Neuroprotective Function of DJ-1 in Parkinson’s Disease

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,854

Mitochondrial Complex I Deficiency in Parkinson's Disease

Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsPreprint

Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., & Ichijo, H. (2002) · Genes & Development · doi:10.1101/gad.992302 · Cited by 1,372

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

Canet-Aviles, R., Wilson, M. A., Miller, D. W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M. J., Ringe, D., Petsko, G. A., & Cookson, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402959101 · Cited by 1,115

Abnormalities of the electron transport chain in idiopathic parkinson's disease

Parker, W. D., Boyson, S. J., & Parks, J. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260606 · Cited by 1,061

DJ‐1 has a role in antioxidative stress to prevent cell death

Taira, T., Saito, Y., Niki, T., Iguchi‐Ariga, S. M. M., Takahashi, K., & Ariga, H. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400074 · Cited by 866

DJ-1, a cancer- and Parkinson’s disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Clements, C. M., McNally, R. S., Conti, B. J., Mak, T. W., & Ting, J. P.-Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607260103 · Cited by 818

DJ-1, a Novel Oncogene Which Transforms Mouse NIH3T3 Cells in Cooperation withras

Nagakubo, D., Taira, T., Kitaura, H., Ikeda, M., Tamai, K., Iguchi‐Ariga, S. M. M., & Ariga, H. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6132 · Cited by 760

Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease

Mizuno, Y., Ohta, S., Tanaka, M., Takamiya, S., Suzuki, K., SATO, T. A., Oya, H., Ozawa, T., & Kagawa, Y. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91141-8 · Cited by 735

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

Kim, R. H., Smith, P. D., Aleyasin, H., Hayley, S. P., Mount, M. P., Pownall, S., Wakeham, A. C., You-Ten, A. J., Kalia, S. K., Horne, P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501282102 · Cited by 711

DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation

Shendelman, S., Jonason, A. S., Martinat, C., Leete, T., & Abeliovich, A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020362 · Cited by 610

ROS, stress‐activated kinases and stress signaling in cancer

Benhar, M., Engelberg, D., & Levitzki, A. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf094 · Cited by 600

DJ-1, a novel regulator of the tumor suppressor PTEN

Kim, R. H., Peters, M., Jang, Y., Shi, W., Pintilie, M., Fletcher, G. C., DeLuca, C., Silvester, J., Zhou, L., Snow, B. E., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.010 · Cited by 547

Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

Goldberg, M. S., Pisani, A., Haburčák, M., Vortherms, T. A., Kitada, T., Costa, C., Tong, Y., Martella, G., Tscherter, A., Martins, A., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.041 · Cited by 532

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1Preprint

Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., & Ichijo, H. (2008) · Genes & Development · doi:10.1101/gad.1640108 · Cited by 530

Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases

Choi, J., Sullards, M. C., Olzmann, J. A., Rees, H. D., Weintraub, S. T., Bostwick, D. E., Gearing, M., Levey, A. I., Chin, L., & Li, L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509079200 · Cited by 489

Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

Hauser, D. N., & Hastings, T. G. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.10.011 · Cited by 487

The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

Bandopadhyay, R. (2004) · Brain · doi:10.1093/brain/awh054 · Cited by 475

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

Craig, K. J. T., McCoy, M. K., Blackinton, J. G., Beilina, A. G., van der Brug, M., Matton, A., Miller, D. W., Maric, D., Cedazo-Mı́nguez, Á., & Cookson, M. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq430 · Cited by 467

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

Zhang, L., Shimoji, M., Thomas, B., Moore, D. J., Yu, S.-W., Marupudi, N. I., Torp, R., Torgner, I. A., Ottersen, O. P., Dawson, T. M., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi211 · Cited by 425

Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation

Kadowaki, H., Nishitoh, H., Urano, F., Sadamitsu, C., Matsuzawa, A., Takeda, K., Masutani, H., Yodoi, J., Urano, Y., NAGANO, T., et al. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401528 · Cited by 425

