience · doi:10.1038/nn.2942 · Cited by 124

Multiple Molecular Interactions Determine the Clustering of Caspr2 and Kv1 Channels in Myelinated Axons

Horresh, I., Poliak, S., Grant, S. G. N., Bredt, D. S., Rasband, M. N., & Peles, E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3398-08.2008 · Cited by 123

Loss-of-function GJA12/Connexin47 mutations cause Pelizaeus–Merzbacher-like disease

Orthmann‐Murphy, J. L., Enriquez, A. D., Abrams, C. K., & Scherer, S. S. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.01.010 · Cited by 123

Gap junctions in inherited human disorders of the central nervous system

Abrams, C. K., & Scherer, S. S. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.08.015 · Cited by 123

Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging

Auer, F., Vagionitis, S., & Czopka, T. (2018) · Current Biology · doi:10.1016/j.cub.2018.01.017 · Cited by 123

Actin Plays a Role in Both Changes in Cell Shape and Gene- Expression Associated with Schwann Cell Myelination

Fernández‐Valle, C., Gorman, D., Gomez, A. M., & Bunge, M. B. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00241.1997 · Cited by 122

Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica

Ratelade, J., Asavapanumas, N., Ritchie, A. M., Wemlinger, S. M., Bennett, J. L., & Verkman, A. S. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1172-z · Cited by 122

Multiple functions of the paranodal junction of myelinated nerve fibers

Rosenbluth, J. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22013 · Cited by 121

Gap junction communication in myelinating glia

Nualart-Marti, A., Solsona, C., & Fields, R. D. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.01.024 · Cited by 120

Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction

Hagemann, T. L., Gaeta, S. A., Smith, M. A., Johnson, D. A., Johnson, J. A., & Messing, A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi248 · Cited by 120

Astroglial control of oligodendrocyte survival mediated by PDGF and Leukemia Inhibitory Factor-like protein

Gard, A. L., Burrell, M., Pfeiffer, S. E., Rudge, J. S., & Williams, W. C. (1995) · Development · doi:10.1242/dev.121.7.2187 · Cited by 120

Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)

Chitu, V., Gokhan, S., Gulinello, M., Branch, C. A., Patil, M., Basu, R., Stoddart, C., Mehler, M. F., & Stanley, E. R. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.12.001 · Cited by 119

The Structure of Myelin Sheaths in the Central Nervous System of Xenopus laevis (Daudin)

Peters, A. (1960) · The Journal of Cell Biology · doi:10.1083/jcb.7.1.121 · Cited by 119

Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis

Singh, S., Dallenga, T., Winkler, A., Roemer, S., Maruschak, B., Siebert, H., Brück, W., & Stadelmann, C. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0831-8 · Cited by 118

β1-Integrin Signaling Mediates Premyelinating Oligodendrocyte Survival But Is Not Required for CNS Myelination and Remyelination

Benninger, Y., Colognato, H., Buerki‐Thurnherr, T., Franklin, R. J. M., Leone, D. P., Atanasoski, S., Nave, K., ffrench‐Constant, C., Suter, U., & Relvas, J. B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0444-06.2006 · Cited by 117

All Wrapped Up: Environmental Effects on Myelination

Forbes, T. A., & Gallo, V. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.06.009 · Cited by 117

Phosphatidylinositol 4,5-Bisphosphate-Dependent Interaction of Myelin Basic Protein with the Plasma Membrane in Oligodendroglial Cells and Its Rapid Perturbation by Elevated Calcium

Nawaz, S., Kippert, A., Saab, A. S., Werner, H. B., Lang, T., Nave, K.-A., & Simons, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3955-08.2009 · Cited by 116

A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier

Ho, T. S., Zollinger, D. R., Chang, K.-J., Xu, M., Cooper, E. C., Stankewich, M. C., Bennett, V., & Rasband, M. N. (2014) · Nature Neuroscience · doi:10.1038/nn.3859 · Cited by 116

Cellular Mechanism of Myelination in the Central Nervous System

Robertis, E. D. P. D., Gerschenfeld, H. M., & Wald, F. (1958) · The Journal of Cell Biology · doi:10.1083/jcb.4.5.651 · Cited by 116

Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata

Brites, P. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg236 · Cited by 116

Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex

Yates, R. L., Esiri, M. M., Palace, J. A., Jacobs, B. M., Perera, R., & DeLuca, G. C. (2017) · Annals of Neurology · doi:10.1002/ana.24997 · Cited by 116

Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system

Çolakoğlu, G., Bergstrom-Tyrberg, U., Berglund, E. O., & Ranscht, B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313769110 · Cited by 115

Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination

Redmond, S., Mei, F., Eshed‐Eisenbach, Y., Osso, L. A., Leshkowitz, D., Shen, Y. A., Kay, J. N., Aurrand‐Lions, M., Lyons, D. A., Peles, E., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.021 · Cited by 115

Axonal selection and myelin sheath generation in the central nervous system

Simons, M., & Lyons, D. A. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.04.007 · Cited by 114

Axonal Loss and Neurofilament Phosphorylation Changes Accompany Lesion Development and Clinical Progression in Multiple Sclerosis

Schirmer, L., Antel, J. P., Brück, W., & Stadelmann, C. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00466.x · Cited by 112

Retention of a cell adhesion complex at the paranodal junction requires the cytoplasmic region of Caspr

Gollan, L., Sabanay, H., Poliak, S., Berglund, E. O., Ranscht, B., & Peles, E. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200203050 · Cited by 111

Tight junctions potentiate the insulative properties of small CNS myelinated axons

Devaux, J. J., & Gow, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200808034 · Cited by 111

Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity

Battefeld, A., Klooster, J., & Kole, M. H. P. (2016) · Nature Communications · doi:10.1038/ncomms11298 · Cited by 110

Axon-glia interaction and membrane traffic in myelin formation

White, R., & Krämer‐Albers, E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00284 · Cited by 109

Glial ankyrins facilitate paranodal axoglial junction assembly

Chang, K.-J., Zollinger, D. R., Susuki, K., Sherman, D. L., Makara, M. A., Brophy, P., Cooper, E. C., Bennett, V., Mohler, P. J., & Rasband, M. N. (2014) · Nature Neuroscience · doi:10.1038/nn.3858 · Cited by 109

GJA12 mutations in children with recessive hypomyelinating leukoencephalopathy

Bugiani, M., Shahwan, S. A., Lamantea, E., Bizzi, A., Bakhsh, E., Moroni, I., Balestrini, M. R., Uziel, G., & Zeviani, M. (2006) · Neurology · doi:10.1212/01.wnl.0000223832.66286.e4 · Cited by 109

Comparative immunopathogenesis of acute disseminated encephalomyelitis, neuromyelitis optica, and multiple sclerosis

Wingerchuk, D. M., & Lucchinetti, C. F. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3280be58d8 · Cited by 109

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

Schirmer, L., Möbius, W., Zhao, C., Cruz-Herranz, A., Haim, L. B., Cordano, C., Shiow, L. R., Kelley, K. W., Sadowski, B., Timmons, G. M., et al. (2018) · eLife · doi:10.7554/elife.36428 · Cited by 109

Pelizaeus-Merzbacher Disease

Koeppen, A. H., & Robitaille, Y. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.9.747 · Cited by 107

Oligodendrocytes and the control of myelination in vivo: new insights from the rat anterior medullary velum

Butt, A. M., & Berry, M. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000215)59:4<477::aid-jnr2>3.0.co;2-j · Cited by 107

Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death

Veto, S., Acs, P., Bauer, J., Lassmann, H., Berente, Z., Setalo, G., Borgulya, G., Sumegi, B., Komoly, S., Gallyas, F., et al. (2010) · Brain · doi:10.1093/brain/awp337 · Cited by 107

Hereditary diffuse leukoencephalopathy with spheroids: clinical, pathologic and genetic studies of a new kindred

Baba, Y., Ghetti, B., Baker, M. C., Uitti, R. J., Hutton, M. L., Yamaguchi, K., Bird, T., Lin, W., DeLucia, M. W., Dickson, D. W., et al. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0046-z · Cited by 106

Hyaluronan accumulation and arrested oligodendrocyte progenitor maturation in vanishing white matter disease

Bugiani, M., Postma, N. L., Polder, E., Dieleman, N., Scheffer, P. G., Sim, F. J., van der Knaap, M. S., & Boor, I. (2013) · Brain · doi:10.1093/brain/aws320 · Cited by 105

Developmental Regulation of TREM2 and DAP12 Expression in the Murine CNS: Implications for Nasu-Hakola Disease

