Determinants of hypovitaminosis D in pregnant women and their newborns in a sunny region
Open accessAbstract
Introduction.This study aims to assess the factors associated with 25-hydroxy vitamin D (25(OH)D) levels in pregnant women and their newborns in a sunny region.Materials and Methods.This cross-sectional study was conducted in 2012 in Isfahan, Iran. It comprised 100 nulliparous singleton pregnant women, selected by random cluster sampling. Laboratory tests were assessed before delivery in mothers and after delivery in their infants’ umbilical cord blood. ThePfor trend of variables was assessed across the air quality index (AQI) quartiles. The associations of AQI and 25(OH)D were assessed by multiple linear regression after adjustment for age, body mass index, and dietary intake.Results.Sera of 98 mothers and an equal number of newborns were analyzed. The median (interquartile range, IQR) of serum 25(OH)D of mothers and neonates was 15.1(12.6, 18.2) ng/mL in mothers and 15.7(12.0, 18.1) ng/mL in neonates, respectively. AQI had an inverse association with serum 25(OH)D (Beta = −0.58,P=0.04). The corresponding figure was also inverse and significant for newborns (Beta (SE)= −0.51(0.04),P=0.01).Conclusion.The independent inverse association of 25(OH)D with air quality can explain the high prevalence of hypovitaminosis D in pregnant women living in this sunny region.
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The low prevalence estimates for AD in China and PDD in Iran and UAE despite high prevalence of low vitamin D status may be due to methodological issues (screening and diagnostic characteristics) and underreporting.
“However, the low prevalence estimate for AD in China and PDD in Iran and UAE despite having high prevalence of low vitamin D status [56,57,58] may be due to methodological issues (screening and diagnostic characteristics) and underreporting.”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [57]
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- [24]The Institute of Medicine, Food and Nutrition Board Dietary Reference Intakes for Calcium and Vitamin D 2010 Washington, DC, USA National Academy Press
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- Authors
- Kelishadi, R., Sharifi-Ghazvini, F., Poursafa, P., Mehrabian, F., Farajian, S., Yousefy, H., Movahedian, M., & Sharifi-Ghazvini, S.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- University of Isfahan (IR)
- Ferdowsi University of Mashhad (IR)
- Corresponding author
- Kelishadi, Roya
- Venue
- International Journal of Endocrinology
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-6
- ISSN
- 1687-8337 (ISSN-L)
- 1687-8345
- PMC
- PMC3713371
- OpenAlex
- W1971099293
- Cited by
- 22
- References
- 54
- Citations by year
- 2025: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 3
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Isfahan University of Medical Sciences
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Keywords
- vitamin D deficiency, 25-hydroxyvitamin D, pregnancy, neonates, umbilical cord blood, air quality index, air pollution, sun exposure, nulliparous women, Isfahan
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