CoChat
Sign Up
Cited by 28Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Astrocytes and developmental plasticity in fragile X.

Open access
Cheng, Connie, Sourial, Mary, Doering, Laurie C.·2012·Neural Plasticity
DOI 10.1155/2012/197491PMC PMC3403619
Open this paper in CoChat — free accountOpen PDF

Abstract

A growing body of research indicates a pivotal role for astrocytes at the developing synapse. In particular, astrocytes are dynamically involved in governing synapse structure, function, and plasticity. In the postnatal brain, their appearance at synapses coincides with periods of developmental plasticity when neural circuits are refined and established. Alterations in the partnership between astrocytes and neurons have now emerged as important mechanisms that underlie neuropathology. With overall synaptic function standing as a prominent link to the expression of the disease phenotype in a number of neurodevelopmental disorders and knowing that astrocytes influence synapse development and function, this paper highlights the current knowledge of astrocyte biology with a focus on their involvement in fragile X syndrome.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1155/2012/197491

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • FMRP expression in astrocytes appears essential for normal synapse formation and function.

    “FMRP expression in astrocytes appears essential for normal synapse formation and function (Cheng et al., 2012; Bagni and Zukin, 2019).”

    From Astrocytes in fragile X syndrome (2024) · cites this paper as Cheng et al., 2012

    Section 7 reports that FMR1-knockout astrocytes altered synaptic protein markers in cocultured neurons, while wild-type astrocytes prevented those changes. But Section 7.1 says it remains uncertain whether lack of astrocytic FMRP causes the alterations, and the reported measurements do not establish synaptic function. Calling astrocytic FMRP expression essential for normal formation and function goes beyond the paper's findings. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 107