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

Irrcher, I., Aleyasin, H., Seifert, E. L., Hewitt, S. J., Chhabra, S., Phillips, M., Lutz, A. K., Rousseaux, M. W. C., Bevilacqua, L., Jahani‐Asl, A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq288 · Cited by 394

The role of pathogenic DJ‐1 mutations in Parkinson's disease

Abou‐Sleiman, P. M., Healy, D. G., Quinn, N. P., Lees, A. J., & Wood, N. W. (2003) · Annals of Neurology · doi:10.1002/ana.10675 · Cited by 392

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

Krebiehl, G., Ruckerbauer, S., Burbulla, L. F., Kieper, N., Maurer, B., Waak, J., Wolburg, H., Gizatullina, Z. Z., Gellerich, F. N., Woitalla, D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009367 · Cited by 381

Sensitivity to Oxidative Stress in DJ-1-Deficient Dopamine Neurons: An ES- Derived Cell Model of Primary Parkinsonism

Martinat, C., Shendelman, S., Jonason, A. S., Leete, T., Beal, M. F., Yang, L., Floß, T., & Abeliovich, A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020327 · Cited by 366

Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells

Kinumi, T., Kimata, J., Taira, T., Ariga, H., & Niki, E. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.110 · Cited by 365

The Oxidation State of DJ-1 Regulates its Chaperone Activity Toward α-Synuclein

Zhou, W., Zhu, M., Wilson, M. A., Petsko, G. A., & Fink, A. L. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.12.030 · Cited by 361

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

Yokota, T., Sugawara, K., Ito, K., Takahashi, R., Ariga, H., & Mizusawa, H. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.056 · Cited by 356

DJ-1 Up-regulates Glutathione Synthesis during Oxidative Stress and Inhibits A53T α-Synuclein Toxicity

Zhou, W., & Freed, C. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507124200 · Cited by 355

Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death

Junn, E., Taniguchi, H., Jeong, B. S., Zhao, X. S., Ichijo, H., & Mouradian, M. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409635102 · Cited by 321

Mitochondrial localization of DJ‐1 leads to enhanced neuroprotection

Junn, E., Jang, W. H., Zhao, X., Jeong, B. S., & Mouradian, M. M. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.21831 · Cited by 320

The 1.1-Å resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

Wilson, M. A., Collins, J. L., Hod, Y., Ringe, D., & Petsko, G. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133288100 · Cited by 319

DJ-1 Positively Regulates the Androgen Receptor by Impairing the Binding of PIASxα to the Receptor

Takahashi, K., Taira, T., Niki, T., Seino, C., Iguchi‐Ariga, S. M. M., & Ariga, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101730200 · Cited by 313

Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer.

Naour, F. L., Misek, D. E., Krause, M. C., Deneux, L., Giordano, T. J., Scholl, S., & Hanash, S. (2001) · PubMed · Cited by 306

DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin

Mitsumoto, A., & Nakagawa, Y. (2001) · Free Radical Research · doi:10.1080/10715760100301381 · Cited by 285

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

Hao, L.-Y., Giasson, B. I., & Bonini, N. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911175107 · Cited by 270

Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function

Olzmann, J. A., Brown, K., Wilkinson, K. D., Rees, H. D., Huai, Q., Ke, H., Levey, A. I., Li, L., & Chin, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311017200 · Cited by 270

Age-dependent Motor Deficits and Dopaminergic Dysfunction in DJ-1 Null Mice

Chen, L., Cagniard, B., Mathews, T. A., Jones, S. R., Koh, H. C., Ding, Y., Carvey, P. M., Ling, Z., Kang, U. J., & Zhuang, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413955200 · Cited by 268

Crystal Structure of Human DJ-1, a Protein Associated with Early Onset Parkinson's Disease

Tao, X., & Tong, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304221200 · Cited by 260

Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat

Mitsumoto, A., Nakagawa, Y., Takeuchi, A., Okawa, K., Iwamatsu, A., & Takanezawa, Y. (2001) · Free Radical Research · doi:10.1080/10715760100300831 · Cited by 256

The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis

Xu, J., Zhong, N., Wang, H., Elias, J. E., Kim, C. Y., Woldman, I., Pifl, C., Gygi, S. P., Geula, C., & Yankner, B. A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi134 · Cited by 250

