Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract

Mutations affecting segment number and polarity in Drosophila

Nüsslein-Volhard, C., & Wieschaus, E. (1980) · Nature · doi:10.1038/287795a0 · Cited by 4,370

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.-P., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01014-0 · Cited by 2,030

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

Hahn, H., Wicking, C., Zaphiropoulos, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A. B., Gillies, S., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81268-4 · Cited by 2,022

Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

Johnson, R. L., Rothman, A. L., Xie, J., Goodrich, L. V., Bare, J. W., Bonifas, J. M., Quinn, A. G., Myers, R. M., Cox, D. R., Epstein, E. H., et al. (1996) · Science · doi:10.1126/science.272.5268.1668 · Cited by 1,857

The Atlas of Mouse Development

Kaufman, M. H. (1992) · Medical Entomology and Zoology · Cited by 1,750

Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein

Nonaka, S., Tanaka, Y., Okada, Y., Takeda, S., Harada, A., Kanai, Y., Kido, M., & Hirokawa, N. (1998) · Cell · doi:10.1016/s0092-8674(00)81705-5 · Cited by 1,617

Genetics and biology of pancreatic ductal adenocarcinoma

Hezel, A. F., Kimmelman, A. C., Stanger, B. Z., Bardeesy, N., & DePinho, R. A. (2006) · Genes & Development · doi:10.1101/gad.1415606 · Cited by 1,577

Linking Colorectal Cancer to Wnt Signaling

Bienz, M., & Clevers, H. (2000) · Cell · doi:10.1016/s0092-8674(00)00122-7 · Cited by 1,515

Vertebrate Smoothened functions at the primary cilium

Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. R., & Reiter, J. F. (2005) · Nature · doi:10.1038/nature04117 · Cited by 1,481

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

Thayer, S. P., di Magliano, M. P., Heiser, P. W., Nielsen, C. M., Roberts, D. J., Lauwers, G. Y., Qi, Y. P., Gysin, S., Castillo, C. F.-D., Yajnik, V., et al. (2003) · Nature · doi:10.1038/nature02009 · Cited by 1,480

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Chen, J. K., Taipale, J., Cooper, M. K., & Beachy, P. A. (2002) · Genes & Development · doi:10.1101/gad.1025302 · Cited by 1,465

Hedgehog signalling in the mouse requires intraflagellar transport proteins

Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., Niswander, L., & Anderson, K. V. (2003) · Nature · doi:10.1038/nature02061 · Cited by 1,425

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

Bitgood, M. J., & McMahon, A. P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0010 · Cited by 1,370

Activating Smoothened mutations in sporadic basal-cell carcinoma

Xie, J., Murone, M., Luoh, S.-M., Ryan, A., Gu, Q., Zhang, C., Bonifas, J. M., Lam, C.-W., Hynes, M., Goddard, A., et al. (1998) · Nature · doi:10.1038/34201 · Cited by 1,334

Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context

Mikels, A. J., & Nusse, R. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040115 · Cited by 1,252

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

Berman, D. M., Karhadkar, S. S., Maitra, A., Montes de Oca, R., Gerstenblith, M. R., Briggs, K., Parker, A. R., Shimada, Y., Eshleman, J. R., Watkins, D. N., et al. (2003) · Nature · doi:10.1038/nature01972 · Cited by 1,251

Advances in Male Contraception

Page, S. T., Amory, J. K., & Bremner, W. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0041 · Cited by 1,134

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling

He, X. C., Zhang, J., Tong, W.-G., Tawfik, O., Ross, J., Scoville, D. H., Tian, Q., Zeng, X., He, X., Wiedemann, L. M., et al. (2004) · Nature Genetics · doi:10.1038/ng1430 · Cited by 1,065

Induction of Pancreatic Differentiation by Signals from Blood Vessels

Lammert, E., Cleaver, O., & Melton, D. (2001) · Science · doi:10.1126/science.1064344 · Cited by 1,050

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

Ericson, J., Rashbass, P., Schedl, A., Brenner-Morton, S., Kawakami, A., van Heyningen, V, Jessell, T. M., & Briscoe, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80323-2 · Cited by 1,043

Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

Wang, B., Fallon, J. F., & Beachy, P. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80678-9 · Cited by 1,014

Small molecule modulation of Smoothened activity

Chen, J. K., Taipale, J., Young, K. E., Maiti, T., & Beachy, P. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182542899 · Cited by 992

Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function

Haycraft, C. J., Banizs, B., Aydin-Son, Y., Zhang, Q., Michaud, E. J., & Yoder, B. K. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010053 · Cited by 902

Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A. (1998) · Science · doi:10.1126/science.280.5369.1603 · Cited by 848

Hedgehog signals regulate multiple aspects of gastrointestinal development

Ramalho-Santos, M., Melton, D. A., & McMahon, A. P. (2000) · Development · doi:10.1242/dev.127.12.2763 · Cited by 845

The Hedgehog Response Network: Sensors, Switches, and Routers

Lum, L., & Beachy, P. A. (2004) · Science · doi:10.1126/science.1098020 · Cited by 838

