The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology
Open accessAbstract
Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata , Smilax China, and Trigonella foenum graecum . This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the treatment of various types of disorders such as cancer, hypercholesterolemia, inflammation, and several types of infections. Due to its pharmacological and industrial importance, several extraction and analytical procedures have been developed and applied over the years to isolate, detect, and quantify diosgenin, not only in its natural sources and pharmaceutical compositions, but also in animal matrices for pharmacodynamic, pharmacokinetic, and toxicological studies. Within these, HPLC technique coupled to different detectors is the most commonly analytical procedure described for this compound. However, other alternative methods were also published. Thus, the present review aims to provide collective information on the most recent pharmacological data on diosgenin and on the most relevant analytical techniques used to isolate, detect, and quantify this compound as well.
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“Following the promising effects of 20E, the phytosteroid DSG, found in fenugreek and yams, has also attracted considerable attention for its potential therapeutic and performance-enhancing properties [42].”
From How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study (2025) · cites this paper as [42]
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Cites
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- 10.1007/s13659-012-0014-3 · DOI
- 2013, American Pharmaceutical Review, 16, 36
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The Dioscorea Genus (Yam)—An Appraisal of Nutritional and Therapeutic Potentials
Obidiegwu, J. E., Lyons, J. B., & Chilaka, C. A. (2020) · Foods · doi:10.3390/foods9091304 · Cited by 288
Suresh, J., Pradheesh, G., Alexramani, V., Sundrarajan, M., & Hong, S. I. (2018) · Advances in Natural Sciences Nanoscience and Nanotechnology · doi:10.1088/2043-6254/aaa6f1 · Cited by 254
Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review
Sethi, G., Shanmugam, M. K., Warrier, S. R., Mérarchi, M., Arfuso, F., Kumar, A. P., & Bishayee, A. (2018) · Nutrients · doi:10.3390/nu10050645 · Cited by 254
Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants
Christ, B., Xu, C., Xu, M., Li, F., Wada, N., Mitchell, A. J., Han, X., Wen, M., Fujita, M., & Weng, J. (2019) · Nature Communications · doi:10.1038/s41467-019-11286-7 · Cited by 204
Singh, A. K., Singh, D. K., Kharwar, R. N., White, J. F., & Gond, S. K. (2021) · Microorganisms · doi:10.3390/microorganisms9010197 · Cited by 198
Metadata
- Authors
- Jesus, M., Martins, A. P. J., Gallardo, E., & Silvestre, S.
- Affiliations
- University of Beira Interior (PT)
- CICS-UBI, Health Sciences Research Centre, Universidade da Beira Interior, Covilhã, Portugal
- Corresponding author
- Silvestre, Samuel
- Venue
- Journal of Analytical Methods in Chemistry
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-16
- ISSN
- 2090-8865 (ISSN-L)
- 2090-8873
- PMC
- PMC5225340
- OpenAlex
- W2562710635
- Cited by
- 273
- References
- 124
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 44 · 2023: 44 · 2022: 41 · 2021: 34 · 2020: 26 · 2019: 29 · 2018: 15 · 2017: 2 · 2016: 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Analytical Methods in Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- POCI (POCI-01-0145-FEDER-007491, UID/Multi/00709/2013)
- COMPETE 2020 (POCI-01-0145-FEDER-007491, UID/Multi/00709/2013)
- Operational Programme Competitiveness and Internationalisation in Axis I (POCI-01-0145-FEDER-007491, UID/Multi/00709/2013)
- Strengthening Research (POCI-01-0145-FEDER-007491, UID/Multi/00709/2013)
- Technological Development and Innovation (POCI-01-0145-FEDER-007491, UID/Multi/00709/2013)
- Fundação para a Ciência e a Tecnologia (POCI-01-0145-FEDER-007491, UID/Multi/00709/2013)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
- Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
- Keywords
- diosgenin, pharmacology, analytical methods, HPLC, phytochemicals, extraction, quantification, pharmacokinetics, toxicology, cancer, hypercholesterolemia, inflammation, infection
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