Thrash, J. C., Torbett, B. E., & Carson, M. J. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9657-1 · Cited by 104

Oligomers of Mutant Glial Fibrillary Acidic Protein (GFAP) Inhibit the Proteasome System in Alexander Disease Astrocytes, and the Small Heat Shock Protein αB-Crystallin Reverses the Inhibition

Tang, G., Perng, M. D., Wilk, S., Quinlan, R. A., & Goldman, J. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.067975 · Cited by 104

Integrin-mediated axoglial interactions initiate myelination in the central nervous system

Câmara, J., Wang, Z., Nunes‐Fonseca, C., Friedman, H. C., Grove, M., Sherman, D. L., Komiyama, N. H., Grant, S. G. N., Brophy, P., Peterson, A. C., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200807010 · Cited by 104

The Unfolded Protein Response in Vanishing White Matter Disease

van der Voorn, J. P., van Kollenburg, B., Bertrand, G. A. M., van Haren, K. P., Scheper, G. C., Powers, J. M., & van der Knaap, M. S. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000178446.41595.3a · Cited by 102

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction

Patzig, J., Erwig, M. S., Tenzer, S., Kusch, K., Dibaj, P., Möbius, W., Goebbels, S., Schaeren‐Wiemers, N., Nave, K., & Werner, H. B. (2016) · eLife · doi:10.7554/elife.17119 · Cited by 102

Axonal loss in the multiple sclerosis spinal cord revisited

Petrova, N., Carassiti, D., Altmann, D. R., Baker, D., & Schmierer, K. (2017) · Brain Pathology · doi:10.1111/bpa.12516 · Cited by 101

Neuropathology and Genetics of Pelizaeus‐Merzbacher Disease

SEITELBERGER, F. (1995) · Brain Pathology · doi:10.1111/j.1750-3639.1995.tb00603.x · Cited by 100

WAVE1 Is Required for Oligodendrocyte Morphogenesis and Normal CNS Myelination

Kim, H.-J., DiBernardo, A. B., Sloane, J. A., Rasband, M. N., Solomon, D., Kosaras, B., Kwak, S. P., & Vartanian, T. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4921-05.2006 · Cited by 99

Myelin‐associated glycoprotein modulates expression and phosphorylation of neuronal cytoskeletal elements and their associated kinases

Dashiell, S. M., Tanner, S. L., Pant, H. C., & Quarles, R. H. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00927.x · Cited by 98

Ballooning of myelin sheaths in normally aged macaques

Feldman, M. L., & Peters, A. (1998) · Journal of Neurocytology · doi:10.1023/a:1006926428699 · Cited by 98

CNP overexpression induces aberrant oligodendrocyte membranes and inhibits MBP accumulation and myelin compaction

Yin, X., Peterson, J. W., Gravel, M., Braun, P. E., & Trapp, B. D. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19971015)50:2<238::aid-jnr12>3.0.co;2-4 · Cited by 98

Foamy cells with oligodendroglial phenotype in childhood ataxia with diffuse central nervous system hypomyelination syndrome

Wong, K., Armstrong, R. C., Gyure, K. A., Morrison, A. L., Rodriguez, D., Matalon, R. K., Johnson, T., Wollmann, R. L., Gilbert, E., Le, T. Q., et al. (2000) · Acta Neuropathologica · doi:10.1007/s004010000234 · Cited by 98

Astrocyte associations with nodes of Ranvier: ultrastructural analysis of HRP-filled astrocytes in the mouse optic nerve

Butt, A. M., Duncan, A., & Berry, M. (1994) · Journal of Neurocytology · doi:10.1007/bf01184072 · Cited by 97

Influence of White Matter Hyperintensities on the Cognition of Patients With Parkinson Disease

Lee, S., Kim, J., Yoo, J.-Y., Song, I., Kim, B., Jung, S. L., Yang, D., Kim, Y.-I., Jeong, D., & Lee, K.-S. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181d71a13 · Cited by 95

Morphometric comparison of the human corpus callosum in professional musicians and non-musicians by using in vivo magnetic resonance imaging.

