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Cited by 274Stroke Rehabilitation and RecoveryCardiac Health and Mental HealthAcute Ischemic Stroke Management

Depression after Stroke and Risk of Mortality: A Systematic Review and Meta-Analysis

Open access
Bartoli, Francesco, Lillia, Nicoletta, Lax, Annamaria, Crocamo, Cristina, Mantero, Vittorio, Carrà, Giuseppe, Agostoni, Elio, Clerici, Massimo·2013·Stroke Research and Treatment
DOI 10.1155/2013/862978PMC PMC3606772
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Abstract

Background.Depression after stroke may have great burden on the likelihood of functional recovery and long-term outcomes.Objective. To estimate the association between depression after stroke and subsequent mortality.Methods. A systematic search of articles using PubMed and Web of Science databases was performed. Odds ratios (ORs) and hazard ratios (HRs) were used as association measures for pooled analyses, based on random-effects models.Results. Thirteen studies, involving 59,598 subjects suffering from stroke (6,052 with and 53,546 without depression), had data suitable for meta-analysis. The pooled OR for mortality at followup in people suffering from depression after stroke was 1.22 (1.02–1.47). Subgroups analyses highlighted that only studies with medium-term followup (2–5 years) showed a statistically significant association between depression and risk of death. Four studies had data suitable for further analysis of pooled HR. The meta-analysis revealed a HR for mortality of 1.52 (1.02–2.26) among people with depression after stroke.Conclusions. Despite some limitations, this paper confirms the potential role of depression on post stroke mortality. The relationship between depression and mortality after stroke seems to be related to the followup duration. Further research is needed to clarify the nature of the association between depression after stroke and mortality.

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  • Depression increases the risk of recurrent events and mortality in patients with existing CVD.

    “Although these studies focused on incident CVD, considerable evidence also demonstrates that depression increases the risk of recurrent events and mortality in patients with existing CVD. 46,47”

    From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [47]

    The Results (§3.3; page not provided) report an association between poststroke depression and higher subsequent mortality, supporting the mortality portion for patients with prior stroke. The paper does not establish an increased risk of recurrent cardiovascular events, and its findings do not cover patients with existing CVD generally. The Clinical Perspectives (§4.3) also says the nature of the depression–mortality relationship remains unknown, so the claim's causal wording is stronger than the evidence. (LLM, conf=0.87)

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Research works printed but not linked: 1

  1. [38]Review Manager (RevMan) Version 5.1. 2011 Copenhagen, Denmark The Nordic Cochrane Centre, The Cochrane Collaboration

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Authors
Bartoli, F., Lillia, N., Lax, A., Crocamo, C., Mantero, V., Carrà, G., Agostoni, E., & Clerici, M.
Affiliations
  • University of Milano-Bicocca (IT)
  • Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
  • Azienda Ospedaliera San Gerardo (IT)
Corresponding author
Bartoli, Francesco
ORCID
Venue
Stroke Research and Treatment
Publisher
Wiley
Published
2013
Volume
2013
Pages
1-11
ISSN
  • 2042-0056 (ISSN-L)
  • 2090-8105
DOI
10.1155/2013/862978
PMC
PMC3606772
OpenAlex
W2028963855
Cited by
273
References
54
Citations by year
2026: 6 · 2025: 18 · 2024: 16 · 2023: 19 · 2022: 19 · 2021: 33 · 2020: 30 · 2019: 30 · 2018: 32 · 2017: 19 · 2016: 21 · 2015: 13 · 2014: 13 · 2013: 4
FWCI
2.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Stroke Research and Treatment (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
post-stroke depression, stroke, mortality, follow-up duration, functional recovery, long-term outcomes

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