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Centella asiatica(L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential
Open accessAbstract
This paper covers the studies relevant to neuroprotective activity of Centella asiatica (L.) Urban, also known as "Gotu Kola." The plant is native to the Southeast Asia and has been used traditionally as brain tonic in ayurvedic medicine. The neuroprotective effect of C. asiatica has been searched using the key words "Centella, Centella asiatica, gotu kola, Asiatic pennywort, neuroprotection, and memory" through the electronic databases including Sciencedirect, Web of Science, Scopus, Pubmed, and Google Scholar. According to the literature survey, C. asiatica (gotu kola) has been reported to have a comprehensive neuroprotection by different modes of action such as enzyme inhibition, prevention of amyloid plaque formation in Alzheimer's disease, dopamine neurotoxicity in Parkinson's disease, and decreasing oxidative stress. Therefore, C. asiatica could be suggested to be a desired phytopharmaceutical with neuroprotective effect emerged from traditional medicine.
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“Asiatic acid and its derivatives have shown a promising memory improving effect [65] by improving ACh synthesis [66,67].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [67]
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Metadata
- Authors
- Orhan, I. E.
- Affiliations
- Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
- Venue
- Evidence-based Complementary and Alternative Medicine
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-8
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC3359802
- OpenAlex
- W2071066258
- Cited by
- 238
- References
- 88
- Citations by year
- 2026: 19 · 2025: 26 · 2024: 21 · 2023: 23 · 2022: 17 · 2021: 31 · 2020: 16 · 2019: 15 · 2018: 18 · 2017: 12 · 2016: 9 · 2015: 13 · 2014: 7 · 2013: 6 · 2012: 3
- FWCI
- 22.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Eastern Mediterranean University Institutional Repository (Eastern Mediterranean University) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- Centella asiatica, neuroprotection, traditional medicine, Ayurveda, Alzheimer's disease, amyloid plaques, Parkinson's disease, dopamine neurotoxicity, oxidative stress, memory, herbal medicine, enzyme inhibition
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