Cited by 212Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsNerve injury and regeneration

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Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review

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Venkatesan, Ramu, Ji, Eunhee, Kim, Sun Yeou·2015·BioMed Research International

DOI 10.1155/2015/814068PMC PMC4446472

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Abstract

Alzheimer's disease (AD), characterized by progressive dementia and deterioration of cognitive function, is an unsolved social and medical problem. Age, nutrition, and toxins are the most common causes of AD. However, currently no credible treatment is available for AD. Traditional herbs and phytochemicals may delay its onset and slow its progression and also allow recovery by targeting multiple pathological causes by antioxidative, anti-inflammatory, and antiamyloidogenic properties. They also regulate mitochondrial stress, apoptotic factors, free radical scavenging system, and neurotrophic factors. Neurotrophins such as BDNF, NGF, NT3, and NT4/5 play a vital role in neuronal and nonneuronal responses to AD. Neurotrophins depletion accelerates the progression of AD and therefore, replacing such neurotrophins may be a potential treatment for neurodegenerative disease. Here, we review the phytochemicals that mediate the signaling pathways involved in neuroprotection specifically neurotrophin-mediated activation of Trk receptors and members of p75(NTR) superfamily. We focus on representative phenolic derivatives, iridoid glycosides, terpenoids, alkaloids, and steroidal saponins as regulators of neurotrophin-mediated neuroprotection. Although these phytochemicals have attracted attention owing to their in vitro neurotrophin potentiating activity, their in vivo and clinical efficacy trials has yet to be established. Therefore, further research is necessary to prove the neuroprotective effects in preclinical models and in humans.

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Authors: Venkatesan, R., Ji, E., & Kim, S. Y.
Affiliations: Gachon University (KR)
Corresponding author: Kim, Sun Yeou
ORCID: Venkatesan, Ramu
Ji, Eunhee
Kim, Sun Yeou
Venue: BioMed Research International
Publisher: Wiley
Published: 2015
Volume: 2015
Pages: 1-22
ISSN: 1110-7243 (ISSN-L)
2314-6133
2314-6141
DOI: 10.1155/2015/814068
PMC: PMC4446472
OpenAlex: W2136484866
Cited by: 212
References: 174
Citations by year: 2026: 21 · 2025: 35 · 2024: 15 · 2023: 23 · 2022: 14 · 2021: 21 · 2020: 12 · 2019: 15 · 2018: 17 · 2017: 18 · 2016: 17 · 2015: 4
FWCI: 4.47
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: BioMed Research International (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Korean government (NRF-2014M3A9B6069338)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: Alzheimer's disease, phytochemicals, neurotrophins, neuroprotection, Trk receptors, p75 neurotrophin receptor, brain-derived neurotrophic factor, nerve growth factor, neurotrophin-3, iridoid glycosides, terpenoids, alkaloids, steroidal saponins, phenolic compounds, neurodegenerative diseases, mitochondrial stress, apoptosis, oxidative stress, anti-inflammatory activity
MeSH terms: Alzheimer Disease, Animals, Humans, Phytotherapy, Plants, Medicinal, Polysaccharides, Plant Preparations

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Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review

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