The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Role of Gut Microbiota in the Aetiology of Obesity: Proposed Mechanisms and Review of the Literature
Open accessAbstract
The aetiology of obesity has been attributed to several factors (environmental, dietary, lifestyle, host, and genetic factors); however none of these fully explain the increase in the prevalence of obesity worldwide. Gut microbiota located at the interface of host and environment in the gut are a new area of research being explored to explain the excess accumulation of energy in obese individuals and may be a potential target for therapeutic manipulation to reduce host energy storage. Several mechanisms have been suggested to explain the role of gut microbiota in the aetiology of obesity such as short chain fatty acid production, stimulation of hormones, chronic low-grade inflammation, lipoprotein and bile acid metabolism, and increased endocannabinoid receptor system tone. However, evidence from animal and human studies clearly indicates controversies in determining the cause or effect relationship between the gut microbiota and obesity. Metagenomics based studies indicate that functionality rather than the composition of gut microbiota may be important. Further mechanistic studies controlling for environmental and epigenetic factors are therefore required to help unravel obesity pathogenesis.
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Cites
1 retracted
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RetractedAn obesity-associated gut microbiome with increased capacity for energy harvest
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Human gut microbes associated with obesity
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The gut microbiota as an environmental factor that regulates fat storage
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Obesity alters gut microbial ecology
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Host-Bacterial Mutualism in the Human Intestine
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Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
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Microbiota and SCFA in lean and overweight healthy subjects
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Cited by
Cuevas-Sierra, A., Ramos-Lopez, O., Riezu-Boj, J. I., Milagro, F. I., & Martinez, J. A. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy078 · Cited by 523
Mohr, A. E., Jäger, R., Carpenter, K. C., Kerksick, C. M., Purpura, M., Townsend, J. R., West, N. P., Black, K., Gleeson, M., Pyne, D. B., et al. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00353-w · Cited by 378
“is observed, leading to the chronic low-grade inflammation often implicated in obesity [69].”
BackgroundBenedé-Ubieto, R., Cubero, F. J., & Nevzorova, Y. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2331460 · Cited by 242
Cardiometabolic Benefits of Intermittent Fasting
Varady, K. A., Cienfuegos, S., Ezpeleta, M., & Gabel, K. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-052020-041327 · Cited by 186
Manca, C., Boubertakh, B., Leblanc, N., Deschênes, T., Lacroix, S., Martin, C., Houde, A., Veilleux, A., Flamand, N., Muccioli, G. G., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000424 · Cited by 152
Metadata
- Authors
- Khan, M. J., Gerasimidis, K., Edwards, C. A., & Shaikh, M. G.
- Venue
- Journal of Obesity
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-27
- ISSN
- 2090-0708 (ISSN-L)
- 2090-0716
- OpenAlex
- W2520965303
- Cited by
- 295
- References
- 26
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- gold
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- Khan, M. J., Gerasimidis, K., Edwards, C. A., & Shaikh, M. G. (2016). Role of Gut Microbiota in the Aetiology of Obesity: Proposed Mechanisms and Review of the Literature. Journal of Obesity. https://doi.org/10.1155/2016/7353642
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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