Cited by 131Moringa oleifera research and applicationsMedicinal Plants and NeuroprotectionAntioxidants, Aging, Portulaca oleracea

Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia

Open access

Abstract

To date, the preventive strategy against dementia is still essential due to the rapid growth of its prevalence and the limited therapeutic efficacy. Based on the crucial role of oxidative stress in age-related dementia and the antioxidant and nootropic activities of Moringa oleifera, the enhancement of spatial memory and neuroprotection of M. oleifera leaves extract in animal model of age-related dementia was determined. The possible underlying mechanism was also investigated. Male Wistar rats, weighing 180-220 g, were orally given M. oleifera leaves extract at doses of 100, 200, and 400 mg/kg at a period of 7 days before and 7 days after the intracerebroventricular administration of AF64A bilaterally. Then, they were assessed memory, neuron density, MDA level, and the activities of SOD, CAT, GSH-Px, and AChE in hippocampus. The results showed that the extract improved spatial memory and neurodegeneration in CA1, CA2, CA3, and dentate gyrus of hippocampus together with the decreased MDA level and AChE activity but increased SOD and CAT activities. Therefore, our data suggest that M. oleifera leaves extract is the potential cognitive enhancer and neuroprotectant. The possible mechanism might occur partly via the decreased oxidative stress and the enhanced cholinergic function. However, further explorations concerning active ingredient(s) are still required.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1155/2013/695936

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 4

  1. [15]Ijeomah AU Ugwuona FU Abdullahi H Phytochemical composition and antioxidant properties of Hibiscus sabdariffa and Moringa oleifera Nigerian Journal of Agriculture, Food and Environment 2012 8 1 10 16
  2. [16]Ugwu Okechukwu PC Nwodo Okwesili FC Joshua Parker E Abubakar B Ossai Emmanuel C Odo Christian E Phytochemical and acute toxicity studies of Moringa oleifera ethanol leaf extract International Journal of Life Science BiotechNology and Pharma Research 2013 2 66 71
  3. [21]Hanin I Mantione CR Fisher A Cortin S Davis KL Growdon JH Usdin E Wurtman RJ AF64A-induced neurotoxicity: a potential animal model in Alzheimer's disease Alzheimer's Disease: A Report of Progress in Research 1982 17 New York, NY, USA Raven Press 267 270
  4. [44]Ganguly R Guha D Alteration of brain monoamines & EEG wave pattern in rat model of alzheimer’s disease & protection by Moringa oleifera Indian Journal of Medical Research 2008 128 6 744 751 2-s2.0-61849104057 19246799

Cited by

Sorted by citations

Authors
Sutalangka, C., Wattanathorn, J., Muchimapura, S., & Thukham-mee, W.
Affiliations
Khon Kaen University (TH)
Corresponding author
Wattanathorn, Jintanaporn
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2013
Volume
2013
Pages
1-9
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
OpenAlex
W2149516433
Cited by
131
References
46
Citations by year
2026: 4 · 2025: 19 · 2024: 16 · 2023: 8 · 2022: 15 · 2021: 22 · 2020: 15 · 2019: 5 · 2018: 11 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 2
FWCI
4.42
Type
journal article
Language
en
Open access
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Higher Education Research Promotion
  • National Research University Project of Thailand
  • Khon Kaen University
  • The National Research Council of Thailand
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Moringa oleifera research and applications
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords
Moringa oleifera, age-related dementia, memory impairment, neurodegeneration, neuroprotection, oxidative stress, antioxidant activity, nootropic activity, spatial memory, hippocampus, acetylcholinesterase, cholinergic activity, lipid peroxidation, superoxide dismutase, catalase, glutathione peroxidase, AF64A, nootropic drugs
MeSH terms
Acetylcholinesterase, Aging, Animals, Cell Count, Dementia, Disease Models, Animal, Escape Reaction, Hippocampus, Male, Malondialdehyde, Phytotherapy, Memory, Memory Disorders, Models, Biological, Nerve Degeneration, Neurons, Plant Extracts, Lipid Peroxidation, Biomarkers, Rats, Wistar, Oxidative Stress, Plant Leaves, Moringa oleifera, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review