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Cited by 53

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm

Fleischman, Angela G.·2015·Mediators of Inflammation
DOI 10.1155/2015/606819PMC PMC4619974
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Abstract

Our understanding of inflammation’s role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An inflammatory response to the neoplastic clone may be responsible for some pathologic aspects of MPN. Moreover, JAK2V617F mutated hematopoietic stem and progenitor cells are resistant to inflammation, and this gives the neoplastic clone a selective advantage allowing for its clonal expansion. Because inflammation plays a central role in MPN inflammation is a logical therapeutic target in MPN.

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Registry

Crossref · 10.1155/2015/606819

Cites

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Statistics

Figures

Figure 1 Putative role of inflammation in shaping MPN disease phenotype.
Figure 1 Putative role of inflammation in shaping MPN disease phenotype.CC BY · PubMed Central
Figure 2 Model of inflammation as a driver of expansion of the JAK2V617F clone in MPN. JAK2V617F-mutated hematopoietic stem cells (HSC) are resistant to inflammation giving them a selective advantage in environments with high inflammation.
Figure 2 Model of inflammation as a driver of expansion of the JAK2V617F clone in MPN. JAK2V617F-mutated hematopoietic stem cells (HSC) are resistant to inflammation giving them a selective advantage in environments with high inflammation.CC BY · PubMed Central

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Metadata

Authors
Fleischman, A. G.
Venue
Mediators of Inflammation
Publisher
Wiley
Published
2015-01
Volume
2015
Issue
1
ISSN
  • 0962-9351
  • 1466-1861
DOI
10.1155/2015/606819
PMC
PMC4619974
Cited by
53
References
62
Language
en
Licence
creativecommons.org/licenses/by/3.0/ (vor, 283 d)

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Data sources

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.