Toxicology and risk assessment of coumarin: Focus on human data
Abstract
Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties. For the carcinogenic effect, a genotoxic mechanism was considered possible, but was discounted by the European Food Safety Authority in 2004 based on new evidence. This allowed the derivation of a tolerable daily intake (TDI) for the first time, and a value of 0.1 mg/kg body weight was arrived at based on animal hepatotoxicity data. However, clinical data on hepatotoxicity from patients treated with coumarin as medicinal drug is also available. This data revealed a subgroup of the human population being more susceptible for the hepatotoxic effect than the animal species investigated. The cause of the high susceptibility is currently unknown; possible mechanisms are discussed. Using the human data, a TDI of 0.1 mg/kg body weight was derived, confirming that of the European Food Safety Authority. Nutritional exposure may be considerably, and is mainly due to use of cassia cinnamon, which is a popular spice especially, used for cookies and sweet dishes. To estimate exposure to coumarin during the Christmas season in Germany, a telephone survey was performed with more than 1000 randomly selected persons. Heavy consumers of cassia cinnamon may reach a daily coumarin intake corresponding to the TDI.
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Ceylon cinnamon contains only traces of coumarin.
“unlike Ceylon cinnamon (Cinnamomum zeylanicum or Cinnamomum verum), coming from Sri Lanka and Madagascar, which contains only traces of coumarin [19].”
For cassia species, coumarin levels are of concern [19].
“For the cassia species however, coumarin levels are of concern [19].”
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- Authors
- Abraham, K., Wöhrlin, F., Lindtner, O., Heinemeyer, G., & Lampen, A.
- Affiliations
- German Federal Institute for Risk Assessment (BfR) (DE)
- Corresponding author
- Abraham, Klaus
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2010-02
- Volume
- 54
- Issue
- 2
- Pages
- 228-239
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W1972248486
- Cited by
- 292
- References
- 264
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 21 · 2023: 28 · 2022: 29 · 2021: 21 · 2020: 32 · 2019: 17 · 2018: 15 · 2017: 17 · 2016: 11 · 2015: 16 · 2014: 11 · 2013: 7 · 2012: 8
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- OpenAgrar (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Toxicity and Pharmacological Properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- coumarins, hepatotoxicity, carcinogenicity, genotoxicity, tolerable daily intake, risk assessment, telephone surveys
- MeSH terms
- Animals, Biotransformation, Coumarins, Edema, Flavoring Agents, Humans, Liver Neoplasms, Lymphedema, Plants, Medicinal, Species Specificity, Venous Insufficiency, Risk Assessment, Toxicity Tests, Chemical and Drug Induced Liver Injury
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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