Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Saponins as cytotoxic agents: a review

Podolak, I., Galanty, A., & Sobolewska, D. (2010) · Phytochemistry Reviews · doi:10.1007/s11101-010-9183-z · Cited by 718

Extraction and quantification of saponins: A review

Cheok, C. Y., Salman, H. A. K., & Sulaiman, R. (2014) · Food Research International · doi:10.1016/j.foodres.2014.01.057 · Cited by 450

Anticancer steroids: linking natural and semi-synthetic compounds

Salvador, J. A. R., Carvalho, J. F. S., Neves, M. A. C., Silvestre, S., Leitão, A. J., Silva, M. M., & Melo, M. L. S. E. (2012) · Natural Product Reports · doi:10.1039/c2np20082a · Cited by 283

Antioxidative and Hypolipidemic Effects of Diosgenin, a Steroidal Saponin of Yam (Dioscorea spp.), on High-Cholesterol Fed Rats

Son, I. S., Kim, J. H., Sohn, H. Y., Son, K. H., Kim, J., & Kwon, C.-S. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70472 · Cited by 243

Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression

Chen, P.-S., Shih, Y., Huang, H.-C., & Cheng, H.-W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020164 · Cited by 225

Antifungal Activity of C-27 Steroidal Saponins

Yang, C.-R., Zhang, Y., Jacob, M. R., Khan, S. I., Zhang, Y.-J., & Li, X.-C. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.5.1710-1714.2006 · Cited by 221

High-performance thin layer chromatography: A powerful analytical technique in pharmaceutical drug discovery

Attimarad, M., Ahmed, K. M., Al‐Dhubiab, B. E., & Sreeharsha, N. (2011) · Pharmaceutical Methods · doi:10.4103/2229-4708.84436 · Cited by 211

Cancer Chemopreventive and Therapeutic Effects of Diosgenin, a Food Saponin

Raju, J., & Mehta, R. (2009) · Nutrition and Cancer · doi:10.1080/01635580802357352 · Cited by 210

Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells

Li, F., Fernandez, P. P., Rajendran, P., Hui, K. M., & Sethi, G. (2010) · Cancer Letters · doi:10.1016/j.canlet.2009.12.003 · Cited by 207

Cancer cell signaling pathways targeted by spice-derived nutraceuticals

Sung, B., Prasad, S., Yadav, V. R., & Aggarwal, B. B. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.630551 · Cited by 204

The Dioscorea Genus (Yam)—An Appraisal of Nutritional and Therapeutic Potentials

Obidiegwu, J. E., Lyons, J. B., & Chilaka, C. A. (2020) · Foods · doi:10.3390/foods9091304 · Cited by 288

Green synthesis and characterization of zinc oxide nanoparticle using insulin plant ( Costus pictus D. Don ) and investigation of its antimicrobial as well as anticancer activities

Suresh, J., Pradheesh, G., Alexramani, V., Sundrarajan, M., & Hong, S. I. (2018) · Advances in Natural Sciences Nanoscience and Nanotechnology · doi:10.1088/2043-6254/aaa6f1 · Cited by 254

Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review

Sethi, G., Shanmugam, M. K., Warrier, S. R., Mérarchi, M., Arfuso, F., Kumar, A. P., & Bishayee, A. (2018) · Nutrients · doi:10.3390/nu10050645 · Cited by 254

Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants

Christ, B., Xu, C., Xu, M., Li, F., Wada, N., Mitchell, A. J., Han, X., Wen, M., Fujita, M., & Weng, J. (2019) · Nature Communications · doi:10.1038/s41467-019-11286-7 · Cited by 204

Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and Challenges

Singh, A. K., Singh, D. K., Kharwar, R. N., White, J. F., & Gond, S. K. (2021) · Microorganisms · doi:10.3390/microorganisms9010197 · Cited by 198

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Semwal, P., Painuli, S., Abu-Izneid, T., Rauf, A., Sharma, A., Daştan, S. D., Kumar, M., Alshehri, M. M., Taheri, Y., Das, R., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1035441 · Cited by 195

