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miR-155 Regulated Inflammation Response by the SOCS1-STAT3-PDCD4 Axis in Atherogenesis
Open accessAbstract
Inflammation response plays a critical role in all phases of atherosclerosis (AS). Increased evidence has demonstrated that miR-155 mediates inflammatory mediators in macrophages to promote plaque formation and rupture. However, the precise mechanism of miR-155 remains unclear in AS. Here, we also found that miR-155 and PDCD4 were elevated in the aortic tissue of atherosclerotic mice and ox-LDL treated RAW264.7 cells. Further studies showed that miR-155 not only directly inhibited SOCS1 expression, but also increased the expression of p-STAT and PDCD4, as well as the production of proinflammation mediators IL-6 and TNF-α. Downregulation of miR-155 and PDCD4 and upregulation of SOCS1 obviously decreased the IL-6 and TNF-α expression. In addition, inhibition of miR-155 levels in atherosclerotic mice could notably reduce the IL-6 and TNF-α level in plasma and aortic tissue, accompanied with increased p-STAT3 and PDCD4 and decreased SOCS1. Thus, miR-155 might mediate the inflammation in AS via the SOCS1-STAT3-PDCD4 axis. These results provide a rationale for intervention of intracellular miR-155 as possible antiatherosclerotic targets.
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“Recently, it was shown that PDCD4 is also an important factor for inflammatory diseases such as asthma [86] and atherosclerosis [87,88].”
From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [88]
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Cites
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Tedgui, A., & Mallat, Z. (2006) · Physiological Reviews · doi:10.1152/physrev.00024.2005 · Cited by 1,751
Herrington, W. G., Lacey, B., Sherliker, P., Armitage, J., & Lewington, S. (2016) · Circulation Research · doi:10.1161/circresaha.115.307611 · Cited by 1,528
Accumulation of miR-155 and BIC RNA in human B cell lymphomas
Eis, P. S., Tam, W., Sun, L., Chadburn, A., Li, Z., Gomez, M. F., Lund, E., & Dahlberg, J. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500613102 · Cited by 1,322
Pervasive roles of microRNAs in cardiovascular biology
Small, E. M., & Olson, E. N. (2011) · Nature · doi:10.1038/nature09783 · Cited by 1,180
Sheedy, F. J., Palsson-McDermott, E., Hennessy, E. J., Martin, C., O'Leary, J. J., Ruan, Q., Johnson, D. S., Chen, Y., & O'Neill, L. A. J. (2010) · Nature Immunology · doi:10.1038/ni.1828 · Cited by 1,005
Inflammation in Atherosclerosis: Transition From Theory to Practice
Libby, P., Okamoto, Y., Rocha, V. Z., & Folco, E. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0706 · Cited by 799
Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
Siveen, K. S., Sikka, S., Surana, R., Dai, X., Zhang, J., Kumar, A. P., Tan, B. K. H., Sethi, G., & Bishayee, A. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.12.005 · Cited by 645
SOCS regulation of the JAK/STAT signalling pathway
Croker, B. A., Kiu, H., & Nicholson, S. E. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.010 · Cited by 633
Ouimet, M., Ediriweera, H. N., Gundra, U. M., Sheedy, F. J., Ramkhelawon, B., Hutchison, S. B., Rinehold, K., van Solingen, C., Fullerton, M. D., Cecchini, K., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81676 · Cited by 394
Regulation of the MIR155 host gene in physiological and pathological processes
Elton, T. S., Selemon, H., Elton, S. M., & Parinandi, N. L. (2013) · Gene · doi:10.1016/j.gene.2012.12.009 · Cited by 393
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- 2011, Science Signaling, 4
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Zhang, L., Zhang, L., Chen, H., & Xu, X. (2024) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2024.0059 · Cited by 4
Singh, A., Bhoumick, A., & Sen, P. (2025) · FEBS Journal · doi:10.1111/febs.70046 · Cited by 3
Rachmawati, E., Rohman, M. S., Sargowo, D., Kalsum, U., Lyrawati, D., & Lukitasari, M. (2021) · F1000Research · doi:10.12688/f1000research.74198.1 · Cited by 3
Bakhashab, S., Banafea, G. H., Ahmed, F., Bagatian, N., Subhi, O., Schulten, H.-J., & Pushparaj, P. N. (2024) · PLoS ONE · doi:10.1371/journal.pone.0314446 · Cited by 3
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Fan, F., & Shang, D.-J. (2026) · Metabolism Open · doi:10.1016/j.metop.2026.100459 · Cited by 1