Öztürk, H., Tasçioglu, B., Aktekin, M., et al. (2002) · PubMed · Cited by 93

Astrocyte‐specific overexpression of insulin‐like growth factor‐I promotes brain overgrowth and glial fibrillary acidic protein expression

Ye, P., Popken, G., Kemper, A., McCarthy, K. D., Popko, B., & D’Ercole, A. J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20288 · Cited by 93

Greater loss of axons in primary progressive multiple sclerosis plaques compared to secondary progressive disease

Tallantyre, E. C., Bo, L., Al-Rawashdeh, O., Owens, T., Polman, C. H., Lowe, J., & Evangelou, N. (2009) · Brain · doi:10.1093/brain/awp106 · Cited by 93

Neuronal loss, demyelination and volume change in the multiple sclerosis neocortex

Carassiti, D., Altmann, D. R., Petrova, N., Pakkenberg, B., Scaravilli, F., & Schmierer, K. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12405 · Cited by 93

Acceleration of conduction velocity linked to clustering of nodal components precedes myelination

Freeman, S. A., Desmazières, A., Simonnet, J., Gatta, M., Pfeiffer, F., Aigrot, M. S., Rappeneau, Q., Guerreiro, S., Michel, P. P., Yanagawa, Y., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419099112 · Cited by 91

Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell–mediated dendrite and synapse loss

Kreutzfeldt, M., Bergthaler, A., Fernandez, M., Brück, W., Steinbach, K., Vorm, M., Coras, R., Blümcke, I., Bonilla, W. V., Fleige, A., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122143 · Cited by 90

Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line

Raasakka, A., Ruskamo, S., Kowal, J., Barker, R. D., Baumann, A., Martel, A., Tuusa, J. T., Myllykoski, M., Bürck, J., Ulrich, A. S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05364-3 · Cited by 90

Nodes of Ranvier Act as Barriers to Restrict Invasion of Flanking Paranodal Domains in Myelinated Axons

Thaxton, C., Pillai, A. M., Pribisko, A. L., Dupree, J. L., & Bhat, M. A. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.016 · Cited by 88

Autosomal dominant diffuse leukoencephalopathy with neuroaxonal spheroids

van der Knaap, M. S., Naidu, S., Kleinschmidt-DeMasters, B. K., Kamphorst, W., & Weinstein, H. C. (2000) · Neurology · doi:10.1212/wnl.54.2.463 · Cited by 88

A unified cell biological perspective on axon–myelin injury

Simons, M., Misgeld, T., & Kerschensteiner, M. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201404154 · Cited by 88

Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica

Guo, Y. X., Weigand, S. D., Popescu, B. F. G., Lennon, V. A., Parisi, J. E., Pittock, S. J., Parks, N. E., Clardy, S. L., Howe, C. L., & Lucchinetti, C. F. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1682-1 · Cited by 88

Increased density of oligodendrocytes in childhood ataxia with diffuse central hypomyelination (CACH) syndrome: neuropathological and biochemical study of two cases

Rodriguez, D., Gélot, A., Gaspera, B. D., Robain, O., Ponsot, G., Sarliève, L. L., Ghandour, S., Pompidou, A. J., Dautigny, A., Aubourg, P. R., et al. (1999) · Acta Neuropathologica · doi:10.1007/s004010051016 · Cited by 87

Tamoxifen accelerates the repair of demyelinated lesions in the central nervous system

Gonzalez, G. A., Hofer, M. P., Syed, Y. A., Amaral, A. I., Rundle, J., Rahman, S., Zhao, C., & Kotter, M. R. N. (2016) · Scientific Reports · doi:10.1038/srep31599 · Cited by 86

Alexander Disease Mutant Glial Fibrillary Acidic Protein Compromises Glutamate Transport in Astrocytes

Tian, R., Wu, X., Hagemann, T. L., Sosunov, A. A., Messing, A., McKhann, G. M., & Goldman, J. E. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181d3cb52 · Cited by 86

Human glial chimeric mice reveal astrocytic dependence of JC virus infection

Kondo, Y., Windrem, M. S., Zou, L., Chandler-Militello, D., Schanz, S. J., Auvergne, R. M., Betstadt, S. J., Harrington, A. R., Johnson, M. D., Kazarov, A. R., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76629 · Cited by 86

Oligodendrocyte Progenitor Cell Susceptibility to Injury in Multiple Sclerosis

Cui, Q., Kuhlmann, T., Miron, V. E., Leong, S. Y., Fang, J. Q., Gris, P., Kennedy, T. E., Almazán, G., & Antel, J. P. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.04.016 · Cited by 86

Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children

Lalive, P. H., Häusler, M., Maurey, H., Mikaeloff, Y., Tardieu, M., Wiendl, H., Schroeter, M., Hp, H., Kieseier, B., & Menge, T. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510389220 · Cited by 86

Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis

Lagumersindez-Denis, N., Wrzos, C., Mack, M., Winkler, A., van der Meer, F., Reinert, M., Hollasch, H., Flach, A., Brühl, H., Cullen, E., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1706-x · Cited by 86

Diversity of oligodendrocytes and their progenitors

Dimou, L., & Simons, M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.09.015 · Cited by 86

Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients

Kantor, L., Harding, H. P., Ron, D., Schiffmann, R., Kaneski, C. R., Kimball, S. R., & Elroy‐Stein, O. (2005) · Human Genetics · doi:10.1007/s00439-005-0024-x · Cited by 85

Phenotypic Conversions of “Protoplasmic” to “Reactive” Astrocytes in Alexander Disease

Sosunov, A. A., Guilfoyle, E., Wu, X., McKhann, G. M., & Goldman, J. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4506-12.2013 · Cited by 84

Changing relation between onset of myelination and axon diameter range in developing feline white matter

Remahl, S., & Hildebrand, C. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90216-7 · Cited by 84

GJA12 mutations are a rare cause of Pelizaeus-Merzbacher-like disease

Henneke, M., Combes, P., Diekmann, S., Bertini, E., Brockmann, K., Burlina, A. P., Kaiser, J., Ohlenbusch, A., Plecko, B., Rodriguez, D., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000284828.84464.35 · Cited by 83

Spinal cord multiple sclerosis lesions in Japanese patients: Schwann cell remyelination occurs in areas that lack glial fibrillary acidic protein (GFAP)

Itoyama, Y., Ohnishi, A., Tateishi, J., Kuroiwa, Y., & de Webster, H. F. (1985) · Acta Neuropathologica · doi:10.1007/bf00687001 · Cited by 83

Membrane domain organization of myelinated axons requires βII spectrin

Zhang, C., Susuki, K., Zollinger, D. R., Dupree, J. L., & Rasband, M. N. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201308116 · Cited by 81

A common mechanism of PLP/DM20 misfolding causes cysteine-mediated endoplasmic reticulum retention in oligodendrocytes and Pelizaeus–Merzbacher disease

Dhaunchak, A. S., & Nave, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704975104 · Cited by 81

Acute disseminated encephalomyelitis

Tenembaum, S. N. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52910-7.00048-9 · Cited by 80

On the association between perinodal astrocytic processes and the node of Ranvier in the C.N.S.

Raine, C. S. (1984) · Journal of Neurocytology · doi:10.1007/bf01148316 · Cited by 79

N-WASP is required for membrane wrapping and myelination by Schwann cells

Novak, N., Bar, V., Sabanay, H., Frechter, S., Jaegle, M., Snapper, S. B., Meijer, D., & Peles, E. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010013 · Cited by 79

Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate

Brück, W., Popescu, B. F. G., Lucchinetti, C. F., Markovic‐Plese, S., Gold, R., Thal, D. R., & Metz, I. (2012) · Annals of Neurology · doi:10.1002/ana.23621 · Cited by 78

The relationship between internodal length and fibre diameter in the spinal cord of the cat

Murray, J. A., & Blakemore, W. F. (1980) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(80)80004-9 · Cited by 78

Alexander's Disease: Clues to Diagnosis

Pridmore, C. L., Baraitser, M., Harding, B. N., Boyd, S. G., Kendall, B. E., & Brett, E. M. (1993) · Journal of Child Neurology · doi:10.1177/088307389300800205 · Cited by 78

PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus‐Merzbacher disease

Karim, S. A., Barrie, J. A., McCulloch, M. C., Montague, P., Edgar, J. M., Kirkham, D., Anderson, T. J., Nave, K. A., Griffiths, I. R., & McLaughlin, M. (2006) · Glia · doi:10.1002/glia.20465 · Cited by 77

The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier

Amor, V., Zhang, C., Vainshtein, A., Zhang, A., Zollinger, D. R., Eshed‐Eisenbach, Y., Brophy, P., Rasband, M. N., & Peles, E. (2017) · eLife · doi:10.7554/elife.21392 · Cited by 77