An underutilized orphan tuber crop—Chinese yam : a review

Epping, J., & Laibach, N. (2020) · Planta · doi:10.1007/s00425-020-03458-3 · Cited by 174

Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases

Parama, D., Boruah, M., Yachna, K., Rana, V., Banik, K., Harsha, C., Thakur, K. K., Dutta, U., Arya, A., Mao, X., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118182 · Cited by 155

Green synthesis and characterization of hexagonal shaped MgO nanoparticles using insulin plant ( Costus pictus D. Don) leave extract and its antimicrobial as well as anticancer activity

Suresh, J., Pradheesh, G., Alexramani, V., Sundrarajan, M., & Hong, S. I. (2018) · Advanced Powder Technology · doi:10.1016/j.apt.2018.04.003 · Cited by 131

Potential compound from herbal food of Rhizoma Polygonati for treatment of COVID-19 analyzed by network pharmacology: Viral and cancer signaling mechanisms

Mu, C., Sheng, Y., Wang, Q., Amin, A., Li, X., & Xie, Y. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104149 · Cited by 127

Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances

Cai, B., Zhang, Y., Wang, Z., Xu, D., Jia, Y., Guan, Y., Liao, A., Liu, G., Chun, C., & Li, J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3153082 · Cited by 124

The role of diosgenin in diabetes and diabetic complications

Gan, Q., Wang, J., Hu, J., Lou, G., Xiong, H., Peng, C., Zheng, S., & Huang, Q. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105575 · Cited by 119

Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research

Passos, F. R. S., Araújo-Filho, H. G., Monteiro, B. S., Shanmugam, S., Araújo, A. A. D. S., Almeida, J. R. G. D. S., Thangaraj, P., Quintans‐Júnior, L. J., & Quintans, J. D. S. S. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153842 · Cited by 114

The origin and evolution of the diosgenin biosynthetic pathway in yam

Cheng, J. G., Chen, J., Liu, X., Li, X., Zhang, W., Dai, Z., Lu, L., Zhou, X., Cai, J., Zhang, X., et al. (2020) · Plant Communications · doi:10.1016/j.xplc.2020.100079 · Cited by 89

Diosgenin-loaded niosome as an effective phytochemical nanocarrier: physicochemical characterization, loading efficiency, and cytotoxicity assay

Hajizadeh, M. R., Parvaz, N., Barani, M., Khoshdel, A., Fahmidehkar, M. A., Mahmoodi, M., & Torkzadeh‐Mahani, M. (2019) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-019-00277-0 · Cited by 74

Dioscorea Plants: A Genus Rich in Vital Nutra-pharmaceuticals-A Review.

Salehi, B., Şener, B., Kılıç, M., Sharifi‐Rad, J., Naz, R., Yousaf, Z., Mudau, F. N., Fokou, P. V. T., Ezzat, S. M., Bishbishy, M. H. E., et al. (2019) · PubMed Central · doi:10.22037/ijpr.2019.112501.13795 · Cited by 71

Evaluation of antioxidant, anti-inflammatory and anticancer activities of diosgenin enriched Paris polyphylla rhizome extract of Indian Himalayan landraces

Gupta, D. D., Mishra, S., Verma, S. S., Shekher, A., Rai, V., Awasthee, N., Das, T. J., Paul, D., Das, S. K., Tag, H., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113842 · Cited by 64

Cardiotoxicity of doxorubicin-based cancer treatment: What is the protective cognition that phytochemicals provide us?

