The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response
Open accessAbstract
The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and activate a set of signaling pathways termed the Unfolded Protein Response (UPR). The UPR can promote cellular repair and sustained survival by reducing the load of unfolded proteins through upregulation of chaperones and global attenuation of protein synthesis. Research into ER stress and the UPR continues to grow at a rapid rate as many new investigators are entering the field. There are also many researchers not working directly on ER stress, but who wish to determine whether this response is activated in the system they are studying: thus, it is important to list a standard set of criteria for monitoring UPR in different model systems. Here, we discuss approaches that can be used by researchers to plan and interpret experiments aimed at evaluating whether the UPR and related processes are activated. We would like to emphasize that no individual assay is guaranteed to be the most appropriate one in every situation and strongly recommend the use of multiple assays to verify UPR activation.
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Cites
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THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
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Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress
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Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice
Fu, J., Wei, B., Wen, T., Johansson, M. E. V., Liu, X., Bradford, E., Thomsson, K. A., McGee, S., Mansour, L., Tong, M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45538 · Cited by 366
Heat shock proteins: Cellular and molecular mechanisms in the central nervous system
Stetler, R. A., Gan, Y., Zhang, W., Liou, A. K., Gao, Y., Cao, G., & Chen, J. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.05.002 · Cited by 305
New directions in ER stress-induced cell death
Logue, S. E., Cleary, P., Saveljeva, S., & Samali, A. (2013) · Apoptosis · doi:10.1007/s10495-013-0818-6 · Cited by 278
Self-citationKurita, K. L., Glassey, E., & Linington, R. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507743112 · Cited by 156
Metadata
- Authors
- Samali, A., FitzGerald, U., Deegan, S., & Gupta, S.
- Venue
- International Journal of Cell Biology
- Publisher
- Wiley
- Published
- 2010
- Volume
- 2010
- Pages
- 1-11
- ISSN
- 1687-8876 (ISSN-L)
- 1687-8884
- OpenAlex
- W2160159279
- Cited by
- 257
- References
- 42
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- gold
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