The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Serum Circulating microRNA Profiling for Identification of Potential Breast Cancer Biomarkers
Open accessAbstract
MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that can regulate gene expression, thereby affecting crucial processes in cancer development. miRNAs offer great potential as biomarkers for cancer detection because of their remarkable stability in blood and their characteristic expression in different diseases. We investigated whether quantitative RT-PCR miRNA profiling on serum could discriminate between breast cancer patients and healthy controls. We performed miRNA profiling on serum from breast cancer patients, followed by construction of ROC (Receiver Operating Characteristic) curves to determine the sensitivity and specificity of the assay. We found that seven miRNAs (miR-10b, miR-21, miR-125b, miR-145, miR-155 miR-191 and miR-382) had different expression patterns in serum of breast cancer patients compared to healthy controls. ROC curve analyses revealed that three serum miRNAs could be valuable biomarkers for distinguishing BC from normal controls. Additionally, a combination of ROC curve analyses of miR-145, miR-155 and miR-382 showed better sensitivity and specificity of our assay. miRNA profiling in serum has potential as a novel method for breast cancer detection in the Mexican population.
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Cites
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1997 · Cited by 7,590
A microRNA expression signature of human solid tumors defines cancer gene targets
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MicroRNA Gene Expression Deregulation in Human Breast Cancer
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Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes
Zampetaki, A., Kiechl, S., Drozdov, I., Willeit, P., Mayr, U., Prokopi, M., Mayr, A., Weger, S., Oberhollenzer, F., Bonora, E., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.226357 · Cited by 1,283
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Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis
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Altered MicroRNA Expression Confined to Specific Epithelial Cell Subpopulations in Breast Cancer
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Direct Serum Assay for MicroRNA-21 Concentrations in Early and Advanced Breast Cancer
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Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer
Roth, C., Rack, B., Müller, V., Janni, W., Pantel, K., & Schwarzenbach, H. (2010) · Breast Cancer Research · doi:10.1186/bcr2766 · Cited by 430
Circulating microRNAs in breast cancer and healthy subjects
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Cited by
Circulating miRNAs: Roles in cancer diagnosis, prognosis and therapy
Cheng, G. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.09.001 · Cited by 334
Precision medicine and radiogenomics in breast cancer: new approaches toward diagnosis and treatment
Pinker, K., Chin, J., Melsaether, A. N., Morris, E. A., & Moy, L. (2018) · Radiology · doi:10.1148/radiol.2018172171 · Cited by 275
miR-191: an emerging player in disease biology
Nagpal, N., & Kulshreshtha, R. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00099 · Cited by 168
Gonzalez-Villasana, V., Rashed, M. H., Gonzalez-Cantú, Y., Bayraktar, R., Menchaca-Arredondo, J. L., Vazquez-Guillen, J. M., Rodriguez-Padilla, C., Lopez-Berestein, G., & Resendez-Perez, D. (2019) · Disease Markers · doi:10.1155/2019/6852917 · Cited by 53
Circulating microRNAs as Promising Tumor Biomarkers
(2014) · Advances in Clinical Chemistry · doi:10.1016/bs.acc.2014.09.007 · Cited by 40
Metadata
- Authors
- Mar-Aguilar, F., Mendoza-Ramírez, J. A., Malagón-Santiago, I., Espino-Silva, P. K., Santuario-Facio, S. K., Ruiz-Flores, P., Rodríguez-Padilla, C., & Reséndez-Pérez, D.
- Venue
- Disease Markers
- Publisher
- Hindawi Limited
- Published
- 2013
- Volume
- 34
- Issue
- 3
- Pages
- 163-169
- ISSN
- 0278-0240 (ISSN-L)
- 1875-8630
- OpenAlex
- W4247249962
- Cited by
- 280
- References
- 34
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Mar-Aguilar, F., Mendoza-Ramírez, J. A., Malagón-Santiago, I., Espino-Silva, P. K., Santuario-Facio, S. K., Ruiz-Flores, P., Rodríguez-Padilla, C., & Reséndez-Pérez, D. (2013). Serum Circulating microRNA Profiling for Identification of Potential Breast Cancer Biomarkers. Disease Markers. https://doi.org/10.1155/2013/259454
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