Liu, C., Ma, X., Zhuang, J., Liu, L., & Sun, C. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105062 · Cited by 61

Highly Selective Sensing Platform Utilizing Graphene Oxide and Multiwalled Carbon Nanotubes for the Sensitive Determination of Tramadol in the Presence of Co‐Formulated Drugs

Mohamed, M. A., Atty, S. A., Salama, N. N., & Banks, C. E. (2016) · Electroanalysis · doi:10.1002/elan.201600668 · Cited by 60

Synthesis and Characterization of Diosgenin Encapsulated Poly-ε-Caprolactone-Pluronic Nanoparticles and Its Effect on Brain Cancer Cells

Rabha, B., Bharadwaj, K. K., Baishya, D., Sarkar, T., Edinur, H. A., & Pati, S. (2021) · Polymers · doi:10.3390/polym13081322 · Cited by 58

Potato Glycoalkaloids: occurrence, biological activities and extraction for biovalorisation – a review

Benkeblia, N. (2019) · International Journal of Food Science & Technology · doi:10.1111/ijfs.14330 · Cited by 55

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Hu, Y., Chen, X., Hu, M., Zhang, D., Yuan, S., Li, P., & Feng, L. (2022) · Chinese Medicine · doi:10.1186/s13020-022-00666-9 · Cited by 61

A synthetic diosgenin primary amine derivative attenuates LPS-stimulated inflammation via inhibition of NF-κB and JNK MAPK signaling in microglial BV2 cells

Cai, B., Seong, K.-J., Bae, S., Chun, C., Kim, W.-J., & Jung, J. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.05.021 · Cited by 56

The Emerging Role of Natural Products in Cancer Treatment

Ghosh, S., Das, S., Sinha, K., Ghosh, B., Sen, K., Ghosh, N., & Sil, P. C. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03786-3 · Cited by 54

Comprehensive review on natural pharmacophore tethered 1,2, 3‐triazoles as active pharmaceuticals

Rammohan, A., Venkatesh, B. C., Basha, N. M., Zyryanov, G. V., & Nageswararao, M. (2022) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14148 · Cited by 51

Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins

Sobolewska, D., Galanty, A., Grabowska, K., Makowska‐Wąs, J., Wróbel‐Biedrawa, D., & Podolak, I. (2020) · Phytochemistry Reviews · doi:10.1007/s11101-020-09661-0 · Cited by 53

Ethnomedicobotanical study of indigenous knowledge on medicinal plants used for the treatment of reproductive problems in Nalbari district, Assam, India

Adhikari, P. P., Talukdar, S., & Borah, A. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.07.024 · Cited by 52

Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications

Alu'datt, M. H., Rababah, T., Al‐ali, S., Tranchant, C. C., Gammoh, S., Alrosan, M., Kubow, S. J., Tan, T., & Ghatasheh, S. (2024) · Journal of Food Science · doi:10.1111/1750-3841.16970 · Cited by 51

Assessment of behavioral changes and antitumor effects of silver nanoparticles synthesized using diosgenin in mice model

Rajadurai, U. M., Hariharan, A., Siva, D., Ameén, F., Dawoud, T. M. S., Alwakeel, S., Palanivel, I., Prabha, A. L., & Jacob, J. A. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102766 · Cited by 50

Diosgenin: Chemistry, extraction, quantification and health benefits

Arya, P., Munshi, M., & Kumar, P. (2022) · Food Chemistry Advances · doi:10.1016/j.focha.2022.100170 · Cited by 50

Diosgenin and Its Analogs: Potential Protective Agents Against Atherosclerosis

Wang, D., & Wang, X. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s368836 · Cited by 47

The greater yam (Dioscorea alata L.): A review of its phytochemical content and potential for processed products and biofortification

Lebot, V., Lawac, F., & Legendre, L. (2022) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2022.104987 · Cited by 49

The effect of propolis plus Hyoscyamus niger L. methanolic extract on clinical symptoms in patients with acute respiratory syndrome suspected to COVID ‐19: A clinical trial

Kosari, M., Noureddini, M., Khamechi, S. P., Najafi, A., Ghaderi, A., Sehat, M., & Banafshe, H. R. (2021) · Phytotherapy Research · doi:10.1002/ptr.7116 · Cited by 48

Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway

Chen, S., Sun, S., Feng, Y., Li, X., Yin, G., Liang, P., Yu, W., Meng, D., Zhang, X., Liu, H., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175808 · Cited by 45

Phytomedicines Used for Diabetes Mellitus in Ghana: A Systematic Search and Review of Preclinical and Clinical Evidence