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

Goodrich, L. V., Johnson, R. L., Milenkovic, L., McMahon, J. A., & Scott, M. P. (1996) · Genes & Development · doi:10.1101/gad.10.3.301 · Cited by 824

Mutations in SUFU predispose to medulloblastoma

Taylor, M. D., Liu, L., Raffel, C., Hui, C.-C., Mainprize, T. G., Zhang, X., Agatep, R., Chiappa, S., Gao, L., Lowrance, A., et al. (2002) · Nature Genetics · doi:10.1038/ng916 · Cited by 806

Communicating with Hedgehogs

Hooper, J. E., & Scott, M. P. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1622 · Cited by 804

Two Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse

McGrath, J., Somlo, S., Makova, S., Tian, X., & Brueckner, M. (2003) · Cell · doi:10.1016/s0092-8674(03)00511-7 · Cited by 797

De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine

Haramis, A.-P. G., Begthel, H., van den Born, M., van Es, J., Jonkheer, S., Offerhaus, G. J. A., & Clevers, H. (2004) · Science · doi:10.1126/science.1093587 · Cited by 796

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

Chuang, P.-T., & McMahon, A. P. (1999) · Nature · doi:10.1038/17611 · Cited by 795

Patched acts catalytically to suppress the activity of Smoothened

Taipale, J., Cooper, M. K., Maiti, T., & Beachy, P. A. (2002) · Nature · doi:10.1038/nature00989 · Cited by 794

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

St-Onge, L., Sosa-Pineda, B., Chowdhury, K., Mansouri, A., & Gruss, P. (1997) · Nature · doi:10.1038/387406a0 · Cited by 791

Familial adenomatous polyposis

Galiatsatos, P., & Foulkes, W. D. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00375.x · Cited by 757

cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine

Madison, B. B., Dunbar, L., Qiao, X. T., Braunstein, K., Braunstein, E., & Gumucio, D. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204935200 · Cited by 747

Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors

Jung, J., Zheng, M., Goldfarb, M., & Zaret, K. S. (1999) · Science · doi:10.1126/science.284.5422.1998 · Cited by 721

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

Park, H. L., Bai, C., Platt, K. A., Matise, M. P., Beeghly, A., Hui, C. C., Nakashima, M., & Joyner, A. L. (2000) · Development · doi:10.1242/dev.127.8.1593 · Cited by 718

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

Hui, C.-C., & Joyner, A. L. (1993) · Nature Genetics · doi:10.1038/ng0393-241 · Cited by 706

Lipoprotein particles are required for Hedgehog and Wingless signalling

Panáková, D., Sprong, H., Marois, E., Thiele, C., & Eaton, S. (2005) · Nature · doi:10.1038/nature03504 · Cited by 703

Sonic hedgehog is essential to foregut development

Litingtung, Y., Lei, L., Westphal, H., & Chiang, C. (1998) · Nature Genetics · doi:10.1038/1717 · Cited by 696

Wnt signaling in the intestinal epithelium: from endoderm to cancer

Gregorieff, A., & Clevers, H. (2005) · Genes & Development · doi:10.1101/gad.1295405 · Cited by 679

Thyroid Development and Its Disorders: Genetics and Molecular Mechanisms

De Felice, M., & Di Lauro, R. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0028 · Cited by 659

The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

Incardona, J. P., Gaffield, W., Kapur, R. P., & Roelink, H. (1998) · Development · doi:10.1242/dev.125.18.3553 · Cited by 656

Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm

Rossi, J. M., Dunn, N. R., Hogan, B. L. M., & Zaret, K. S. (2001) · Genes & Development · doi:10.1101/gad.904601 · Cited by 644

The VATER association

Quan, L., & Smith, D. W. (1973) · The Journal of Pediatrics · doi:10.1016/s0022-3476(73)80024-1 · Cited by 640

Sonic hedgehog regulates branching morphogenesis in the mammalian lung

Pepicelli, C. V., Lewis, P. M., & McMahon, A. P. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70446-4 · Cited by 639

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis

Howe, J. R., Bair, J. L., Sayed, M. G., Anderson, M. E., Mitros, F. A., Petersen, G. M., Velculescu, V. E., Traverso, G., & Vogelstein, B. (2001) · Nature Genetics · doi:10.1038/88919 · Cited by 629

Notochord repression of endodermal Sonic hedgehog permits pancreas development

Hebrok, M., Kim, S. K., & Melton, D. A. (1998) · Genes & Development · doi:10.1101/gad.12.11.1705 · Cited by 628

A bipotential precursor population for pancreas and liver within the embryonic endoderm

Deutsch, G., Jung, J., Zheng, M., Lóra, J., & Zaret, K. S. (2001) · Development · doi:10.1242/dev.128.6.871 · Cited by 611

Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node

Zhang, X. M., Ramalho-Santos, M., & McMahon, A. P. (2001) · Cell · doi:10.1016/s0092-8674(01)00385-3 · Cited by 606

Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.

Gualdi, R., Bossard, P., Zheng, M., Hamada, Y., Coleman, J. R., & Zaret, K. S. (1996) · Genes & Development · doi:10.1101/gad.10.13.1670 · Cited by 588

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.

