The DOI matches its Crossref record; 173 of the 174 references it cites were found in a registry or an index.
Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review
Open accessAbstract
Alzheimer's disease (AD), characterized by progressive dementia and deterioration of cognitive function, is an unsolved social and medical problem. Age, nutrition, and toxins are the most common causes of AD. However, currently no credible treatment is available for AD. Traditional herbs and phytochemicals may delay its onset and slow its progression and also allow recovery by targeting multiple pathological causes by antioxidative, anti-inflammatory, and antiamyloidogenic properties. They also regulate mitochondrial stress, apoptotic factors, free radical scavenging system, and neurotrophic factors. Neurotrophins such as BDNF, NGF, NT3, and NT4/5 play a vital role in neuronal and nonneuronal responses to AD. Neurotrophins depletion accelerates the progression of AD and therefore, replacing such neurotrophins may be a potential treatment for neurodegenerative disease. Here, we review the phytochemicals that mediate the signaling pathways involved in neuroprotection specifically neurotrophin-mediated activation of Trk receptors and members of p75(NTR) superfamily. We focus on representative phenolic derivatives, iridoid glycosides, terpenoids, alkaloids, and steroidal saponins as regulators of neurotrophin-mediated neuroprotection. Although these phytochemicals have attracted attention owing to their in vitro neurotrophin potentiating activity, their in vivo and clinical efficacy trials has yet to be established. Therefore, further research is necessary to prove the neuroprotective effects in preclinical models and in humans.
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“such evidence allows us to project a scenario where AD could have possible preventive treatments and/or have a slowing palliative effect in patients who already suffer from it [73,74,75].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [74]
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Metadata
- Authors
- Venkatesan, R., Ji, E., & Kim, S. Y.
- Affiliations
- Gachon University (KR)
- Corresponding author
- Kim, Sun Yeou
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-22
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC4446472
- OpenAlex
- W2136484866
- Cited by
- 212
- References
- 174
- Citations by year
- 2026: 21 · 2025: 35 · 2024: 15 · 2023: 23 · 2022: 14 · 2021: 21 · 2020: 12 · 2019: 15 · 2018: 17 · 2017: 18 · 2016: 17 · 2015: 4
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Korean government (NRF-2014M3A9B6069338)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- Alzheimer's disease, phytochemicals, neurotrophins, neuroprotection, Trk receptors, p75 neurotrophin receptor, brain-derived neurotrophic factor, nerve growth factor, neurotrophin-3, iridoid glycosides, terpenoids, alkaloids, steroidal saponins, phenolic compounds, neurodegenerative diseases, mitochondrial stress, apoptosis, oxidative stress, anti-inflammatory activity
- MeSH terms
- Alzheimer Disease, Animals, Humans, Phytotherapy, Plants, Medicinal, Polysaccharides, Plant Preparations
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