Adinortey, M. B., Agbeko, R., Boison, D., Ekloh, W., Kuatsienu, L. E., Biney, E. E., Affum, O. O., Kwarteng, J., & Nyarko, A. K. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/6021209 · Cited by 47

Cerebroprotection by dioscin after experimental subarachnoid haemorrhage via inhibiting NLRP3 inflammasome through SIRT1‐dependent pathway

Zhang, X., Lu, Y., Li, W., Tao, T., Wang, W., Gao, S., Zhou, Y., Guo, Y., Liu, C., Zhuang, Z., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15507 · Cited by 44

Targeting transforming growth factor‐ß signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin

Tewari, D., Priya, A., Bishayee, A., & Bishayee, A. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.795 · Cited by 46

LC-MS/MS and GC-MS Identification of Metabolites from the Selected Herbs and Spices, Their Antioxidant, Anti-Diabetic Potential, and Chemometric Analysis

Kiani, H. S., Ali, B., Al‐Sadoon, M. K., Al-Otaibi, H. S., & Ali, A. (2023) · Processes · doi:10.3390/pr11092721 · Cited by 42

Comparative Transcriptome Analysis Identifies Putative Genes Involved in Dioscin Biosynthesis in Dioscorea zingiberensis

Li, J., Liang, Q., Li, C., Liu, M., & Zhang, Y. (2018) · Molecules · doi:10.3390/molecules23020454 · Cited by 38

Ophiopogonin D′, a Natural Product From Radix Ophiopogonis, Induces in Vitro and in Vivo RIPK1-Dependent and Caspase-Independent Apoptotic Death in Androgen-Independent Human Prostate Cancer Cells

Lu, Z., Wang, H., Zhu, M., Song, W., Wang, J., Wu, C.-P., Kong, Y., Guo, J., Li, N., Liu, J., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00432 · Cited by 37

Recent developments in the enzymatic modifications of steroid scaffolds

Wang, H., & Abe, I. (2024) · Organic & Biomolecular Chemistry · doi:10.1039/d4ob00327f · Cited by 36

Recent Advances in Metabolites from Medicinal Plants in Cancer Prevention and Treatment

Mir, M. A., Hamdani, S. S., Sheikh, B. A., & Mehraj, U. (2019) · Current Immunology Reviews · doi:10.2174/1573395515666191102094330 · Cited by 35

Diosgenin a steroidal compound: An emerging way to cancer management

Arya, P., & Kumar, P. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.14005 · Cited by 38

Diosgenin and Its Fenugreek Based Biological Matrix Affect Insulin Resistance and Anabolic Hormones in a Rat Based Insulin Resistance Model

Kiss, R., Pesti‐Asbóth, G., Szarvas, M. M., Stündl, L., Cziáky, Z., Hegedűs, C., Kovács, D. K., Badale, A., Máthé, E., Szilvássy, Z., et al. (2019) · BioMed Research International · doi:10.1155/2019/7213913 · Cited by 34

Exploring the medicinally important secondary metabolites landscape through the lens of transcriptome data in fenugreek (Trigonella foenum graecum L.)

Naika, M. B. N., Sathyanarayanan, N., Sajeevan, R. S., Bhattacharyya, T., Ghosh, P., Iyer, M., Mahita, J., Joshi, A. G., Harini, K., Shafi, K. M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-17779-8 · Cited by 34

Diosgenin protects retinal pigment epithelial cells from inflammatory damage and oxidative stress induced by high glucose by activating AMPK/Nrf2/HO‐1 pathway

Yang, H., & Gao, X. (2022) · Immunity Inflammation and Disease · doi:10.1002/iid3.698 · Cited by 34

Endophytic sources of diosgenin, a natural steroid with multiple therapeutic values

Biswas, D., Nazir, R., Biswas, P., Kumar, V., Nandy, S., Mukherjee, A., Dey, A., & Pandey, D. K. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.04.009 · Cited by 33

Elevated expression of diosgenin-related genes and stimulation of the defense system in Trigonella foenum-graecum (Fenugreek) by cold plasma treatment