Crystal Structures of Human DJ-1 and Escherichia coli Hsp31, Which Share an Evolutionarily Conserved Domain

Lee, S., Kim, S. J., Kim, I.-K., Ko, J., Jeong, C., Kim, G.-H., Park, C., Kang, S.-O., Suh, P., Lee, H.-S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304517200 · Cited by 242

Apoptosis Signal-Regulating Kinase 1 Plays a Pivotal Role in Angiotensin II–Induced Cardiac Hypertrophy and Remodeling

Izumiya, Y., Kim, S., Izumi, Y., Yoshida, K., Yoshiyama, M., Matsuzawa, A., Ichijo, H., & Iwao, H. (2003) · Circulation Research · doi:10.1161/01.res.0000100665.67510.f5 · Cited by 230

The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease

Honbou, K., Suzuki, N. N., Horiuchi, M., Niki, T., Taira, T., Ariga, H., & Inagaki, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305878200 · Cited by 224

Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling

Yamaguchi, O., Higuchi, Y., Hirotani, S., Kashiwase, K., Nakayama, H., Hikoso, S., Takeda, T., Watanabe, T., Asahi, M., Taniike, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2136717100 · Cited by 222

DJ-1 Decreases Bax Expression through Repressing p53 Transcriptional Activity

Fan, J. Y., Ren, H., Jia, N., Fei, E., Zhou, T. G., Jiang, P., Wu, M., & Wang, G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707176200 · Cited by 219

Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease

Tang, B., Xiong, H., Sun, P., Zhang, Y., Wang, D., Hu, Z., Zhu, Z.-H., Ma, H., Pan, Q., Xia, J., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl104 · Cited by 218

Parkinson’s disease‐associated DJ‐1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction

Wang, X., Petrie, T. G., Liu, Y., Liu, J., Fujioka, H., & Zhu, X. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07734.x · Cited by 217

The roles of ASK family proteins in stress responses and diseases

Hattori, K., Naguro, I., Runchel, C., & Ichijo, H. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-9 · Cited by 216

DJ-1 binds to mitochondrial complex I and maintains its activity

Hayashi, T., Ishimori, C., Takahashi-Niki, K., Taira, T., Kim, Y.-C., Maita, H., Maita, C., Ariga, H., & Iguchi‐Ariga, S. M. M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.10.025 · Cited by 199

DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.

Niki, T., Takahashi-Niki, K., Taira, T., Iguchi‐Ariga, S. M. M., & Ariga, H. (2003) · PubMed · Cited by 197

Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson’s disease

Waragai, M., Wei, J., Fujita, M., Nakai, M., Ho, G. J., Masliah, E., Akatsu, H., Yamada, T., & Hashimoto, M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.011 · Cited by 197

Regulation of astrocyte inflammatory responses by the Parkinson's disease‐associated gene DJ–1

Waak, J., Weber, S. S., Waldenmaier, A., Görner, K., Alunni‐Fabbroni, M., Schell, H., Weisenhorn, D. M. V., Pham, T., Reumers, V., Baekelandt, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125153 · Cited by 190

Mitochondrial involvement in Parkinson's disease

Orth, M. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00124-3 · Cited by 188

Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities

Shinbo, Y., Niki, T., Taira, T., Ooe, H., Takahashi-Niki, K., Maita, C., Seino, C., Iguchi‐Ariga, S. M. M., & Ariga, H. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401704 · Cited by 184

DJ-1 Transcriptionally Up-regulates the Human Tyrosine Hydroxylase by Inhibiting the Sumoylation of Pyrimidine Tract-binding Protein-associated Splicing Factor

Zhong, N., Kim, C. Y., Rizzu, P., Geula, C., Porter, D. R., Pothos, E. N., Squitieri, F., Heutink, P., & Xu, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601935200 · Cited by 181

PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model

Inden, M., Taira, T., Kitamura, Y., Yanagida, T., Tsuchiya, D., Takata, K., Yanagisawa, D., Nishimura, K., Taniguchi, T., Kiso, Y., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.06.004 · Cited by 180