  1. [1]Verkhratsky A Rodriguez JJ Parpura V Neurotransmitters and integration in neuronal-astroglial networks Neurochemical Research. In press 22476701
  2. [2]Bolton MM Eroglu C Look who is weaving the neural web: glial control of synapse formation Current Opinion in Neurobiology 2009 19 5 491 497 2-s2.0-70450212390 19879129
  3. [3]Jacobs S Cheng C Doering LC Probing astrocyte function in fragile x syndrome Results and Problems in Cell Differentiation 2012 54 15 31 22009345
  4. [4]Wang DD Bordey A The astrocyte odyssey Progress in Neurobiology 2008 86 4 342 367 2-s2.0-56949092726 18948166 PMC2613184
  5. [5]Kimelberg HK The problem of astrocyte identity Neurochemistry International 2004 45 2-3 191 202 2-s2.0-2442488159 15145537
  6. [6]Araque A Carmignoto G Haydon PG Dynamic signaling between astrocytes and neurons Annual Review of Physiology 2001 63 795 813 2-s2.0-0035047691 11181976
  7. [8]Pacey LKK Doering LC Developmental expression of FMRP in the astrocyte lineage: implications for fragile X syndrome GLIA 2007 55 15 1601 1609 2-s2.0-35048886071 17823967
  8. [9]Zhang Y Barres BA Astrocyte heterogeneity: an underappreciated topic in neurobiology Current Opinion in Neurobiology 2010 20 5 588 594 2-s2.0-77957021581 20655735
  9. [10]Kettemann H Ransom BR The Concept of Neuroglia: A Historical Perspective 2005 2 edition Oxford, UK Oxford University Press
  10. [11]Kettenmann H Verkhratsky A Neuroglia: the 150 years after Trends in Neurosciences 2008 31 12 653 659 2-s2.0-56349139546 18945498
  11. [12]Kettenmann H Verkhratsky A Neuroglia—living nerve glue Fortschritte der Neurologie-Psychiatrie 2011 79 10 588 597 21989511
  12. [13]Sofroniew MV Vinters HV Astrocytes: biology and pathology Acta Neuropathologica 2010 119 1 7 35 2-s2.0-77649189116 20012068 PMC2799634
  13. [14]Witcher MR Park YD Lee MR Sharma S Harris KM Kirov SA Three-dimensional relationships between perisynaptic astroglia and human hippocampal synapses GLIA 2010 58 5 572 587 2-s2.0-77749339879 19908288 PMC2845925
  14. [15]Freeman MR Specification and morphogenesis of astrocytes Science 2010 330 6005 774 778 2-s2.0-78149314205 21051628 PMC5201129
  15. [16]Bushong EA Martone ME Jones YZ Ellisman MH Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains Journal of Neuroscience 2002 22 1 183 192 2-s2.0-0036139877 11756501 PMC6757596
  16. [17]Cahoy JD Emery B Kaushal A A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function Journal of Neuroscience 2008 28 1 264 278 2-s2.0-38149129457 18171944 PMC6671143
  17. [18]Rothstein JD Martin L Levey AI Localization of neuronal and glial glutamate transporters Neuron 1994 13 3 713 725 2-s2.0-0028060648 7917301
  18. [19]Hewett JA Determinants of regional and local diversity within the astroglial lineage of the normal central nervous system Journal of Neurochemistry 2009 110 6 1717 1736 2-s2.0-69949186235 19627442
  19. [20]Alonso M Ortega-Pérez I Grubb MS Bourgeois JP Charneau P Lledo PM Turning astrocytes from the rostral migratory stream into neurons: a role for the olfactory sensory organ Journal of Neuroscience 2008 28 43 11089 11102 2-s2.0-56549114333 18945916 PMC6671355
  20. [21]Morrens J van den Broeck W Kempermann G Glial cells in adult neurogenesis GLIA 2012 60 2 159 174 22076934
  21. [22]Kriegstein A Alvarez-Buylla A The glial nature of embryonic and adult neural stem cells Annual Review of Neuroscience 2009 32 149 184 2-s2.0-67651036549 PMC3086722 19555289
  22. [23]Allaman I Bélanger M Magistretti PJ Astrocyte-neuron metabolic relationships: for better and for worse Trends in Neurosciences 2011 34 2 76 87 2-s2.0-79551591722 21236501
  23. [24]Theodosis DT Poulain DA Oliet SHR Activity-dependent structural and functional plasticity of astrocyte-neuron interactions Physiological Reviews 2008 88 3 983 1008 2-s2.0-50249237863 18626065
  24. [25]Ventura R Harris KM Three-dimensional relationships between hippocampal synapses and astrocytes Journal of Neuroscience 1999 19 16 6897 6906 2-s2.0-0033566709 10436047 PMC6782870
