The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
Abstract
The Hedgehog family of secreted morphogenetic proteins acts through a complex evolutionary conserved signaling pathway to regulate patterning events during development and in the adult organism. In this review I discuss the role of Hedgehog signaling in the development, postnatal maintenance, and carcinogenesis of the gastrointestinal tract. Three mammalian hedgehog genes, sonic hedgehog (Shh), indian hedgehog (Ihh), and desert hedgehog (Dhh) have been identified. Shh and Ihh are important endodermal signals in the endodermal-mesodermal cross-talk that patterns the developing gut tube along different axes. Mutations in Shh, Ihh, and downstream signaling molecules lead to a variety of gross malformations of the murine gastrointestinal tract including esophageal atresia, tracheoesophageal fistula, annular pancreas, midgut malrotation, and duodenal and anal atresia. These congenital malformations are also found in varying constellations in humans, suggesting a possible role for defective Hedgehog signaling in these patients. In the adult, Hedgehog signaling regulates homeostasis in several endoderm-derived epithelia, for example, the stomach, intestine, and pancreas. Finally, growth of carcinomas of the proximal gastrointestinal tract such as esophageal, gastric, biliary duct, and pancreatic cancers may depend on Hedgehog signaling offering a potential avenue for novel therapy for these aggressive cancers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutations affecting segment number and polarity in Drosophila
Nüsslein-Volhard, C., & Wieschaus, E. (1980) · Nature · doi:10.1038/287795a0 · Cited by 4,370
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.-P., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01014-0 · Cited by 2,030
Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Hahn, H., Wicking, C., Zaphiropoulos, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A. B., Gillies, S., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81268-4 · Cited by 2,022
Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
Johnson, R. L., Rothman, A. L., Xie, J., Goodrich, L. V., Bare, J. W., Bonifas, J. M., Quinn, A. G., Myers, R. M., Cox, D. R., Epstein, E. H., et al. (1996) · Science · doi:10.1126/science.272.5268.1668 · Cited by 1,857
The Atlas of Mouse Development
Kaufman, M. H. (1992) · Medical Entomology and Zoology · Cited by 1,750
Nonaka, S., Tanaka, Y., Okada, Y., Takeda, S., Harada, A., Kanai, Y., Kido, M., & Hirokawa, N. (1998) · Cell · doi:10.1016/s0092-8674(00)81705-5 · Cited by 1,617
Genetics and biology of pancreatic ductal adenocarcinoma
Hezel, A. F., Kimmelman, A. C., Stanger, B. Z., Bardeesy, N., & DePinho, R. A. (2006) · Genes & Development · doi:10.1101/gad.1415606 · Cited by 1,577
Linking Colorectal Cancer to Wnt Signaling
Bienz, M., & Clevers, H. (2000) · Cell · doi:10.1016/s0092-8674(00)00122-7 · Cited by 1,515
Vertebrate Smoothened functions at the primary cilium
Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. R., & Reiter, J. F. (2005) · Nature · doi:10.1038/nature04117 · Cited by 1,481
Research works printed but not linked: 10
- 10.1001/archsurg.1979.01370340031004 · doi:10.1001/archsurg.1979.01370340031004
- 10.1002/ar.1092350208 · doi:10.1002/ar.1092350208
- 10.1097/01.LAB.0000101729.25140.0C · doi:10.1097/01.lab.0000101729.25140.0c
- 10.1042/BST0331509 · doi:10.1042/bst0331509
- 10.1152/ajpgi.1997.272.5.G1209 · doi:10.1152/ajpgi.1997.272.5.g1209
- 10.1002/1096-8628(20001113)95:2<169::AID-AJMG15>3.0.CO;2-Z · doi:10.1002/1096-8628(20001113)95:2<169::aid-ajmg15>3.0.co;2-z
- 10.1002/ar.1092170405 · doi:10.1002/ar.1092170405
- 10.1002/ar.1092300210 · doi:10.1002/ar.1092300210
- Soriano L.Differentiation of epithelium of the digestive tube in vitro.J Embryol Exp Morphol14: 119–128, 1965. · doi:10.1242/dev.14.2.119
- 10.1002/path.1763 · doi:10.1002/path.1763
Cited by
Hedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
A paracrine requirement for hedgehog signalling in cancer
Yauch, R. L., Gould, S. E., Scales, S. J., Tang, T., Tian, H., Ahn, C. P., Marshall, D., Fu, L., Januario, T., Kallop, D., et al. (2008) · Nature · doi:10.1038/nature07275 · Cited by 961
Vertebrate Endoderm Development and Organ Formation
Zorn, A. M., & Wells, J. M. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113344 · Cited by 812
Primary Cilia and Signaling Pathways in Mammalian Development, Health and Disease
Veland, I. R., Awan, A., Pedersen, L. B., Yoder, B. K., & Christensen, S. T. (2009) · Nephron Physiology · doi:10.1159/000208212 · Cited by 279
Intestinal mucosal atrophy and adaptation
Shaw, D. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i44.6357 · Cited by 133
Mechanisms and Strategies to Overcome Drug Resistance in Colorectal Cancer
Haynes, J., & Manogaran, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051988 · Cited by 82
Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels
Matz-Soja, M., Aleithe, S., Marbach, E., Böttger, J., Arnold, K., Schmidt-Heck, W., Kratzsch, J., & Gebhardt, R. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-11 · Cited by 60
Building gut from scratch — progress and update of intestinal tissue engineering
Tullie, L., Jones, B. C., De Coppi, P., & Li, V. S. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00586-x · Cited by 27
Metadata
- Authors
- van den Brink, G. R.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2007-10
- Volume
- 87
- Issue
- 4
- Pages
- 1343-1375
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2100562940
- Cited by
- 301
- References
- 210
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