Induction of Reactive Oxygen Species by Bisphenol A and Abrogation of Bisphenol A-Induced Cell Injury by DJ-1

Ooe, H., Taira, T., Iguchi‐Ariga, S. M. M., & Ariga, H. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi278 · Cited by 168

Mitochondrial dysfunction in parkinson's disease

Mizuno, Y., Yoshino, H., Ikebe, S.-I., Hattori, N., Kobayashi, T., Shimoda‐Matsubayashi, S., Matsumine, H., & Kondo, T. (1998) · Annals of Neurology · doi:10.1002/ana.410440715 · Cited by 164

Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress

Li, H. M., Niki, T., Taira, T., Iguchi‐Ariga, S. M. M., & Ariga, H. (2005) · Free Radical Research · doi:10.1080/10715760500260348 · Cited by 160

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage

Aleyasin, H., Rousseaux, M. W. C., Phillips, M., Kim, R. H., Bland, R. J., Callaghan, S. M., Slack, R. S., During, M. J., Mak, T. W., & Park, D. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709379104 · Cited by 160

Evolutionary and functional relationships within the DJ1 superfamily

Bandyopadhyay, S., & Cookson, M. (2004) · BMC Evolutionary Biology · doi:10.1186/1471-2148-4-6 · Cited by 150

Pathological properties of the Parkinson?s disease-associated protein DJ-1 in a-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick?s disease

Neumann, M., M�ller, V., G�rner, K., Kretzschmar, H. A., Haass, C., & Kahle, P. J. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0834-2 · Cited by 148

DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3

Shinbo, Y., Taira, T., Niki, T., Iguchi‐Ariga, S. M. M., & Ariga, H. (2005) · International Journal of Oncology · doi:10.3892/ijo.26.3.641 · Cited by 147

DJ‐1 colocalizes with tau inclusions: A link between parkinsonism and dementia

Rizzu, P., Hinkle, D. A., Zhukareva, V. A., Bonifati, V., Severijnen, L.-A. W. F. M., Martínez, D., Ravid, R., Kamphorst, W., Eberwine, J. H., Lee, V. M. ‐., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10782 · Cited by 146

Oxidizable Residues Mediating Protein Stability and Cytoprotective Interaction of DJ-1 with Apoptosis Signal-regulating Kinase 1

Waak, J., Weber, S. S., Görner, K., Schall, C., Ichijo, H., Stehle, T., & Kahle, P. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806902200 · Cited by 145

PARK7 and Nucleoside Diphosphate Kinase A as Plasma Markers for the Early Diagnosis of Stroke

Allard, L., Burkhard, P. R., Lescuyer, P., Burgess, J., Walter, N., Hochstrasser, D. F., & Sanchez, J. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.053942 · Cited by 142

Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death‐associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by α‐lipoic acid

Karunakaran, S., Diwakar, L., Saeed, U., Agarwal, V., Ramakrishnan, S., Iyengar, S., & Ravindranath, V. (2007) · The FASEB Journal · doi:10.1096/fj.06-7580com · Cited by 140

Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling

Shiizaki, S., Naguro, I., & Ichijo, H. (2012) · Advances in Biological Regulation · doi:10.1016/j.jbior.2012.09.006 · Cited by 138

Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage

Chen, J., Li, L., & Chin, L. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq113 · Cited by 138

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

Iriyama, T., Takeda, K., Nakamura, H. K., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.32 · Cited by 127

Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7)

Hering, R., Strauss, K. M., Tao, X., Bauer, A., Woitalla, D., Mietz, E.-M., Petrovic, S., Bauer, P., Schaible, W., Müller, T. H., et al. (2004) · Human Mutation · doi:10.1002/humu.20089 · Cited by 123

Crystal structure of DJ‐1/RS and implication on familial Parkinson's disease1

Huai, Q., Sun, Y., Wang, H., Chin, L., Li, L., Robinson, H. H., & Ke, H. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00764-6 · Cited by 119

DJ-1 Protects Dopaminergic Neurons against Rotenone-Induced Apoptosis by Enhancing ERK-Dependent Mitophagy

