ROS, stress‐activated kinases and stress signaling in cancer
Open accessAbstract
Anticancer therapy is frequently efficient in early stages of the disease, whereas advanced tumors are usually resistant to the same treatments. The molecular basis for this change is not entirely understood. Many anticancer agents are DNA- or cytoskeleton-damaging drugs that show some specificity towards dividing cells. However, recent studies show that these agents also activate stress-signaling cascades that may play a role in eliciting the observed therapeutic effects. We discuss recent findings that suggest that induction of stress signaling in oncogenically transformed cells is integrated into apoptotic pathways. Reactive oxygen species (ROS) and stress-activated protein kinases (SAPKs), which are potentiated in recently transformed cells, emerge as key effectors of cell death. In advanced tumors, however, these agents are downregulated and, consequently, death signaling is suppressed. Such changes in ROS and SAPK activity levels during the course of tumor development may underlie the changes in responsiveness to anticancer therapy.
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Oxidative stress may modulate signal transduction pathways associated with malignancy.
“Oxidative stress may also modulate signal transduction pathways associated with malignancy [53].”
From The utility of iron chelators in the management of inflammatory disorders (2015) · cites this paper as [53]
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- Authors
- Benhar, M., Engelberg, D., & Levitzki, A.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Venue
- The EMBO Reports
- Published
- 2002-05-01
- Volume
- 3
- Issue
- 5
- Pages
- 420-425
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC1084107
- OpenAlex
- W2025810127
- Cited by
- 600
- References
- 0
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 16 · 2021: 16 · 2020: 18 · 2019: 27 · 2018: 29 · 2017: 37 · 2016: 25 · 2015: 28 · 2014: 40 · 2013: 48 · 2012: 55
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- EMBO Reports (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- reactive oxygen species, c-Jun N-terminal kinase, stress signaling, cancer, apoptosis, DNA-damaging agents, oncogenic transformation, tumor progression
- MeSH terms
- Animals, Humans, Neoplasms, Signal Transduction, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Mitogen-Activated Protein Kinases
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