The Life and Death of Oligodendrocytes in Vanishing White Matter Disease

van Haren, K. P., van der Voorn, J. P., Peterson, D. R., van der Knaap, M. S., & Powers, J. M. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.6.618 · Cited by 76

Fundamental Problems in the Pathology of Multiple Sclerosis and Allied Demyelinating Diseases

LUMSDEN, C. E. (1951) · BMJ · doi:10.1136/bmj.1.4714.1035 · Cited by 76

Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination

Schultz, V., van der Meer, F., Wrzos, C., Scheidt, U., Bahn, E., Stadelmann, C., Brück, W., & Junker, A. (2017) · Glia · doi:10.1002/glia.23167 · Cited by 75

Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: Co-localization of CD8 + T cells with JCV-infected glial cells

Wüthrich, C., Kesari, S., Kim, W., et al. (2006) · Journal of NeuroVirology · doi:10.1080/13550280600716604 · Cited by 74

Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system

Bakhti, M., Snaidero, N., Schneider, D., Aggarwal, S., Möbius, W., Janshoff, A., Eckhardt, M., Nave, K., & Simons, M. (2013) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1220104110 · Cited by 74

CNS live imaging reveals a new mechanism of myelination: The liquid croissant model

Sobottka, B., Ziegler, U., Kaech, A., Becher, B., & Goebels, N. (2011) · Glia · doi:10.1002/glia.21228 · Cited by 73

2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase Binds to Actin‐Based Cytoskeletal Elements in an Isoprenylation‐Independent Manner

Angelis, D. A. D., & Braun, P. E. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67030943.x · Cited by 73

Endoplasmic Reticulum Stress in PLP-Overexpressing Transgenic Rats: Gray Matter Oligodendrocytes Are More Vulnerable than White Matter Oligodendrocytes

Bauer, J., Bradl, M., Klein, M., Leisser, M., Deckwerth, T. L., Wekerle, H., & Lassmann, H. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.1.12 · Cited by 71

Astrocyte pathology in Alexander disease causes a marked inflammatory environment

Olabarria, M., Putilina, M., Riemer, E. C., & Goldman, J. E. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1469-1 · Cited by 71

Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes

Nevin, Z. S., Factor, D. C., Karl, R. T., Douvaras, P., Laukka, J. J., Windrem, M. S., Goldman, S. A., Fossati, V., Hobson, G. M., & Tesar, P. J. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.03.005 · Cited by 71

Differences in the Reponses to Apheresis Therapy of Patients With 3 Histopathologically Classified Immunopathological Patterns of Multiple Sclerosis

Stork, L., Ellenberger, D., Beißbarth, T., Friede, T., Lucchinetti, C. F., Brück, W., & Metz, I. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.4842 · Cited by 71

Quantitative magnetization transfer imaging of pre-lesional white-matter changes in multiple sclerosis

Fazekas, F., Ropele, S., Enzinger, C., Seifert‐Held, T., & Strasser‐Fuchs, S. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms860oa · Cited by 70

Ultrastructural and light‐microscopic studies of the developing feline spinal cord white matter. I. The nodes of Ranvier

Hildebrand, C. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb10979.x · Cited by 70

A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter

Geva, M., Cabilly, Y., Assaf, Y., Mindroul, N., Marom, L., Raini, G., Pinchasi, D., & Elroy‐Stein, O. (2010) · Brain · doi:10.1093/brain/awq180 · Cited by 70

Nasu–Hakola disease and primary microglial dysfunction

Bianchin, M. M., Martin, K. C., de Souza, A. C., de Oliveira, M. A., & de Mello Rieder, C. R. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.17-c1 · Cited by 69

The emerging functions of oligodendrocytes in regulating neuronal network behaviour

de Hoz, L., & Simons, M. (2014) · BioEssays · doi:10.1002/bies.201400127 · Cited by 69

In situ evidence of JC virus control by CD8+ T cells in PML-IRIS during HIV infection

Martin‐Blondel, G., Bauer, J., Cuvinciuc, V., Uro‐Coste, E., Debard, A., Massip, P., Delisle, M., Lassmann, H., Marchou, B., Mars, L. T., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a43e6d · Cited by 69

A RADIAL COMPONENT OF CENTRAL MYELIN SHEATHS

Peters, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.11.3.733 · Cited by 69

C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica

Phuan, P., Zhang, H., Asavapanumas, N., Leviten, M. W., Rosenthal, A., Tradtrantip, L., & Verkman, A. S. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1128-3 · Cited by 68