Gao, H., Yang, W., Qi, Z., Lu, L., Duan, C., Zhao, C., & Yang, H. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.06.034 · Cited by 117

Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease

Waragai, M., Nakai, M., Wei, J., Fujita, M., Mizuno, H., Ho, G. J., Masliah, E., Akatsu, H., Yokochi, F., & Hashimoto, M. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.08.010 · Cited by 114

EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR‐targeting tyrosine kinase inhibitors

Takeuchi, K., & Ito, F. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07450.x · Cited by 109

Olmesartan Prevents Cardiovascular Injury and Hepatic Steatosis in Obesity and Diabetes, Accompanied by Apoptosis Signal Regulating Kinase-1 Inhibition

Yamamoto, E., Dong, Y., Kataoka, K., Yamashita, T., Tokutomi, Y., Matsuba, S., Ichijo, H., Ogawa, H., & Kim‐Mitsuyama, S. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.112292 · Cited by 109

Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-Å resolution

Du, X., Choi, I., Kim, R., Wang, W., Jancarik, J., Yokota, H. A., & Kim, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.260503597 · Cited by 108

DJ-1 Null Dopaminergic Neuronal Cells Exhibit Defects in Mitochondrial Function and Structure: Involvement of Mitochondrial Complex I Assembly

Heo, J. Y., Park, J. H., Kim, S. J., Seo, K. S., Han, J., Lee, S. H., Kim, J., Park, J., Park, S. K., Lim, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032629 · Cited by 104

Molecular Cloning and Expression of Rat Contraception Associated Protein 1 (CAP1), a Protein Putatively Involved in Fertilization

Wagenfeld, A., Gromoll, J., & Cooper, T. G. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9512 · Cited by 103

Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN

Ariga (2009) · International Journal of Oncology · doi:10.3892/ijo_00000451 · Cited by 103

DJ-1 Protects against Neurodegeneration Caused by Focal Cerebral Ischemia and Reperfusion in Rats

Yanagisawa, D., Kitamura, Y., Inden, M., Takata, K., Taniguchi, T., Morikawa, S., Morita, M., Inubushi, T., Tooyama, I., Taira, T., et al. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600553 · Cited by 102

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes

Jain, D., Jain, R., Eberhard, D., Eglinger, J., Bugliani, M., Piemonti, L., Marchetti, P., & Lammert, E. (2012) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjs025 · Cited by 100

Oxidized DJ-1 Inhibits p53 by Sequestering p53 from Promoters in a DNA-Binding Affinity-Dependent Manner

Kato, I., Maita, H., Takahashi-Niki, K., Saito, Y., Noguchi, N., Iguchi‐Ariga, S. M. M., & Ariga, H. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.01350-12 · Cited by 98

DJ-1 protects against dopamine toxicity

Lev, N., Ickowicz, D., Barhum, Y., Lev, S., Melamed, E., & Offen, D. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0134-4 · Cited by 96

DJ-1 Binds Androgen Receptor Directly and Mediates Its Activity in Hormonally Treated Prostate Cancer Cells

Tillman, J., Yuan, J., Gu, G., Fazli, L., Ghosh, R., Flynt, A. S., Gleave, M. E., Rennie, P. S., & Kasper, S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4556 · Cited by 95

Secretion of DJ-1 into the serum of patients with Parkinson's disease

Maita, C., Tsuji, S., Yabe, I., Hamada, S., Ogata, A., Maita, H., Iguchi‐Ariga, S. M. M., Sasaki, H., & Ariga, H. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.11.027 · Cited by 94

Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening

Giaime, E., Yamaguchi, H., Gautier, C., Kitada, T., & Shen, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040501 · Cited by 94

Oxidative Stress Induction of DJ‐1 Protein in Reactive Astrocytes Scavenges Free Radicals and Reduces Cell Injury

Yanagida, T., Tsushima, J., Kitamura, Y., Yanagisawa, D., Takata, K., Shibaike, T., Yamamoto, A., Taniguchi, T., Yasui, H., Taira, T., et al. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.1.7985 · Cited by 93