Sander, M., Neubüser, A., Kalamaras, J., Ee, H. C., Martin, G. R., & German, M. S. (1997) · Genes & Development · doi:10.1101/gad.11.13.1662 · Cited by 587

Regulation of early lung morphogenesis: questions, facts and controversies

Cardoso, W. V., & Lü, J. (2006) · Development · doi:10.1242/dev.02310 · Cited by 585

Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development

Shook, D., & Keller, R. (2003) · Mechanisms of Development · doi:10.1016/j.mod.2003.06.005 · Cited by 582

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

Lee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581

Nodal Flow and the Generation of Left-Right Asymmetry

Hirokawa, N., Tanaka, Y., Okada, Y., & Takeda, S. (2006) · Cell · doi:10.1016/j.cell.2006.03.002 · Cited by 571

Sporadic medulloblastomas contain PTCH mutations.

Raffel, C., Jenkins, R. B., Frederick, L. A., Hebrink, D. M., Alderete, B. E., Fults, D. W., & James, C. D. (1997) · PubMed · Cited by 570

Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus

Motoyama, J., Liu, J., Mo, R., Ding, Q., Post, M., & Hui, C.-C. (1998) · Nature Genetics · doi:10.1038/1711 · Cited by 560

Autoproteolysis in hedgehog protein biogenesis

Lee, J., Ekker, S., von Kessler, D., Porter, J., Sun, B., & Beachy, P. (1994) · Science · doi:10.1126/science.7985023 · Cited by 547

Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate.

Augeron, C., & LABOISSE, C. L. (1984) · PubMed · Cited by 538

FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left–right determination

Tanaka, Y., Okada, Y., & Hirokawa, N. (2005) · Nature · doi:10.1038/nature03494 · Cited by 535

Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut

Roberts, D. J., Johnson, R. L., Burke, A. C., Nelson, C. E., Morgan, B. A., & Tabin, C. (1995) · Development · doi:10.1242/dev.121.10.3163 · Cited by 535

Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain

Porter, J. A., Ekker, S. C., Park, W.-J., von Kessler, D. P., Young, K. E., Chen, C.-H., Ma, Y., Woods, A. S., Cotter, R. J., Koonin, E. V., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80074-4 · Cited by 533

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

Denef, N., Neubüser, D., Perez, L., & Cohen, S. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00056-8 · Cited by 531

Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors

Thomas, P. Q., Brown, A., & Beddington, R. S. P. (1998) · Development · doi:10.1242/dev.125.1.85 · Cited by 528

Vertebrate Endoderm Development

Wells, J. M., & Melton, D. A. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.393 · Cited by 522

Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation

Pan, Y., Bai, C. B., Joyner, A. L., & Wang, B. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.9.3365-3377.2006 · Cited by 518

Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1

Lewis, P. M., Dunn, M. P., McMahon, J. A., Logan, M., Martin, J. F., St-Jacques, B., & McMahon, A. P. (2001) · Cell · doi:10.1016/s0092-8674(01)00369-5 · Cited by 513

GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome

Kang, S., Graham, J. M., Olney, A. H., & Biesecker, L. G. (1997) · Nature Genetics · doi:10.1038/ng0397-266 · Cited by 513

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

Porter, J. A., von Kessler, D. P., Ekker, S. C., Young, K. E., Lee, J. J., Moses, K., & Beachy, P. A. (1995) · Nature · doi:10.1038/374363a0 · Cited by 503

Morphogenesis

Hogan, B. L. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80562-0 · Cited by 497

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

Liu, A., Wang, B., & Niswander, L. A. (2005) · Development · doi:10.1242/dev.01894 · Cited by 494

Mechanism of Nodal Flow: A Conserved Symmetry Breaking Event in Left-Right Axis Determination

Okada, Y., Takeda, S., Tanaka, Y., Belmonte, J.-C. I., & Hirokawa, N. (2005) · Cell · doi:10.1016/j.cell.2005.04.008 · Cited by 489

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Frank-Kamenetsky, M., Zhang, X. M., Bottega, S., Guicherit, O., Wichterle, H., Dudek, H., Bumcrot, D., Wang, F. Y., Jones, S., Shulok, J., et al. (2002) · Journal of Biology · doi:10.1186/1475-4924-1-10 · Cited by 488

A freely diffusible form of Sonic hedgehog mediates long-range signalling

Zeng, X., Goetz, J. A., Suber, L. M., Scott, W. J., Schreiner, C. M., & Robbins, D. J. (2001) · Nature · doi:10.1038/35079648 · Cited by 484

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

Hui, C.-C., Slusarski, D., Platt, K. A., Holmgren, R., & Joyner, A. L. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1097 · Cited by 480

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

Huangfu, D., & Anderson, K. V. (2006) · Development · doi:10.1242/dev.02169 · Cited by 476

Genetic Elimination of Suppressor of Fused Reveals an Essential Repressor Function in the Mammalian Hedgehog Signaling Pathway