She, J.-H., Yu, Y., Gao, B.-Y., Song, J.-Y., Cao, L., Wang, M., Yan, X.-L., Chang, L.-P., & Shi, G.-J. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1770481 · Cited by 1
Micromanaging Inflammation and Tissue Repair
Das, A., & Roy, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-820719-2.00021-1 · Cited by 1
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Bulls, V. (2023) · Science Insights · doi:10.15354/si.23.re570 · Cited by 1
Rachmawati, E., Rohman, M. S., Sargowo, D., Kalsum, U., Lyrawati, D., & Lukitasari, M. (2023) · F1000Research · doi:10.12688/f1000research.74198.3 · Cited by 1
Shafieipour, S., & Mohammadtaghizadeh, M. (2024) · Human Gene · doi:10.1016/j.humgen.2024.201277 · Cited by 1
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Фанилевич, Г. И., Beylerli, O., & Alyshov, A. B. (2020) · HERALD of North-Western State Medical University named after I I Mechnikov · doi:10.17816/mechnikov202012111-20 · Cited by 1
MicroRNAs and immunomodulation by vitamin D
Li, D. (2019) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1
Deciphering the Molecular Role of Non-coding RNA in Malignant Cardiac Disease
(2020) · Biointerface Research in Applied Chemistry · doi:10.33263/briac114.1174711764
Rachmawati, E., Rohman, M. S., Sargowo, D., Kalsum, U., Lyrawati, D., & Lukitasari, M. (2023) · F1000Research · doi:10.12688/f1000research.74198.2
Decoding the Interplay of Genes and MicroRNAs in Cardiovascular Disease
Gholamzad, A., Moulaeian, M., Khatibi, M., Nourikhani, M., Gholamzad, M., & Goudarzi, Y. (2023) · Journal de Téhéran · doi:10.61186/jhgg.7.1.2
The role of the therapeutic potential of noncoding RNAs in fungal keratitis. A studies review
Nami, S., Marofi, F., Hazratian, T., Spotin, A., Tapeh, B. E. G., Torab, Z., & Hassanpour, P. (2023) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000357
Sadeghi, T., Zaki‐Dizaji, M., Dolatabad, M. R., & Taheri, Z. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01619-3
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Panchakshari, P. M., Charmanna, S. O., Srinivasa, S., & Santhekadur, P. K. (2026) · SAGE Open Medicine · doi:10.1177/20503121261416802
Cong, C., Wang, Y., & Liu, J. S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1746043
Byeon, H. W., Choi, J., Cho, H. W., Kim, H. J., Park, S. O., Uyangaa, E., Kim, K., & Eo, S. K. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1818106
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Gao, X., Zhang, J., Kong, X., Xue, Y., & Fan, W. (2026) · Inflammation · doi:10.1007/s10753-026-02551-1 · Cited by 1
Zhang, R., Wu, Y., Kou, T., Liu, Y., Chen, H., Li, R., & Liu, Y. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103460
Regulatory role of noncoding RNAs in infections caused by Rhabdoviridae family viruses
Mohammadzadeh, F. Z., Nabavi, A., & Karimian, M. (2026) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2026.105991
Programmed cell death protein 4 (PDCD4): a pleiotropic regulator in cardiovascular diseases
Zheng, M., & Jiang, X. (2026) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-026-01237-4
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Metadata
- Authors
- Ye, J., Guo, R., Shi, Y., Qi, F., Guo, C., & Yang, L.
- Affiliations
- Army Medical University (CN)
- Kunming General Hospital of Chengdu Military Command (CN)
- Department of Cardiology, Kunming General Hospital of Chengdu Military Area, Yunnan 650032, China
- Corresponding author
- Yang, Lixia
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-14
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC5098093
- OpenAlex
- W2533066341
- Cited by
- 127
- References
- 49
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 14 · 2023: 19 · 2022: 11 · 2021: 9 · 2020: 21 · 2019: 18 · 2018: 8 · 2017: 5
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- miR-155, atherosclerosis, atherogenesis, inflammation, SOCS1, STAT3, PDCD4, macrophages, interleukin-6, TNF-α, oxidized LDL, microRNA
- MeSH terms
- RAW 264.7 Cells, Suppressor of Cytokine Signaling 1 Protein, Animals, Aorta, Apolipoproteins E, Inflammation, Male, Tumor Necrosis Factor-alpha, Signal Transduction, RNA-Binding Proteins, RNA, Small Interfering, MicroRNAs, Atherosclerosis, STAT3 Transcription Factor, Apoptosis Regulatory Proteins, Mice
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