The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor‐Associated Macrophages
Open accessAbstract
Tumor‐Associated Macrophages (TAMs) are abundantly present in the stroma of solid tumors and modulate several important biological processes, such as neoangiogenesis, cancer cell proliferation and invasion, and suppression of adaptive immune responses. Myeloid C‐type lectin receptors (CLRs) constitute a large family of transmembrane carbohydrate‐binding receptors that recognize pathogens as well as endogenous glycoproteins. Several lines of evidence demonstrate that some CLRs can inhibit the immune response. In this study we investigated TAM‐associated molecules potentially involved in their immune suppressive activity. We found that TAMs isolated from human ovarian carcinoma samples predominantly express the CLRs Dectin‐1, MDL‐1, MGL, DCIR, and most abundantly the Mannose Receptor (MR). Components of carcinomatous ascites and purified tumoral mucins (CA125 and TAG‐72) bound the MR and induced its internalization. MR engagement by tumoral mucins and by an agonist anti‐MR antibody modulated cytokine production by TAM toward an immune‐suppressive profile: increase of IL‐10, absence of IL‐12, and decrease of the Th1‐attracting chemokine CCL3. This study highlights that tumoral mucin‐mediated ligation of the MR on infiltrating TAM may contribute to their immune suppressive phenotype.
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Cites
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Self-citationMonocyte and macrophage heterogeneity
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Microenvironmental regulation of metastasis
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Alternative Activation of Macrophages: An Immunologic Functional Perspective
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Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma
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Macrophage Polarization Comes of Age
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Self- and nonself-recognition by C-type lectins on dendritic cells
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Cited by
Macrophages as tools and targets in cancer therapy
Mantovani, A., Allavena, P., Marchesi, F., & Garlanda, C. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00520-5 · Cited by 1,807
Self-citationUnderstanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
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TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy
Molgora, M., Esaulova, E., Vermi, W., Hou, J., Chen, Y., Luo, J., Brioschi, S., Bugatti, M., Omodei, A. S., Ricci, B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.07.013 · Cited by 656
“Flow cytometric analysis of the tumor infiltrate of MC38 showed that TREM2 deficiency was associated with reduced representation of yet another subset of macrophages expressing CD206 (Figure S1F) that have been previously involved in immunosuppression (Allavena et al., 2010; Mantovani et al., 2017), whereas no obvious…”
Martinez-Pomares, L. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0512231 · Cited by 531
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Metadata
- Authors
- Allavena, P., Chieppa, M., Bianchi, G., Solinas, G., Fabbri, M., Laskarin, G., & Mantovani, A.
- Venue
- Journal of Immunology Research
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 2010
- Issue
- 1
- Pages
- 547179-547179
- ISSN
- 2314-7156 (ISSN-L)
- 2314-8861
- OpenAlex
- W2115974802
- Cited by
- 170
- References
- 11
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Allavena, P., Chieppa, M., Bianchi, G., Solinas, G., Fabbri, M., Laskarin, G., & Mantovani, A. (2010). Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor‐Associated Macrophages. Journal of Immunology Research. https://doi.org/10.1155/2010/547179
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