Mechanism of the development of obesity in animals with hypothalamic lesions.
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Brain centers in the hypothalamus receive peripheral signals that reflect an organism's nutritional state as part of a feedback loop or loops that maintain homeostatic control of body weight.
“brain centers in the hypothalamus receive peripheral signals that reflect an organism's nutritional state as part of a feedback loop or loops that maintain homeostatic control of body weight (14,15).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [14]
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Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
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“These observations led Anand and Brobeck (24, 25) to conceptualize LH as a “feeding center” for elaboration of “urge to eat” normally restrained by signals from VMH.”
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Self-citationLeptin and Obesity: Role and clinical implication.
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“Earlier studies revealed that lesions of the ARC, VMH, or DMH could lead to hyperphagia and obesity in rats (29, 30), and lesions of the LH can lead to anaphylaxis (31).”
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“Destruction of distinct hypothalamic regions, particularly the ventromedial nucleus (VMH) but also the paraventricular and dorsomedial nucleus, induces hyperphagia (Brobeck, 1946; Anand and Brobeck, 1951; Powley et al., 1980; Aravich and Scalfani, 1983; Weingarten et al., 1985; Tokunaga et al., 1986; Bernadis and Berl…”
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“Interestingly, AGRP and POMC-immunoreactive fibers are not found in the ventromedial hypothalamic nucleus, even though this region contains abundant MC3R mRNA and a-MSH binding sites and has been referred to historically as a “satiety center” (Brobeck, 1946).”
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“In fact, Brobeck (41) attributed the first inference to this relationship in the clinical description of the association between a case of rapid weight gain and a tumour of this region.”
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“…areas lead to hyperphagia and obesity (Ranson et al., 1938; Hetherington, 1941; Hetherington & Ranson, 1942; Hetherington, 1944; Brobeck et al., 1943; Brobeck, 1946; Anand & Brobeck, 1951), while bilateral lesions in the lateral hypothalamus lead to cessation of food intake (Anand & Brobeck, 1951).”
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“The profound regulatory influence of hypothalamic subregions in energy intake and feeding behavior was first revealed by lesion studies in rats [Anand and Brobeck, 1951; Brobeck, 1946; Grossman, 1975; Hetherington and Ranson, 1942; Jansen and Hutchison, 1969; Marshall and Mayer, 1956; Oomura, 1973].”
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“…functions including sleep-wake transitions (Adamantidis et al., 2007, 2010; Carter et al., 2009), feeding (Anand and Brobeck, 1951), energy balance (Brobeck, 1946), stress (Bonnavion et al., 2015) and reward (Olds and Milner, 1954; Hoebel and Teitelbaum, 1962) and plays a critical role in…”
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“Bernhard Mohr described his patient, a 57 year old woman who experienced rapid weight gain, became obese within one year, and suffered from multiple neurological deficits, reviewed here (Brobeck, 1946).”
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SEX DIFFERENCES IN HYPERPHAGIA AND BODY WEIGHT FOLLOWING HYPOTHALAMIC DAMAGE*
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BackgroundIntragastric pair feeding fails to prevent VMH obesity or hyperinsulinemia
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“The VMH is a brain region that had long been thought to be important for body weight regulation (Brobeck, 1946; Gold, 1970).”
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- Authors
- Brobeck, J. R.
- Corresponding author
- Brobeck, John R.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1946-10-01
- Volume
- 26
- Issue
- 4
- Pages
- 541-559
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2311863019
- Cited by
- 488
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 11 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 12 · 2016: 1 · 2015: 18 · 2014: 10 · 2013: 3 · 2012: 8
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- obesity, hypothalamic lesions, hypothalamus, feeding behavior, energy homeostasis, animal models of obesity
- MeSH terms
- Animals, Hypothalamus, Obesity
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