Mitochondrial localization of DJ‐1 leads to enhanced neuroprotection
Open accessAbstract
Mutations in DJ‐1 (PARK7) cause recessively inherited Parkinson's disease. DJ‐1 is a multifunctional protein with antioxidant and transcription modulatory activity. Its localization in cytoplasm, mitochondria, and nucleus is recognized, but the relevance of this subcellular compartmentalization to its cytoprotective activity is not fully understood. Here we report that under basal conditions DJ‐1 is present mostly in the cytoplasm and to a lesser extent in mitochondria and nucleus of dopaminergic neuroblastoma SK‐N‐BE(2)C cells. Upon oxidant challenge, more DJ‐1 translocates to mitochondria within 3 hr and subsequently to the nucleus by 12 hr. The predominant DJ‐1 species in both mitochondria and nucleus is a dimer believed to be the functional form. Mutating cysteine 106, 53, or 46 had no impact on the translocation of DJ‐1 to mitochondria. To study the relative neuroprotective activity of DJ‐1 in mitochondria and nucleus, DJ‐1 cDNA constructs fused to the appropriate localization signal were transfected into cells. Compared with 30% protection against oxidant‐induced cell death in wild‐type DJ‐1‐transfected cells, mitochondrial targeting of DJ‐1 provided a significantly stronger (55%) cytoprotection based on lactate dehydrogenase release. Nuclear targeting of DJ‐1 preserved cells equally as well as the wild‐type protein. These observations suggest that the time frame for the translocation of DJ‐1 from the cytoplasm to mitochondria and to the nucleus following oxidative stress is quite different and that dimerized DJ‐1 in mitochondria is functional as an antioxidant not related to cysteine modification. These findings further highlight the multifaceted functions of DJ‐1 as a cytoprotector in different cellular compartments. © 2008 Wiley‐Liss, Inc.
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DJ-1 exposed to oxidative stress undergoes oxidation of Cysteine106 and translocates from cytoplasm to mitochondria or to the nucleus.
“DJ-1 exposed to oxidative stress undergoes oxidation of Cysteine106 and translocates from cytoplasm to mitochondria or to the nucleus (Junn et al. 2009).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Junn et al. 2009
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- Authors
- Junn, E., Jang, W. H., Zhao, X., Jeong, B. S., & Mouradian, M. M.
- Affiliations
- Inje University (KR)
- Corresponding author
- Mouradian, M. Maral
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2008-08-18
- Volume
- 87
- Issue
- 1
- Pages
- 123-129
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- PMC
- PMC2752655
- OpenAlex
- W2143048992
- Cited by
- 320
- References
- 43
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 12 · 2023: 18 · 2022: 21 · 2021: 24 · 2020: 19 · 2019: 16 · 2018: 23 · 2017: 16 · 2016: 18 · 2015: 10 · 2014: 24 · 2013: 23 · 2012: 19
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS053517, R01NS059869, NS059869, R21NS053517)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- DJ-1, Parkinson's disease, mitochondrial localization, subcellular compartmentalization, oxidative stress, neuroprotection, protein dimerization, antioxidant activity, nuclear translocation, cysteine modification, dopaminergic neurons
- MeSH terms
- Protein Deglycase DJ-1, Analysis of Variance, Cell Nucleus, Cysteine, Humans, Hydrogen Peroxide, Mitochondria, Mutation, Neuroblastoma, Transfection, Oncogene Proteins, Oxidants, Cell Death, Apoptosis, Neuroprotective Agents, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins
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