Cited by 373Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingCoenzyme Q10 studies and effects

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Neuroprotective Function of DJ-1 in Parkinson’s Disease

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Ariga, Hiroyoshi, Takahashi-Niki, Kazuko, Kato, Izumi, Maita, Hiroshi, Niki, Takeshi, Iguchi-Ariga, Sanae M. M.·2013·Oxidative Medicine and Cellular Longevity

DOI 10.1155/2013/683920PMC PMC3671546

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Abstract

Parkinson’s disease (PD) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial dysfunction are thought to be major causes of neurodegeneration in PD. Although genetic and environmental factors are thought to affect the onset of PD, precise mechanisms at the molecular level have not been elucidated. The DJ-1 gene is a causative gene for familial PD ( park7 ) and also an oncogene. DJ-1 has various functions, including transcriptional regulation, antioxidative stress reaction, and chaperone, protease, and mitochondrial regulation, and its activity is regulated by its oxidative status, especially that of cysteine 106 (C106) of DJ-1. Excess oxidation of DJ-1, which renders DJ-1 inactive, has been observed in patients with sporadic PD and Alzheimer’s disease, suggesting that DJ-1 also participates in the onset and pathogenesis of sporadic PD as well as familial PD. DJ-1 is also a stress sensor and its expression is increased upon various stresses, including oxidative stress. In this review, we describe functions of DJ-1 against oxidative stress and possible roles of DJ-1 in the pathogenesis of PD.

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Authors: Ariga, H., Takahashi-Niki, K., Kato, I., Maita, H., Niki, T., & Iguchi-Ariga, S. M. M.
Affiliations: Hokkaido University (JP)
Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo 060-8589, Japan
Corresponding author: Ariga, Hiroyoshi
ORCID: Maita, Hiroshi
Venue: Oxidative Medicine and Cellular Longevity
Publisher: Wiley
Published: 2013
Volume: 2013
Pages: 1-9
ISSN: 1942-0994 (ISSN-L)
1942-0900
DOI: 10.1155/2013/683920
PMC: PMC3671546
OpenAlex: W1974927898
Cited by: 373
References: 117
Citations by year: 2026: 12 · 2025: 22 · 2024: 24 · 2023: 22 · 2022: 36 · 2021: 30 · 2020: 45 · 2019: 37 · 2018: 27 · 2017: 44 · 2016: 33 · 2015: 21 · 2014: 12 · 2013: 8
FWCI: 3.22
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Institutional Repositories DataBase (IRDB) (submittedVersion)
Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University) (submittedVersion)
Funders: National Institute of Biomedical Innovation
Japan Society for the Promotion of Science (25830071, 25430059, 24650191, 23790970)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
Keywords: DJ-1, Parkinson's disease, neuroprotection, oxidative stress, mitochondrial dysfunction, dopaminergic neuron loss, substantia nigra, familial parkinsonism, sporadic Parkinson's disease, stress sensors, chaperone activity, protease function, transcriptional regulation
MeSH terms: Animals, Dopamine, Humans, Mitochondria, Parkinson Disease, Oncogene Proteins, Oxidative Stress, Neuroprotective Agents

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Neuroprotective Function of DJ-1 in Parkinson’s Disease

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