A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation

Fogli, A., Dionisi‐Vici, C., Deodato, F., Bartuli, A., Boespflug‐Tanguy, O., & Bertini, E. (2002) · Neurology · doi:10.1212/01.wnl.0000041666.76863.47 · Cited by 68

Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination

Lee, N. J., Ha, S.-K., Sati, P., Absinta, M., Luciano, N. J., Lefeuvre, J., Schindler, M. K., Leibovitch, E. C., Ryu, J. K., Petersen, M. A., et al. (2018) · Brain · doi:10.1093/brain/awy082 · Cited by 68

Relations between axons and oligodendroglial cells during initial myelination. II. The individual axon

Remahl, S., & Hildebrand, C. (1990) · Journal of Neurocytology · doi:10.1007/bf01186817 · Cited by 67

Synaptic pathology in the cerebellar dentate nucleus in chronic multiple sclerosis

Albert, M., Barrantes‐Freer, A., Lohrberg, M., Antel, J. P., Prineas, J. W., Palkovits, M., Wolff, J. R., Brück, W., & Stadelmann, C. (2016) · Brain Pathology · doi:10.1111/bpa.12450 · Cited by 67

Organization of myelin in the mouse somatosensory barrel cortex and the effects of sensory deprivation

Barrera, K., Chu, P., Abramowitz, J. M., Steger, R., Ramos, R. L., & Brumberg, J. C. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22060 · Cited by 66

Incisures of Schmidt-Lanterman

Ghabriel, M. N., & Allt, G. (1981) · Progress in Neurobiology · doi:10.1016/0301-0082(81)90003-4 · Cited by 66

Hypomyelinating leukodystrophies — a molecular insight into the white matter pathology

Charzewska, A., Wierzba, J., Iżycka‐Świeszewska, E., Bekiesińska‐Figatowska, M., Jurek, M., Gintowt, A., Kłosowska, A., Bal, J., & Hoffman‐Zacharska, D. (2016) · Clinical Genetics · doi:10.1111/cge.12811 · Cited by 66

Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis

Michailidou, I., Naessens, D. M. P., Hametner, S., Guldenaar, W., Kooi, E., Geurts, J. J. G., Baas, F., Lassmann, H., & Ramaglia, V. (2016) · Glia · doi:10.1002/glia.23090 · Cited by 66

p53 Inhibits JC Virus DNA Replicationin Vivoand Interacts with JC Virus Large T-Antigen

Staib, C., PESCH, J., Gerwig, R., Gerber, J., Brehm, U., STANGL, A., & Grummt, F. (1996) · Virology · doi:10.1006/viro.1996.0241 · Cited by 65

Disorders of Astrocytes: Alexander Disease as a Model

Olabarria, M., & Goldman, J. E. (2017) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100218 · Cited by 65

A high throughput drug screening assay to identify compounds that promote oligodendrocyte differentiation using acutely dissociated and purified oligodendrocyte precursor cells

Lariosa-Willingham, K. D., Rosler, E. S., Tung, J. S., Dugas, J. C., Collins, T. L., & Leonoudakis, D. (2016) · BMC Research Notes · doi:10.1186/s13104-016-2220-2 · Cited by 65

Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica

Tradtrantip, L., Yao, X., Su, T., Smith, A. J., & Verkman, A. S. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1734-6 · Cited by 65

Potential Mechanisms of the Human Polyomavirus JC in Neural Oncogenesis

Valle, L. D., White, M. K., & Khalili, K. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318180e631 · Cited by 64

Myelin basic protein as a "PI(4,5)P2-modulin": a new biological function for a major central nervous system protein.

Musse, A. A., Gao, W., Homchaudhuri, L., Boggs, J., & Harauz, G. (2008) · Biochemistry · doi:10.1021/bi801302b · Cited by 64

N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination

Jin, F., Dong, B., Georgiou, J., Jiang, Q., Zhang, J., Bharioke, A., Qiu, F., Lommel, S., Feltri, M. L., Wrabetz, L. G., et al. (2011) · Development · doi:10.1242/dev.058677 · Cited by 64

Alexander Disease: A Genetic Disorder of Astrocytes

Brenner, M., Goldman, J. E., Quinlan, R. A., & Messing, A. (2008) · Springer eBooks · doi:10.1007/978-0-387-79492-1_24 · Cited by 61