Ebrahimibasabi, E., Ebrahimi, A., Momeni, M., & Amerian, M. R. (2020) · Scientia Horticulturae · doi:10.1016/j.scienta.2020.109494 · Cited by 33

Simultaneous quantification of allantoin and steroidal saponins in yam (Dioscorea spp.) powders

Lebot, V., Faloye, B., Okon, E. U., & Guèye, B. (2019) · Journal of Applied Research on Medicinal and Aromatic Plants · doi:10.1016/j.jarmap.2019.02.001 · Cited by 32

Regulation of reactive oxygen species by phytochemicals for the management of cancer and diabetes

Lim, H. M., & Park, S. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2025574 · Cited by 31

Metabolome Profiling of Eight Chinese Yam (Dioscorea polystachya Turcz.) Varieties Reveals Metabolite Diversity and Variety Specific Uses

Zeng, X., Liu, D., & Huang, L. (2021) · Life · doi:10.3390/life11070687 · Cited by 29

Mechanistic inhibition of gastric cancer-associated bacteria Helicobacter pylori by selected phytocompounds: A new cutting-edge computational approach

Akash, S., Bayıl, İ., Mahmood, S., Mukerjee, N., Mili, T. A., Dhama, K., Rahman, M. A., Maitra, S., Mohany, M., Al-Rejaie, S. S., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20670 · Cited by 29

Assessing Therapeutic Value and Side Effects of Key Botanical Compounds for Optimized Medical Treatments

Al‐Shuhaib, M. B. S., & Al‐Shuhaib, J. M. B. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401754 · Cited by 29

A Network Pharmacology Approach to Uncover the Mechanisms of Shen‐Qi‐Di‐Huang Decoction against Diabetic Nephropathy

Di, S., Han, L., Wang, Q., Liu, X., Yang, Y., Li, F., Zhao, L., & Tong, X. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/7043402 · Cited by 28

Nephroprotective role of diosgenin in gentamicin-induced renal toxicity: biochemical, antioxidant, immunological and histopathological approach

Mishra, P., Mandlik, D. S., Arulmozhi, S., & Mahadik, K. R. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-021-00318-z · Cited by 28

Exploring the potential of diosgenin as a promising antitumor agent through comprehensive spectroscopic characterization, solvent–solute interactions, topological properties, Hirshfeld surface, and molecular docking interactions with 2NZT and 2I1V proteins

Kumar, A. R., Selvaraj, S., Vickram, A. S., Mol, G. P. S., Awasthi, S., Thirunavukkarasu, M., Selvaraj, M., & Basumatary, S. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.125349 · Cited by 27

An Antivirulence Approach for Preventing Cryptococcus neoformans from Crossing the Blood-Brain Barrier via Novel Natural Product Inhibitors of a Fungal Metalloprotease

Aaron, P. A., Vu, K., & Gelli, A. (2020) · mBio · doi:10.1128/mbio.01249-20 · Cited by 27

Diosgenin Loaded Polymeric Nanoparticles with Potential Anticancer Efficacy

Sharma, N., Singhal, M., Kumari, R. M., Gupta, N., Manchanda, R., Syed, A., Bahkali, A. H., & Nimesh, S. (2020) · Biomolecules · doi:10.3390/biom10121679 · Cited by 27

Diosgenin Modulates Oxidative Stress and Inflammation in High-Fat Diet-Induced Obesity in Mice

Khateeb, S., Albalawi, A. E., & Alkhedaide, A. Q. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s355677 · Cited by 27

Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis

Cai, D., Qi, J., Yang, Y., Zhang, W., Zhou, F., Jia, X., Guo, W., Huang, X., Gao, F., Chen, H., et al. (2019) · Molecules · doi:10.3390/molecules24224025 · Cited by 26

Costus afer: A Systematic Review of Evidence-Based Data in support of Its Medicinal Relevance

Boison, D., Adinortey, C. A., Babanyinah, G. K., Quasie, O., Agbeko, R., Wiabo-Asabil, G. K., & Adinortey, M. B. (2019) · Scientifica · doi:10.1155/2019/3732687 · Cited by 26

Diosgenin increased DDX3 expression in hepatocellular carcinoma.