14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy

Thandavarayan, R. A., Watanabe, K., Ma, M., Veeraveedu, P. T., Gurusamy, N., Palaniyandi, S. S., Zhang, S., Muslin, A. J., Kodama, M., & Aizawa, Y. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.02.003 · Cited by 91

SP22: A Novel Fertility Protein From a Highly Conserved Gene Family

Welch, J. E., Barbee, R. R., Roberts, N. L., Suarez, J. D., & Klinefelter, G. R. (1998) · Journal of Andrology · doi:10.1002/j.1939-4640.1998.tb02029.x · Cited by 88

Human DJ-1-specific Transcriptional Activation of Tyrosine Hydroxylase Gene

Ishikawa, S., Taira, T., Takahashi-Niki, K., Niki, T., Ariga, H., & Iguchi‐Ariga, S. M. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.137034 · Cited by 84

DJ-1 knock-down impairs astrocyte mitochondrial function

Larsen, N. J., Ambrosi, G., Mullett, S. J., Berman, S. B., & Hinkle, D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.016 · Cited by 82

Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1

Ito, G., Ariga, H., Nakagawa, Y., & Iwatsubo, T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.058 · Cited by 81

Oxidized DJ-1 Interacts with the Mitochondrial Protein BCL-XL

Ren, H., Fu, K., Wang, D., Mu, C., & Wang, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.207134 · Cited by 80

DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity

Mullett, S. J., & Hinkle, D. A. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07175.x · Cited by 78

Oxidative Status of DJ-1-dependent Activation of Dopamine Synthesis through Interaction of Tyrosine Hydroxylase and 4-Dihydroxy-l-phenylalanine (l-DOPA) Decarboxylase with DJ-1

Ishikawa, S., Taira, T., Niki, T., Takahashi-Niki, K., Maita, C., Maita, H., Ariga, H., & Iguchi‐Ariga, S. M. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019950 · Cited by 77

Mutational screening of the mortalin gene (HSPA9) in Parkinson’s disease

de Mena, L., Coto, E., Sánchez-Ferrero, E., Ribacoba, R., Guisasola, L. M., Salvador, C., Estrada, M. B., & Álvarez, V. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0273-2 · Cited by 75

DJ‐1‐binding compounds prevent oxidative stress‐induced cell death and movement defect in Parkinson’s disease model rats

Miyazaki, S., Yanagida, T., Nunome, K., Ishikawa, S., Inden, M., Kitamura, Y., Nakagawa, S., Taira, T., Hirota, K., Niwa, M., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05327.x · Cited by 72

A New Evolutionary Paradigm for the Parkinson Disease Gene DJ-1

Lucas‐Lledó, J. I., & Marı́n, I. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msl186 · Cited by 71

Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death

Kim, S., Park, Y.-J., Hwang, I.-Y., Youdim, M. B. H., Park, K., & Oh, Y. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.035 · Cited by 66

Pro-Survival Role for Parkinson's Associated Gene DJ-1 Revealed in Trophically Impaired Dopaminergic Neurons

Aron, L., Klein, P., Pham, T.-T., Kramer, E. R., Wurst, W., & Klein, R. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000349 · Cited by 59

DJ‐1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age

Mullett, S., Hamilton, R. L., & Hinkle, D. (2009) · Neuropathology (Kyoto. 1993) · doi:10.1111/j.1440-1789.2008.00955.x · Cited by 57

Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats

Kitamura, Y., Watanabe, S., Taguchi, M., Takagi, K., Kawata, T., Takahashi-Niki, K., Yasui, H., Maita, H., Iguchi-Ariga, S. M., & Ariga, H. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-48 · Cited by 57

Sumoylation is critical for DJ‐1 to repress p53 transcriptional activity

Fan, J., Ren, H., Fei, E., Jia, N., Ying, Z., Jiang, P., Wu, M., & Wang, G. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.03.003 · Cited by 57

The Parkinson's disease-related genes act in mitochondrial homeostasis

Sai, Y., Zou, Z., Peng, K., & Dong, Z. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.007 · Cited by 55

Monomer DJ-1 and Its N-Terminal Sequence Are Necessary for Mitochondrial Localization of DJ-1 Mutants