Svärd, J., Henricson, K. H., Persson-Lek, M., Rozell, B., Lauth, M., Bergström, Å., Ericson, J., Toftgård, R., & Teglund, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.013 · Cited by 468

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

Apelqvist, Å., Ahlgren, U., & Edlund, H. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00340-x · Cited by 444

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

May, S. R., Ashique, A. M., Karlen, M., Wang, B., Shen, Y., Zarbalis, K., Reiter, J., Ericson, J., & Peterson, A. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.08.050 · Cited by 428

Pathology of Genetically Engineered Mouse Models of Pancreatic Exocrine Cancer: Consensus Report and Recommendations

Hruban, R. H., Adsay, N. V., Albores-Saavedra, J., Anver, M. R., Biankin, A. V., Boivin, G. P., Furth, E. E., Furukawa, T., Klein, A., Klimstra, D. S., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2168 · Cited by 414

Regulation of pancreas development by hedgehog signaling

Hebrok, M., Kim, S. K., St-Jacques, B., McMahon, A. P., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.22.4905 · Cited by 412

Expression of Cdx‐2 in the mouse embryo and placenta: Possible role in patterning of the extra‐embryonic membranes

Beck, F., Erler, T., Russell, A., & James, R. (1995) · Developmental Dynamics · doi:10.1002/aja.1002040302 · Cited by 406

Notochord to endoderm signaling is required for pancreas development

Kim, S. K., Hebrok, M., & Melton, D. A. (1997) · Development · doi:10.1242/dev.124.21.4243 · Cited by 405

Intercellular signals regulating pancreas development and function

Kim, S. K., & Hebrok, M. (2001) · Genes & Development · doi:10.1101/gad.859401 · Cited by 402

Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

Litingtung, Y., & Chiang, C. (2000) · Nature Neuroscience · doi:10.1038/79916 · Cited by 392

The Cell Surface Membrane Proteins Cdo and Boc Are Components and Targets of the Hedgehog Signaling Pathway and Feedback Network in Mice

Tenzen, T., Allen, B. L., Cole, F., Kang, J.-S., Krauss, R. S., & McMahon, A. P. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.004 · Cited by 389

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

Tabata, T., Eaton, S., & Kornberg, T. B. (1992) · Genes & Development · doi:10.1101/gad.6.12b.2635 · Cited by 387

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

van den Brink, G. R., Bleuming, S. A., Hardwick, J. C. H., Schepman, B. L., Offerhaus, G. J., Keller, J. J., Nielsen, C., Gaffield, W., van Deventer, S. J. H., Roberts, D. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1304 · Cited by 385

Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9

Li, H., Arber, S., Jessell, T. M., & Edlund, H. (1999) · Nature Genetics · doi:10.1038/12669 · Cited by 378

Epithelial hedgehog signals pattern the intestinal crypt-villus axis

Madison, B. B., Braunstein, K., Kuizon, E., Portman, K., Qiao, X. T., & Gumucio, D. L. (2005) · Development · doi:10.1242/dev.01576 · Cited by 377

Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.

Pietsch, T., Waha, A., Koch, A., Kraus, J., Albrecht, S., Tonn, J. C., Sörensen, N., Berthold, F., Henk, B., Schmandt, N., et al. (1997) · PubMed · Cited by 373

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

Chen, M.-H., Li, Y.-J., Kawakami, T., Xu, S.-M., & Chuang, P.-T. (2004) · Genes & Development · doi:10.1101/gad.1185804 · Cited by 368

Early mouse endoderm is patterned by soluble factors from adjacent germ layers

Wells, J. M., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.8.1563 · Cited by 366

A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural Tube

Briscoe, J., Chen, Y., Jessell, T. M., & Struhl, G. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00271-4 · Cited by 363

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mahlapuu, M., Enerbäck, S., & Carlsson, P. (2001) · Development · doi:10.1242/dev.128.12.2397 · Cited by 359

Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT‐29 selected for growth in sugar‐free medium and its inhibition by glucose

Zweibaum, A., Pinto, M., Chevalier, G., Dussaulx, E., Triadou, N., Lacroix, B., Haffen, K., Brun, J., & Rousset, M. (1985) · Journal of Cellular Physiology · doi:10.1002/jcp.1041220105 · Cited by 341

The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm

Mahlapuu, M., Ormestad, M., Enerbäck, S., & Carlsson, P. (2001) · Development · doi:10.1242/dev.128.2.155 · Cited by 332

Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched

Ma, Y., Erkner, A., Gong, R., Yao, S., Taipale, J., Basler, K., & Beachy, P. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00977-7 · Cited by 327

Novel Lipid Modifications of Secreted Protein Signals

Mann, R. K., & Beachy, P. A. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073933 · Cited by 322

Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung

Serls, A. E., Doherty, S., Parvatiyar, P., Wells, J. M., & Deutsch, G. H. (2005) · Development · doi:10.1242/dev.01570 · Cited by 316

Abnormal gastrointestinal development in PDGF-A and PDGFR-α deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis

Karlsson, L., Lindahl, P., Heath, J. K., & Betsholtz, C. (2000) · Development · doi:10.1242/dev.127.16.3457 · Cited by 316

Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion

Bijlsma, M. F., Spek, C. A., Zivkovic, D., van de Water, S., Rezaee, F., & Peppelenbosch, M. P. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040232 · Cited by 314

Mechanisms of Left–Right Determination in Vertebrates

Capdevila, J., Vogan, K. J., Tabin, C. J., & Izpisúa Belmonte, J. C. (2000) · Cell · doi:10.1016/s0092-8674(00)80619-4 · Cited by 312

Epithelial-mesenchymal signaling during the regionalization of the chick gut

Roberts, D. J., Smith, D. M., Goff, D. J., & Tabin, C. J. (1998) · Development · doi:10.1242/dev.125.15.2791 · Cited by 310

Control of gut differentiation and intestinal-type gastric carcinogenesis

Yuasa, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1141 · Cited by 307

Hedgehog/Ras interactions regulate early stages of pancreatic cancer

Pasca di Magliano, M., Sekine, S., Ermilov, A., Ferris, J., Dlugosz, A. A., & Hebrok, M. (2006) · Genes & Development · doi:10.1101/gad.1470806 · Cited by 307

Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog

Bumcrot, D. A., Takada, R., & Mcmahon, A. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.2294 · Cited by 300

Oxysterols Are Novel Activators of the Hedgehog Signaling Pathway in Pluripotent Mesenchymal Cells

Dwyer, J. R., Sever, N., Carlson, M., Nelson, S. F., Beachy, P. A., & Parhami, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611741200 · Cited by 300

Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions

Williams, J. A., Guicherit, O. M., Zaharian, B. I., Xu, Y., Chai, L., Wichterle, H., Kon, C., Gatchalian, C., Porter, J. A., Rubin, L. L., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0732813100 · Cited by 299

A Novel Somatic Mouse Model to Survey Tumorigenic Potential Applied to the Hedgehog Pathway

Mao, J., Ligon, K. L., Rakhlin, E. Y., Thayer, S. P., Bronson, R. T., Rowitch, D., & McMahon, A. P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0657 · Cited by 296

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission

Greaves, L. C., Preston, S. L., Tadrous, P. J., Taylor, R. W., Barron, M. J., Oukrif, D., Leedham, S. J., Deheragoda, M., Sasieni, P., Novelli, M. R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505903103 · Cited by 293

Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse

Lawson, K. A., Pedersen, R. A., & Geer, S. V. D. (1987) · Development · doi:10.1242/dev.101.3.627 · Cited by 277

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

Marcotullio, L. D., Ferretti, E., Greco, A., De Smaele, E., Po, A., Sico, M. A., Alimandi, M., Giannini, G., Maroder, M., Screpanti, I., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1510 · Cited by 275

Multiple left-right asymmetry defects in Shh −/− mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Lefty-1

Tsukui, T., Capdevila, J., Tamura, K., Ruiz-Lozano, P., Rodriguez-Esteban, C., Yonei-Tamura, S., Magallón, J., Chandraratna, R. A. S., Chien, K., Blumberg, B., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11376 · Cited by 272

Paneth cell differentiation in the developing intestine of normal and transgenic mice.

Bry, L., Falk, P., Huttner, K., Ouellette, A., Midtvedt, T., & Gordon, J. I. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10335 · Cited by 272

Orchestrating ontogenesis: variations on a theme by sonic hedgehog

Ingham, P. W., & Placzek, M. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1969 · Cited by 271

One hundred years of positional information.

Wolpert, L. (1996) · Trends in Genetics · doi:10.1016/s0168-9525(96)80019-9 · Cited by 265

Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor

Kim, S. K., & Melton, D. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13036 · Cited by 265

Cdo Functions at Multiple Points in the Sonic Hedgehog Pathway, and Cdo-Deficient Mice Accurately Model Human Holoprosencephaly

Zhang, W., Kang, J.-S., Cole, F., Yi, M.-J., & Krauss, R. S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.005 · Cited by 260

Differentiation and self-renewal in the mouse gastrointestinal epithelium

Gordon, J. I., & Hermiston, M. L. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90047-7 · Cited by 255

Role of endothelial cells in early pancreas and liver development

Lammert, E., Cleaver, O., & Melton, D. (2003) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00332-5 · Cited by 254

Renewal of the epithelium in the descending colon of the mouse. I. Presence of three cell populations: vacuolated-columnar, mucous and argentaffin

Chang, W. W. L., & Leblond, C. P. (1971) · American Journal of Anatomy · doi:10.1002/aja.1001310105 · Cited by 252

Multisite Protein Kinase A and Glycogen Synthase Kinase 3β Phosphorylation Leads to Gli3 Ubiquitination by SCF βTrCP

Tempé, D., Casas, M., Karaz, S., Blanchet-Tournier, M.-F., & Concordet, J.-P. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02183-05 · Cited by 249

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

Mohler, J., & Vani, K. (1992) · Development · doi:10.1242/dev.115.4.957 · Cited by 246

Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production

Ormestad, M., Astorga, J., Landgren, H., Wang, T., Johansson, B. R., Miura, N., & Carlsson, P. (2006) · Development · doi:10.1242/dev.02252 · Cited by 245

