The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases
Open accessAbstract
A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter cotranslationally in the ER lumen, which contains resident molecular chaperones and folding factors that assist their maturation. Native proteins are released from the ER lumen and are transported through the secretory pathway to their final intra- or extracellular destination. Folding-defective polypeptides are exported across the ER membrane into the cytosol and destroyed. Cellular and organismal homeostasis relies on a balanced activity of the ER folding, quality control, and degradation machineries as shown by the dozens of human diseases related to defective maturation or disposal of individual polypeptides generated in the ER.
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Cites
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Mechanisms, regulation and functions of the unfolded protein response
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One step at a time: endoplasmic reticulum-associated degradation
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Endoplasmic reticulum stress signalling-from basic mechanisms to clinical applications
Almanza, A., Carlesso, A., Chintha, C., Creedican, S., Doultsinos, D., Leuzzi, B., Luís, A., McCarthy, N., Montibeller, L., More, S., et al. (2019) · The FEBS Journal · doi:10.1111/febs.14608 · Cited by 1,034
A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress
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Metadata
- Authors
- Hebert, D. N., & Molinari, M.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2007-10
- Volume
- 87
- Issue
- 4
- Pages
- 1377-1408
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2071767667
- Cited by
- 671
- References
- 20
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Hebert, D. N., & Molinari, M. (2007). In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases. Physiological Reviews. https://doi.org/10.1152/physrev.00050.2006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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