Yu, H., Liu, Y., Niu, C., & Cheng, Y. (2018) · Europe PMC (PubMed Central) · Cited by 26

Cheilocostus speciosus extract-assisted naringenin-encapsulated poly-ε-caprolactone nanoparticles: evaluation of anti-proliferative activities

Rabha, B., Bharadwaj, K. K., Boro, N., Ghosh, A., Gogoi, S. K., Varma, R. S., & Baishya, D. (2021) · Green Chemistry · doi:10.1039/d1gc02260a · Cited by 25

Fabrication and Assessment of Diosgenin Encapsulated Stearic Acid Solid Lipid Nanoparticles for Its Anticancer and Antidepressant Effects Using in vitro and in vivo Models

Khan, H., Nazir, S., Farooq, R. K., Khan, I. N., & Javed, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.806713 · Cited by 29

Switchgrass Metabolomics Reveals Striking Genotypic and Developmental Differences in Specialized Metabolic Phenotypes

Li, X., Sarma, S. J., Sumner, L. W., Jones, A. D., & Last, R. L. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01306 · Cited by 24

Fenugreek derived diosgenin as an emerging source for diabetic therapy

Tak, Y., Kaur, M., Chitranashi, A., Samota, M. K., Verma, P., Bali, M., & Kumawat, C. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1280100 · Cited by 31

Diosgenin: an important natural pharmaceutical active ingredient

Huang, N., Yu, D., Wu, J., & Du, X.-W. (2021) · Food Science and Technology · doi:10.1590/fst.94521 · Cited by 24

An update on the biological and pharmacological activities of diosgenin

Kim, J. K., & Park, S. U. (2018) · EXCLI journal · doi:10.17179/excli2017-894 · Cited by 24

Use of genome editing technologies for genetic improvement of crops of tropical origin

Rojas-Vásquez, R., & Gatica-Arias, A. (2019) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-019-01707-2 · Cited by 23

Effects of diosgenin on the skeletal system in rats with experimental type 1 diabetes

Londzin, P., Kisiel-Nawrot, E., Kocik, S., Janas, A., Trawczyński, M., Cegieła, U., & Folwarczna, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110342 · Cited by 23

Pharmacokinetic Profile and Oral Bioavailability of Diosgenin, Charantin, and Hydroxychalcone From a Polyherbal Formulation

Salunkhe, R., Gadgoli, C. H., Naik, A. A., & Patil, N. S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.629272 · Cited by 22

Diosgenin protects against alveolar bone loss in ovariectomized rats via regulating long non‑coding RNAs

Zhang, Z., Chen, Y., Xiang, L., Wang, Z., Xiao, G. G., & Ju, D. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6681 · Cited by 22

Diosgenin exerts its tumor suppressive function via inhibition of Cdc20 in osteosarcoma cells

Long, C., Chen, J., Zhou, H., Jiang, T., Fang, X., Hou, D., Liu, P., & Duan, H. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1568748 · Cited by 22

Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review

Iweala, E., Adurosakin, O. E., Ugochukwu, I., Omonhinmin, C. A., Dania, O. E., & Ugbogu, E. A. (2024) · Sci · doi:10.3390/sci6020036 · Cited by 21

Yam as functional food: bioactive properties, health benefits, and applications

Tareen, M. B. K., Saeed, N., Sultan, M., Chen, X., Li, J., & Yan, S. (2025) · Food, Nutrition and Health. · doi:10.1007/s44403-025-00022-3 · Cited by 21

Development of HP-TLC method for rapid quantification of sugars, catechins, phenolic acids and saponins to assess Yam (Dioscorea spp.) tuber flour quality

Lebot, V., Malapa, R., & Molisalé, T. (2018) · Plant Genetic Resources · doi:10.1017/s1479262118000333 · Cited by 21

Plant based steroidal and triterpenoid sapogenins: Chemistry on diosgenin and biological aspects

