Endoplasmic reticulum stress signalling-from basic mechanisms to clinical applications

Hallmarks of Cancer: The Next Generation

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Calcium's Role in Mechanotransduction during Muscle Development

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Molecular Biology of the Cell

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Signal integration in the endoplasmic reticulum unfolded protein response

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Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

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Calcium Signaling

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

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XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

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An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

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Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

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Immunogenic cell death in cancer and infectious disease

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Mitochondrial free radical generation, oxidative stress, and aging

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Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study

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Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

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Perk is essential for translational regulation and cell survival during the unfolded protein response

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumPreprint

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Dithiothreitol, a New Protective Reagent for SH Groups *

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Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

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ER stress-induced cell death mechanisms

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ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

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Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

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Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?

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ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

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ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

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XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

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A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

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Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

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Plasma cell differentiation requires the transcription factor XBP-1

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Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

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COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

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Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response

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Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

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ERAD: the long road to destruction

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Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8

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Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

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The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

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Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

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Necroptosis

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Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1

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Oxidative protein folding in eukaryotes

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A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein Response

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Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.Preprint

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Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

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Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

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Control of mitochondrial morphology by a human mitofusin

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A Mutation in the Vesicle-Trafficking Protein VAPB Causes Late-Onset Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis

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Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

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Endoplasmic Reticulum Stress and Associated ROS

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Measuring ER Stress and the Unfolded Protein Response Using Mammalian Tissue Culture System

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A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsPreprint

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The Transmembrane Kinase Ire1p Is a Site-Specific Endonuclease That Initiates mRNA Splicing in the Unfolded Protein Response

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An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis

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The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

Feng, B., Yao, P. M., Li, Y., Devlin, C. M., Zhang, D., Harding, H. P., Sweeney, M., Rong, J. X., Kuriakose, G., Fisher, E. A. A., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb1035 · Cited by 886 · see citing works

From acute ER stress to physiological roles of the Unfolded Protein Response

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Poly-ε-caprolactone Coated and Functionalized Porous Titanium and Magnesium Implants for Enhancing Angiogenesis in Critically Sized Bone Defects

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Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E., & Mori, M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14550 · Cited by 858 · see citing works

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

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Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Quirós, P. M., Prado, M. A., Zamboni, N., D’Amico, D., Williams, R. W., Finley, D., Gygi, S. P., & Auwerx, J. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201702058 · Cited by 832 · see citing works

Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond

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CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells

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XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

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IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

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MAM: more than just a housekeeper

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Cloning of mammalian Ire1 reveals diversity in the ER stress responses

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Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

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Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium

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Targeted disruption of the chop gene delays endoplasmic reticulum stress-mediated diabetes

Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E., & Mori, M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214550 · Cited by 752 · see citing works

PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress

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An atlas of combinatorial transcriptional regulation in mouse and man

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Mammalian Genes Coordinately Regulated by Growth Arrest Signals and DNA-Damaging Agents

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Protein Folding and Modification in the Mammalian Endoplasmic Reticulum

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A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response

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In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases

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XBP1

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Getting RIDD of RNA: IRE1 in cell fate regulation

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DNA damage-inducible transcripts in mammalian cells.

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