The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage
Open accessAbstract
Stroke is a leading cause of death worldwide. Ischemic stroke is caused by blockage of blood vessels in the brain leading to tissue death, while intracerebral hemorrhage (ICH) occurs when a blood vessel ruptures, exposing the brain to blood components. Both are associated with glial toxicity and neuroinflammation. Microglia, as the resident immune cells of the central nervous system (CNS), continually sample the environment for signs of injury and infection. Under homeostatic conditions, they have a ramified morphology and phagocytose debris. After stroke, microglia become activated, obtain an amoeboid morphology, and release inflammatory cytokines (the M1 phenotype). However, microglia can also be alternatively activated, performing crucial roles in limiting inflammation and phagocytosing tissue debris (the M2 phenotype). In rodent models, microglial activation occurs very early after stroke and ICH; however, their specific roles in injury and repair remain unclear. This review summarizes the literature on microglial responses after ischemic stroke and ICH, highlighting the mediators of microglial activation and potential therapeutic targets for each condition.
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Cites
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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Cited by
Depletion of microglia exacerbates postischemic inflammation and brain injury
Jin, W.-N., Shi, S. X.-Y., Li, Z., Li, M., Wood, K., Gonzales, R. J., & Liu, Q. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17694185 · Cited by 351
Microglia Phenotypes in Aging and Neurodegenerative Diseases
Wendimu, M. Y., & Hooks, S. B. (2022) · Cells · doi:10.3390/cells11132091 · Cited by 336
Factors influencing the blood-brain barrier permeability
Zhao, Y., Gan, L., Ren, L., Lin, Y., Ma, C., & Lin, X. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147937 · Cited by 291
Vascular disruption and blood–brain barrier dysfunction in intracerebral hemorrhage
Keep, R. F., Zhou, N., Xiang, J., Andjelkovic, A. V., Hua, Y., & Xi, G. (2014) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-11-18 · Cited by 220
Yuan, L., Liu, S., Bai, X., Gao, Y., Liu, G., Wang, X., Liu, D., Li, T., Hao, A., & Wang, Z. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0541-7 · Cited by 213
Metadata
- Authors
- Taylor, R. A., & Sansing, L. H.
- Venue
- Clinical and Developmental Immunology
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-10
- ISSN
- 1740-2522 (ISSN-L)
- 1740-2530
- OpenAlex
- W2153168701
- Cited by
- 394
- References
- 12
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- gold
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