The DOI matches its Crossref record.
Human Sperm Cryopreservation: Update on Techniques, Effect on DNA Integrity, and Implications for ART
Open accessAbstract
Cryopreservation of human spermatozoa—introduced in the 1960's—has been recognized as an efficient procedure for management of male fertility before therapy for malignant diseases, vasectomy or surgical infertility treatments, to store donor and partner spermatozoa before assisted reproduction treatments and to ensure the recovery of a small number of spermatozoa in severe male factor infertility. Despite the usefulness of it, cryopreservation may lead to deleterious changes of sperm structure and function: while the effects of cryopreservation on cells are well documented, to date there is no agreement in the literature on whether or not cryopreservation affects sperm chromatin integrity or on the use of a unique and functional protocol for the freezing-thawing procedure. Therefore, sperm cryopreservation is an important component of fertility management and much of its successful application seems to affect the reproductive outcome of assisted reproduction technologies (ART): appropriate use of cryoprotectants before and sperm selection technologies after cryopreservation seem to have the greatest impact on preventing DNA fragmentation, thus improving sperm cryosurvival rates.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Sperm cryopreservation: A review on current molecular cryobiology and advanced approaches
Hezavehei, M., Sharafi, M., Kouchesfahani, H. M., Henkel, R., Agarwal, A., Esmaeili, V., & Shahverdi, A. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.05.012 · Cited by 411
Kopeika, J., Thornhill, A., & Khalaf, Y. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmu063 · Cited by 326
Sperm DNA Fragmentation: A New Guideline for Clinicians
Agarwal, A., Majzoub, A., Baskaran, S., Panner Selvam, M. K., Cho, C. L., Henkel, R., Finelli, R., Leisegang, K., Sengupta, P., Barbarosie, C., et al. (2020) · The World Journal of Men's Health · doi:10.5534/wjmh.200128 · Cited by 316
Semen analysis of subfertility caused by testicular carcinoma
Ghasemi, B., Mosadegh Mehrjardi, A., Jones, C., & Ghasemi, N. (2020) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.18502/ijrm.v13i7.7371 · Cited by 9
Metadata
- Authors
- Di Santo, M., Tarozzi, N., Nadalini, M., & Borini, A.
- Venue
- Advances in Urology
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-12
- ISSN
- 1687-6369 (ISSN-L)
- 1687-6377
- OpenAlex
- W2029611175
- Cited by
- 344
- References
- 0
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Human Sperm Cryopreservation: Update on Techniques, Effect on DNA Integrity, and Implications for ART. https://app.cochat.ai/papers/10.1155/2012/854837
- The paper
- Di Santo, M., Tarozzi, N., Nadalini, M., & Borini, A. (2012). Human Sperm Cryopreservation: Update on Techniques, Effect on DNA Integrity, and Implications for ART. Advances in Urology. https://doi.org/10.1155/2012/854837
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