  25. [26]Halassa MM Fellin T Takano H Dong JH Haydon PG Synaptic islands defined by the territory of a single astrocyte Journal of Neuroscience 2007 27 24 6473 6477 2-s2.0-34250317399 17567808 PMC6672436
  26. [27]Barker AJ Ullian EM Astrocytes and synaptic plasticity Neuroscientist 2010 16 1 40 50 2-s2.0-77949558705 20236948
  27. [28]Pfrieger FW Barres BA Synaptic efficacy enhanced by glial cells in vitro Science 1997 277 5332 1684 1687 2-s2.0-0030773837 9287225
  28. [29]Nägler K Mauch DH Pfrieger FW Glia-derived signals induce synapse formation in neurones of the rat central nervous system Journal of Physiology 2001 533 3 665 679 2-s2.0-0035875555 11410625 PMC2278670
  29. [30]Ullian EM Sapperstein SK Christopherson KS Barres BA Control of synapse number by glia Science 2001 291 5504 657 661 2-s2.0-0035951508 11158678
  30. [31]Bornstein P Sage EH Matricellular proteins: extracellular modulators of cell function Current Opinion in Cell Biology 2002 14 5 608 616 2-s2.0-0036775425 12231357
  31. [32]Mauch DH Nagler K Schumacher S CNS synaptogenesis promoted by glia-derived cholesterol Science 2001 294 5545 1354 1357 11701931
  32. [33]Thiele C Hannah MJ Fahrenholz F Huttner WB Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles Nature Cell Biology 2000 2 1 42 49 2-s2.0-0033792318 10620806
  33. [34]Christopherson KS Ullian EM Stokes CCA Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis Cell 2005 120 3 421 433 2-s2.0-13544273916 15707899
  34. [35]Adams J Lawler JC The thrombospondins The International Journal of Biochemistry & Cell Biology 2004 36 6 961 968 15094109 PMC2885884
  35. [37]Molofsky AV Krenick R Ullian E Astrocytes and disease: a neurodevelopmental perspective Genes & Development 2012 26 9 891 907 22549954 PMC3347787
  36. [40]Bartsch S Bartsch U Dorries U Expression of tenascin in the developing and adult cerebellar cortex Journal of Neuroscience 1992 12 3 736 749 2-s2.0-0026560651 1372043 PMC6576029
  37. [41]Nakic M Manahan-Vaughan D Reymann KG Schachner M Long-term potentiation in vivo increases rat hippocampal tenascin-C expression Journal of Neurobiology 1998 37 3 393 404 9828045
  38. [42]Evers MR Salmen B Bukalo O Impairment of L-type Ca2+ channel-dependent forms of hippocampal synaptic plasticity in mice deficient in the extracellular matrix glycoprotein tenascin-C Journal of Neuroscience 2002 22 16 7177 7194 2-s2.0-0037104764 12177213 PMC6757873
  39. [43]Pyka M Busse C Seidenbecher C Gundelfinger ED Faissner A Astrocytes are crucial for survival and maturation of embryonic hippocampal neurons in a neuron-glia cell-insert coculture assay Synapse 2011 65 1 41 53 2-s2.0-78049388741 20506382
  40. [45]Eroglu C The role of astrocyte-secreted matricellular proteins in central nervous system development and function Journal of Cell Communication and Signaling 2009 3 3-4 167 176 2-s2.0-72449175160 19904629 PMC2778595
  41. [46]Stevens B Allen NJ Vazquez LE The classical complement cascade mediates CNS synapse elimination Cell 2007 131 6 1164 1178 2-s2.0-36849076770 18083105
  42. [47]Chu Y Jin X Parada I Enhanced synaptic connectivity and epilepsy in C1q knockout mice Proceedings of the National Academy of Sciences of the United States of America 2010 107 17 7975 7980 2-s2.0-77952403414 20375278 PMC2867906
  43. [48]Hama H Hara C Yamaguchi K Miyawaki A PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes Neuron 2004 41 3 405 415 2-s2.0-1242271191 14766179
  44. [50]Murai EB Pasquale KK Eph receptors and ephrins in neuron-astrocyte communication at synapses GLIA 2011 59 11 1567 1578 21850709
  45. [51]Fellin T Communication between neurons and astrocytes: relevance to the modulation of synaptic and network activity Journal of Neurochemistry 2009 108 3 533 544 2-s2.0-58149334892 19187090
  46. [52]Penzes P Cahill ME Jones KA Vanleeuwen JE Woolfrey KM Dendritic spine pathology in neuropsychiatric disorders Nature Neuroscience 2011 14 3 285 293 2-s2.0-79951960867 21346746 PMC3530413