Pathak, N., & Negi, A. S. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116915 · Cited by 20

The phytoestrogen, diosgenin, directly stimulates ovarian cell functions in two farm animal species

Sirotkin, A. V., Alexa, R., Alwasel, S. H., & Harrath, A. H. (2019) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2019.04.002 · Cited by 20

Antidiabetic activity of root tubers of Asparagus gonoclados Baker in streptozotocin induced diabetic rats

Rajasekhar, A., Peddanna, K., Vedasree, N., Munirajeswari, P., Nagaraju, N., Badri, K. R., & Chippada, A. R. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112027 · Cited by 20

Peptidases: promising antifungal targets of the human fungal pathogen, Cryptococcus neoformans

Gutierrez‐Gongora, D., & Geddes‐McAlister, J. (2022) · FACETS · doi:10.1139/facets-2021-0157 · Cited by 22

Diosgenin, a steroidal sapogenin, arrests arthritis through modulation of inflammatory cytokines and oxidative stress biomarkers in Wistar rats

Javed, M., Saleem, A., & Akhtar, M. F. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01244-7 · Cited by 19

Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-α by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1

Yang, W. S., Moon, S. Y., Lee, M. J., Lee, E. K., & Park, S.-K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484396 · Cited by 19

Health Benefits of Bioactive Compounds from Vegetables

Rashmi, H. B., & Negi, P. S. (2020) · Springer eBooks · doi:10.1007/978-981-15-1761-7_5 · Cited by 19

Diosgenin prevents periodontitis by inhibiting inflammation and promoting osteogenic differentiation

Cong, S., Peng, Q., Cao, L., Yi, Q., Liu, Y., Li, L., Tong, Q., & Liang, D. (2023) · Oral Diseases · doi:10.1111/odi.14708 · Cited by 18

Pharmacologically active compounds from latex-bearing plants

Warowicka, A., Nawrot, R., & Goździcka‐Józefiak, A. (2019) · Advances in botanical research · doi:10.1016/bs.abr.2019.11.002 · Cited by 20

Characterization of the interaction of diosgenin with human serum albumin and α1-acid glycoprotein using biophysical and bioinformatic tools

Bakar, K. A., Lam, S. D., Sidek, H. M., & Feroz, S. R. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.112865 · Cited by 17

CURRENT HIGHLIGHTS ON BIOCHEMICAL AND PHARMACOLOGICAL PROFILE OF DIOSCOREA ALATA : A REVIEW

Kaur, B., Khatun, S., & Suttee, A. (2021) · PLANT ARCHIVES · doi:10.51470/plantarchives.2021.v21.s1.085 · Cited by 17

Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

Zhao, H., Zhang, X., Zhang, B., & Qu, X. (2021) · Open Life Sciences · doi:10.1515/biol-2021-0075 · Cited by 17

Phytochemical Profiling of Tupistra nutans Wall. ex Lindl. Inflorescence Extract and Evaluation of Its Antioxidant Activity and Toxicity in Hepatocarcinoma (HepG2) and Fibroblast (F111) Cells

Roy, A. C., Prasad, A., & Ghosh, I. (2022) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-022-04145-7 · Cited by 19

Therapeutic potential and research progress of diosgenin for lipid metabolism diseases

Zhang, S., Liang, P., Feng, Y., Yin, G., Sun, F., Ma, C., & Zhang, F. (2022) · Drug Development Research · doi:10.1002/ddr.21991 · Cited by 18

Terpenes

Xavier, V., Spréa, R. M., Finimundy, T. C., Heleno, S. A., Amaral, J. S., Barros, L., & Ferreira, I. C. F. R. (2023) · Springer eBooks · doi:10.1007/978-3-031-18587-8_5 · Cited by 20

Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy

Mori, A., Ishikawa, K., Saiki, S., Hatano, T., Oji, Y., Okuzumi, A., Fujimaki, M., Koinuma, T., Ueno, S., Imamichi, Y., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223113 · Cited by 17

