The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.
Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View
Open accessAbstract
Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitro and in vivo studies for EOs and their constituents. This review also highlights in-depth various mechanisms of action of different EOs and their constituents reported in the treatment strategies for different types of cancer. The current review indicates that EOs and their constituents act by multiple pathways and mechanisms involving apoptosis, cell cycle arrest, antimetastatic and antiangiogenic, increased levels of reactive oxygen and nitrogen species (ROS/RNS), DNA repair modulation, and others to demonstrate their antiproliferative activity in the cancer cell. The effect of EOs and their constituents on tumour suppressor proteins (p53 and Akt), transcription factors (NF-κ B and AP-1), MAPK-pathway, and detoxification enzymes like SOD, catalase, glutathione peroxidase, and glutathione reductase has also been discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jemal, A., Bray, F., Center, M. M., Ferlay, J., Ward, E., & Forman, D. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,679
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 21,293
Biological effects of essential oils—A review
Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.106 · Cited by 7,929
Cellular response to oxidative stress: Signaling for suicide and survival*
Martindale, J. L., & Holbrook, N. J. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10119 · Cited by 2,297
Plants as a source of anti-cancer agents
Cragg, G. M., & Newman, D. J. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.05.011 · Cited by 2,034
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
Wang, M., Wu, W., Wu, W., Rosidi, B., Zhang, L., Wang, H., & Iliakis, G. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl840 · Cited by 820
Proceedings of the American Association for Cancer Research.
Konings, E. J. M., van den Brandt, P. A., Saris, W. H. M., Brants, H. A. M., & Goldbohm, R. A. (2001) · Cited by 764
Sarkadi, B., Homolya, L., Szakács, G., & Váradi, A. (2006) · Physiological Reviews · doi:10.1152/physrev.00037.2005 · Cited by 726
Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: An update
Soldani, C., & Scovassi, A. I. (2002) · Apoptosis · doi:10.1023/a:1016119328968 · Cited by 697
Mutation research/fundamental and molecular mechanisms of mutagenesis
Williams, K., & Sobol, R. W. (2013) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2013.04.009 · Cited by 674
Cited by
Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems
Sharifi-Rad, J., Sureda, A., Tenore, G., Daglia, M., Sharifi-Rad, M., Valussi, M., Tundis, R., Sharifi-Rad, M., Loizzo, M., Ademiluyi, A., et al. (2017) · Molecules · doi:10.3390/molecules22010070 · Cited by 889
Anticancer and antibacterial effects of a clove bud essential oil-based nanoscale emulsion system
Nirmala, M. J., Durai, L., Gopakumar, V., & Nagarajan, R. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s211047 · Cited by 94
Rajkowska, K., Nowak, A., Kunicka-Styczyńska, A., & Siadura, A. (2016) · RSC Advances · doi:10.1039/c6ra21108a · Cited by 55
Guesmi, F., Tyagi, A. K., Prasad, S., & Landoulsi, A. (2018) · Oncotarget · doi:10.18632/oncotarget.25955 · Cited by 39
Guesmi, F., Bellamine, H., & Landoulsi, A. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0107 · Cited by 27
Metadata
- Authors
- Gautam, N., Mantha, A. K., & Mittal, S.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-23
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W2041786147
- Cited by
- 288
- References
- 164
- FWCI
- 23.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View. https://app.cochat.ai/papers/10.1155/2014/154106
- The paper
- Gautam, N., Mantha, A. K., & Mittal, S. (2014). Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View. BioMed Research International. https://doi.org/10.1155/2014/154106
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
