The DOI matches its Crossref record; 207 of the 207 references it cites were found in a registry or an index.
Roles of Zinc Signaling in the Immune System
Open accessAbstract
Zinc (Zn) is an essential micronutrient for basic cell activities such as cell growth, differentiation, and survival. Zn deficiency depresses both innate and adaptive immune responses. However, the precise physiological mechanisms of the Zn-mediated regulation of the immune system have been largely unclear. Zn homeostasis is tightly controlled by the coordinated activity of Zn transporters and metallothioneins, which regulate the transport, distribution, and storage of Zn. There is growing evidence that Zn behaves like a signaling molecule, facilitating the transduction of a variety of signaling cascades in response to extracellular stimuli. In this review, we highlight the emerging functional roles of Zn and Zn transporters in immunity, focusing on how crosstalk between Zn and immune-related signaling guides the normal development and function of immune cells.
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Cites
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Cabot, C., Martos, S., Llugany, M., Gallego, B., Tolrà, R., & Poschenrieder, C. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01171 · Cited by 363
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Metadata
- Authors
- Hojyo, S., & Fukada, T.
- Venue
- Journal of Immunology Research
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-21
- ISSN
- 2314-7156 (ISSN-L)
- 2314-8861
- OpenAlex
- W2545530165
- Cited by
- 294
- References
- 207
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