  47. [53]Fiala JC Spacek J Harris KM Dendritic spine pathology: cause or consequence of neurological disorders? Brain Research Reviews 2002 39 1 29 54 2-s2.0-0036082812 12086707
  48. [54]Harms KJ Dunaevsky A Dendritic spine plasticity: looking beyond development Brain Research 2007 1184 1 65 71 2-s2.0-36348975910 16600191
  49. [55]Haber M Zhou L Murai KK Cooperative astrocyte and dendritic spine dynamics at hippocampal excitatory synapses Journal of Neuroscience 2006 26 35 8881 8891 2-s2.0-33748281357 16943543 PMC6675342
  50. [56]Nishida H Okabe S Direct astrocytic contacts regulate local maturation of dendritic spines Journal of Neuroscience 2007 27 2 331 340 2-s2.0-33846205911 17215394 PMC6672072
  51. [57]Dillon C Goda Y The actin cytoskeleton: integrating form and function at the synapse Annual Review of Neuroscience 2005 28 25 55 2-s2.0-23244440196 16029114
  52. [58]Liu QS Xu Q Kang J Nedergaard M Astrocyte activation of presynaptic metabotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission Neuron Glia Biology 2004 1 4 307 316 16755304 PMC1474019
  53. [59]Li YX Zhang Y Lester HA Schuman EM Davidson N Enhancement of neurotransmitter release induced by brain-derived neurotrophic factor in cultured hippocampal neurons Journal of Neuroscience 1998 18 24 10231 10240 2-s2.0-0032534964 9852560 PMC6793341
  54. [61]Hensch TK Critical period plasticity in local cortical circuits Nature Reviews Neuroscience 2005 6 11 877 888 2-s2.0-27644551416 16261181
  55. [62]Haydon PG Glia: listening and talking to the synapse Nature Reviews Neuroscience 2001 2 3 185 193 2-s2.0-0035287432 11256079
  56. [63]Perea G Araque A Glial calcium signaling and neuron-glia communication Cell Calcium 2005 38 3-4 375 382 2-s2.0-24644466492 16105683
  57. [64]Volterra A Meldolesi J Astrocytes, from brain glue to communication elements: The revolution continues Nature Reviews Neuroscience 2005 6 8 626 640 2-s2.0-23044435896 16025096
  58. [65]Zorec R Araque A Carmignoto G Haydon PG Verkhratsky A Parpura V Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route ASN Neuro 2012 4 2 e00080 PMC3310306 22313347
  59. [66]Verkhratsky A Rodriguez JJ Parpura V Calcium signalling in astroglia Molecular and Cellular Endocrinology 2012 353 1-2 45 56 21945602
  60. [68]Araque A Navarrete M Glial cells in neuronal network function Philosophical Transactions of the Royal Society B 2010 365 1551 2375 2381 2-s2.0-77955745277 PMC2894949 20603358
  61. [69]Parpura A Verkhratsky V Neuroglia at the crossroads of homeostasis, metabolism and signaling: evolution of the concept ASN Neuro 2012 4 4 e00087 PMC3342593 22455879
  62. [70]Paixão S Klein R Neuron-astrocyte communication and synaptic plasticity Current Opinion in Neurobiology 2010 20 4 466 473 2-s2.0-77956651400 20471242
  63. [71]Bezzi P Domercq M Vesce S Volterra A Neuron-astrocyte cross-talk during synaptic transmission: physiological and neuropathological implications Progress in Brain Research 2001 132 255 265 2-s2.0-0035783991 11544994
  64. [72]Parpura V Basarsky TA Liu F Jeftinija K Jeftinija S Haydon PG Glutamate-mediated astrocyte-neuron signalling Nature 1994 369 6483 744 747 2-s2.0-0028225677 7911978
  65. [73]Butt AM ATP: a ubiquitous gliotransmitter integrating neuron-glial networks Seminars in Cell and Developmental Biology 2011 22 2 205 213 2-s2.0-79953205512 21376829
  66. [74]Oliet SHR Mothet JP Regulation of N-methyl-d-aspartate receptors by astrocytic d-serine Neuroscience 2009 158 1 275 283 2-s2.0-58149459159 18358625
  67. [75]Panatier A Theodosis DT Mothet JP Glia-derived d-serine controls NMDA receptor activity and synaptic memory Cell 2006 125 4 775 784 2-s2.0-33646522699 16713567
  68. [76]Bonansco C Couve A Perea G Ferradas CA Roncagliolo M Fuenzalida M Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity European Journal of Neuroscience 2011 33 8 1483 1492 2-s2.0-79954630672 21395864