Sonic hedgehog regulates gastric gland morphogenesis in man and mouse

Van Den Brink, G. R., Hardwick, J. C. H., Peppelenbosch, M. P., Van Deventer, S. J. H., Tytgat, G. N. J., Brink, M. A., & Ten Kate, F. J. (2001) · Gastroenterology · doi:10.1053/gast.2001.26261 · Cited by 241

The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation

Yao, S., Lum, L., & Beachy, P. (2006) · Cell · doi:10.1016/j.cell.2006.02.040 · Cited by 235

Divergence of Hedgehog Signal Transduction Mechanism between Drosophila and Mammals

Varjosalo, M., Li, S.-P., & Taipale, J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.014 · Cited by 230

Anorectal Malformations Caused by Defects in Sonic Hedgehog Signaling

Mo, R., Kim, J. H., Zhang, J., Chiang, C., Hui, C.-C., & Kim, P. C. W. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61747-6 · Cited by 223

Epithelial Cells and Their Neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer

Powell, D. W., Adegboyega, P. A., Di Mari, J. F., & Mifflin, R. C. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00075.2005 · Cited by 223

Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system.

Hermiston, M. L., Wong, M. H., & Gordon, J. I. (1996) · Genes & Development · doi:10.1101/gad.10.8.985 · Cited by 222

Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog

Motoyama, J., Takabatake, T., Takeshima, K., & Hui, C.-C. (1998) · Nature Genetics · doi:10.1038/ng0298-104 · Cited by 216

Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors

Kenney, A. M., Widlund, H. R., & Rowitch, D. H. (2004) · Development · doi:10.1242/dev.00891 · Cited by 214

Activin receptor patterning of foregut organogenesis

Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H., Harmon, E. B., Lee, J. S., & Melton, D. A. (2000) · Genes & Development · doi:10.1101/gad.14.15.1866 · Cited by 212

Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.

Undén, A. B., Holmberg, E., Lundh-Rozell, B., Ståhle‐Bäckdahl, M., Zaphiropoulos, P. G., Toftgård, R., & Vořechovský, I. (1996) · PubMed · Cited by 202

Intraflagellar Transport and Cilium-Based Signaling

Scholey, J. M., & Anderson, K. V. (2006) · Cell · doi:10.1016/j.cell.2006.04.013 · Cited by 199

Cloning, Expression, and Chromosomal Location of SHH and IHH: Two Human Homologues of the Drosophila Segment Polarity Gene Hedgehog

Marigo, V., Roberts, D. J., Lee, S. M. K., Tsukurov, O., Levi, T., Gastier, J. M., Epstein, D. J., Gilbert, D. J., Copeland, N. G., Seidman, C. E., et al. (1995) · Genomics · doi:10.1006/geno.1995.1104 · Cited by 198

Dynamics of epithelial cells in the corpus of the mouse stomach. II. Outward migration of pit cells

Karam, S. M., & Leblond, C. P. (1993) · The Anatomical Record · doi:10.1002/ar.1092360203 · Cited by 193

Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused

Cooper, A. F., Yu, K. P., Brueckner, M., Brailey, L. L., Johnson, L., McGrath, J. M., & Bale, A. E. (2005) · Development · doi:10.1242/dev.02021 · Cited by 193

VACTERL association, epidemiologic definition and delineation

Rittler, M., Paz, J. E., & Castilla, E. E. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960628)63:4<529::aid-ajmg4>3.0.co;2-j · Cited by 191

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

Zhu, A. J., Zheng, L., Suyama, K., & Scott, M. P. (2003) · Genes & Development · doi:10.1101/gad.1080803 · Cited by 189

Cholesterol modification restricts the spread of Shh gradient in the limb bud

Li, Y., Zhang, H., Litingtung, Y., & Chiang, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600124103 · Cited by 187

Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas

Ma, X., Chen, K., Huang, S., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi130 · Cited by 184

Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling

Kawakami, T., Kawcak, T., Li, Y.-J., Zhang, W., Hu, Y., & Chuang, P.-T. (2002) · Development · doi:10.1242/dev.00178 · Cited by 183

Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes

Incardona, J. P., Gruenberg, J., & Roelink, H. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00895-3 · Cited by 183

The Phenotypic Spectrum of GLI3 Morphopathies Includes Autosomal Dominant Preaxial Polydactyly Type-IV and Postaxial Polydactyly Type-A/B; No Phenotype Prediction from the Position of GLI3 Mutations

Radhakrishna, U., Bornholdt, D., Scott, H. S., Patel, U. C., Rossier, C., Engel, H., Bottani, A., Chandal, D., Blouin, J.-L., Solanki, J. V., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302557 · Cited by 183

Mouse Dispatched homolog1 Is Required for Long-Range, but Not Juxtacrine, Hh Signaling

Caspary, T., Garcı́a-Garcı́a, M. J., Huangfu, D., Eggenschwiler, J. T., Wyler, M. R., Rakeman, A. S., Alcorn, H. L., & Anderson, K. V. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01147-8 · Cited by 182

