Cited by 489Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

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Mechanism of the development of obesity in animals with hypothalamic lesions.

Brobeck, John R.·1946·Physiological Reviews

DOI 10.1152/physrev.1946.26.4.541

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“…functions including sleep-wake transitions (Adamantidis et al., 2007, 2010; Carter et al., 2009), feeding (Anand and Brobeck, 1951), energy balance (Brobeck, 1946), stress (Bonnavion et al., 2015) and reward (Olds and Milner, 1954; Hoebel and Teitelbaum, 1962) and plays a critical role in…”
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“Bernhard Mohr described his patient, a 57 year old woman who experienced rapid weight gain, became obese within one year, and suffered from multiple neurological deficits, reviewed here (Brobeck, 1946).”
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Ventromedial hypothalamic lesions and changes in body weight and food consumption in male and female rats.
Cox, V. C., Kakolewski, J. W., & Valenstein, E. S. (1969) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0026755 · Cited by 72
Neuropeptide Y is associated with changes in appetite-associated hypothalamic nuclei but not food intake in a hypophagic avian model
Newmyer, B. A., Nandar, W., Webster, R. I., Gilbert, E. R., Siegel, P. B., & Cline, M. A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.015 · Cited by 71
Metabolic regulation as a control for lipid disorders. I. Influence of (—)-hydroxycitrate on experimentally induced obesity in the rodent
Sullivan, C., & Triscari, J. M. (1977) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/30.5.767 · Cited by 71
The relationship between stimulation voltage and rate of hypothalamic self-stimulation in the rat.
Reynolds, R. W. (1958) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0048362 · Cited by 71
MATERNAL OBESITY
Sheldon, J. H. (1949) · The Lancet · doi:10.1016/s0140-6736(49)91457-9 · Cited by 71
Sex differences in brain developing in the presence or absence of gonads
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“The VMH is a brain region that had long been thought to be important for body weight regulation (Brobeck, 1946; Gold, 1970).”
Background
The physiological role of brown adipose tissue1
Joel, C. D. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050109 · Cited by 68

Authors: Brobeck, J. R.
Corresponding author: Brobeck, John R.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 1946-10-01
Volume: 26
Issue: 4
Pages: 541-559
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.1946.26.4.541
OpenAlex: W2311863019
Cited by: 488
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 11 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 12 · 2016: 1 · 2015: 18 · 2014: 10 · 2013: 3 · 2012: 8
FWCI: 8.93
Type: journal article
Language: en
Open access: closed
Locations: Physiological Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: obesity, hypothalamic lesions, hypothalamus, feeding behavior, energy homeostasis, animal models of obesity
MeSH terms: Animals, Hypothalamus, Obesity

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Mechanism of the development of obesity in animals with hypothalamic lesions.

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