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Cited by 71Alzheimer's disease research and treatmentsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease

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Siwek, Magdalena Elisabeth, Müller, Ralf, Henseler, Christina, Trog, Astrid, Lundt, Andreas, Wormuth, Carola, Broich, Karl, Ehninger, Dan +2 more·2015·Neural Plasticity
DOI 10.1155/2015/781731PMC PMC4398951
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Abstract

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by impairment of memory function. The 5XFAD mouse model was analyzed and compared with wild-type (WT) controls for aberrant cortical excitability and hippocampal theta oscillations by using simultaneous video-electroencephalogram (EEG) monitoring. Seizure staging revealed that 5XFAD mice exhibited cortical hyperexcitability whereas controls did not. In addition, 5XFAD mice displayed a significant increase in hippocampal theta activity from the light to dark phase during nonmotor activity. We also observed a reduction in mean theta frequency in 5XFAD mice compared to controls that was again most prominent during nonmotor activity. Transcriptome analysis of hippocampal probes and subsequent qPCR validation revealed an upregulation of Plcd4 that might be indicative of enhanced muscarinic signalling. Our results suggest that 5XFAD mice exhibit altered cortical excitability, hippocampal dysrhythmicity, and potential changes in muscarinic signaling.

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Authors
Siwek, M. E., Müller, R., Henseler, C., Trog, A., Lundt, A., Wormuth, C., Broich, K., Ehninger, D., Weiergräber, M., & Papazoglou, A.
Affiliations
  • Federal Institute for Drugs and Medical Devices (DE)
  • University of Cologne (DE)
  • University of Bonn (DE)
  • German Center for Neurodegenerative Diseases (DE)
Corresponding author
Weiergräber, Marco
ORCID
Venue
Neural Plasticity
Publisher
Wiley
Published
2015
Volume
2015
Pages
1-17
ISSN
  • 1687-5443 (ISSN-L)
  • 2090-5904
DOI
10.1155/2015/781731
PMC
PMC4398951
OpenAlex
W1996001613
Cited by
71
References
98
Citations by year
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FWCI
4.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Neural Plasticity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DZNE Pub (submittedVersion, other-oa)
Funders
Federal Institute for Drugs and Medical Devices
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
Alzheimer's disease, 5xFAD mice, hippocampal theta oscillations, cortical excitability, cortical hyperexcitability, circadian rhythm, theta frequency, muscarinic signaling, hippocampal transcriptome
MeSH terms
Alzheimer Disease, Animals, Cerebral Cortex, Disease Models, Animal, Electroencephalography, Female, Hippocampus, Male, Mice, Transgenic, Motor Activity, Seizures, Theta Rhythm, Gene Expression, Amyloid beta-Protein Precursor, Mice, Presenilin-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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