The VACTERL association: lessons from the Sonic hedgehog pathway

Kim, J., Kim, P., & Hui, C. (2001) · Clinical Genetics · doi:10.1034/j.1399-0004.2001.590503.x · Cited by 174

Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment

Qualtrough, D., Buda, A., Gaffield, W., Williams, A. C., & Paraskeva, C. (2004) · International Journal of Cancer · doi:10.1002/ijc.20227 · Cited by 170

Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract

van den Brink, G. R., Hardwick, J. C. H., Nielsen, C., Xu, C., ten Kate, F. J., Glickman, J., van Deventer, S. J. H., Roberts, D. J., & Peppelenbosch, M. P. (2002) · Gut · doi:10.1136/gut.51.5.628 · Cited by 169

Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation

Manley, N. R. (2000) · Seminars in Immunology · doi:10.1006/smim.2000.0263 · Cited by 162

A novel function for Hedgehog signalling in retinal pigment epithelium differentiation

Perron, M., Boy, S., Amato, M. A., Viczian, A., Koebernick, K., Pieler, T., & Harris, W. A. (2003) · Development · doi:10.1242/dev.00391 · Cited by 158

Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development

Kioussi, C., O’Connell, S., St-Onge, L., Treier, M., Gleiberman, A. S., Gruss, P., & Rosenfeld, M. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14378 · Cited by 158

Hedgehog signaling regulation of insulin production by pancreatic beta-cells.

Thomas, M. K., Rastalsky, N., Lee, J. H., & Habener, J. F. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2039 · Cited by 156

MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome

van Bokhoven, H., Celli, J., van Reeuwijk, J., Rinne, T., Glaudemans, B., van Beusekom, E., Rieu, P. N. M. A., Newbury-Ecob, R. A., Chiang, C. C., & Brunner, H. G. (2005) · Nature Genetics · doi:10.1038/ng1546 · Cited by 154

Lectins are sensitive tools for defining the differentiation programs of mouse gut epithelial cell lineages

Falk, P., Roth, K. A., & Gordon, J. I. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.266.6.g987 · Cited by 152

Bmp signaling is required for intestinal growth and morphogenesis

Batts, L. E., Polk, D. B., DuBois, R. N., & Kulessa, H. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20741 · Cited by 152

The dynamics of the cycle

Bussell, K. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1612 · Cited by 151

BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation

Kang, J.-S., Mulieri, P. J., Hu, Y., Taliana, L., & Krauss, R. S. (2002) · The EMBO Journal · doi:10.1093/emboj/21.1.114 · Cited by 147

Gli2 Is Targeted for Ubiquitination and Degradation by β-TrCP Ubiquitin Ligase

Saleem, M., Thiyagarajan, S., Elcheva, I. A., Saleem, M., Dlugosz, A. A., Mukhtar, H., & Spiegelman, V. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513203200 · Cited by 144

A Cellular Framework for Gut-Looping Morphogenesis in Zebrafish

Horne‐Badovinac, S., Rebagliati, M. R., & Stainier, D. Y. R. (2003) · Science · doi:10.1126/science.1085397 · Cited by 141

Identifying and counting epithelial cell types in the “corpus” of the mouse stomach

Karam, S. M., & Leblond, C. P. (1992) · The Anatomical Record · doi:10.1002/ar.1092320208 · Cited by 137

Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster.

Préat, T. (1992) · Genetics · doi:10.1093/genetics/132.3.725 · Cited by 130

Hedgehog Signal Activation in Gastric Pit Cell and in Diffuse-Type Gastric Cancer

Fukaya, M., Isohata, N., Ohta, H., Aoyagi, K., Ochiya, T., Saeki, N., Yanagihara, K., Nakanishi, Y., Taniguchi, H., Sakamoto, H., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.008 · Cited by 130

Combined activities of hedgehog signaling inhibitors regulate pancreas development

Kawahira, H., Nancy, H., Tzanakakis, E. S., McMahon, A. P., Chuang, P., & Hebrok, M. (2003) · Development · doi:10.1242/dev.00653 · Cited by 127

The developing mouse thyroid: Embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation

Fagman, H., Andersson, L., & Nilsson, M. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20653 · Cited by 126

Hedgehog signaling

Varjosalo, M. T., & Taipale, J. (2006) · Journal of Cell Science · doi:10.1242/jcs.03309 · Cited by 126

Hedgehog signaling in skeletal development

Ehlen, H. W. A., Buelens, L. A., & Vortkamp, A. (2006) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20076 · Cited by 122

Hedgehog signalling: how to get from Smo to Ci and Gli

Østerlund, T., & Kogerman, P. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.02.004 · Cited by 121

Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia

Oniscu, A., James, R. M., Morris, R., Bader, S. A., Malcomson, R. D. G., & Harrison, D. J. (2004) · The Journal of Pathology · doi:10.1002/path.1591 · Cited by 118

Dynamic histology of the antral epithelilum in the mouse stomach: IV. Ultrastructure and renewal of gland cells

Lee, E. R., & Leblond, C. P. (1985) · American Journal of Anatomy · doi:10.1002/aja.1001720306 · Cited by 117

