The DOI matches its Crossref record; 182 of the 182 references it cites were found in a registry or an index.
Nanoparticles for Brain Drug Delivery
Open accessAbstract
The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier (BBB) regulating its homeostasis. BBB is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted number of macromolecules from the blood to the brain, protecting it from injuries and diseases. However, the BBB also significantly precludes the delivery of drugs to the brain, thus, preventing the therapy of a number of neurological disorders. As a consequence, several strategies are currently being sought after to enhance the delivery of drugs across the BBB. Within this review, the recently born strategy of brain drug delivery based on the use of nanoparticles, multifunctional drug delivery systems with size in the order of one-billionth of meters, is described. The review also includes a brief description of the structural and physiological features of the barrier and of the most utilized nanoparticles for medical use. Finally, the potential neurotoxicity of nanoparticles is discussed, and future technological approaches are described. The strong efforts to allow the translation from preclinical to concrete clinical applications are worth the economic investments.
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Cited by
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“However, some studies suggested that nanoparticles may not be internalized by cells and the enhanced drug uptake in the brain is non-specific [29, 42, 43].”
BackgroundOvercoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases
Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708
A holistic approach to targeting disease with polymeric nanoparticles
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Metadata
- Authors
- Masserini, M.
- Venue
- ISRN Biochemistry
- Publisher
- Hindawi Limited
- Published
- 2013-05-21
- Volume
- 2013
- Pages
- 1-18
- ISSN
- 2090-7729 (ISSN-L)
- OpenAlex
- W2011005493
- Cited by
- 489
- References
- 182
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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