Maita, C., Maita, H., Iguchi‐Ariga, S. M. M., & Ariga, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054087 · Cited by 52

DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy

Koide‐Yoshida, S., Niki, T., Ueda, M., Himeno, S., Taira, T., Iguchi‐Ariga, S. M. M., Ando, Y., & Ariga, H. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.19.6.885 · Cited by 49

Protection Against Dopaminergic Neurodegeneration in Parkinson’s Disease–Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson’s Disease–Linked PARK7

Inden, M., Kitamura, Y., Takahashi, K., Takata, K., Ito, N., Niwa, R., Funayama, R., Nishimura, K., Taniguchi, T., Honda, T., et al. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11151fp · Cited by 46

Expression profiles of genes in DJ-1-knockdown and L166P DJ-1 mutant cells

Nishinaga, H., Takahashi-Niki, K., Taira, T., Andreadis, A., Iguchi‐Ariga, S. M. M., & Ariga, H. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.07.053 · Cited by 43

Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis

Yamaguchi, S., Yamane, T., Takahashi-Niki, K., Kato, I., Niki, T., Goldberg, M. S., Shen, J., Ishimoto, K., Doi, T., Iguchi‐Ariga, S. M. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038144 · Cited by 39

DJ‐1, a causative gene product of a familial form of Parkinson's disease, is secreted through microdomains

Tsuboi, Y., Munemoto, H., Ishikawa, S., Matsumoto, K., Iguchi‐Ariga, S. M. M., & Ariga, H. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.043 · Cited by 36

Proteomic identification of p53-dependent protein phosphorylation

Rahman-Roblick, R., Hellman, U., Becker, S., Bader, F. G., Auer, G., Wiman, K. G., & Roblick, U. J. (2008) · Oncogene · doi:10.1038/onc.2008.124 · Cited by 31

Distribution of DJ-1, Parkinson’s Disease-Related Protein PARK7, and Its Alteration in 6-Hydroxydopamine-Treated Hemiparkinsonian Rat Brain

Yanagida, T., Takata, K., Inden, M., Kitamura, Y., Taniguchi, T., Yoshimoto, K., Taira, T., & Ariga, H. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.sc0060098 · Cited by 30

Efficacy of ligand-based targeting for the EGF system in cancer.

Yotsumoto, F., Sanui, A., Fukami, T., Shirota, K., Horiuchi, S., Tsujioka, H., Yoshizato, T., Kuroki, M., & Miyamoto, S. (2009) · PubMed · Cited by 28

Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells

Ishikawa, S., Tanaka, Y., Takahashi-Niki, K., Niki, T., Ariga, H., & Iguchi‐Ariga, S. M. M. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.04.095 · Cited by 21

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

Chaudhuri, J., Bains, Y., Guha, S., Kahn, A., Hall, D., Bose, N., Gugliucci, A., & Kapahi, P. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.014 · Cited by 669

Parkinson's disease: Mechanisms, translational models and management strategies

Raza, C., Anjum, R., & Shakeel, N. U. A. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.03.057 · Cited by 628

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

Jiang, T., Sun, Q., & Chen, S. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.07.005 · Cited by 605

Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

Maiti, P., Manna, J., & Dunbar, G. L. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0099-z · Cited by 557

Historical Perspective: Models of Parkinson’s Disease

Chia, S. J., Tan, E., & Chao, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072464 · Cited by 438

Review Article

Niki, T., & Iguchi-ariga, S. M. M. (2016)

Pathogenesis of DJ-1/PARK7-Mediated Parkinson’s Disease

Skou, L. D., Johansen, S. K., Okarmus, J., & Meyer, M. (2024) · Cells · doi:10.3390/cells13040296 · Cited by 120

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

Biosa, A., Sandrelli, F., Beltramini, M., Greggio, E., Bubacco, L., & Bisaglia, M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.005 · Cited by 94

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

Kahle, P. J., Waak, J., & Gasser, T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.08.003 · Cited by 324

Redox modulatory role of DJ-1 in Parkinson’s disease

Alshammari, Q. A. (2025) · Biogerontology · doi:10.1007/s10522-025-10227-w · Cited by 15