Genetic Deletion of Sonic Hedgehog Causes Hemiagenesis and Ectopic Development of the Thyroid in Mouse

Fagman, H., Grände, M., Gritli-Linde, A., & Nilsson, M. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63745-5 · Cited by 116

Sonic hedgehog Is Required Early in Pancreatic Islet Development

diIorio, P. J., Moss, J. B., Sbrogna, J. L., Karlstrom, R. O., & Moss, L. G. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0573 · Cited by 116

Conditional deletion of β1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality

Jones, R. G., Li, X., Gray, P. D., et al. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602160 · Cited by 111

Arteries define the position of the thyroid gland during its developmental relocalisation

Alt, B., Elsalini, O. A., Schrumpf, P., Haufs, N., Lawson, N. D., Schwabe, G. C., Mundlos, S., Grüters, A., Krude, H., & Rohr, K. B. (2006) · Development · doi:10.1242/dev.02550 · Cited by 110

PPARβ/δ Regulates Paneth Cell Differentiation Via Controlling the Hedgehog Signaling Pathway

Varnat, F., ten Heggeler-Bordier, B., Grisel, P., Boucard, N., Corthesy-Theulaz, I. E., Wahli, W., & Desvergne, B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.004 · Cited by 109

Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo

Roy, S., Qiao, T., Wolff, C., & Ingham, P. W. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00402-x · Cited by 107

Fetal endoderm primarily holds the temporal and positional information required for mammalian intestinal development.

Duluc, I., Freund, J., Leberquier, C., & Kédinger, M. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.1.211 · Cited by 106

Evidence that Loss of Sonic Hedgehog is an Indicator of Helicobater pylori-induced Atrophic Gastritis Progressing to Gastric Cancer

Shiotani, A., Iishi, H., Uedo, N., Ishiguro, S., Tatsuta, M., Nakae, Y., Kumamoto, M., & Merchant, J. L. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41001.x · Cited by 103

Smooth muscle actin expression during rat gut development and induction in fetal skin fibroblastic cells associated with intestinal embryonic epithelium

Kédinger, M., Simon-Assmann, P. M., Bouziges, F., Arnold, C., Alexandra, E., & HAFFEN, K. (1990) · Differentiation · doi:10.1111/j.1432-0436.1990.tb00434.x · Cited by 100

CDO, A Robo-related Cell Surface Protein that Mediates Myogenic Differentiation

Kang, J., Mulieri, P. J., Miller, C., Sassoon, D. A., & Krauss, R. S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.403 · Cited by 100

Hedgehog signaling regulates expansion of pancreatic epithelial cells

Kawahira, H., Scheel, D. W., Smith, S. B., German, M. S., & Hebrok, M. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.008 · Cited by 99

Genetic Mosaic Analysis Reveals That GATA-4 Is Required for Proper Differentiation of Mouse Gastric Epithelium

Jacobsen, C. M., Narita, N., Bielińska, M., Syder, A. J., Gordon, J. I., & Wilson, D. B. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0424 · Cited by 98

Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells

Stepan, V. M., Ramamoorthy, S., Nitsche, H., Zavros, Y. L., Merchant, J. L., & Todisco, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413037200 · Cited by 97

Tail gut endoderm and gut/genitourinary/tail development: a new tissue-specific role forHoxa13

Barbara, P. D. S., & Roberts, D. J. (2002) · Development · doi:10.1242/dev.129.3.551 · Cited by 93

GATA4, 5 and 6 mediate TGFβ maintenance of endodermal gene expression inXenopusembryos

Afouda, B. A., Ciau‐Uitz, A., & Patient, R. K. (2005) · Development · doi:10.1242/dev.01647 · Cited by 88

Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis

Grapin‐Botton, A. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041946ag · Cited by 87

Migration of fetal intestinal intervillous cells in neonatal mice

Calvert, R., & Pothier, P. (1990) · The Anatomical Record · doi:10.1002/ar.1092270208 · Cited by 87

Hh pathway expression in human gut tissues and in inflammatory gut diseases

Nielsen, C. M., Williams, J., van den Brink, G. R., Lauwers, G. Y., & Roberts, D. J. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700197 · Cited by 87

Disruption of hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice

Wang, L. C., Nassir, F., Liu, Z., Ling, L. E., Kuo, F. C., Crowell, T., Olson, D. L., Davidson, N. O., & Burkly, L. C. (2002) · Gastroenterology · doi:10.1053/gast.2002.31102 · Cited by 84

Use of fetal intestinal isografts from normal and transgenic mice to study the programming of positional information along the duodenal-to-colonic axis.

Rubin, D. C., Swietlicki, E. A., Roth, K. A., & Gordon, J. I. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42155-2 · Cited by 83

Feingold syndrome: Clinical review and genetic mapping

Celli, J., van Bokhoven, H., & Brunner, H. G. (2003) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.20471 · Cited by 82

A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development

Tao, H., Shimizu, M., Kusumoto, R., Ono, K., Noji, S., & Ohuchi, H. (2005) · Development · doi:10.1242/dev.01892 · Cited by 80

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