  69. [77]Perea G Navarrete M Araque A Tripartite synapses: astrocytes process and control synaptic information Trends in Neurosciences 2009 32 8 421 431 2-s2.0-68049143450 19615761
  70. [78]Araque A Astrocytes process synaptic information Neuron Glia Biology 2008 4 1 3 10 2-s2.0-64549126867 19250562
  71. [79]Barres BA The mystery and magic of glia: a perspective on their roles in health and disease Neuron 2008 60 3 430 440 2-s2.0-55049084760 18995817
  72. [80]Kimelberg HK Nedergaard M Functions of astrocytes and their potential as therapeutic targets Neurotherapeutics 2010 7 4 338 353 2-s2.0-77957028947 20880499 PMC2982258
  73. [81]Lin YC Koleske AJ Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disorders Annual Review of Neuroscience 2010 33 349 378 2-s2.0-77956997715 PMC3063389 20367247
  74. [82]Ricci G Volpi L Pasquali L Petrozzi L Siciliano G Astrocyte-neuron interactions in neurological disorders Journal of Biological Physics 2009 35 4 317 336 2-s2.0-70349469543 19669420 PMC2750745
  75. [83]McGann JC Lioy DT Mandel G Astrocytes conspire with neurons during progression of neurological disease Current Opinion in Neurobiology. In press PMC3408561 22475461
  76. [84]Parpura V Heneka MT Montana V Glial cells in (patho)physiology Journal of Neurochemistry 2012 121 1 4 27 22251135 PMC3304021
  77. [85]Portera-Cailliau C Which comes first in fragile X syndrome, dendritic spine dysgenesis or defects in circuit plasticity? Neuroscientist 2011 18 1 28 44 21551076
  78. [86]Kaufmann WE Cortell R Kau ASM Autism spectrum disorder in fragile X syndrome: communication, social interaction, and specific behaviors American Journal of Medical Genetics 2004 129 3 225 234 2-s2.0-4444322917 15326621
  79. [87]Rousseau F Labelle Y Bussieres J Lindsay C The fragile x mental retardation syndrome 20 years after the FMR1 gene discovery: an expanding universe of knowledge Clinical Biochemist Reviews 2011 32 3 135 162 PMC3157949 21912443
  80. [88]Santoro MR Bray SM Warren ST Molecular mechanisms of fragile X syndrome: a twenty-year perspective Annual Review of Pathology 2012 7 219 245 22017584
  81. [89]Bassell GJ Warren ST Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function Neuron 2008 60 2 201 214 2-s2.0-53849110899 18957214 PMC3691995
  82. [90]Antar LN Li C Zhang H Carroll RC Bassell GJ Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses Molecular and Cellular Neuroscience 2006 32 1-2 37 48 2-s2.0-33744966575 16631377
  83. [91]Ronesi JA Huber KM Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse Science signaling 2008 1 5 p. pe6 2-s2.0-45149122378 18272470
  84. [92]Huber KM Gallagher SM Warren ST Bear MF Altered synaptic plasticity in a mouse model of fragile X mental retardation Proceedings of the National Academy of Sciences of the United States of America 2002 99 11 7746 7750 2-s2.0-0037188502 12032354 PMC124340
  85. [94]Garber K Smith KT Reines D Warren ST Transcription, translation and fragile X syndrome Current Opinion in Genetics and Development 2006 16 3 270 275 2-s2.0-33646512220 16647847
  86. [95]D’Hulst C Kooy RF Fragile X syndrome: from molecular genetics to therapy Journal of Medical Genetics 2009 46 9 577 584 2-s2.0-69849090240 19724010
  87. [96]Bakker CE Verheij C Willemsen R Fmr1 knockout mice: a model to study fragile X mental retardation Cell 1994 78 1 23 33 2-s2.0-0028246435 8033209
  88. [97]Tucker B Richards RI Lardelli M Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome Human Molecular Genetics 2006 15 23 3446 3458 2-s2.0-33751353757 17065172
  89. [98]Zhang YQ Bailey AM Matthies HJG Drosophila fragile x-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function Cell 2001 107 5 591 603 2-s2.0-0035977134 11733059
  90. [99]den Broeder MJ van der Linde H Brouwer JR Oostra BA Willemsen R Ketting RF Generation and characterization of Fmr1 knockout zebrafish PLoS ONE 2009 4 11 2-s2.0-70949101686 e7910 PMC2774943 19936290