The force awakens: insights into the origin and formation of microglia

Tay, T. L., Hagemeyer, N., & Prinz, M. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.04.003 · Cited by 59

Epigenetic control of oligodendrocyte development: adding new players to old keepers

Liu, J., Moyon, S., Hernandez, M., & Casaccia, P. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.06.002 · Cited by 59

Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin‐2

de Monasterio‐Schrader, P., Patzig, J., Möbius, W., Barrette, B., Wagner, T. L., Kusch, K., Edgar, J. M., Brophy, P., & Werner, H. B. (2013) · Glia · doi:10.1002/glia.22561 · Cited by 58

Permeability of the Paranodal Junction of Myelinated Nerve Fibers

Mierzwa, A. J., Shroff, S., & Rosenbluth, J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4047-10.2010 · Cited by 57

The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease

Sosunov, A. A., McKhann, G. M., & Goldman, J. E. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0425-9 · Cited by 57

Frequent Infection of Cortical Neurons by JC Virus in Patients With Progressive Multifocal Leukoencephalopathy

Wüthrich, C., & Koralnik, I. J. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31823ede59 · Cited by 56

Myelinopathia centralis diffusa (vanishing white matter disease): Evidence of apoptotic oligodendrocyte degeneration in early lesion development

Brück, W., Herms, J. W., Brockmann, K., Schulz‐Schaeffer, W., & Hanefeld, F. A. (2001) · Annals of Neurology · doi:10.1002/ana.1227 · Cited by 56

Lysosomal leukodystrophies

Kohlschütter, A. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59565-2.00029-0 · Cited by 55

Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice

Cho, W., & Messing, A. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.12.012 · Cited by 55

Schmidt-Lantermann incisures in the central nervous system

Blakemore, W. F. (1969) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(69)90069-0 · Cited by 55

Regulation of protein synthesis in lymphoblasts from vanishing white matter patients

van Kollenburg, B., Thomas, A. A. M., Vermeulen, G., Bertrand, G. A. M., van Berkel, C. G. M., Pronk, J. C., Proud, C. G., van der Knaap, M. S., & Scheper, G. C. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.08.009 · Cited by 54

Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions

Wrzos, C., Winkler, A., Metz, I., Kayser, D. M., Thal, D. R., Wegner, C., Brück, W., Nessler, S., Bennett, J. L., & Stadelmann, C. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1220-8 · Cited by 54

Alexander's disease: Further light-, and electron-microscopic observations

Towfighi, J., Young, R. S. K., Sassani, J. W., Ramer, J. C., & Horoupian, D. S. (1983) · Acta Neuropathologica · doi:10.1007/bf00688384 · Cited by 54

Neuropathology for the neuroradiologist: Rosenthal fibers.

Wippold, F. J., Perry, A., & Lennerz, J. K. (2006) · PubMed Central · Cited by 54

Human neural progenitors from different foetal forebrain regions remyelinate the adult mouse spinal cord

Buchet, D., Garcia, C. I., Deboux, C., Nait‐Oumesmar, B., & Evercooren, A. B. (2011) · Brain · doi:10.1093/brain/awr030 · Cited by 53

Regulation and dysregulation of axon infrastructure by myelinating glia

Pan, S., & Chan, J. R. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201702150 · Cited by 53

White matter aging drives microglial diversity

Safaiyan, S., Besson-Girard, S., Kaya, T., Cantuti-Castelvetri, L., Liu, L., Ji, H., Schifferer, M., Gouna, G., Usifo, F., Kannaiyan, N., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.01.027 · Cited by 477

Diagnosis and classification of optic neuritis

Petzold, A., Fraser, C. L., Abegg, M., Alroughani, R., Alshowaeir, D., Alvarenga, R., Andris, C., Asgari, N., Barnett, Y., Battistella, R., et al. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00200-9 · Cited by 330

CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging

Kaya, T., Mattugini, N., Liu, L., Ji, H., Cantuti-Castelvetri, L., Wu, J., Schifferer, M., Groh, J., Martini, R., Besson-Girard, S., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01183-6 · Cited by 224

CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities

Franklin, R. J. M., & Simons, M. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.023 · Cited by 184

White matter aging and its impact on brain function

Groh, J., & Simons, M. (2025) · Neuron · doi:10.1016/j.neuron.2024.10.019 · Cited by 124