Impact of weight regain on metabolic disease risk: a review of human trials.
Open accessAbstract
Dietary restriction interventions are effective for weight loss and reduction of chronic disease risk. Unfortunately, most people tend to regain much of this lost weight within one year after intervention. While some studies suggest that minor degrees of weight regain have no effect on metabolic disease risk parameters, other studies demonstrate a complete reversal in metabolic benefits. In light of these conflicting findings, it is of interest to determine how complete weight maintenance versus mild weight regain affects key risk parameters. These findings would have important clinical implications, as they could help identify a weight regain threshold that could preserve the metabolic benefits of weight loss. Accordingly, this review examined the impact of no weight regain versus mild regain on various metabolic disease risk parameters, including plasma lipids, blood pressure, glucose, and insulin concentrations, in adult subjects.
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Maintaining long-term weight loss is challenging because of metabolic adaptation and difficulty adhering to lifestyle interventions, with weight regain often following weight loss.
“Maintaining long-term weight loss is challenging because of metabolic adaptation 2 and the difficulty of adhering to lifestyle interventions, 3 with weight regain often following weight loss.4”
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- Authors
- Kroeger, C. M., Hoddy, K. K., & Varady, K. A.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Varady, Krista A.
- Venue
- Journal of Obesity
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-8
- ISSN
- 2090-0708 (ISSN-L)
- 2090-0716
- PMC
- PMC4147362
- OpenAlex
- W2157599980
- Cited by
- 55
- References
- 45
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 4 · 2015: 5 · 2014: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Obesity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Heart, Lung, and Blood Institute (1R01HL106228-01)
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- weight regain, weight loss, metabolic disease risk, dietary restriction, weight maintenance, plasma lipids, blood pressure, glucose, insulin
- MeSH terms
- Blood Glucose, Blood Pressure, Body Weight, Humans, Insulin, Lipids, Obesity, Risk Factors, Weight Gain, Weight Loss, Randomized Controlled Trials as Topic, Metabolic Syndrome
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