  91. [100]Dansie IM Ethell LE Casting a net on dendritic spines: the extracellular matrix and its receptors Developmental Neurobiology 2011 71 11 956 981 21834084 PMC3192312
  92. [101]Purpura DP Dendritic spine ’dysgenesis’ and mental retardation Science 1974 186 4169 1126 1128 2-s2.0-0016251748 4469701
  93. [102]Irwin SA Patel B Idupulapati M Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination American Journal of Medical Genetics 2001 98 2 161 167 11223852
  94. [103]Morales J Hiesinger PR Schroeder AJ Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain Neuron 2002 34 6 961 972 2-s2.0-0037071888 12086643
  95. [104]Lee A Li W Xu K Bogert BA Su K Gao FB Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1 Development 2003 130 22 5543 5552 2-s2.0-0345308602 14530299
  96. [105]Zhang YQ Broadie K Fathoming fragile X in fruit flies Trends in Genetics 2005 21 1 37 45 2-s2.0-13144279321 15680513
  97. [106]Pan L Zhang YQ Woodruff E Broadie K The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation Current Biology 2004 14 20 1863 1870 2-s2.0-6944247816 15498496
  98. [107]Nimchinsky EA Oberlander AM Svoboda K Abnormal development of dendritic spines in FMR1 knock-out mice Journal of Neuroscience 2001 21 14 5139 5146 2-s2.0-0035879180 11438589 PMC6762842
  99. [109]Harlow EG Till SM Russell TA Wijetunge LS Kind P Contractor A Critical period plasticity is disrupted in the barrel cortex of Fmr1 knockout mice Neuron 2010 65 3 385 398 2-s2.0-75949119188 20159451 PMC2825250
  100. [110]Wang H Ku L Osterhout DJ Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors Human Molecular Genetics 2004 13 1 79 89 2-s2.0-0346656871 14613971
  101. [111]Pacey LKK Doering LC Developmental expression of FMRP in the astrocyte lineage: implications for fragile X syndrome GLIA 2007 55 15 1601 1609 2-s2.0-35048886071 17823967
  102. [112]Jacobs S Doering LC Astrocytes prevent abnormal neuronal development in the fragile X mouse Journal of Neuroscience 2010 30 12 4508 4514 2-s2.0-77949835797 20335488 PMC6634485
  103. [113]Jacobs S Doering LC Primary Dissociated Astrocyte and Neuron Co-Culture 2009 4 edition New York, NY, USA Humana
  104. [114]Jacobs S Nathwani M Doering LC Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression BMC Neuroscience 2010 11 p. 132 2-s2.0-77957922784 PMC2970604 20955577
  105. [115]Sekino Y Kojima N Shirao T Role of actin cytoskeleton in dendritic spine morphogenesis Neurochemistry International 2007 51 2–4 92 104 2-s2.0-34547488455 17590478
  106. [116]Ballas N Lioy DT Grunseich C Mandel G Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology Nature Neuroscience 2009 12 3 311 317 2-s2.0-60749102039 19234456 PMC3134296
  107. [118]Hampson DR Adusei DC Pacey LKK The neurochemical basis for the treatment of autism spectrum disorders and Fragile X Syndrome Biochemical Pharmacology 2011 81 9 1078 1086 2-s2.0-79953708493 21333634

Cited by

Sorted by citations

Authors
Cheng, C., Sourial, M., & Doering, L. C.
Affiliations
McMaster University (CA)
Corresponding author
Doering, Laurie C.
ORCID
Cheng, Connie
Venue
Neural Plasticity
Publisher
Hindawi Limited
Published
2012
Volume
2012
Pages
1-12
ISSN
  • 1687-5443 (ISSN-L)
  • 2090-5904
DOI
10.1155/2012/197491
PMC
PMC3403619
OpenAlex
W2093270014
Cited by
28
References
11
Citations by year
2025: 1 · 2024: 4 · 2023: 2 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 1
FWCI
0.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Neural Plasticity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
astrocytes, fragile X syndrome, developmental plasticity, synaptic development, synaptic function, astrocyte-neuron interaction, neural circuit refinement, neurodevelopmental disorders, synaptic dysfunction
MeSH terms
Astrocytes, Fragile X Syndrome, Humans, Nervous System Diseases, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses, Fragile X Messenger Ribonucleoprotein 1, Fragile X Mental Retardation Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review