Comparative bioactivity analysis of hydro-methanolic extracts of root, leaf, and inflorescence of Tupistra nutans Wall. ex Lindl: An in vitro study on antioxidant and anti-hepatocellular carcinoma activity

Roy, A. C., Prasad, A., Singh, S., Priya, K., & Ghosh, I. (2023) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2023.102819 · Cited by 16

Diosgenin Supplementation Prevents Lipid Accumulation and Induces Skeletal Muscle-Fiber Hypertrophy in Rats

Kusano, Y., Tsujihara, N., Masui, H., Shibata, T., Uchida, K., & TAKEUCHI, W. (2019) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.65.421 · Cited by 16

Diversified synthesis and α-selective glycosylation of 3-amino-2,3,6-trideoxy sugars

Zeng, J., Wang, R., Yao, W., Zhang, S., Sun, G., Liao, Z., Meng, L., & Wan, Q. (2018) · Organic Chemistry Frontiers · doi:10.1039/c8qo00948a · Cited by 16

Southern African Soap Plants and Screening of Selected Phytochemicals and Quantitative Analysis of Saponin Content

Mohlakoana, M., & Moteetee, A. N. (2021) · Resources · doi:10.3390/resources10100096 · Cited by 15

Identification of the Natural Steroid Sapogenin Diosgenin as a Direct Dual-Specific RORα/γ Inverse Agonist

Schwarz, P. F., Perhal, A. F., Schöberl, L. N., Kraus, M. M., Kirchmair, J., & Dirsch, V. M. (2022) · Biomedicines · doi:10.3390/biomedicines10092076 · Cited by 16

Diosgenin content is a novel criterion to assess memory enhancement effect of yam extracts

Yang, X., Nomoto, K., & Tohda, C. (2020) · Journal of Natural Medicines · doi:10.1007/s11418-020-01451-4 · Cited by 15

Bioactive components to inhibit foam cell formation in atherosclerosis

Singh, S., Changkija, S., Mudgal, R. K., & Ravichandiran, V. (2022) · Molecular Biology Reports · doi:10.1007/s11033-021-07039-9 · Cited by 15

In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum

Okokon, J. E., Etuk, I. C., Thomas, P. S., Drijfhout, F. P., Claridge, T. D. W., & Li, W. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113153 · Cited by 15

Development and Validation of Sensitive HPLC-UV-DAD Method for Determination of Diosgenin in Plants of Species of Dioscorea Genus

da Silva, L. R. G., Cheibub, A. M. D. S. S., Valverde, A. L., & Netto, A. D. P. (2019) · Revista Virtual de Química · doi:10.21577/1984-6835.20190090

DIOSGENIN: AN INTEGRATED REVIEW OF CHEMICAL RESEARCH, ANALYTICAL TECHNIQUES, AI APPLICATIONS, AND SAFETY: A Comprehensive Review

Meghana, D., Bhavana, A., Kasthuri, B., Nikhila, A., Yaswanth, A., Chowdary, D. Y. A., & Madhuri, M. V. B. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.23011253

Estimation of Diosgenin by HPLC in a Dioscorea zingiberensis Collection from Different Local Markets in Middle and South Iraq

Al-Yassiry, Z. A. N., Jebor, M. A., & Al-Alwani, B. (2024) · International Journal of Scientific Research in Biological Sciences

Development and Validation of an HPLC Method for Diosgenin, A Bioactive Compound in the Rhizomes of Chamaecostus cuspidatus

Saliya, H., Madam, J., Patel, H. D., Lakhani, M., Patel, V., Shah, L., Vyas, V., & Shah, M. B. (2025) · Pharmacognosy Research · doi:10.5530/pres.20252199 · Cited by 1

Method Development for Quantitative Determination of Diosgenin from the Seeds of Fenugreek, Trigonella foenum-graecum L.

Sukhanov, A. E., Ставрианиди, А. Н., Кубасова, Е. Д., Panasyuk, A. S., & Buyuklinskaya, O. V. (2020) · Drug development & registration · doi:10.33380/2305-2066-2020-9-3-150-156