Cited by 292Plant chemical constituents analysisPlant Toxicity and Pharmacological PropertiesCarcinogens and Genotoxicity Assessment

Toxicology and risk assessment of coumarin: Focus on human data

Abraham, Klaus, Wöhrlin, Friederike, Lindtner, Oliver, Heinemeyer, Gerhard, Lampen, Alfonso·2010·Molecular Nutrition & Food Research

Abstract

Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties. For the carcinogenic effect, a genotoxic mechanism was considered possible, but was discounted by the European Food Safety Authority in 2004 based on new evidence. This allowed the derivation of a tolerable daily intake (TDI) for the first time, and a value of 0.1 mg/kg body weight was arrived at based on animal hepatotoxicity data. However, clinical data on hepatotoxicity from patients treated with coumarin as medicinal drug is also available. This data revealed a subgroup of the human population being more susceptible for the hepatotoxic effect than the animal species investigated. The cause of the high susceptibility is currently unknown; possible mechanisms are discussed. Using the human data, a TDI of 0.1 mg/kg body weight was derived, confirming that of the European Food Safety Authority. Nutritional exposure may be considerably, and is mainly due to use of cassia cinnamon, which is a popular spice especially, used for cookies and sweet dishes. To estimate exposure to coumarin during the Christmas season in Germany, a telephone survey was performed with more than 1000 randomly selected persons. Heavy consumers of cassia cinnamon may reach a daily coumarin intake corresponding to the TDI.

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Crossref · 10.1002/mnfr.200900281

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Authors
Abraham, K., Wöhrlin, F., Lindtner, O., Heinemeyer, G., & Lampen, A.
Affiliations
German Federal Institute for Risk Assessment (BfR) (DE)
Corresponding author
Abraham, Klaus
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2010-02
Volume
54
Issue
2
Pages
228-239
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W1972248486
Cited by
292
References
264
Citations by year
2026: 22 · 2025: 23 · 2024: 21 · 2023: 28 · 2022: 29 · 2021: 21 · 2020: 32 · 2019: 17 · 2018: 15 · 2017: 17 · 2016: 11 · 2015: 16 · 2014: 11 · 2013: 7 · 2012: 8
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
  • OpenAgrar (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Toxicity and Pharmacological Properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords
coumarins, hepatotoxicity, carcinogenicity, genotoxicity, tolerable daily intake, risk assessment, telephone surveys
MeSH terms
Animals, Biotransformation, Coumarins, Edema, Flavoring Agents, Humans, Liver Neoplasms, Lymphedema, Plants, Medicinal, Species Specificity, Venous Insufficiency, Risk Assessment, Toxicity Tests, Chemical and Drug Induced Liver Injury

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