Cited by 261Medicinal Plants and NeuroprotectionMedicinal Plant Extracts EffectsPhytochemicals and Medicinal Plants

Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats

Veerendra Kumar, M.H, Gupta, Y.K·2002·Journal of Ethnopharmacology

Abstract

Centella asiatica, a plant mentioned in Indian literature has been described to possess CNS effects such as stimulatory-nervine tonic, rejuvenant, sedative, tranquilizer and intelligence promoting property. In the present study aqueous, methanolic and chloroform extracts of C. asiatica were investigated for their effect on cognitive functions in rats. Male Wistar rats of 200-250 g were used to study the effect on learning and memory by using shuttle box, step through, step down and elevated plus maze paradigms. Only the aqueous extract of whole plant (200 mg/kg for 14 days) showed an improvement in learning and memory in both shuttle box and step through paradigms. Therefore, further experiments were conducted with aqueous extract using 100, 200 and 300 mg/kg doses in different paradigms of learning and memory. All doses of aqueous extract increased the number of avoidances in shuttle box and prolonged the step through latency in step through apparatus in a dose dependent manner, while only two doses 200 and 300 mg/kg of aqueous extract showed significant increase in the step down latency in step down apparatus and transfer latency (TL) in elevated plus maze. Among doses of aqueous extract tested on oxidative stress parameters, only 200 and 300 mg/kg showed a significant decrease in the brain levels of malondialdehyde (MDA) with simultaneous significant increase in levels of glutathione. There was a significant increase in the levels of catalase at the 300 mg/kg but no significant change in superoxide dismutase (SOD) levels were observed. The present findings indicate that the aqueous extract of C. asiatica has cognitive enhancing effect and an antioxidant mechanism is involved.

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Crossref · 10.1016/s0378-8741(01)00394-4

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Authors
Veerendra Kumar, M. H., & Gupta, Y. K.
Affiliations
All India Institute of Medical Sciences (IN)
Corresponding author
Gupta, Y.K
Venue
Journal of Ethnopharmacology
Publisher
Elsevier BV
Published
2002-02
Volume
79
Issue
2
Pages
253-260
ISSN
0378-8741 (ISSN-L)
OpenAlex
W2021784041
Cited by
261
References
31
Citations by year
2026: 4 · 2025: 6 · 2024: 14 · 2023: 13 · 2022: 8 · 2021: 13 · 2020: 17 · 2019: 17 · 2018: 14 · 2017: 14 · 2016: 8 · 2015: 15 · 2014: 12 · 2013: 11 · 2012: 17
FWCI
16.58
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Ethnopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Council of Scientific and Industrial Research, India
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Keywords
Centella asiatica, aqueous plant extract, cognitive enhancement, learning and memory, oxidative stress, antioxidant activity, malondialdehyde, glutathione, catalase, superoxide dismutase, brain, neuroprotection
MeSH terms
Animals, Avoidance Learning, Brain, Cognition, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Male, Plant Extracts, Lipid Peroxidation, Biomarkers, Rats, Wistar, Oxidative Stress, Maze Learning, Centella, Rats

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