Terpenes from essential oils and hydrolate of Teucrium alopecurus triggered apoptotic events dependent on caspases activation and PARP cleavage in human colon cancer cells through decreased protein expressions
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// Fatma Guesmi 1, 2 , Amit K. Tyagi 1 , Sahdeo Prasad 1 and Ahmed Landoulsi 2 1 Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA 2 Laboratory of Biochemistry and Molecular Biology, Faculty of Sciences of Bizerte, University of Carthage, Tunis, Tunisia Correspondence to: Fatma Guesmi, email: guesmif10@gmail.com Keywords: Teucrium alopecurus; oily fractions; water soluble fractions; human colon cancer cells; gene expression Received: February 23, 2018 Accepted: July 29, 2018 Published: August 17, 2018 ABSTRACT This study focused on characterizing the Hydrophobic and Hydrophilic fractions of Teucrium alopecurus in the context of cancer prevention and therapy. The goal was also to elucidate the molecular mechanisms involved and to determine its efficacy against cancer by triggering apoptosis and suppressing tumorigenesis in human colon cancer. The data here clearly demonstrated that oily fractions of Teucrium alopecurus act as free radical scavengers, antibacterial agent and inhibited the proliferation of HCT-116, U266, SCC4, Panc28, KBM5, and MCF-7 cells in a time- and concentration-dependent manner. The results of live/dead and colony formation assays further revealed that Teucrium essential oil has the efficacy to suppress the growth of colon carcinoma cells. In addition, essential oil of Teucrium alopecurus induced apoptosis, as indicated by cleavage of caspases-3, -8, and -9 and poly-adenosine diphosphate ribose polymerase. Moreover, Teucrium alopecurus essential oil suppressed gene expression involved in survival, proliferation, invasion, angiogenesis, and metastasis in human colon cancer cells. No sign of toxicity was detected in vivo after treatment with increasing concentrations of essential oil. Oral administration of T.alopecurus inhibited LPS-induced colon inflammation. This anticancer property of this specie Teucrium alopecurus fractions could be due to their phenolic and/or sesquiterpene content (d-limonene, α-Bisabolol, Humulene, Thymol, and (+)-epi-Bicyclosesquiphellandrene). Hence our study reveals the anticancer activity of Teucrium alopecurus oil mediated through the suppression of cell growth, cell proliferation, and the induction of apoptosis of cancer cells. Thus, it has potential to be developed as an anticancer agent; however more in vitro and in vivo studies are warranted.
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α-Humulene demonstrated antiproliferative activity and alteration of the mitochondrial cell membrane in colon cancer cells.
“Some studies reported that α-humulene demonstrated antiproliferative activity and alteration of the mitochondrial cell membrane in colon cancer cells [14,37,42,43,44,45,46].”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [43]
The Discussion (page unavailable) reports that α-humulene was cytotoxic against HCT-116 colon cancer cells, supporting the claim of activity against those cells. It does not report that α-humulene altered the mitochondrial cell membrane; its discussion of a mitochondria-dependent apoptotic pathway does not establish that specific effect. (LLM, conf=0.86)
Experimental — accuracy not yet measuredα-Humulene has shown anti-inflammatory and antitumor activity in lung, colon, prostate, and breast cancer.
“This compound has shown anti-inflammatory and antitumor activity in lung, colon, prostate, and breast cancer.”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [43]
The Discussion (page unavailable) reports that α-humulene was cytotoxic against MCF-7 breast and HCT-116 colon cancer cell lines. It does not report α-humulene activity against lung or prostate cancer, or attribute anti-inflammatory activity specifically to α-humulene; the Introduction discusses those properties for essential oils and terpenes more broadly. (LLM, conf=0.90)
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The Anticancer Potential of Plant Essential Oils: Mechanisms, Applications, and Challenges
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Marijuana, a Journey through the Endocannabinoid System: Unmasking the Paradoxical Effect - Part 1
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Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery
Pattanaik, K. P., Behera, L., Panda, U. R., Moharana, S., Tambe, P., Tripathy, J. P., Majhi, S., Kerry, R. G., & Nayak, S. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1913688
- Authors
- Guesmi, F., Tyagi, A. K., Prasad, S., & Landoulsi, A.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- University of Carthage (TN)
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2018-08-17
- Volume
- 9
- Issue
- 64
- Pages
- 32305-32320
- ISSN
- 1949-2553 (ISSN-L)
- PMC
- PMC6122345
- OpenAlex
- W2885380697
- Cited by
- 39
- References
- 64
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 1
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Oncotarget (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- essential oils, hydrolate, terpenes, colon cancer, apoptosis, caspase activation, PARP cleavage, sesquiterpenes, anticancer activity, free radical scavenging, antibacterial activity, gene expression inhibition, cytotoxicity, D-limonene, humulene, thymol
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